파킨슨씨병 환자에서 편측 담창구파괴술의 효과

조우진,이경진,지철,박성찬,박해관,조정기,조경근,나형균,강준기,최창락,Cho, Woo Jin,Lee, Kyung Jin,Ji, Cheul,Park, Sung Chan,Park, Hea Kwan,Jo, Jung Ki,Cho, Kyung Keun,Rha, Hyung Kyun,Kang, Joon Ki,Choi, Chang Rak 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.8

Objectives : For Parkinsonian patients who had not reacted favorably on drug therapy are good candidate for ventroposterolateral pallidotomy, although not curative. We studied these patients after unilateral pallidotomy, to confirm the effectiveness and safety of this procedure. Methods : We evaluated the 17 patients with idiopathic Parkinson's diesease who had undergone unilateral posteroventral pallidotomy. All patients responded to levodopa initially. Mean age was 55 years(38-75years), and mean duration of disease was 9.8 years(3-20years). Pre-and postoperative evaluation at 3 month intervals included Unified Parkinson's Disease Rating scale(UPDRS) scoring, Hoehn and Yahr(H & Y) staging, and neuropsychological examinations. Results : Pallidotomy significantly improved parkinsonian symptom(tremor, rigidity, bradykinesia, dyskinesia, sensory symptom). Nine of 10 patients who showed dyskinesia preoperatively significant improvement. The mean dose of levodopa in 9 patients was lowered. The mean H & Y score and UPDRS score were improved in on and/or off time in 15 patients. Among patients who were not improved, one patient worsened, and the others showed no change. The mean overall UPDRS off score changed from 76 preoperatively to 44(33%) at 6 months and from 70 to 52(25%) at 1 year. Transient surgical morbidity was showen in four patients and included dysarthria, hypotonia and confusion. Conclusion : We conclude that pallidotomy is safe and effective in patients who have levodopa-reponsive parkinsonism with severe symptom fluctuation. Unilateral pallidotomy also considered helpful to ipsilateral symptom. Unilateral pallidotomy can improve all of parkinsonian's symptom and allow to reduce the levodopa medication. Most of patients show satisfactory results.

Usefulness of the Computed Tomography Venography for Evaluation of Leg Edema Including Deep Vein Thrombosis in Rehabilitation Patients

Ji Hea Chang,이호준,Jae Hyun Kwon,Gi Hyeong Ryu,Heebong Moon,Changjae Kim,남기연,권범선 대한재활의학회 2014 Annals of Rehabilitation Medicine Vol.38 No.6

Objective To investigate the usefulness of computed tomography venography (CTV) for evaluation of leg swelling, especially deep vein thrombosis (DVT), in rehabilitation patients.Methods A hundred twenty-three patients, who had performed CTV performed because of suspected DVT in our clinic, were enrolled. We performed chart reviews retrospectively and categorized CTV findings as follows: DVT distal to inguinal ligament and no compression lesion; DVT proximal to inguinal ligament and no compression lesion; DVT distal to inguinal ligament and anatomical variant (for example, May-Thurner syndrome); DVT due to compression of mass (cancer or cyst); DVT and other incidental abnormal finding; and no DVT and other possible causes of leg swelling.Results DVTs were found in 65 (53%) patients. DVTs were found at distal level (thigh or lower leg) to inguinal ligament in 47 patients. DVTs were found at proximal to inguinal ligament, usually undetectable with duplex ultrasonography, in 6 patients. DVTs caused by external compression, such as femoral vein and cancer mass, were found in 12 patients (10%), which are also not easily detected with duplex ultrasonography. Other various causes of leg edema without DVT were found in 22 (18%) patients.Conclusion CTV can evaluate more extensively venous problems in the pelvis and abdomen and detect other possible causes of leg swelling. Therefore, CTV can be a useful tool not only for easy detection of DVT but also for evaluating differential diagnosis of leg edema in rehabilitation patients.

