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沈秀萬,金宰榮 홍익대학교 산업기술연구소 2003 産業技術 Vol.13 No.-
Porous ceramics mixed with cement were fabricated to develop lightweight insulation bricks and panels with low thermal conductivities. A fine mixture of potter's clay, kaolin, and clay was mixed with portland cement up to 10~50 vol%. Slurries were prepared by adding water and a foaming agent into the powder and ball milling. The foamed slurry was poured into a mold and cured at room temperature for 48 hrs. Samples were fired between 800℃~1000℃ and then compressive strengths were measured. Various sizes of pores were formed in the fired samples and the compressive strength was increased with firing temperature due to porcelain formed as a result of the reaction between cement and clay ingredients. The results of microstructure and strength showed that it is possible to fabricate porous ceramics from cement containing additives.
沈秀萬,金宰泳 弘益大學校 産業技術硏究所 2004 産業技術 Vol.14 No.-
YAG phase formation was studied during calcination of Y₂O₃ or Y hydroxide and nanosized Al₂O₃ powders with various crystal structure (AlOOH, γ-Al₂O₃, and δ-Al₂O₃). The results were compared with those of a mixture of Y₂O₃ and Al₂O₃ nanopowders. Phase development in the powders which had been calcined at temperatures between 600℃∼1200℃ was investigated with XRD. A mixture of nano Al₂O₃ and Y hydroxide powders showed YAG phase in addition to Y₂O₃ and δ-Al₂O₃ at 1200℃. The formation of YAG phase attributes to ease of the reaction between δ-Al₂O₃ nanoparticles and fine Y₂O₃ crystallites which had been decomposed from Y(OH)₃. Whereas, a mixture of nano Al₂O₃ and Y₂O₃ powders did not contain YAG because of slow solid-state reaction between powders.
Jae Kyeom Sim,Sang-Min Lee,Hyung Koo Kang,Kyung Chan Kim,김영삼,김윤성,리원연,Sunghoon Park,So Young Park,박주희,Yun Su Sim,이광하,이연주,Jin Hwa Lee,Heung Bum Lee,Chae-Man Lim,Won-Il Choi,Ji Young Hong,Won Jun Song,Ge 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.3
Background/Aims: There are few studies describing contemporary status of mechanical ventilation in Korea. We investigated changes in management and outcome of mechanical ventilation in Korea. Methods: International, prospective observational cohort studies have been conducted every 6 years since 1998. Korean intensive care units (ICUs) participated in 2010 and 2016 cohorts. We compared 2016 and 2010 Korean data. Results: Two hundred and twenty-six patients from 18 ICUs and 275 patients from 12 ICUs enrolled in 2016 and 2010, respectively. In 2016 compared to 2010, use of non-invasive ventilation outside ICU increased (10.2% vs. 2.5%, p = 0.001). Pressure-control ventilation was the most common mode in both groups. Initial tidal volume (7.1 mL/kg vs. 7.4 mL/kg, p = 0.372) and positive end-expiratory pressure (6 cmH2O vs. 6 cmH2O, p = 0.141) were similar, but peak pressure (22 cmH2O vs. 24 cmH2O, p = 0.011) was lower in 2016. More patients received sedatives (70.7% vs. 57.0%, p = 0.002) and analgesics (86.5% vs. 51.1%, p < 0.001) in 2016. The awakening (48.4% vs. 31.0%, p = 0.002) was more frequently attempted in 2016. The accidental extubation rate decreased to one tenth of what it was in 2010 (1.1% vs. 10.2%, p < 0.001). The ICU mortality did not change (31.4% vs. 35.6%, p = 0.343) but ICU length of stay showed a decreasing trend (9 days vs. 10 days, p = 0.054) in 2016. Conclusions: There were temporal changes in care of patients on mechanical ventilation including better control of pain and agitation, and active attempt of awakening.
