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상수원수 수질변화에 따른 전오존 처리효과 및 경제성 평가
최동훈 ( Dong Hoon Choi ),박진식 ( Jin Sik Park ),문추연 ( Choo Yeun Moon ),이재용 ( Jae Yong Lee ),유동춘 ( Dong Choon Ryu ),장성호 ( Seong Ho Jang ),권기원 ( Ki Won Kwon ),이수애 ( Soo Ae Lee ) 한국환경과학회 2013 한국환경과학회지 Vol.22 No.4
This study, changes in raw water quality is to indicate on the efficiency of ozone treatment of each pollutant as compared to derive the appropriate operating measures. The appropriate selection for injection rate of pre-ozone and did not inject pre-ozone assess changes in the water. When good water quality, you not injected of pre-ozone to evaluate the economic efficiency of electricity and put the most cost-effective ozone concentration were evaluated. Evaluation remove organic matter and chlorophyll-a concentration level in experiments with each factor of the water DOC> 2.5㎎ / L, THMFP> 70㎍ / L, Chl-a> 30㎎/㎥or less constant process, if you do not need to put pre-ozone showed little impact. It also does not put you in pre-ozone appropriate produce enough power rate savings was calculated as approximately 90 million won. Ability to remove organic materials and the ability to produce disinfection byproducts, and cost-effective decisions by considering the concentration of injection if pre-ozone 1 mg/L was investigated by the appropriate concentration of ozone injection.
Thematic Poster : TP-20 ; Lung Function Impairment According to Prior Pulmonary Tuberculosis
( Jae Woo Jung ),( Joo Young Lee ),( Kang Mo Gu ),( Jin Se Kim ),( Ju Young Jang ),( Jae Chol Choi ),( Jong Wook Shin ),( Jae Yeol Kim ),( Byoung Whui Choi ),( In Won Park ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Previous pulmonary tuberculosis (TB) can affect lung function, but a few data exist on long-term follow-up. This study was conducted to evaluate whether prior pulmonary TB was related with lung function impairment in Korean adult population and risk factors of decreased lung function in subjects with prior pulmonary TB. Methods: We used data from the fourth and fifth annual South Korean National Health and Nutrition Examination Survey (Korean NHANES IV) conducted in 2008, 2009, 2010, 2011 and 2012. From a total of 45,811 subjects, 14,967 adult subjects who were at least 40 years of age were included in the study population. The correlation between prior pulmonary TB and chest x-ray abnormality and impaired lung function using questionnaires about diagnosis of pulmonary tuberculosis, chest x-ray and pulmonary lung function were analyzed. The results of pulmonary functions were all adjusted by age, sex and smoking pack-years. Results: Mean age was 57.1years and males were 43.3%. Subjects with preciously diagnosed and treated pulmonary TB were 5.5%. Chest PA with sequale of pulmonary tuberculosis was 7.9%. FEV1%, FEV1/FVC in subjects with prior pulmonary TB were significantly low compared with those without TB (84.89±17.19 vs. 92.58±13.51, P<0.001, and 77.91±7.52 vs. 77.91±7.52, P<0.001, respectively). Subjects with prior pulmonary TB had higher prevalence of COPD compared with those without previous TB (19.5% vs. 6.5%, OR=2.862, 95% CI: 2.344-3.496), also in subjects with normal chest x-ray (9.1% vs. 5.0%, OR=1.702, 95% CI: 1.112-2.607). In subject with prior pulmonary TB, TB sequale on chest x-ray was risk factor of COPD development (OR=2.244, 95% CI: 1.578-3.191). Conclusion: In the current study, previous pulmonary TB morbidity was significantly related with decreased lung function in Korean adults. The evaluation and follow up of pulmonary function in subjects with previous pulmonary TB should be needed.
