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- 검색키워드
- 저자 : JaeWon Kim (검색결과 1,428 건)
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Kim, Kyeong Seok,Yang, Hun Yong,Song, Hosup,Kang, Ye Rim,Kwon, JiHoon,An, JiHye,Son, Ji Yeon,Kwack, Seung Jun,Kim, Young-Mi,Bae, Ok-Nam,Ahn, Mee-Young,Lee, Jaewon,Yoon, Sungpil,Lee, Byung μ,Kim, Hyung TAYLOR & FRANCIS 2017 Journal of Toxicology and Environmental Health Vol.80 No.9
<P>Acute kidney injury (AKI) is associated with increased mortality rate in patients but clinically available biomarkers for disease detection are currently not available. Recently, a new biomarker, selenium-binding protein 1 (SBP1), was identified for detection of nephrotoxicity using proteomic analysis. The aim of this study was to assess the sensitivity of urinary SBP1 levels as an early detection of AKI using animal models such as cisplatin or ischemia/reperfusion (I/R). Sprague-Dawley rats were injected with cisplatin (6 mg/kg, once i.p.) and sacrificed at 1, 3, or 5 days after treatment. Ischemia was achieved by bilaterally occluding both kidneys with a microvascular clamp for 45 min and verified visually by a change in tissue color. After post-reperfusion, urine samples were collected at 9, 24, and 48 hr intervals. Urinary excretion of protein-based biomarkers was measured by Western blot analysis. In cisplatin-treated rats, mild histopathologic alterations were noted at day 1 which became severe at day 3. Blood urea nitrogen (BUN) and serum creatinine (SCr) levels were significantly increased at day 3. Levels of urinary excretion of SBP1, neutrophil gelatinase-associated lipocalin (NGAL), and a tissue inhibitor of metalloproteinase-1 (TIMP-1) were markedly elevated at day 3 and 5 following drug treatment. In the vehicle-treated I/R group, serum levels of BUN and SCr and AST activity were significantly increased compared to sham. Urinary excretion of SBP1 and NGAL rose markedly following I/R. The urinary levels of SBP1, NGAL, TIMP-1, and KIM-1 proteins excreted by AKI patients and normal subjects were compared. Among these proteins, a marked rise in SBP1 was observed in urine of patients with AKI compared to normal subjects. Based upon receiver-operator curves (ROC), SBP1 displayed a higher area under the curve (AUC) scores than levels of SCr, BUN, total protein, and glucose. In particular, SBP1 protein was readily detected in small amounts of urine without purification. Data thus indicate that urinary excretion of SBP1 may be useful as a reliable biomarker for early diagnosis of AKI in patients.</P>
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Curcumin ameliorates cadmium-induced nephrotoxicity in Sprague-Dawley rats
Kim, Kyeong Seok,Lim, Hyun-Jung,Lim, Jong Seung,Son, Ji Yeon,Lee, Jaewon,Lee, Byung Mu,Chang, Seung-Cheol,Kim, Hyung Sik Elsevier 2018 Food and chemical toxicology Vol.114 No.-
<P><B>Abstract</B></P> <P>Chronic exposure to cadmium (Cd) causes remarkable damage to the kidneys, a target organ of accumulated Cd after oral administration. The aim of the present study was to investigate the protective effect of curcumin against Cd-induced nephrotoxicity. Sprague–Dawley male rats were divided into the following four treatment groups: control, curcumin (50 mg/kg, oral), CdCl<SUB>2</SUB>, (25 mg/kg, oral), and pre-treatment with curcumin (50 mg/kg) 1 h prior to the administration of CdCl<SUB>2</SUB> (25 mg/kg, oral) for 7 days. At 24 h after the final treatment, the animals were killed, and the biomarkers associated with nephrotoxicity were measured. Our data indicated that blood urea nitrogen (BUN) and serum creatinine (sCr) levels were significantly reduced by curcumin pre-treatment in CdCl<SUB>2</SUB>-treated animals. Histopathological studies showed hydropic swelling and hypertrophy of the proximal tubular cells in the renal cortex after Cd treatment. Pretreatment with curcumin ameliorated the histological alterations induced by Cd. The urinary excretion of kidney injury molecule-1 (Kim-1), osteopontin (OPN), tissue inhibitor of metalloproteinases 1 (TIMP-1), neutrophil gelatinase-associated lipocalin (NGAL), and netrin-1 significantly reduced by curcumin treatment compared to that in the CdCl<SUB>2</SUB>-treated group. The administration of curcumin provided a significant protective effect against Cd-induced nephrotoxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Curcumin protects against cadmium-induced renal injury. </LI> <LI> Curcumin reduces urinary excretion of AKI biomarkers. </LI> <LI> Curcumin protects against cadmium-induced apoptosis in the kidney. </LI> </UL> </P>
