Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction

Jai-Wun Park,허애영 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.6

Not available

Intraoperative Diagnosis Support Tool for Serous Ovarian Tumors Based on Microarray Data Using Multicategory Machine Learning :

Park, Jee Soo,Choi, Soo Beom,Kim, Hee Jung,Cho, Nam Hoon,Kim, Sang Wun,Kim, Young Tae,Nam, Eun Ji,Chung, Jai Won,Kim, Deok Won Blackwell Scientific Publications 2016 International journal of gynecological cancer Vol.26 No.1

<P>Objectives Serous borderline ovarian tumors (SBOTs) are a subtype of serous ovarian carcinoma with atypical proliferation. Frozen-section diagnosis has been used as an intraoperative diagnosis tool in supporting the fertility-sparing surgery by diagnosing SBOTs with accuracy of 48% to 79%. Using DNA microarray technology, we designed multicategory classification models to support frozen-section diagnosis within 30 minutes. Materials and Methods We systematically evaluated 6 machine learning algorithms and 3 feature selection methods using 5-fold cross-validation and a grid search on microarray data obtained from the National Center for Biotechnology Information. To validate the models and selected biomarkers, expression profiles were analyzed in tissue samples obtained from the Yonsei University College of Medicine. Results The best accuracy of the optimal machine learning model was 97.3%. In addition, 5 features, including the expression of the putative biomarkers SNTN and AOX1, were selected to differentiate between normal, SBOT, and serous ovarian carcinoma groups. Different expression levels of SNTN and AOX1 were validated by real-time quantitative reverse-transcription polymerase chain reaction, Western blotting, and immunohistochemistry. A multinomial logistic regression model using SNTN and AOX1 alone was used to construct a simple-to-use equation that gave a diagnostic test accuracy of 91.9%. Conclusions We identified 2 biomarkers, SNTN and AOX1, that are likely involved in the pathogenesis and progression of ovarian tumors. An accurate diagnosis of ovarian tumor subclasses by application of the equation in conjunction with expression analysis of SNTN and AOX1 would offer a new accurate diagnosis tool in conjunction with frozen-section diagnosis within 30 minutes.</P>

제왕절개술시 감염예방을 위한 Cephradine자궁내 세척법과 정맥내 주입법의 비교연구

최재동,김종욱,이태형,박완석,이승호,정원영 영남대학교 의과대학 1985 Yeungnam University Journal of Medicine Vol.2 No.1