심재만(Jae-Man Sim),이형욱(Hyeong-Wook Lee),신주용(Joo-Yong Shin),김기원(Ki-Won Kim),한영오(Young-Oh Han) 한국전자통신학회 2019 한국전자통신학회 논문지 Vol.14 No.6
본 논문에서는 시각장애인들이 보행 시 장애물이나 위험요소로부터 보다 안전하게 보행 할 수 있도록 보조 장치를 구현하였다. 초음파 센서를 통해 전방에 있는 장애물을 감지하여 거리별, 각도별로 부저의 소리의 간격과 진동의 세기를 다르게 울리도록 했으며 그에 따라 보행자가 상황을 인지할 수 있게 설계하였다. 조도 센서의 CdS 저항값을 이용해 설정해놓은 빛의 밝기보다 주변이 어두워 졌을 시 LED가 자동 점등 되어 주변 보행 자들이 시각장애인을 쉽게 인식할 수 있게 하였으며, 또한 자이로 센서의 기울기를 이용해 보행자가 보조 장치를 놓쳤을 시 부저를 통하여 보조 장치의 위치를 인식할 수 있게 하였다. 그리고 GPS와 블루투스를 이용하여 시각장애인의 위치 및 상황을 보호자에게 전송하여 안전보행을 확인할 수 있게 구현하였다. In this paper, an auxiliary device was implemented to help blind people more safely from obstacles or risk factors while walking. The ultrasonic sensors detect obstacles in the front, so that the noise gap and the vibration intensity of the buzzer can be heard differently by distance and angle, and so the situation can be perceived by pedestrians. When the ambient light becomes darker than the light intensity set using the CdS resistance value of the light sensor, the LED automatically turns on, makes it easier for pedestrians to recognize the position of the auxiliary device through buzzer if the pedestrian misses the aid using the gyro sensor s slope. Moreover, the location and situation of the blind were transmitted to the caregiver to check safety and behavior using GPS and Bluetooth.
TMA로 유도된 접촉성 과민 반응 마우스 질환모델에서 해양성 광천수 도포시의 치료효과
김재진 ( Jae Jin Kim ),김완재 ( Wan Jae Kim ),심재만 ( Jae Man Sim ),최선강 ( Seon Kang Choi ),권순성 ( Soon Sung Kwon ),김정득 ( Jung Duk Kim ),이광호 ( Kwang Ho Lee ) 한국식품영양학회 2010 韓國食品營養學會誌 Vol.23 No.4
Effect of brine mineral water(BMW) on contact hypersensitivity reaction(CHR) was estimated using trimellitic anhydride (TMA) induced CHR in the mouse. BMW exhibited potent inhibitory activity on TMA induced CHR. BMW treatment suppressed the ear swelling, and attenuated hyper-activated lymph nodes stimulated by TMA challenge, thereby reduced their weight. The immunological index was analyzed after BMW administration in CHR. The level of serum IGE was significantly down regulated after BMW treatment. Furthermore, BMW showed inhibitory property of cytokine production. BMW treatment suppressed not only Th2 type cytokine, IL-4 but also pro-inflammatory cytokines such as TNF-α and IL-6. From the histological analysis, the inflammatory context appeared by atopic dermatitis lesion after challenging with TMA are diminished by BMW treatment. Our results suggest that BMW may attenuate the development of CHR, and can be available for functional ingredient.
