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      • SCIESCOPUSKCI등재
      • 단일 처리기간에 의한 들깨의 생육 및 개화조절

        최영환,최영훈,강점순,손병구,김용철,최인수,주우홍 밀양대학교 농업기술개발연구소 2000 農業技術開發硏究所報 Vol.4 No.1

        It's not uncommon for the amount of leaves to be reduced significantly due to the early differentiation of flower-bud by short-day condition when growing perilla for harvesting the leaves in the greenhouse during the winter. This study analyzed the effect of day-length on the growth and regulation of flowering, which are closely related with differentiation of flower and amount of leaves. Development of new leaf was inhibited by short-day treatment for more than 5 days. As the period of short-day was longer, the effect on the development of new leaf inhibition was more evident. Number of leaves was reduced in both 40 days and 110 days short-day treatments as period of short-day length was longer. Short-day treatment for less than 3 days did not induce flowering, but short-day treatment for more than 5 days induced flowering. As the period of short-day treatment was shorter, percentage of flowering was lower and days to flowering was longer. That is, when treated for 20 days, flowering began in 20 days. Seed weight was reduced as the length of short-day treatment was longer.

      • SCIESCOPUSKCI등재
      • 강원도 어도의 설치 현황 및 I형 아이스하버식 어도 적용성 연구

        최한규,최영수,전영수 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B

        The concerned object of the construction industry is environment, It is one of the main purposes of today's construction that human can live reasonably in nature. This study is about the fish-road connecting hydraulic structure in the river with nature. Chapter 2, starting with the general investigation about fish-road and helps comprehension for relatively general fish-road such as necessity, establishment purpose, history, study example, relating domestic law, design condition, consideration and form of fish-road. Chapter 3, containing the present condition of fish-road facilities in Gangwon-Do and thoughts of the problems and general countermeasures of existing fish-road. Chapter 4, Having Examined compatibility by amount of flowing water through hydraulic model test in the Ice harbor I-type model. chapter 5, Analyzation and arrangement to efficient establishment plan of fish-road and the result of the hydraulic model experiment to be beaconed a little in forward fish-road study. In the hydraulic model test result, when we suppose establishment of 1~3 in slope of 1/20, could know that applicable drought flow of the river is 0.06~3.0m/sec in case of Ice harbor I-type which transforming Ice harbor that was invented as studying project of the Ministry of Environment.

      • SCIESCOPUSKCI등재
      • KCI등재

        HPLC를 사용한 쌀 중 잔류농약 동시분석법

        최재천,이영자,김소희,최수영,최희주,정성욱,박흥재,김우성 한국환경과학회 2005 한국환경과학회지 Vol.14 No.4

        A simple and sensitive analytical method based on RP-HPLC with UV detector(225 nm) and mobile phases using 0.1% phosphoric acid and acetonitrile was developed for simultaneous determination of quinclorac, bentazone, 2,4-D, bensulfuron-methyl, dymuron, capropamide, pencycuron, ethofenprox. This method was resulted in recovery of 78~ 96% with RSD 3.3~7.5%. LODs 0.12~0.84 and LOQs 0.34~1.20 ㎎/L. Calibration curves were linear with r of 0.9995~ 0.9999.

      • SCOPUSKCI등재

        만성 B형 간염에서 라미부딘 치료중 발생한 Viral Breakthrough 예의 임상 결과

        안수현,장윤정,오성남,최도원,백수정,정원석,최창원,김경오,임형준,조남영,박종재,김재선,박영태,이명석,연종은,변관수,이창홍 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.4