1985년 3월 1일부터 영남대학교 의과대학 부속병원 산부인과에서 제왕절개술로 분만한 예중 적응이 되는 예에서 Velosef의 자궁강내 세척을 실시한 30예, 정맥주입을 한 35예와 대조군 35예로 총 100예를 연구대상으로 하여 수술후 자궁내 막염 및 감염의 발생빈도를 비교 분석하였고, 연구대상자에 대한 fever index를 산출 비교하여 다음과 같은 연구 결과를 얻었다. 1.역학적 변수에서 Velosef자궁강내 세척군과 Velosef정맥주입군, 대조군 각각은 통계적으로 유의한 차이를 보이지 않음으로써 세 연구군은 서로 유사하였다. 2.감염에 대한 위험인자에서도 각 실험군과 대조군은 통계적으로 유의한 차이를 보이지 않음으로써 연구집단은 서로 감염에 대한 위험인자 분포가 유사하였다. 3.제왕절개술의 적응증에 있어서도 각 실험군과 대조군에서 유사한 분포를 보였으며, 기왕제왕절개술, 아두골반불균형, 둔위 등의 순서를 많았다. 4.수술후 자궁내막염의 발생빈도는 대조군보다 정맥주입군과 자궁강내 세척군이 낮았으며 특히 정맥주입군은 대조군과 통계적으로 유의성을 보였다 (x²= 6.428, d.f. = 1, p<0.05). 5.자궁내막염을 포함한 수술후 감염에서도 정맥주입군, 자궁강내 세척군에서 대조군보다 낮은 발생빈도를 보였으며, 특히 정맥주입군에서 대조군과 통계적으로 유의한 차이를 보였다 (x²= 5.352, d.f. = 1, p<0.05). 6. Fever index는 자궁강내 세척군, 정맥주입군 모두가 대조군에 비해 통계적으로 유의한 차이를 보였다 (t= -3.251, d.f. = 68, p<0.05). 7.수술적응증에 따른 수술후 자궁내막염 발생 빈도에서, 특히 기왕제왕절개술과 아두골반불균형에서 실험군이 대조군에 비해 낮은 경향을 보였다. 8.감염에 대한 위험인자 별 자궁내막염 발생 빈도에서는 진통이 있는 경우, 6시간 이상의 양수파막, 5번 이상의 내진, 응급제왕절개술의 경우에 대조군보다 각 실험군에서 자궁내막염 발생 빈도가 현저히 낮았다. 9.연구대상의 fever index산포도에서 임상적으로 자궁내막염으로 진단된 경우 높은 fever index 수치를 보였다. Febrile morbidity after cesarean section is one of the major problems in obstetric practice. This morbidity is most often due to endometritis. Although parenteral prophylactic antibiotics or antibiotics irrigation has been reported to reduce the incidence of endometritis after cesarean section, its incidence remains high. Among the patients who were undergoing cesarean section at Yeungnam University Hospital form the beginning of March, 1985, three group were evaluated in the orders. 1)30 cases as intrauterine irrigation group with cephradine solution, 2)35 cases as intravenous injection group with cephradine, 3)35 cases as control group are neither irrigated nor injected. Febrile morbidity was also evalutted by means of a fever index. The incidence of clinically diagnosed endometritis in the three group were 6.7%, 2.9%, and 22.9%. As these results, two study groups were markedly reduced the incidence of endometritis than control group. There was no significant difference between the intravenous cephradine injection and control(P<0.05). With the results of fever index analysis, both prophylactic intrauterine irrigation and intravenous injection markedly reduce the incidence of endometritis after cesarean section with stastical significance (P<0.05), and also markedly reduce the febrile degree. .

Cardioembolic Stroke in Atrial Fibrillation-Rationale for Preventive Closure of the Left Atrial Appendage

Boris Leithäuser,Jai-Wun Park 대한심장학회 2009 Korean Circulation Journal Vol.39 No.11

Atrial fibrillation is the most common cardiac arrhythmias, and a major cause of morbidity and mortality due to cardioembolic stroke. The left atrial appendage is the major site of thrombus formation in non-valvular atrial fibrillation. Loss of atrial systole in atrial fibrillation and increased relative risk of associated stroke point strongly toward a role for stasis of blood in left atrial thrombosis, although thrombus formation is multifactorial, and much more than blood flow irregularities are implicated. Oral anticoagulation with vitamin-K-antagonists is currently the most effective prophylaxis for stroke in atrial fibrillation. Unfortunately, this treatment is often contraindicated, particularly in the elderly, in whom risk of stroke is high. Moreover, given the risk of major bleeding, there is reason to be skeptical of the net benefit when warfarin is used in those patients. This work reviews the pathophysiology of cardioembolic stroke and critically spotlights the current status of preventive anticoagulation therapy. Various techniques to exclude the left atrial appendage from circulation were discussed as a considerable alternative for stroke prophylaxis. Atrial fibrillation is the most common cardiac arrhythmias, and a major cause of morbidity and mortality due to cardioembolic stroke. The left atrial appendage is the major site of thrombus formation in non-valvular atrial fibrillation. Loss of atrial systole in atrial fibrillation and increased relative risk of associated stroke point strongly toward a role for stasis of blood in left atrial thrombosis, although thrombus formation is multifactorial, and much more than blood flow irregularities are implicated. Oral anticoagulation with vitamin-K-antagonists is currently the most effective prophylaxis for stroke in atrial fibrillation. Unfortunately, this treatment is often contraindicated, particularly in the elderly, in whom risk of stroke is high. Moreover, given the risk of major bleeding, there is reason to be skeptical of the net benefit when warfarin is used in those patients. This work reviews the pathophysiology of cardioembolic stroke and critically spotlights the current status of preventive anticoagulation therapy. Various techniques to exclude the left atrial appendage from circulation were discussed as a considerable alternative for stroke prophylaxis.

