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Kim, Kyeong Seok,Yang, Hun Yong,Song, Hosup,Kang, Ye Rim,Kwon, JiHoon,An, JiHye,Son, Ji Yeon,Kwack, Seung Jun,Kim, Young-Mi,Bae, Ok-Nam,Ahn, Mee-Young,Lee, Jaewon,Yoon, Sungpil,Lee, Byung μ,Kim, Hyung TAYLOR & FRANCIS 2017 Journal of Toxicology and Environmental Health Vol.80 No.9
<P>Acute kidney injury (AKI) is associated with increased mortality rate in patients but clinically available biomarkers for disease detection are currently not available. Recently, a new biomarker, selenium-binding protein 1 (SBP1), was identified for detection of nephrotoxicity using proteomic analysis. The aim of this study was to assess the sensitivity of urinary SBP1 levels as an early detection of AKI using animal models such as cisplatin or ischemia/reperfusion (I/R). Sprague-Dawley rats were injected with cisplatin (6 mg/kg, once i.p.) and sacrificed at 1, 3, or 5 days after treatment. Ischemia was achieved by bilaterally occluding both kidneys with a microvascular clamp for 45 min and verified visually by a change in tissue color. After post-reperfusion, urine samples were collected at 9, 24, and 48 hr intervals. Urinary excretion of protein-based biomarkers was measured by Western blot analysis. In cisplatin-treated rats, mild histopathologic alterations were noted at day 1 which became severe at day 3. Blood urea nitrogen (BUN) and serum creatinine (SCr) levels were significantly increased at day 3. Levels of urinary excretion of SBP1, neutrophil gelatinase-associated lipocalin (NGAL), and a tissue inhibitor of metalloproteinase-1 (TIMP-1) were markedly elevated at day 3 and 5 following drug treatment. In the vehicle-treated I/R group, serum levels of BUN and SCr and AST activity were significantly increased compared to sham. Urinary excretion of SBP1 and NGAL rose markedly following I/R. The urinary levels of SBP1, NGAL, TIMP-1, and KIM-1 proteins excreted by AKI patients and normal subjects were compared. Among these proteins, a marked rise in SBP1 was observed in urine of patients with AKI compared to normal subjects. Based upon receiver-operator curves (ROC), SBP1 displayed a higher area under the curve (AUC) scores than levels of SCr, BUN, total protein, and glucose. In particular, SBP1 protein was readily detected in small amounts of urine without purification. Data thus indicate that urinary excretion of SBP1 may be useful as a reliable biomarker for early diagnosis of AKI in patients.</P>
Curcumin ameliorates cadmium-induced nephrotoxicity in Sprague-Dawley rats
Kim, Kyeong Seok,Lim, Hyun-Jung,Lim, Jong Seung,Son, Ji Yeon,Lee, Jaewon,Lee, Byung Mu,Chang, Seung-Cheol,Kim, Hyung Sik Elsevier 2018 Food and chemical toxicology Vol.114 No.-
<P><B>Abstract</B></P> <P>Chronic exposure to cadmium (Cd) causes remarkable damage to the kidneys, a target organ of accumulated Cd after oral administration. The aim of the present study was to investigate the protective effect of curcumin against Cd-induced nephrotoxicity. Sprague–Dawley male rats were divided into the following four treatment groups: control, curcumin (50 mg/kg, oral), CdCl<SUB>2</SUB>, (25 mg/kg, oral), and pre-treatment with curcumin (50 mg/kg) 1 h prior to the administration of CdCl<SUB>2</SUB> (25 mg/kg, oral) for 7 days. At 24 h after the final treatment, the animals were killed, and the biomarkers associated with nephrotoxicity were measured. Our data indicated that blood urea nitrogen (BUN) and serum creatinine (sCr) levels were significantly reduced by curcumin pre-treatment in CdCl<SUB>2</SUB>-treated animals. Histopathological studies showed hydropic swelling and hypertrophy of the proximal tubular cells in the renal cortex after Cd treatment. Pretreatment with curcumin ameliorated the histological alterations induced by Cd. The urinary excretion of kidney injury molecule-1 (Kim-1), osteopontin (OPN), tissue inhibitor of metalloproteinases 1 (TIMP-1), neutrophil gelatinase-associated lipocalin (NGAL), and netrin-1 significantly reduced by curcumin treatment compared to that in the CdCl<SUB>2</SUB>-treated group. The administration of curcumin provided a significant protective effect against Cd-induced nephrotoxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Curcumin protects against cadmium-induced renal injury. </LI> <LI> Curcumin reduces urinary excretion of AKI biomarkers. </LI> <LI> Curcumin protects against cadmium-induced apoptosis in the kidney. </LI> </UL> </P>
Kim, Seong Kwang,Shim, Jae-Phil,Geum, Dae-Myeong,Kim, Jaewon,Kim, Chang Zoo,Kim, Han-Sung,Song, Jin Dong,Choi, Sung-Jin,Kim, Dae Hwan,Choi, Won Jun,Kim, Hyung-Jun,Kim, Dong Myong,Kim, Sanghyeon Institute of Electrical and Electronics Engineers 2018 IEEE transactions on electron devices Vol.65 No.5