Jang, Kyung Ku,Lee, Zee-Won,Kim, Bityeoul,Jung, Young Hyun,Han, Ho Jae,Kim, Myung Hee,Kim, Byoung Sik,Choi, Sang Ho American Society for Biochemistry and Molecular Bi 2017 The Journal of biological chemistry Vol.292 No.41
<P>The marine bacterium Vibrio vulnificus causes food-borne diseases, which may lead to life-threatening septicemia in some individuals. Therefore, identifying virulence factors in V. vulnificus is of high priority. We performed a transcriptome analysis on V. vulnificus after infection of human intestinal HT29-methotrexate cells and found induction of plpA, encoding a putative phospholipase, VvPlpA. Bioinformatics, biochemical, and genetic analyses demonstrated that VvPlpA is a phospholipase A(2) secreted in a type II secretion system-dependent manner. Compared with the wild type, the plpA mutant exhibited reduced mortality, systemic infection, and inflammation in mice as well as low cytotoxicity toward the human epithelial INT-407 cells. Moreover, plpA mutation attenuated the release of actin and cytosolic cyclophilin A from INT-407 cells, indicating that VvPlpA is a virulence factor essential for causing lysis and necrotic death of the epithelial cells. plpA transcription was growth phase-dependent, reaching maximum levels during the early stationary phase. Also, transcription factor HlyU and cAMP receptor protein (CRP) mediate additive activation and host-dependent induction of plpA. Molecular biological analyses revealed that plpA expression is controlled via the promoter, P-plpA, and that HlyU and CRP directly bind to P-plpA upstream sequences. Taken together, this study demonstrated that VvPlpA is a type II secretion system-dependent secretory phospholipase A(2) regulated by HlyU and CRP and is essential for the pathogenicity of V. vulnificus.</P>
Identification of polymorphisms in the Caspase-3 gene and their association with lung cancer risk
Jang, Jin Sung,Kim, Kyung Mee,Choi, Jin Eun,Cha, Sung Ick,Kim, Chang Ho,Lee, Won Kee,Kam, Sin,Jung, Tae Hoon,Park, Jae Yong Wiley Subscription Services, Inc., A Wiley Company 2008 Molecular carcinogenesis Vol.47 No.5
<P>Caspase-3 (CASP-3) is a primary effector CASP that executes programmed cell death, and it plays an important role in the development and progression of cancer. Polymorphisms in the CASP-3 gene may influence CASP-3 production and/or activity, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we first screened for polymorphisms in the CASP-3 gene by direct sequencing of genomic DNA samples from 27 healthy Koreans, and then evaluated their associations with lung cancer in a case–control study that consisted of 582 lung cancer patients and 582 healthy controls. Individuals with at least one variant allele of the −928A > G, 77G > A, and 17532A > C polymorphisms were at a significantly decreased risk for lung cancer in comparison to the carriers with each homozygous wild-type allele [adjusted odds ratio (OR) = 0.79, 95% confidence interval (CI) = 0.62–1.00, P = 0.05; adjusted OR = 0.78, 95% CI = 0.61–0.99, P = 0.04; and adjusted OR = 0.74, 95% CI = 0.58–0.95, P = 0.02, respectively]. Consistent with the results of genotyping analysis, the GAGC haplotype carrying the variant allele at all of the −928A > G, 77G > A, and 17532A > C loci was associated with a significantly decreased risk of lung cancer compared to the AGGA haplotype carrying no variant alleles at the three loci (adjusted OR = 0.66, 95% CI = 0.51–0.86, P = 0.002 and Bonferroni corrected P = 0.008). These results suggest that the CASP-3 polymorphisms and their haplotypes contribute to the genetic susceptibility to lung cancer. © 2007 Wiley-Liss, Inc.</P>
Case Reports : Disseminated Mycobacterium intracellulare Infection in an Immunocompetent Host
( Won Young Kim ),( Sun Joo Jang ),( Tae Jin Ok ),( Gwang Un Kim ),( Han Seung Park ),( Jae Chan Leem ),( Bo Hyoung Kang ),( Se Jeong Park ),( Dong Kyu Oh ),( Byung Ju Kang ),( Bo Young Lee ),( Won Ju 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.5
Disseminated Mycobacterium avium complex (MAC) infection can occur in immunocompromised patients, and rarely in immunocompetent subjects. Due to the extensive distribution of the disease, clinical presentation of disseminated MAC may mimic malignancies, and thorough examinations are required in order to make accurate diagnosis. We report a case of disseminated Mycobacterium intracellulare disease in an immunocompetent patient, which involved the lung, lymph nodes, spleen, and multiple bones. F-18 fluorodeoxyglucose positron-emission tomography imaging showed multiple hypermetabolic lesions, which are suggestive of typical hematogenous metastasis. However, there was no evidence of malignancy in serial biopsies, and M. intracellulare was repeatedly cultured from respiratory specimens and bones. Herein, we should know that disseminated infection can occur in the immunocompetent subjects, and it can mimic malignancies.