수확 후 꼭지 유지, 제거에 따른 대추형 방울토마토의 품질 및 미생물 변화

최지원 ( Ji Weon Choi ),이우문 ( Woo Moon Lee ),도경란 ( Kyung Ran Do ),조미애 ( Mi Ae Cho ),김창국 ( Chang Kug Kim ),박미희 ( Me Hea Park ),김지강 ( Ji Gang Kim ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2013 한국식품저장유통학회지 Vol.20 No.1

Red-ripe ``Betatiny`` jujube-shaped cherry tomato fruits via stem maintenance or stem removal were stored at 20℃ for 12 days. Their quality and microbial safety parameters like their respiration rate, weight loss, soluble solids content, tiratable acidity, firmness, hue valus, aerobic microflra, coliform, yeast and mold count, and decay were evaluated during their storage. The jujube-shaped cherry tomato fruits whose stems were removed lost less weight than the fruies whose stems were maintained during their 12 days of storage. The stem removal lowered the resporation more significantly than the stem maintenance, and the formation of novel tissues at the stem scar that resulted from the stem removal was observed morphologically. The SSC, TA and hue value of the skin color decreased after eight storage days, but showed no difference between the stem maintenance and removal. The stem had higher microbial counts like aerobic microflora, coliform, and yeast and mold counts. The stem maintenance showed a short shelf-life because molds grew on the attached stem after five storage days. The shelf-life of the jujube-shaped cherry tomato fruits whose stems were removed was about eight days, but that of the fruits whose stems were maintained and that were stored at 20℃ was only about six days.

EGF Induced RET Inhibitor Resistance in <i>CCDC6-RET</i> Lung Cancer Cells

Chang, Hyun,Sung, Ji Hea,Moon, Sung Ung,Kim, Han-Soo,Kim, Jin Won,Lee, Jong Seok Yonsei University, College of Medicine 2017 Yonsei medical journal Vol.58 No.1

<P><B>Purpose</B></P><P>Rearrangement of the proto-oncogene <I>rearranged during transfection</I> (<I>RET</I>) has been newly identified potential driver mutation in lung adenocarcinoma. Clinically available tyrosine kinase inhibitors (TKIs) target RET kinase activity, which suggests that patients with <I>RET</I> fusion genes may be treatable with a kinase inhibitor. Nevertheless, the mechanisms of resistance to these agents remain largely unknown. Thus, the present study aimed to determine whether epidermal growth factor (EGF) and hepatocyte growth factor (HGF) trigger RET inhibitor resistance in LC-2/ad cells with <I>CCDC6-RET</I> fusion genes.</P><P><B>Materials and Methods</B></P><P>The effects of EGF and HGF on the susceptibility of a <I>CCDC6-RET</I> lung cancer cell line to RET inhibitors (sunitinib, E7080, vandetanib, and sorafenib) were examined.</P><P><B>Results</B></P><P><I>CCDC6-RET</I> lung cancer cells were highly sensitive to RET inhibitors. EGF activated epidermal growth factor receptor (EGFR) and triggered resistance to sunitinib, E7080, vandetanib, and sorafenib by transducing bypass survival signaling through ERK and AKT. Reversible EGFR-TKI (gefitinib) resensitized cancer cells to RET inhibitors, even in the presence of EGF. Endothelial cells, which are known to produce EGF, decreased the sensitivity of <I>CCDC6-RET</I> lung cancer cells to RET inhibitors, an effect that was inhibited by EGFR small interfering RNA (siRNA), anti-EGFR antibody (cetuximab), and EGFR-TKI (Iressa). HGF had relatively little effect on the sensitivity to RET inhibitors.</P><P><B>Conclusion</B></P><P>EGF could trigger resistance to RET inhibition in <I>CCDC6-RET</I> lung cancer cells, and endothelial cells may confer resistance to RET inhibitors by EGF. E7080 and other RET inhibitors may provide therapeutic benefits in the treatment of RET-positive lung cancer patients.</P>

Poster Session : PS 0907 ; Lower GI Tract : Clinical Course of Patients with Crohn`s Disease Diagnosed by Bowel Resection in Korea: Results from the Connect Study