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Kim, Seong Kwang,Shim, Jae-Phil,Geum, Dae-Myeong,Kim, Jaewon,Kim, Chang Zoo,Kim, Han-Sung,Song, Jin Dong,Choi, Sung-Jin,Kim, Dae Hwan,Choi, Won Jun,Kim, Hyung-Jun,Kim, Dong Myong,Kim, Sanghyeon Institute of Electrical and Electronics Engineers 2018 IEEE transactions on electron devices Vol.65 No.5
<P>In this paper, we fabricated In<SUB>0.53</SUB>Ga<SUB>0.47</SUB>As-on insulator (OI) MOSFETs on Si substrates with different doping types to mimic ground plane doping using direct wafer bonding and epitaxial lift-off (ELO) techniques. We investigated the impact of doping types on the ground plane and the backgate biasing, which are important and preferable components in monolithic 3-D (M3D) integration, on the electrical properties of MOSFETs, such as the threshold voltage ( <TEX>${V} _{T}$</TEX>) and the effective mobility ( <TEX>$\mu _{\textsf {eff}}$</TEX>). It was found that <TEX>${V} _{T}$</TEX> and <TEX>$\mu _{\textsf {eff}}$</TEX> were significantly modulated by the backsubstrate doping and the backbiasing. These observations were explained by the change of carrier distributions, which were confirmed by technology computer-aided design simulation. Furthermore, we investigated the reusability of InP donor substrates for sequential epitaxial growth after ELO process toward a cost-effective M3D integration with the In<SUB>0.53</SUB>Ga<SUB>0.47</SUB>As channel.</P>
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Kim, Jaewon,Lee, Heesung,Kim, Seong Kwang,Kim, Junyeap,Park, Jaewon,Choi, Sung-Jin,Kim, Dae Hwan,Kim, Dong Myong IEEE 2016 IEEE transactions on electron devices Vol.63 No.11
<P>Separate extraction of source (RS) from drain resistance (RD) is important in the systematic modeling of electrical characteristics and investigation of physical mechanism related to the performance and reliability in MOSFETs and their integrated circuits. We report a hybrid open drain method (ODM), as a fully current-based characterization technique, for a comprehensive separation of asymmetric source and drain resistance components in a single MOSFET. In the hybrid ODM, the ODM through the parasitic bipolar transistor is combined with the dualsweep combinational transconductance technique, the channel resistance method, and the parasitic junction current method. We fully considered the asymmetry in the source and the drain possibly caused by the layout, process, and degradation under bias. We successfully extracted the resistance components with R-Se = 6.66-7.35 Omega, R-De = 7.64-8.34 Omega, RSo = 0.78-8.07 Omega, R-Do = 1.11-10.08 Omega, and R-SUB = 6.29-9.17 Omega in the n-channel MOSFETs. R-Se (R-De) is the VGS-independent external source (drain) resistance. R-So (R-Do) is the VGS-independent external spreading source (drain) resistance and RSi (RDi) is the VGS-dependent intrinsic source (drain) resistance, respectively. RSUB is the substrate resistance. The hybrid ODM is expected to be useful in the characterization of parasitic resistances in each MOSFET with asymmetry caused by the layout, process, and degradation without using multiple devices with different channel length (L) and width (W) for measurement.</P>
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Heesung Lee,Junyeap Kim,Jaewon Kim,Seong Kwang Kim,Yongwoo Lee,Jae-Young Kim,Jun Tae Jang,Jaewon Park,Sung-Jin Choi,Dae Hwan Kim,Dong Myong Kim IEEE 2017 IEEE electron device letters Vol.38 No.5
