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Evaluation of vaccines for the SAT 1, SAT 2, and SAT 3 serotypes of Foot-and-Mouth Disease in pigs
Hye-Eun Jo(Hye-Eun Jo),Su-Hwa You(Su-Hwa You),Joo-Hyung Choi(Joo-Hyung Choi),Mi-Kyeong Ko(Mi-Kyeong Ko),Sung Ho Shin(Sung Ho Shin),Hyundong Jo(Hyundong Jo),Min Ja Lee(Min Ja Lee),Su-Mi Kim(Su-Mi Kim) 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-
( Hyundong Jo ),( Ha Young Jang ),( Gi Soo Youn ),( Donggyu Kim ),( Chae Yeon Lee ),( Jae Hee Jang ),( Soo Young Choi ),( Jong-gab Jun ),( Jinseu Park ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.8
Human immunodeficiency virus-1 (HIV-1) transactivator of transcription (Tat) is an important viral factor in neuroinflammation. Hindsiipropane B, present in Celastrus hindsii, possesses various biological mechanisms including antiinflammatory activity. In this report, we explored the regulatory activity of hindsiipropane B on HIV-1 Tat-mediated chemokine production and its mode of action in astrocytes. Hindsiipropane B significantly alleviated HIV-1 Tat-mediated production of inflammatory chemokines, CCL2, CXCL8, and CXCL10. Hindsiipropane B inhibited expression of HDAC6, which is important regulator in HIV-1 Tat-mediated chemokine production. Hindsiipropane B diminished HIV-1 Tat-mediated reactive oxygen species (ROS) generation and NADPH oxidase activation/expression. Furthermore, hindsiipropane B inhibited HIV-1 Tat-mediated signaling cascades including MAPK, NF-κB, and AP-1. These data suggest that hindsiipropane B exerts its inhibitory effects on HIV-1 Tat-mediated chemokine production via down-regulating the HDAC6-NADPH oxidase- MAPK-NF-κB/AP-1 signaling axis, and could serve as a therapeutic lead compound against HIV-1 Tat-associated neuroinflammation. [BMB Reports 2018; 51(8): 394-399]
FAST ANDROID IMPLIMENTATION OF MONTE CARLO SIMULATION FOR PRICING EQUITY-LINKED SECURITIES
HANBYEOL JANG,HYUNDONG KIM,SUBEOM JO,HANRIM KIM,SERI LEE,JUWON LEE,JUNSEOK KIM 한국산업응용수학회 2020 Journal of the Korean Society for Industrial and A Vol.24 No.1
In this article, we implement a recently developed fast Monte Carlo simulation (MCS) for pricing equity-linked securities (ELS), which is most commonly issued autocallable structured financial derivative in South Korea, on the mobile platform. The fast MCS is based on Brownian bridge technique. Although mobile platform devices are easy to carry around, mobile platform devices are slow in computation compared to desktop computers. Therefore, it is essential to use a fast algorithm for pricing ELS on the mobile platform. The computational results demonstrate the practicability of Android application implementation for pricing ELS.
Intervehicle Communication: Cox-Fox Modeling
Youngmin Jeong,Jo Woon Chong,Hyundong Shin,Win, M. Z. IEEE 2013 IEEE journal on selected areas in communications Vol.31 No.9
<P>Safety message dissemination in a vehicular ad-hoc network (VANET) requires vehicle-to-vehicle (V2V) communication with low latency and high reliability. The dynamics of vehicle passing and queueing as well as high mobility create distinctive propagation characteristics of wireless medium and inevitable uncertainty in space-time patterns of the vehicle density on a road. It is therefore of great importance to account for random vehicle locations in V2V communication. In this paper, we characterize intervehicle communication in a random field of vehicles, where a beacon or head vehicle (transmitter) broadcasts safety or warning messages to neighboring client vehicles (receivers) randomly located in a cluster on the road. To account for a doubly stochastic property of the VANET, we first model vehicle's random locations as a stationary Cox process with Fox's H-distributed random intensity (vehicle concentration) and derive the distributional functions of the lth nearest client's distance from the beacon in such a Fox Cox field of vehicles. We then consolidate this spatial randomness of receiving vehicles into a path loss model and develop a triply-composite Fox channel model that combines key wireless propagation effects such as the distance-dependent path loss, large-scale fading (shadowing), and small-scale fading (multipath fading). In Fox channel modeling, each constituent propagation effect is described as Fox's H-variate, culminating again in Fox's H-variate for the received power or equivalently the instantaneous signal-to-noise ratio at the lth nearest client vehicle. Due to versatility of Fox's H-functions, this stochastic channel model can encompass a variety of well-established or generalized statistical propagation models used in wireless communication; be well-fitted to measurement data in diverse propagation environments by varying parameters; and facilitate a unifying analysis for fundamental physical-layer performances, such as error probability and channel capacity, using again the language of Fox's H-functions. This work serves to develop a unifying framework to characterize V2V communication in a doubly stochastic VANET by averaging both the small- and large-scale fading effects as well as the (random) distance-dependent path losses.</P>
Joo-Hyung Choi,Su-Hwa You,고미경,Hye Eun Jo,Sung Ho Shin,Hyundong Jo,이민자,Su-Mi Kim,김병한,Jong-Soo Lee,박종현 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.5
Background: The quality of a vaccine depends strongly on the effects of the adjuvants applied simultaneously with the antigen in the vaccine. The adjuvants enhance the protective effect of the vaccine against a viral challenge. Conversely, oil-type adjuvants leave oil residue inside the bodies of the injected animals that can produce a local reaction in the muscle. The long-term immunogenicity of mice after vaccination was examined. ISA206 or ISA15 oil adjuvants maintained the best immunity, protective capability, and safety among the oil adjuvants in the experimental group. Objectives: This study screened the adjuvant composites aimed at enhancing foot-and-mouth disease (FMD) immunity. The C-type lectin or toll-like receptor (TLR) agonist showed the most improved protection rate. Methods: Experimental vaccines were fabricated by mixing various known oil adjuvants and composites that can act as immunogenic adjuvants (gel, saponin, and other components) and examined the enhancement effect on the vaccine. Results: The water in oil (W/O) and water in oil in water (W/O/W) adjuvants showed better immune effects than the oil in water (O/W) adjuvants, which have a small volume of oil component. The W/O type left the largest amount of oil residue, followed by W/O/W and O/W types. In the mouse model, intramuscular inoculation showed a better protection rate than subcutaneous inoculation. Moreover, the protective effect was particularly weak in the case of inoculation in fatty tissue. The initial immune reaction and persistence of long-term immunity were also confirmed in an immune reaction on pigs. Conclusions: The new experimental vaccine with immunostimulants produces improved immune responses and safety in pigs than general oil-adjuvanted vaccines.