NMR and X-ray Study Revealing the Rigidity of Zeolitic Imidazolate Frameworks

Morris, William,Stevens, Caitlin J.,Taylor, R. E.,Dybowski, C.,Yaghi, Omar M.,Garcia-Garibay, Miguel A. American Chemical Society 2012 The Journal of Physical Chemistry Part C Vol.116 No.24

<P>NMR relaxation studies and spectroscopic measurements of zeolitic imidazolate framework-8 (ZIF-8) are reported. The dominant nuclear spin–lattice relaxation (<I>T</I><SUB>1</SUB>) mechanism for ZIF-8 in air arises from atmospheric paramagnetic molecular oxygen. The <SUP>13</SUP>C <I>T</I><SUB>1</SUB> measurements indicate that the oxygen interacts primarily with the imidazolate ring rather than the methyl substituent. Similar relaxation behavior was also observed in a ZIF with an unsubstituted ring, ZIF-4. Single-crystal X-ray diffraction was used to provide data for the study of the thermal ellipsoids of ZIF-8 at variable temperatures from 100 to 298 K, which further confirmed the rigid nature of this ZIF framework. These results highlight a rigid ZIF framework and are in contrast with dynamic metal–organic frameworks based on benzenedicarboxylate linking groups, for which the relaxation reflects the dynamics of the benzenedicarboxylate moiety.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-24/jp303907p/production/images/medium/jp-2012-03907p_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp303907p'>ACS Electronic Supporting Info</A></P>

Advances in pharmaceutical materials and processing

Morris, Kenneth R.,Nail, Steven L.,Peck, Garnet E.,Byrn, Stephen R.,Griesser, Ulrich J.,Stowell, Joseph G.,Hwang, Sung-Joo,Park, Kinam 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

Advances in pharmaceutical materials and processing require new generations of pharmaceutical technologies, which in turn require an improved understanding of each step in the unit processes of dosage form development. The unit processes range from raw material qualification to final product release using process monitoring of critical steps. The authors illustrate some recent research trends in understanding and improving pharmaceutical materials and processing through the use of experience obtained within several research programs at Purdue University (West Lafayette, IN, USA).

Toenail selenium levels and prevalence of dyslipidaemia among Korean adults

Jang, Jiyoung,Morris, J. Steven,Park, Kyong Cambridge University Press 2017 The British journal of nutrition Vol.118 No.6

<B>Abstract</B><P>Multiple studies have elucidated the antioxidant properties of Se, which are now well known among the nutrition and biomedical science communities. Recently, considerable interest has been focused on the possible association between Se exposure and risk of metabolic disease, such as lipid dysregulation; however, there is limited epidemiological data on this topic. The present study aimed to investigate associations between toenail Se levels and dyslipidaemia or individual lipid levels, and to examine the effect of dietary supplement use on these associations. We analysed baseline data from a cohort in the Yeungnam area, including 232 men and 269 women. Information on demographic, dietary and lifestyle characteristics was obtained through a self-reported questionnaire. Se levels in toenail specimens were measured using neutron activation analysis. Fasting blood lipid levels were measured during medical examinations. After adjusting for multiple confounding variables, we observed no association between toenail Se levels and dyslipidaemia or individual lipid profiles. However, the association was modified by dietary supplement use. Among the supplement users, higher toenail Se levels were associated with a higher prevalence of lipid dysregulation, whereas non-users exhibited a lower prevalence of lipid dysregulation. Associations between toenail Se levels, lipid levels and dyslipidaemia may be influenced by taking dietary supplements. Future large-scale, prospective cohort studies should be conducted to further evaluate the association between Se levels in the body and metabolic health effects in light of increasing rates of dietary supplement use.</P>

Demographic and lifestyle factors and selenium levels in men and women in the U.S.

Kyong Park,Eric Rimm,David Siscovick,Donna Spiegelman,J. Steven Morris,Dariush Mozaffarian 한국영양학회 2011 Nutrition Research and Practice Vol.5 No.4

Selenium is an antioxidant trace element linked to cardiovascular disease and cancer. Although diet is a major source, relatively little else is known about independent determinants of selenium levels in free-living humans. In this study, we aimed to investigate the independent demographic, lifestyle, and dietary determinants of selenium levels in 1,997 men and 1,905 women in two large prospective U.S. cohorts. Toenail selenium levels were quantified using neutron activation analysis. Diet, geographic residence, demographic, and environmental factors were assessed by validated self-administered questionnaires. Multivariate generalized linear models were conducted to assess the independent relations of these factors with toenail selenium levels, correcting for measurement error in the diet. In multivariable-adjusted analyses, independent predictors of higher selenium were male gender (6.3% higher levels); living in West and Northern-Midwest U.S. regions (8.9% and 7.4% higher than Southern-Midwest regions, respectively); consumption of beef and bread products (between 0.7 - 2.5% higher per daily serving); and selenium supplement use (6.9% higher than non-users); whereas cigarette smoking (5-10% lower than never smokers) , older age (0.6% lower per 5 years), and consumption of eggs, white rice, dairy products, coffee, and alcohol (between 0.1 to 2.0% lower per daily serving) were associated with lower selenium. Multiple dietary and non-dietary factors independently predicted selenium levels, suggesting that both consumption and non-dietary processes (e.g., related to oxidant status) may affect levels. Significant geographic variation in selenium levels exists in the US.

Demographic and lifestyle factors and selenium levels in men and women in the U.S.

Park, Kyong,Rimm, Eric,Siscovick, David,Spiegelman, Donna,Morris, J. Steven,Mozaffarian, Dariush The Korean Nutrition Society 2011 Nutrition Research and Practice Vol. No.

Selenium is an antioxidant trace element linked to cardiovascular disease and cancer. Although diet is a major source, relatively little else is known about independent determinants of selenium levels in free-living humans. In this study, we aimed to investigate the independent demographic. lifestyle, and dietary determinants of selenium levels in 1,997 men and 1,905 women in two large prospective U.S. cohorts. Toenail selenium levels were quantified using neutron activation analysis. Diet, geographic residence, demographic, and environmental factors were assessed by validated self-administered questionnaires. Multivariate generalized linear models were conducted to assess the independent relations of these factors with toenail selenium levels, correcting for measurement error in the diet. In multi variable-adjusted analyses, independent predictors of higher selenium were male gender (6.3% higher levels); living in West and Northern-Midwest U.S. regions (8.9% and 7.4% higher than Southern-Midwest regions, respectively); consumption of beef and bread products (between 0.7 - 2.5% higher per daily serving); and selenium supplement use (6.9% higher than non-users); whereas cigarette smoking (5-10% lower than never smokers), older age (0.6% lower per 5 years), and consumption of eggs, white rice, dairy products, coffee, and alcohol (between 0.1 to 2.0% lower per daily serving) were associated with lower selenium. Multiple dietary and non-dietary factors independently predicted selenium levels, suggesting that both consumption and non-dietary processes (e.g.. related to oxidant status) may affect levels. Significant geographic variation in selenium levels exists in the US.