<P>In this paper, we fabricated In<SUB>0.53</SUB>Ga<SUB>0.47</SUB>As-on insulator (OI) MOSFETs on Si substrates with different doping types to mimic ground plane doping using direct wafer bonding and epitaxial lift-off (ELO) techniques. We investigated the impact of doping types on the ground plane and the backgate biasing, which are important and preferable components in monolithic 3-D (M3D) integration, on the electrical properties of MOSFETs, such as the threshold voltage ( <TEX>${V} _{T}$</TEX>) and the effective mobility ( <TEX>$\mu _{\textsf {eff}}$</TEX>). It was found that <TEX>${V} _{T}$</TEX> and <TEX>$\mu _{\textsf {eff}}$</TEX> were significantly modulated by the backsubstrate doping and the backbiasing. These observations were explained by the change of carrier distributions, which were confirmed by technology computer-aided design simulation. Furthermore, we investigated the reusability of InP donor substrates for sequential epitaxial growth after ELO process toward a cost-effective M3D integration with the In<SUB>0.53</SUB>Ga<SUB>0.47</SUB>As channel.</P>
Kim, Jaewon,Lee, Heesung,Kim, Seong Kwang,Kim, Junyeap,Park, Jaewon,Choi, Sung-Jin,Kim, Dae Hwan,Kim, Dong Myong IEEE 2016 IEEE transactions on electron devices Vol.63 No.11
<P>Separate extraction of source (RS) from drain resistance (RD) is important in the systematic modeling of electrical characteristics and investigation of physical mechanism related to the performance and reliability in MOSFETs and their integrated circuits. We report a hybrid open drain method (ODM), as a fully current-based characterization technique, for a comprehensive separation of asymmetric source and drain resistance components in a single MOSFET. In the hybrid ODM, the ODM through the parasitic bipolar transistor is combined with the dualsweep combinational transconductance technique, the channel resistance method, and the parasitic junction current method. We fully considered the asymmetry in the source and the drain possibly caused by the layout, process, and degradation under bias. We successfully extracted the resistance components with R-Se = 6.66-7.35 Omega, R-De = 7.64-8.34 Omega, RSo = 0.78-8.07 Omega, R-Do = 1.11-10.08 Omega, and R-SUB = 6.29-9.17 Omega in the n-channel MOSFETs. R-Se (R-De) is the VGS-independent external source (drain) resistance. R-So (R-Do) is the VGS-independent external spreading source (drain) resistance and RSi (RDi) is the VGS-dependent intrinsic source (drain) resistance, respectively. RSUB is the substrate resistance. The hybrid ODM is expected to be useful in the characterization of parasitic resistances in each MOSFET with asymmetry caused by the layout, process, and degradation without using multiple devices with different channel length (L) and width (W) for measurement.</P>
Heesung Lee,Junyeap Kim,Jaewon Kim,Seong Kwang Kim,Yongwoo Lee,Jae-Young Kim,Jun Tae Jang,Jaewon Park,Sung-Jin Choi,Dae Hwan Kim,Dong Myong Kim IEEE 2017 IEEE electron device letters Vol.38 No.5
<P>Amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) are investigated for a possible application to infrared (IR) photodetector through subgap density-ofstates over the forbidden bandgap. The origin of the sub-bandgap(hν <;E<SUB>g</SUB>) photo-response in a-IGZO TFTs is due to optically pumped electrons from the photo-responsive subgap states (E<SUB>C</SUB>-E<SUB>ph</SUB><;E<SUB>t</SUB><;E<SUB>F</SUB>). Among the sub-bandgap lights, we investigate the reproducible IR photo-response in a-IGZO TFTs as a photodetector without the persistent photoconductivity(PPC) effect. In this letter, we characterize the IR photo-response mechanism through various optical and electrical measurements on the wavelength, optical power, bias-modulated quasi-Fermi level, and photoresponsive states. This result is expected to provide independent and/or integrated IR detector with transparent substrate combined with a-IGZO TFTs.</P>
Jaewon KIM,Minyoul Kim,Mi-Jeong Lee,Yeon-Jung LEE,Hak Ryul Kim,Ju-Ock Nam,최문보,Dongyup Hahn 한국곤충학회 2020 Entomological Research Vol.50 No.1
The yellow-legged hornet, Vespa velutina nigrithorax, is an invasive social wasp found in temperate regions and is recognized as a hazardous insect, as it often attacks humans and honeybees. Nidus vespae (nests of social wasps) are traditionally used as a medicinal ingredient; thus, V. v. nigrithorax may be useful as a biological resource. Extracts of Nidus vespae built by V. v. nigrithorax were examined for their antibacterial activity screening against six food-borne pathogenic bacteria, and the ethyl acetate and butanol layer of the extract exhibited inhibitory activity against the pathogenic bacteria. We determined the antibacterial activity of Nidus vespae built by V. v. nigrithorax for the first time.
Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma
Kim, Suyeon,Kim, Jaewon,Jung, Yeonjoo,Jun, Yukyung,Jung, Yeonhwa,Lee, Hee-Young,Keum, Juhee,Park, Byung Jo,Lee, Jinseon,Kim, Jhingook,Lee, Sanghyuk,Kim, Jaesang Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.7
In this study, we describe a novel function of TNNC1 (Troponin C1, Slow Skeletal and Cardiac Type), a component of actin-bound troponin, as a tumor suppressor of lung adenocarcinoma (LUAD). First, the expression of TNNC1 was strongly down-regulated in cancer tissues compared to matched normal lung tissues, and down-regulation of TNNC1 was shown to be strongly correlated with increased mortality among LUAD patients. Interestingly, TNNC1 expression was enhanced by suppression of KRAS, and ectopic expression of TNNC1 in turn inhibited KRAS<SUP>G12D</SUP>-mediated anchorage independent growth of NIH3T3 cells. Consistently, activation of KRAS pathway in LUAD patients was shown to be strongly correlated with down-regulation of TNNC1. In addition, ectopic expression of TNNC1 inhibited colony formation of multiple LUAD cell lines and induced DNA damage, cell cycle arrest and ultimately apoptosis. We further examined potential correlations between expression levels of TNNC1 and various clinical parameters and found that low-level expression is significantly associated with invasiveness of the tumor. Indeed, RNA interference-mediated down-regulation of TNNC1 led to significant enhancement of invasiveness in vitro. Collectively, our data indicate that TNNC1 has a novel function as a tumor suppressor and is targeted for down-regulation by KRAS pathway during the carcinogenesis of LUAD.
Kim, Tae Hyung,Lee, Young Jun,Lee, Ena,Kim, Min Sun,Kwack, Seung Jun,Kim, Kyu Bong,Chung, Ki Kyung,Kang, Tae Seok,Han, Soon Young,Lee, Jaewon,Lee, Byung Mu,Kim, Hyung Sik Informa UK (TaylorFrancis) 2009 Journal of toxicology and environmental health. Pa Vol.72 No.21
<P>Polybrominated diphenyl ethers (PBDE) are a class of brominated flame retardants that are recognized as global environmental contaminants with potential adverse effects on human health. This study examined the effects of prenatal exposure to PBDE on reproductive organs, neuronal development, and levels of thyroid hormones. Pregnant rats were exposed to the vehicle or deca-bromodiphenyl ether (BDE) (BDE-209; 5, 40, or 320 mg/kg body weight/d) during gestation days (GD) 6-18. There was a significant decrease in body weight gain in F1 male offspring exposed to high-dose (320 mg/kg) BDE-209. Significant increases in thyroid weight and a decrease in adrenal weight were observed in high-dose BDE-209. Thyroxine (T4) concentrations were significantly lower in F1 female offspring exposed to BDE-209 at postnatal day (PND) 42. This reduction was more pronounced in the group exposed to higher doses. A low dose (5 mg/kg) of BDE-209 significantly reduced serum estradiol concentration in female offspring but did not affect testosterone levels in males. There was no significant effect on hippocampal neurogenesis in BDE-209 treatment groups. In conclusion, there was no apparent association between thyroid hormone concentrations and low birth weight in F1 rats after gestational exposure to BDE-209.</P>
Kim, Na Young,Kim, Tae Hyung,Lee, Ena,Patra, Nabanita,Lee, Jaewon,Shin, Mi Ok,Kwack, Seung Jun,Park, Kui Lea,Han, Soon Young,Kang, Tae Seok,Kim, Seung Hee,Lee, Byung Mu,Kim, Hyung Sik Taylor Francis 2010 Journal of toxicology and environmental health. Pa Vol.73 No.21
<P>Phospholipase D (PLD) is an enzyme that catalyzes the hydrolysis of phosphatidyl choline (PC) to generate phosphatidic acid (PA) and choline. PLD is believed to play an important role in cell proliferation, survival signaling, cell transformation, and tumor progression. However, it remains to be determined whether enhanced expression of PLD in liver is sufficient to induce hepatotoxicity. The aim of this study was to investigate the possible role of PLD in di(2-ethylhexyl) phthalate (DEHP)-induced hepatotoxicity in Sprague-Dawley rats. The phthalate, DEHP (500 mg/kg/d), was administered orally, daily to prepubertal rats (4 wk of age, weighing approximately 70-90 g) for 1, 7, or 28 d. In this study, protein expression levels of PLD1/2, peroxisome proliferator-activated receptor (PPAR), and cytochrome P-450 (CYP) were determined by Western blot analysis using specific antibodies. Liver weight was significantly increased in the DEHP treatment groups. Immunohistochemical analysis demonstrated that DEHP produced strong staining of proliferating cell nuclear antigen (PCNA) at 28 d of exposure, suggestive of hepatocyte proliferation. A significant rise in PLD1/2 expression was observed in liver of DEHP-exposed rats after 7 d. Further, PPAR관, constitutive androstane receptor (CAR), pregnane X receptor (PXR), and CYP2B1 protein expression levels were markedly elevated in DEHP-treated groups. Our results suggest that DEHP significantly enhanced the expression of PLD, which may be correlated with PPAR관-induced hepatotoxicity through a complex interaction with nuclear receptors including CAR and PXR.</P>