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Jang, Young Kyoung,Lyoo, Chul Hyoung,Park, Seongbeom,Oh, Seung Jun,Cho, Hanna,Oh, Minyoung,Ryu, Young Hoon,Choi, Jae Yong,Rabinovici, Gil D.,Kim, Hee Jin,Moon, Seung Hwan,Jang, Hyemin,Lee, Jin San,Jag Springer-Verlag 2018 European journal of nuclear medicine and molecular Vol.45 No.3
<P>Conclusions AV-1451 is more sensitive and specific to Alzheimer's disease type tau and shows lower off-target binding, while THK5351 may mirror non-specific neurodegeneration.</P>
Jang Hyemin,Na Moonkyong,Bahng Wook,Lee Jung Woo 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.80 No.2
Diamond is a promising material for next-generation power electronic devices used in high voltage and high temperature, but intrinsic defects introduced during the growth cause the degradation of electrical properties. There is a need to improve the crystal defect analysis method of analyzing large areas as non-destructive. Herein, the inclination of threading dislocations in an on-axis single-crystal free-standing diamond grown by microwave plasma-enhanced chemical vapor deposition (MPCVD) was analyzed using synchrotron white beam X-ray topography (SWBXRT). The majority of dislocations in CVD-grown diamond were known as [001] threading dislocation; however, SWBXRT indicated that the dislocations were not exact [001], but inclined from [001] direction. Dislocation inclination vector was calculated by g = <444> diffraction images, which determined direction and angle from [001] direction. The exact [001] dislocation accounted for 20% of investigated dislocations, and the remaining dislocations inclined randomly from the [001] direction with 7°–12°. The threading dislocations in the off-axis sample inclined in a particular direction due to step-flow dominant growth. The sample analyzed in this paper has no dependence on a particular direction due to localized step-flow caused by on-axis growth. Threading dislocations in an on-axis diamond inclined with a similar degree of well-controlled off-axis sample.
Hyemin Lim,Sung Han Park,A-Ram Kim,Hyeon-So Ji,Ung-Han Yoon,Tae-Ho Kim,Soo-Chul Park,Jang-Ho Hahn,Gang-Seob Lee 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
In plants, the Dof (DNA binding with One Finger) proteins are plant-specific transcription factors with a particular class of zinc-finger DNA-binding domain. The Dof genes have been predicted 30 different Dof genes in the rice Oryza sativa genome by phylogenetic analysis. The mostly Dof proteins contain a conserved region of 50 amino acids with a C2-C2 zinc finger motifs that binds a cis-regulatory element sequence 5’-T/AAAAG-3’. We found that a member of the DOF transcription factor family, Dof1 gene of rice, was expressed to wound from Ds insertion mutant population. Sequencing of the flanking regions of the transposon insertion site indicated that the gene-trap had been inserted near the front of the second exon of OsDof1 gene in chromosome 7. Genomic southern analysis revealed that mutant line contained a single copy of Ds gene trap. The Ds tagged rice mutant line, OsDof1::Ds, wound-inducible GUS expression was identified. To analyze the cis-acting elements, we constructed fusion genes with the OsDof1 promoter fused to the β-glucuronidase (GUS) reporter gene and transformed Arabidopsis and rice plants with these constructs. Wound-induced GUS expression was observed in the leaves of transgenic OsDof1::GUS rice and Arabidospsis plants. These results showed that, OsDof1 protein might be involved in stress responses and growth regulation in plant, might plays a role as a transcription regulator in stress response signal transduction pathways of plant.
Renal infarction caused by paradoxical embolism through a patent foramen ovale
( Hyemin Jeong ),( Hyun Woo Lee ),( Ji Young Joung ),( Yoon Young Cho ),( Dongmo Je ),( Kyungmin Huh ),( Hye Ryoun Jang ),( Wooseong Huh ) 대한신장학회 2012 Kidney Research and Clinical Practice Vol.31 No.3
A 48-year-old man presented with acute right flank pain. A computed tomography scan revealed right renal infarction. Because he had no thrombosis in the renal vessels and no clear embolic source, a further examination was performed to find the cause of the renal infarction. On transesophageal echocardiography, a right- to-left shunt during the Valsalva maneuver established a diagnosis of patent foramen ovale. This is a case of paradoxical embolism through a PFO leading to renal infarction.