황재성 ( Jae-sung Hwang ),박원만 ( Won- Man Park ),안수미 ( Soo-mi Ahn ),강병영 ( Beyong-young Kang ),이병곤 ( Byeong-gon Lee ),심영철 ( Young- Chul Sim ) 대한화장품학회 2000 대한화장품학회지 Vol.26 No.1
Coenzyme Q10(CoQ10)은 피부를 포함한 모든 생체조직에 존재하는 널리 알려진 조효소이다. 전자전달에 관여하는 퀴논링은 세포에서 에너지를 생성하기 위한 매우 중요한 기능을 가지고 있다. CoQ10 은 피부에서 항산화제로서 연구되어 왔으며, 최근 외용제로써 노화억제와 주름개선작용에 대해 보고된 바 있다. 이런 보고들은 CoQ10 이 항산화제로서 산화-환원작용을 통해 피부의 방어기능에 중요한 역할을 한다는 점을 시사하며, 일반적으로 산화-환원작용은 피부에서 흑화과정의 조절에도 많은 영향을 미친다. 따라서 본 연구자들은 CoQ10 이 피부의 색소조절기능이 있는지 알아보고자 하였다. 인체 정상 색소세포에 CoQ10을 0.05-0.5 mM 처리한 결과 0.5, 0.25mM 에서 멜라닌의 생함성을 약 50% 저해하였으며 이는 알려진 미백제인 Kojic acid 나 vitamin C 와 유사한 수준이었다. 또한, CoQ10 은 인체 정상 색소세포에서 자외선이나 세포내 cAMP 증가 유도물질에 의한 멜라닌 생성을 억제하였다. 그러나 tyrosinase inhibitor 인 kojic acid 와는 달리, in vitro tyrosine hydroxylase 의 억제효과는 보이지 않았다. CoQ10을 자외선으로 tanning 을 유도시킨 brown guinea pig 에 4 주간 도포하고 육안 및 chromameter 를 이용하여 미백효과를 측정한 결과, vehicle 처리군에 비해 미백효과가 있음을 확인할 수 있었다. 이상의 결과에서 coenzyme Q10 은 in vitro 및 in vivo 에서 미백효과를 지닌 물질임을 확인할 수 있었다. Coenzyme Q10 is found in all tissues including skin and it is the well-known coenzyme for mitochondrial enzymes. The electron and proton transfer functions of the quinone ring are of fundamental importance for the oxidative phosphorylation pathway to generate energy in the cells. Coenzyme Q10 has been studied as a potent antioxidant molecule in the skin. It is involved in the skin’s response to UVR irradiation. The concentration of this antioxidant in UVR exposed skin is higher than in non-exposed skin. However, recent studies have also shown that coenzyme Q10 is one of the first antioxidants to be depleted when skin is UVR-irradiated. This indicates that coenzyme Q10 is primarily involved in defense mechanisms of the skin. Therefore, we questioned whether coen2yme Q10 shows regulatory effect of melanogenesis. Here we report that coenzyme Q10 inhibits melanin neosynthesis of normal human melanocytes grown in culture, and lightens UVB-induced hyperpigmentation of the guinea pig skin in vivo. We treated human melanocytes with 0.05mM to 0.5mM of coenzyme Q10 for a total of two days. This inhibited melanin neosynthesis of cultured human melanocytes dose-dependently. The inhibitory effects of coenzyme Q10 was as effective as kojic acid or vitamin C on cultured human melanocytes. CoQlO didn’t have direct inhibitory effect on tyrosinase activity in in vitro tyrosine hydroxylase activity. To further clarify the effect of coenzyme Q10 on the melanogenesis, we established UVB-induced hyperpigmentation on the shaved backs of brownish guinea pigs. The UVB intensity was 500mJ/cm<sup>2</sup> and the total energy dose was 1,500 mJ/cm<sup>2</sup>. The animals were exposed to UVB radiation one times a week for three consecutive weeks. Coenzyme Q10, kojic acid, Arbutin, vitamin C(1% in vehicle) or vehicle alone as a control were then topically applied daily to the hyperpigmented areas twelve times per week for four successive weeks. The lightening effect was evaluated by visual scoring, chromameter and immunohistochemistry. Coenzyme Q10 had lightening effect on the UVB-induced hyperpigmentation without any other side effects, whereas another compounds showed weak lightening efficacies. Therefore, these results suggest that coenzyme Q10 may be useful for solving physiological hyperpigmenting problems for cosmetic purposes.