<P>Amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) are investigated for a possible application to infrared (IR) photodetector through subgap density-ofstates over the forbidden bandgap. The origin of the sub-bandgap(hν <;E<SUB>g</SUB>) photo-response in a-IGZO TFTs is due to optically pumped electrons from the photo-responsive subgap states (E<SUB>C</SUB>-E<SUB>ph</SUB><;E<SUB>t</SUB><;E<SUB>F</SUB>). Among the sub-bandgap lights, we investigate the reproducible IR photo-response in a-IGZO TFTs as a photodetector without the persistent photoconductivity(PPC) effect. In this letter, we characterize the IR photo-response mechanism through various optical and electrical measurements on the wavelength, optical power, bias-modulated quasi-Fermi level, and photoresponsive states. This result is expected to provide independent and/or integrated IR detector with transparent substrate combined with a-IGZO TFTs.</P>
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Kim, Jaewon,Lee, Kyung Eun,Kim, Kyung Hwan,Wi, Sungun,Lee, Sangheon,Nam, Seunghoon,Kim, Chunjoong,Kim, Sang Ouk,Park, Byungwoo Elsevier 2017 Carbon Vol.114 No.-
<P>Graphene has been intensively adopted into boosting the electrochemical performances of battery electrode materials due to its superior nature. In the case of Li4Ti5O12 (LTO), the application of graphene has been specifically focused on ameliorating the low electronic conductivity of LTO. So far, these attempts aiming to increase the composite's electronic conductivity involved thick graphene layers, which inevitably hindered Li-ion diffusion and eventually harmed the electrochemical kinetics in LTO's surface. In this work, high quality minimum-impurity graphene oxide was prepared by means of thorough cleaning and dialysis, which enabled each single-layered graphene to successfully wrap individual LTO particles. The resulting single-layer graphene-wrapped LTO exhibits an excellent specific capacity of 130 mAh g(-1) even at a lithiation/delithiation of 30 degrees C. Such a high rate capability is one of the highest values among the reported LTO with comparable sizes (similar to 200 nm). To uncover the reasons for such high performance, electrochemical properties from varied graphene contents were juxtaposed for comparison, and as a result, number of graphene layers and the corresponding kinetic parameters were found correlated. With adequate validity, single graphene layer was revealed to be the uttermost optimum for both Li+ diffusion and electronic conduction. (C) 2016 Elsevier Ltd. All rights reserved.</P>
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Kim, Jung A,Kim, Doyoun,Won, Seoung Youn,Han, Kyung Ah,Park, Dongseok,Cho, Eunju,Yun, Nayoung,An, Hyun Joo,Um, Ji Won,Kim, Eunjoon,Lee, Jie-Oh,Ko, Jaewon,Kim, Ho Min Elsevier 2017 Neuron Vol.94 No.6
<P><B>Summary</B></P> <P>Membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor proteins (MDGAs) bind directly to neuroligin-1 (NL1) and neuroligin-2 (NL2), thereby respectively regulating excitatory and inhibitory synapse development. However, the mechanisms by which MDGAs modulate NL activity to specify development of the two synapse types remain unclear. Here, we determined the crystal structures of human NL2/MDGA1 Ig1-3 complex, revealing their stable 2:2 arrangement with three interaction interfaces. Cell-based assays using structure-guided, site-directed MDGA1 mutants showed that all three contact patches were required for the MDGA’s negative regulation of NL2-mediated synaptogenic activity. Furthermore, MDGA1 competed with neurexins for NL2 via its Ig1 domain. The binding affinities of both MDGA1 and MDGA2 for NL1 and NL2 were similar, consistent with the structural prediction of similar binding interfaces. However, MDGA1 selectively associated with NL2, but not NL1, in vivo. These findings collectively provide structural insights into the mechanism by which MDGAs negatively modulate synapse development governed by NLs/neurexins.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Crystal structure of neuroligin-2 (NL2) in complex with MDGA1 Ig1-Ig3 domains </LI> <LI> MDGA1 Ig1-Ig2 domains interact with NL2 dimer with 2:2 stoichiometry </LI> <LI> MDGA1 competes with Nrx1β for NL2 binding via their overlapping binding site on NL2 </LI> <LI> MDGA1 selectively forms complexes with NL2, but not NL1, in vivo </LI> </UL> </P>