( Ji Min Lee ),( Kang Moon Lee ),( Yoon Yung Chung ),( Dae Bum Kim ),( Hyewon Lee ),( Hea Jung Sung ),( Yeon Ji Kim ),( Woo Chul Chung ),( Chang Nyol Paik ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Backgound: The previous European studies revealed that early surgery led to a more stable clinical course than surgery performed during the course of disease.The aim of this study was to compare the clinical course of CD following bowel resection performed at the time of diagnosis (early surgery) and during the course of the disease (late surgery). Methods: Total 1337 medical records were reviewed in the population-based cohort database which includes CD patients diagnosed before 2009 in Korea. We selected data of patients who underwent bowel resection. Age, sex, disease phenotype, time of surgery, medication history such as corticosteroid, immunomodulators, and biologics, admission history, and further operation history were assessed. The Statistical analysis: Logistic regression, Gehan`s wilcoxon method and Cox`s proportional hazards regression model. Results: 278 CD patients who had undergone bowel resection were involved. Among them, 109 patients underwent surgery at the time of diagnosis, while 169 underwent surgery 90.31 months (range 1-277) after diagnosis. The mean follow-up period after surgery was 97.7 months (range 1-323). Use of systemic steroids and biologics is signifi cantly higher in late surgery group than early surgery group (p = 0.004, and 0.013, respectively). Higher use of immunomodulators was shown in late surgery group than early surgery group with borderline signifi cance (p = 0.061). Early surgery was associated with lower clinical recurrence represented by use of biologics (Wilcoxon test p=0.015).Early surgery and less use of steroids were independent variables associated with less use of biologics by multivariate analysis. Conclusion: Early surgery is associated with less use of steroids and maintains longer clinical remission period compared to late surgery.

Poster Session : PS 0973 ; Long Term Follow Up of Gallstone Associated Complication According to Management after Gallstone Pancreatitis

( Hea Jung Sung ),( Woo Chul Chung ),( Kang Moon Lee ),( Chang Nyol Paik ),( Dae Bum Kim ),( Ji Min Lee ),( Yoon Yung Chung ),( Hyewon Lee ),( Yeon Oh Jeong ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Gallstone pancreatitis (GSP) is a common condition, accounting for 30-40% of all pancreatitis cases. The recommended therapy for reducing the risk of recurrent attack is cholecystectmoy, and endoscopic sphincterotomy (EST) is another therapeutic option after GSP. We aimed to access the long term results of GSP using cholecystectomy and endoscopic sphincterotomy. In addition, characteristics were evaluated when recurrent biliary symptoms happened. Methods: A consecutive series of patients who had GSP and more than 6 months follow up period were included. A total 171 episodes of AGP were enrolled in 148 patients. Results: Mean follow up period was 58 month (range 6-360 month). For prevention of recurrent biliary event, 30 (18%) had a cholecystectomy, 46 (27%) had an EST, and 25 (15%) had both procedures. 66 patients had no defi nitive treatment. Recurrent biliary events (pancreatitis, cholangitis, biliary pain) happened in 2 patients of cholecystectomy following by EST and 3 patients of cholecystectomy group. In non-surgical group, 14 patients of EST group, and 22 patients of no treatment group suffered from recurrent biliary symptoms (P<0.01). Recurrent pancreatitis was happened in 2 patients of EST group and 17 patients of conservative group (3% vs 26%, P=0.03). There was only one case of recurrent pancreatitis with previous cholecystectomy with EST, but, no signifi cant benefi t compared with cholecystectomy only group. Conclusions: Cholecystectomy provide additional protection for recurrent GSP as well as other biliary events. In non-surgical patients, EST offers more protective effect for the further bouts of pancreatitis.

산모혈청 및 신생아 제대혈청내 동, 아연 농도에 관한 연구

이혜경,정지태,독고영창 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.3

The trace elements are so called because they constitute less than 0.01% of the weight of the human body however, despite their relative scarity, their atoms are present in large numbers and each is belived to play an important role in human growth and developement. In spite of their importance, the knowledge about it was a little, because of difficulties in measuring these substances. Introducing of Atomic Absorption Spectrophotometer has resulted in more increase in our understanding of the serum values and roles of trace elements, especially copper and zinc. There weren't any reference values for concentrations of copper and zinc, in maternal blood at delivery as well as cord blood in Korea. For 45 births, the concentrations of trace elements, copper and zinc, were determined in maternal and cord blood at delivery. The results were obtained as follow : 1) Copper level in maternal blood was 129.66±39.42㎍/dl. 2) Zinc level in maternal blood was 67.91±15.71㎍/dl. 3) Copper level in cord blood was 33.20±17.74㎍/dl. 4) Zinc level in cord blood was 67.33±17.70㎍/dl. 5) Copper concentration in maternal blood was 4 times higher than copper concentration in cord blood, but there weren't statistically significant correlatioins.

