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Prevalence and outcome of BRCA mutation in Korean epithelial ovarian cancer women
( Jg Yoo ),( Jh Kim ),( Sj Lee ),( Ys Lee ),( Hn Lee ),( Kh Lee ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: To determine the prevalence and progression free survival of BRCA gene mutation carriers in Korean epithelial ovarian cancer patients. 방법: This multi-centered retrospective study included 91 epithelial ovarian cancer women diagnosed histopathologically during January 1, 2010 to December 31, 2015, who have had BRCA mutation test during their follow-up period. Strong family history group was defined as patients having breast cancer history or having 1st degree relatives who were diagnosed of ovarian or breast cancer. We calculated the prevalence of BRCA mutation on each groups. PFS was calculated for 62 patients who has been diagnosed with advanced stage of high grade serous carcinoma, clear cell carcinoma, and endometrioid adenocarcinoma. Median PFS was calculated and compared on BRCA mutation status. 결과: 18/91 (19.78%) patients having BRCA1 mutation and 5/91 (5.49%) patients having BRCA2 mutation were identified. 12 BRCA mutation patients out of 21 patients with strong family history group (57.14%) were identified. 22/23 (95.65%) of BRCA mutation patients were diagnosed with high grade serous carcinoma, and 1/23 (4.35%) was diagnosed with endometrioid adenocarcinoma histopathologically. In wild type BRCA group, 6/68(8.82%) of BRCA mutation carriers were found, and they were all BRCA1 mutations. Median PFS was shorter for wild type BRCA patients compared to BRCA1/2 mutation group (20 months versus 52 months), but no significant difference was found(p=0.184). Mean follow-up period was 28.4 months[3-73months]. 결론: The prevalence of gBRCA1/2 mutation in epithelial ovarian cancer patients in Korea seems to be higher than previously reported. No significant difference was found on median PFS between wild type BRCA group and BRCA mutation group, and this consequence result from relatively short follow- up period, recurrence was not happened to over a half of patients. Larger sample size and longer follow up period is needed for the following study.
지제근(JG Chi),홍석호(SH Hong),조면현(MH Cho),류성현(SH Yoo),오창학(CH Oh) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.8
A case of the thoracoventropagus at full term consist of 2 males delivered by cesarean section is presented with brief review of literature.
유금준(GJ Yoo),강경주(KJ Kang),김중근(JG Kim),곽태로(TR Gwag) 대한산부인과학회 1987 Obstetrics & Gynecology Science Vol.30 No.6
저자들은 개인병원에서 소파수술후 지속적인 성기출혈을 주소로하여 내원한 47세의 경산부에서 희귀한 자궁경관임신을 경험하여 자궁전적출술을 시행하였고 병리조직학적 검사에서 확진되었기에 문헌적 고찰과 함께 보고하는 바이다 A case of cervial pregnancy which is recently experienced in our department is presented with a brief review of related literatures
Cho, SR,Ock, SA,Yoo, JG,Mohana kumar, B,Choe, SY,Rho, GJ Blackwell Verlag GmbH 2005 Reproduction in domestic animals Vol.40 No.2
<P>Contents</P><P>The present study was designed to examine the effects of cell-cycle synchronization protocols, such as confluent, roscovitine treatment and serum starvation, in bovine foetal fibroblasts on synchronization accuracy at G0/G1, viability, apoptosis, necrosis and ploidy for use as a nuclei donor. The cells in 5–10 passages were randomly allocated into three treated groups. Cells were cultured either in Dulbecco's modified Eagle's medium (DMEM) + 10% foetal bovine serum (FBS) until 90% confluent (group 1, confluent), in DMEM + 10% FBS + 30 <I>μ</I>M roscovitine for 12 h (group 2, roscovitine), or in DMEM + 0.5% FBS for 5 days (group 3, serum starvation). Most of the cells (>80%) in all groups were arrested at the G0/G1 stage. Although the rates did not differ, cells in group 1 showed an increased cell population arrested at the G0/G1 phase. Significantly (p < 0.05) higher rates of apoptosis occurred in group 3 than in group 1 and 2 (10% vs 6% and 6%, respectively). No differences in chromosomal abnormality were observed among groups. However, by increasing the number of cell culture passages up to 15, significantly (p < 0.05) higher chromosomal abnormality was observed than in 5 and 10 passages (39% vs 28% and 23%, respectively) in group 1. The results clearly indicated that bovine foetal fibroblasts could be effectively synchronized at G0/G1 stages by all the three different treatments, confluent, roscovitine and serum starvation. However, cells in confluent showed reduced apoptosis and necrosis when they underwent 5–10 passages, exhibiting increased percentage of cells with stable chromosome diversity. Hence, cells in confluent merit further studies before they could be used as nuclear donors.</P>
윤승찬(SC Yoon),우성현(SH Yoo),이현복(HB Lee),홍숙호(SH Hong),민부기(BG Min),박영하(YH Park),지제근(JG Chi) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.2
저자 등은 최근 을지병원 산부인과에서 경험한 27세의 경산부에서 질식분만 후 단안증으로 판명된 1례를 보고하며 그 분류 및 발생원인 등에 관하여 문헌적고찰과 함께 보고하는 바이다. This curious malformation in which the eyes are fused together(Synophalmia), which derived its name from cyclops, the one eyed giant of Greek legend, is a common fetal ocular anomaly, such a serious degree of maldevelopment is incompatible with survival and is therefore usually encountered by obstetricians rather than ophthalmic surgeion. Authors report a case of cyclops associated hydroamnios in 27 years old, para 1-0-0-1, diagnosed rule out fetal anomaly with sonogram(B-mode), delivered in the 34 weeks pregnancy due to vaginal spotting, and labor pain. We have experienced one case of cyclops to present one case with brief review of concerned literature.
자궁내막유착증의 자궁내시경치료 후에 발생한 화농성척추염 (Pyogenic Spondylitis) 1 례
임헌정,김동진,기광수,유범준,양승옥,박중기 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11
Hysteroscopy is an endoscopic procedure generally free of complication. The potential risks of hysteroscopy include uterine perforation, bleeding, infection, thermal trauma, complications related to anesthesia, and complications related to the distending media. The pulmonary edema and water intoxication by intravasation of distending medium is a serious complication. Postoperative infection after operative hysteroscopy is rare and may arise as endometritis, pyometra, parametritis or pelvic infection. However, it has not been reported for pyogenic spondylitis. The authors have experienced a case of pyogenic spondylitis after hysteroscopic treatment of uterine synechiae and report our experience with a brief review of the literature.