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RISS 인기검색어
- 검색키워드
- 저자 : Jianwen Guo (검색결과 3 건)
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Shuhui Guo,Jianmin Chen,Ye Yang,Xiaolu Li,Yun Tang,Yuchang Gui,Jianquan Chen,Jianwen Xu 대한척추신경외과학회 2023 Neurospine Vol.20 No.3
Objective: Electroacupuncture (EA) has a definite effect on the treatment of spinal cord injuries (SCIs), but its underlying molecular mechanism remains unclear. Meanwhile, MiR-106b-5p is an autophagy- and apoptosis-related microribonucleic acid, but whether it regulates the progression of autophagy and apoptosis in SCIs is yet undetermined. As such, this study aimed to elucidate the involvement of miR-106b-5p in the EA treatment of an SCI. Methods: The miR-106b-5p level was detected by quantitative real-time polymerase chain reaction. In vitro, SH-SY5Y cells were transfected with miR-106b-5p mimics or inhibitors to regulate the miR-106b-5p expression, while in vivo, SCI rats were treated with EA for 7 days at the bilateral Zusanli (ST36) and Jiaji (EX-B2) acupoints. The motor function was evaluated using the Basso-Beattie-Bresnahan (BBB) criteria. Further, autophagic vacuoles, pathological damage, and neuronal cell morphology were observed by transmission electron microscopy, as well as by hematoxylin and eosin and Nissl staining, respectively. Results: The miR-106b-5p level, which can interact directly with Beclin-1 by influencing its expression, as well as the expressions of P62, Caspase-3, and Bax, was upregulated after an SCI, but it decreased after EA. Moreover, the ratio of LC3-II to LC3-I was upregulated after EA. EA can enhance autophagy, reduce neuronal apoptosis, and minimize motor dysfunction and histopathological deficits after an SCI. More importantly, however, all the above effects induced by EA can be reversed after an injection of miR-106-5p agomir to produce an overexpression of miR-106b-5p. Conclusion: EA treatment could downregulate miR-106b-5p to alleviate SCI-mediated injuries by promoting autophagy and inhibiting apoptosis.
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Autonomous exploration for radioactive sources localization based on radiation field reconstruction
Xulin Hu,Junling Wang,Jianwen Huo,Ying Zhou,Yunlei Guo,Li Hu Korean Nuclear Society 2024 Nuclear Engineering and Technology Vol.56 No.4
In recent years, unmanned ground vehicles (UGVs) have been used to search for lost or stolen radioactive sources to avoid radiation exposure for operators. To achieve autonomous localization of radioactive sources, the UGVs must have the ability to automatically determine the next radiation measurement location instead of following a predefined path. Also, the radiation field of radioactive sources has to be reconstructed or inverted utilizing discrete measurements to obtain the radiation intensity distribution in the area of interest. In this study, we propose an effective source localization framework and method, in which UGVs are able to autonomously explore in the radiation area to determine the location of radioactive sources through an iterative process: path planning, radiation field reconstruction and estimation of source location. In the search process, the next radiation measurement point of the UGVs is fully predicted by the design path planning algorithm. After obtaining the measurement points and their radiation measurements, the radiation field of radioactive sources is reconstructed by the Gaussian process regression (GPR) model based on machine learning method. Based on the reconstructed radiation field, the locations of radioactive sources can be determined by the peak analysis method. The proposed method is verified through extensive simulation experiments, and the real source localization experiment on a Cs-137 point source shows that the proposed method can accurately locate the radioactive source with an error of approximately 0.30 m. The experimental results reveal the important practicality of our proposed method for source autonomous localization tasks.
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Dabao Fan,Daxing Zeng,Ya Liu,Wenjuan Lu,Yulei Hou,Zirong Zhou,Jianwen Guo 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.4
This study investigates the factors affecting the topology of Rubik’s cube mechanism (RCM) and presents the synthesis theory of RCM. First, the revolute axis symmetry of the RCM is described and analyzed, and the general expression needed for the revolute axis to meet the symmetry is introduced. Next, the symmetry expression of the revolute pair contact surface (RPCS) of the RCM is given. The intersection between the RPCSs is analyzed via the adjacency matrix, and the adjacency matrix characteristics are given along with the motion characteristics of RCM. After determining the RPCS intersection, its topology is studied. Finally, the synthesis theory of RCM is presented, and the synthesis process and flowchart are proposed. The regular hexahedron RCMs with different topological structures are obtained after applying the synthesis theory. Hence, the theory proposed in this study provides strong theoretical support for the synthesis of other new RCMs.
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