Poster Session : PS 0968 ; The Implications of a Positive Glucose Breath Test in Patients with Cholecystectomy

( Yeon Ji Kim ),( Hea Jung Sung ),( Hyewon Lee ),( Yeon Oh Jeong ),( Yoon Yung Chung ),( Dae Bum Kim ),( Ji Min Lee ),( Woo Chul Chung ),( Kang Moon Lee ),( Chang Nyol Paik ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Small intestinal bacterial overgrowth (SIBO) could be associated with postcholecystectomy patients. We aim to evaluate prevalence and characteristics of SIBO in patients with intestinal symptoms according to the history of cholecystectomy Methods: Sixty-two postcholecystectomy patients and 145 functional gastrointestinal disease (FGID) patients, and 30 healthy controls undergoing hydrogen (H2)-methane (CH4) glucose breath test (GBT) were reviewed. The GBT positivity (+) indicating the presence of SIBO, gas types and bowel symptoms were surveyed. Results: The GBT + were signifi cantly higher in postcholecystectomy patients (46.8%) than those in FGID patients (26.2%) (p < 0.01), or those in controls (13.3%) (p < 0.01), respectively. In the gas types, the GBT (H2) + in postcholecystectomy patients was signifi cantly higher than those in FGID patients (43.5% vs. 20%, p = 0.02). The positivity to fasting GBT (H2) among the GBT + patients with cholecystectomy was 76% (22 of 29), as diagnosed by elevated fasting H2 level. The GBT + group had higher symptom scores in abdominal discomfort, bloating, chest discomfort, early satiety, nausea and tenesmus, than those of the GBT - group Conclusions: The SIBO with high levels of baseline H2 might be the important etiologic factor of upper intestinal symptoms for postcholecystectomy patients

공진단(供辰丹)이 알츠하이머형 치매 환자에게 미치는 영향

정효창 ( Hyo Chang Jung ),장하정 ( Ha Jeong Jang ),성우용 ( Woo Yong Sung ),이승현 ( Seung Hyun Lee ),손지형 ( Ji Hyung Son ),한승헤 ( Seung Hea Han ) 대한한방신경정신과학회 2004 동의신경정신과학회지 Vol.15 No.2

요부 테이핑 처치가 남성 고등학교 유도선수의 등속성 근기능, 체력 및 정적·동적 균형에 미치는 영향

김창균(Kim, Chang-Gyun),강민정(Kang, Min-Jung),안지영(Ahn, Ji-Young),이진석(Lee, Jin-Seok),박해찬(Park, Hea-Chan),윤성진(Yoon, Sung-Jin) 한국체육과학회 2018 한국체육과학회지 Vol.27 No.5

The purpose of this study was to investigate the effects of lumbar elastic taping treatment on isokinetic function, fitness, static and dynamic balance in high school judo players. Sixteen high school judo players participated in a lumbar elastic taping treatment, control treatment at weekly intervals, respectively. Also, subjects performed isokinetic function, fitness, balance measurement according to each treatment. As a results, 120°/sec flexor peak torque was the higher in lumbar elastic taping treatment than in control treatment. Leg anterior/posterior index(API) was the lower in lumbar elastic taping treatment than in control treatment. Right leg overall stability index(OSI), left leg OSI, Right leg API, left leg API, Right leg medial/lateral index(MLI) were the lower in lumbar elastic taping treatment than in control treatment, respectively. Back strength was the higher in lumbar elastic taping treatment than in control treatment. In conclusion, lumbar elastic taping treatment is effective for dynamic balance, and may be a positive lumbar strength and power.