간경변증 및 간세포암 환자에 있어서 문맥의 원간성 혈류

최흥재(Heung Jai Choi),박인서(In Suh Park),이상인(Sang In Lee),김원호(Won Ho Kim),이문형(Moon Hyung Lee),정재복(Jae Bock Jung),윤여운(Yoe Wun Yoon) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3

N/A Hepatofugal flow (reversed flow) of portal vein is very rare, and its diagnosis is not so easy. Variable invasive procedures had been tried to demonstrate this rare hemodynamic change of portal vein, however there was many probrems in the routine clinical use of those procedures. Since clinical application of Doppler flowmetry system, repetitive observation of portal hemodynamics in physiologic condition has become easy. We observed 1 case of liver cirrhosis and 3 cases of bepatcellular carcinoma combined with liver cirrhosis who showed reversed flow of portal vein among 72 cases and 42 cases each other. All patients with hepatocellular carcinoma had thrombosis in main portal vein, and one of them showed hepatofugal flow of splenic vein. One patient with liver cirrhosis who had suffered spontaneous hepatic encephalopathy, had large splenorenal shunt and reversed flow of splenic vein.

재첩과 굴 패각의 소성 특성

박흥재(Heung Jai Park),이병호(Byung Ho Lee),이봉헌(Bong Hun Lee),정성욱(Seong Uk Jeong),정징운(Jing Wun Jeong),정운(Un Jeong) 大韓環境工學會 2001 대한환경공학회지 Vol.23 No.11

Oleifolioside B-mediated autophagy promotes apoptosis in A549 human non-small cell lung cancer cells

JIN, CHENG-YUN,YU, HAI YANG,PARK, CHEOL,HAN, MIN HO,HONG, SU HYUN,KIM, KYOUNG-SOOK,LEE, YOUNG-CHOON,CHANG, YOUNG-CHAE,CHEONG, JAEHUN,MOON, SUNG-KWON,KIM, GI-YOUNG,MOON, HYUNG-IN,KIM, WUN-JAE,LEE, JAI- Spandidos Publications 2013 International journal of oncology Vol.43 No.6

Oleifolioside A Mediates Caspase-Independent Human Cervical Carcinoma HeLa Cell Apoptosis Involving Nuclear Relocation of Mitochondrial Apoptogenic Factors AIF and EndoG

Yu, Hai Yang,Jin, Cheng-Yun,Kim, Kyoung-Sook,Lee, Young-Choon,Park, Shin-Hyung,Kim, Gi-Young,Kim, Wun-Jae,Moon, Hyung-In,Choi, Yung Hyun,Lee, Jai-Heon American Chemical Society 2012 Journal of agricultural and food chemistry Vol.60 No.21

<P>Apoptosis, the main type of programmed cell death, plays an essential role in a variety of biological events. Whereas “classical” apoptosis is dependent on caspase activation, caspase-independent death is increasingly recognized as an alternative pathway. To develop new anticancer agents, oleifolioside A was isolated from Dendropanax morbifera Leveille and the biochemical mechanisms of oleifolioside A-induced apoptosis in HeLa cells were investigated. Exposure to oleifolioside A resulted in caspase activation and typical features of apoptosis, although cell death was not prevented by caspase inhibition. Oleifolioside A treatment induced up-regulation of Bad, loss of mitochondrial membrane potential, nuclear relocation of mitochondrial factors, apoptosis-inducing factor (AIF), endonuclease G (EndoG), and apoptosis induction. This is the first report of anticancer activity of oleifolioside A, and nuclear translocation of AIF and EndoG in oleifolioside A-treated HeLa cells might represent an alternative death signaling pathway in the absence of caspase activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2012/jafcau.2012.60.issue-21/jf3014475/production/images/medium/jf-2012-014475_0006.gif'></P>