Kim, Hyemin,Kim, Dongkyu,Jang, Mi-Jin,Han, Yong-Mahn Elsevier 2012 Biochemical and biophysical research communication Vol.424 No.2
<P>Pluripotent stem cells (PSCs) have unique transcriptional regulatory networks and epigenetic states that are involved in maintaining pluripotency. In this study, the transcriptional levels and histone modifications of lineage-specific genes were compared for human ESC (hESC) lines and human induced pluripotent stem cell (hiPSC) lines. Expression of the pluripotency marker genes, OCT4, SOX2, and NANOG, was largely modulated in hESCs by permissive histone marks, whereas hiPSC lines showed differential histone modifications in the gene promoters. The permissive histone mark, H3K4me3, predominantly contributed to expression of the oncogene, c-MYC, in hESC lines, whereas histone modifications of the c-MYC promoter varied between hiPSC lines. Interestingly, the transcriptional levels and epigenetic marks in the promoters of the developmental genes such as SOX17, T, and NESTIN varied among individual hiPSC lines. In particular, a partially-reprogrammed hiPSC cell line showed lower frequencies of permissive and repressive histone marks in the promoters of most genes, indicating incomplete epigenetic reprogramming. Our data indicate that respective hPSCs have distinct epigenetic signatures of lineage-specific genes, thereby leading to in their propensities to follow a particular differentiation pathway.</P>
Pathogenic Characteristics and Antibiotic Resistance of Bacterial Isolates from Farmstead Cheeses
Kyeonga Jang,Jeeyeon Lee,Heeyoung Lee,Sejeong Kim,Jimyeong Ha,Yukyung Choi,Hyemin Oh,Yohan Yoon,Soomin Lee 한국축산식품학회 2018 한국축산식품학회지 Vol.38 No.1
The objective of this study was to investigate the pathogenicity and antimicrobial resistance of foodborne pathogens isolated from farmstead cheeses. Twenty-seven isolates, including 18 Bacillus cereus, two Escherichia coli, and seven Staphylococcus aureus, were subjected to polymerase chain reaction (PCR) to detect virulence genes and toxin genes, and the antibiotic resistances of the isolates were determined. All E. coli isolates were determined by PCR to be non-pathogenic. Among the 18 B. cereus isolates, 17 isolates (94.4%) were diarrheal type, as indicated by the presence of nheA, entFM, hbIC, cytK and bceT genes, and one isolate (5.6%) was emetic type, based on the presence of the CER gene. Among the seven S. aureus isolates, three (42.9%) had the mecA gene, which is related to methicillin-resistance. Most B. cereus isolates (94.7%) showed antibiotic resistance to oxacillin and penicillin G, and some strains also showed resistance to ampicillin (26.3%), erythromycin (5.3%), tetracycline (10.5%), and vancomycin (5.3%). These results indicate that microbial food safety measures for farmstead cheese must be implemented in Korea because antibiotic resistant foodborne pathogens, with resistance even to vancomycin, harboring virulence genes were found to be present in the final products of farmstead cheese.
인슐레이터&스트럿베어링 설계인자별 조립(압입력/이탈력) 영향성 연구
안혜민(Hyemin Ahn),장민(Min Jang) 한국자동차공학회 2023 한국자동차공학회 학술대회 및 전시회 Vol.2023 No.11
Strutbearing is typically applied in conjunction with Macpherson sturt. This is Because the Strut comple is directly fixed at Knuckle that has rotational motion by moving of Steering wheel. Strutbearing is positioned next to the insulator. So Fit-in force and Fit-out force between two parts affect directly on assembly facilities, working conditions and quality-related issues. This is why we should to consider engineering the assembly concept. This paper aims to establish reference data of design specification by building up the quantitative Data Base of design factors for engineering assembly concept. In this paper, We set up the major design factors and level which are related to assembly concept and then combine them in various cases for engineering analysis and experiment focusing on fit-in force and fit-out force. Consequently, We checked the correlation as quantitative D/B between design factors and both forces, and the side effect from some design factors