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Hepatic damage exacerbates cisplatin-induced acute kidney injury in Sprague-Dawley rats
Kim, Ji Su,Son, Ji Yeon,Kim, Kyeong Seok,Lim, Hyun Jung,Ahn, Mee-Young,Kwack, Seung Jun,Kim, Young-Mi,Lee, Kwang Youl,Lee, Jaewon,Lee, Byung Mu,Kim, Hyung Sik Informa UK (TaylorFrancis) 2018 Journal of toxicology and environmental health. Pa Vol.81 No.11
<P>The objective of this study was to elucidate the effect of hepatic damage on cisplatin (CDDP)-induced acute kidney injury (AKI). Thioacetamide (TAA, 150 mg/kg), a hepatotoxicant, was intraperitoneally (i.p.) injected to male Sprague-Dawley rats for 3 d prior to CDDP (5 mg/kg, i.p.) injection. All animals were sacrificed 5 d after CDDP treatment, and urine or blood was obtained to measure various parameters. No significant changes in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity were observed after CDDP treatment. However, pretreatment with TAA significantly elevated ALT and AST activity. Serum blood urea nitrogen and creatinine levels significantly increased in CDDP-treated group compared to control. In addition, urinary excretion of novel protein-based biomarkers such as neutrophil gelatinase-associated lipocalin, vascular endothelial growth factor, kidney injury molecule-1, and tissue inhibitor of metalloproteinase-1 rose markedly in the CDDP-treated group. In particular, pretreatment with TAA markedly elevated CDDP-induced urinary excretion of protein-based nephrotoxic biomarkers compared with CDDP alone. Hematoxylin and eosin staining demonstrated that pretreatment with TAA following CDDP injection led to more severe tubular damage and apoptosis in rats compared with CDDP alone. Antioxidant status was significantly reduced in kidneys following pretreatment with TAA prior to CDDP. These findings indicate that liver injury enhanced the vulnerability of kidney to CDDP-induced AKI and this phenomenon may be associated with severe apoptotic damage.</P>
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Kim, Na Young,Kim, Tae Hyung,Lee, Ena,Patra, Nabanita,Lee, Jaewon,Shin, Mi Ok,Kwack, Seung Jun,Park, Kui Lea,Han, Soon Young,Kang, Tae Seok,Kim, Seung Hee,Lee, Byung Mu,Kim, Hyung Sik Taylor Francis 2010 Journal of toxicology and environmental health. Pa Vol.73 No.21
<P>Phospholipase D (PLD) is an enzyme that catalyzes the hydrolysis of phosphatidyl choline (PC) to generate phosphatidic acid (PA) and choline. PLD is believed to play an important role in cell proliferation, survival signaling, cell transformation, and tumor progression. However, it remains to be determined whether enhanced expression of PLD in liver is sufficient to induce hepatotoxicity. The aim of this study was to investigate the possible role of PLD in di(2-ethylhexyl) phthalate (DEHP)-induced hepatotoxicity in Sprague-Dawley rats. The phthalate, DEHP (500 mg/kg/d), was administered orally, daily to prepubertal rats (4 wk of age, weighing approximately 70-90 g) for 1, 7, or 28 d. In this study, protein expression levels of PLD1/2, peroxisome proliferator-activated receptor (PPAR), and cytochrome P-450 (CYP) were determined by Western blot analysis using specific antibodies. Liver weight was significantly increased in the DEHP treatment groups. Immunohistochemical analysis demonstrated that DEHP produced strong staining of proliferating cell nuclear antigen (PCNA) at 28 d of exposure, suggestive of hepatocyte proliferation. A significant rise in PLD1/2 expression was observed in liver of DEHP-exposed rats after 7 d. Further, PPAR관, constitutive androstane receptor (CAR), pregnane X receptor (PXR), and CYP2B1 protein expression levels were markedly elevated in DEHP-treated groups. Our results suggest that DEHP significantly enhanced the expression of PLD, which may be correlated with PPAR관-induced hepatotoxicity through a complex interaction with nuclear receptors including CAR and PXR.</P>
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