Jang, Eunha,Kim, Jong-Heon,Lee, Shinrye,Kim, Jae-Hong,Seo, Jung-Wan,Jin, Myungwon,Lee, Maan-Gee,Jang, Il-Sung,Lee, Won-Ha,Suk, Kyoungho The American Association of Immunologists, Inc. 2013 JOURNAL OF IMMUNOLOGY Vol.191 No.10
<P>Astrocytes provide structural and functional support for neurons, as well as display neurotoxic or neuroprotective phenotypes depending upon the presence of an immune or inflammatory microenvironment. This study was undertaken to characterize multiple phenotypes of activated astrocytes and to investigate the regulatory mechanisms involved. We report that activated astrocytes in culture exhibit two functional phenotypes with respect to pro- or anti-inflammatory gene expression, glial fibrillary acidic protein expression, and neurotoxic or neuroprotective activities. The two distinct functional phenotypes of astrocytes were also demonstrated in a mouse neuroinflammation model, which showed pro- or anti-inflammatory gene expression in astrocytes following challenge with classical or alternative activation stimuli; similar results were obtained in the absence of microglia. Subsequent studies involving recombinant lipocalin-2 (LCN2) protein treatment or <I>Lcn2</I>-deficient mice indicated that the pro- or anti-inflammatory functionally polarized phenotypes of astrocytes and their intracellular signaling pathway were critically regulated by LCN2 under in vitro and in vivo conditions. Astrocyte-derived LCN2 promoted classical proinflammatory activation of astrocytes but inhibited IL-4–STAT6 signaling, a canonical pathway involved in alternative anti-inflammatory activation. Our results suggest that the secreted protein LCN2 is an autocrine modulator of the functional polarization of astrocytes in the presence of immune or inflammatory stimuli and that LCN2 could be targeted therapeutically to dampen proinflammatory astrocytic activation and related pathologies in the CNS.</P>
Warpage Behavior and Life Prediction of a Chip-on-Flex Package Under a Thermal Cycling Condition
Jae-Won Jang,Kyoung-Lim Suk,Jin-Hyoung Park,Kyung-Wook Paik,Soon-Bok Lee IEEE 2014 IEEE transactions on components, packaging, and ma Vol.4 No.7
<P>Flip-chip assembly has been widely adapted to various electronic devices due to advantages, such as miniaturization of electronic devices and high density integration. The chip-on-flex (COF) package used in this paper is a flip-chip package with an anisotropic conductive adhesive flim (ACF) interconnection and shows flexible features and reduced thickness compared with chip-on-board (COB) packages. All electronic packages experience temperature variation during service conditions and under environmental changes. Under temperature variation, stresses emerge due to the differences in the coefficient of thermal expansion among components. In order to evaluate the thermomechanical reliability of a COF package, a thermal cycling (TC) test was conducted. A moiré experiment using Twyman/Green interferometry was performed to observe the warpage behavior of the package under a TC condition. Through the experiment, the rate of change of chip warpage with respect to temperature (dw/dT) as a parameter of the thermal damage model was obtained. A finite element analysis (FEA) was also performed to calculate the maximum shear stress at the ACF layer as another parameter of the model. From the experiment and FEA results, the thermal damage model can accurately represent the TC life of the COF package. However, based on observations of different warpage behavior of the COF package compared with a COB package from the moiré experiment, a modified thermal damage model that can predict the TC life of both packages more accurately was proposed.</P>