        목적: 만성 B형 간염의 치료 중 발생하는 약제 내성 변이종은 임상적으로는 치료 중 음전되었던 혈청 HBV DNA가 다시 양전되는 viral breakthrough 로 진단할 수 있다. 현재 약제 내성 변이종이 발생했을 경우라도 라미부딘 치료를 계속 유지하는 것을 권장하고 있으나, viral breakthrough 발생 예들의 장기적 임상경과가 아직도 불명확하여 이것을 일반화하기는 어려운 상황이다. 이에 라미부딘 사용 중 viral breakthrough 가 발생한 예들을 대상으로 그 임상경과를 알아보고자 하였다. 대상과 방법: 9개월 이상 라미부딘을 투약한 만성 B형 간염 환자로 viral breakthrough가 발생한 74명을 대상으로 하였다(남/여 54/20, 평균연령 42세). Viral breakthrough 후 혈청 ALT치, 총 빌리루빈치, HBV DNA 역가, HBeAg, anti-HBe를 정기적으로 검사하면서 임상경과를 관찰하였다. Viral breakthrough 후 라미부딘의 투약기간은 평균 13개 월(1-41개월)이었다. 결과: Viral breakthrough 발생후 혈청 ALT치가 정상으로 유지되었던 환자는 8예(11%)에 불과했고 나머지 66예(89%)에서는 ALT치가 증가하였으며, 이중 30예(41%)에서 급성 악화(ALT 정상 상한치의 5배 이상 상승)를 보였다. 급성악화는 viral breakthrough 후 3개월 내에 19예 (63%)에서 발생하여 3개월 내에 발생한 예가 많았으나 12개월 이상 지나서 나타나는 예도 약 20%에서 있었다. 비대상성 악화는 6예에서 관찰되었다. Viral breakthrough 후 급성악화가 일어난 예와 없었던 예의 비교에서 급성악화를 예측할 수 있는 인자는 발견할 수 없었다. Viral breakthrough 후 발견할 수 없었다. Viral breakthrough 후 HBeAg이 음전된 예는 8예(11%)였으나 그 임상경과는 양호하지 않았다. 결론: 만성 B형 간염 환자 에서 라미부딘 투여 중 발생한 viral breakthrough 예 중 상당수에서 급성악화가 발생하였으며, HBeAg 이 소실되더라도 그 임상경과는 양호하지만은 않았다. Viral breakthrough 발생 후 주의 깊은 임상경과 의 관찰이 요구되며, 앞으로 viral breakthrough 후 급성악화 예에 대한 대규모 연구와 적절한 치료방향의 제시가 이루어져야 할 것으로 생각된다. Background/Aims: Long-term lamivudine therapy can induce the emergence of lamivudine resistant hepatitis B virus (HBV) mutants. Clinically emergence of the mutant is expressed by the reappearance of disappeared HBV DNA in serum. Continued lamivudine treatment has been usually recommended in cases of viral breakthrough. However, the clinical outcome in patients with viral breakthrough is not clear. The aim of this study was to investigate the clinical course of chronic hepatitis B patients after viral breakthrough during lamivudine therapy. Methods: A total of 74 patients with chronic hepatitis B who showed viral breakthrough after at least 6 months of lamivudine treatment were included in this study. They had positive HBeAg and HBV DNA before treatment. The median follow-up duration after breakthrough was 13 months. Results: After viral breakthrough, only 8 patients (11%) maintained normal ALT levels and 66 patients (89%) showed elevation of ALT. 30 patients (41%) showed acute exacerbation of hepatitis (ALT increase over five-times upper normal limit). These acute exacerbations occurred within three months after breakthrough in 19 patients (63%). In the cases of acute exacerbation, 6 patients showed decompensated progression such as elevation of serum total bilirubin. One of them died of hepatic failure. A predictive factor for acute exacerbation was not found. HBeAg seroconversion occurred in 8 patients after viral breakthrough but their clinical course was highly variable. Conclusions: Chronic hepatitis B patients who had viral breakthrough during lamivudine therapy should be followed carefully and regularly in mind of potential clinical deterioration. New strategies are needed to manage the cases of acute exacerbation after viral breakthrough.(Korean J Hepatol 2002;8:389-396)

      • KCI등재

        사설 골프연습장 회원들의 스포츠사회화 요인과 생활적응 및 삶의 질의 관계

        최영수(Choi Young-Soo),한정훈(Han Jung-Hun) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.4

        This study aims at discovering the relationship between life Adaptation and Quality of Life with Sports Socialization by Golf Interest Group Members for Golf Practice Range . Objects for this study were adults who live in young-dong area as of 2008 and participate in Golf Interest Group Members for Golf Practice Range. 316 people were sampled through stratified cluster random sampling after sampling framework was set up. Only valid samples were encoded according to a certain coding guidelines. After inputting each of the coded data into computer, the researcher computed the data according to analytical purpose through the Statistics program of SPSS 14.0 version for Windows. On the basis of the above research method and findings, the induced conclusion was as follows: There were some reciprocal influences in the relationship between life Adaptation and Quality of Life with Sports Socialization Golf Interest Group Members for Golf Practice Range.

      • 천식환아와 정상아에서 β_2-아드레날린 수용체 유전자 다형에 관한 연구

        홍수종,김봉성,김자형,오홍범,이무송,최수옥,김미영,오선영,박양,고영률 대한소아알레르기 및 호흡기학회 2002 소아알레르기 및 호흡기학회지 Vol.12 No.4

        목적: 천식의 치료에 있어서 염증조절제의 역할이 강조되고 있기는 하지만, 아직 β_2- 아드레날린 수용체와 반응하여 기도 수축을 이완시키는 β_2- 항진제의 역할은 중요하다. 근래에 β_2- 아드레날린 수용체 유전자 다형과 관련하여, Gly16과 중증 천식 및 야간 천식과 관련이 있고, Glu27은 천식에서 기도과민성의 감소와 관련이 있으며, Gly16 Gln27 일배체형은 아토피군에서 야간 기침과 관련이 있다고 보고되었다. 본 연구에서 천식환자와 정상군에서 β_2- 아드레날린 수용체 유전자 다형이 차이가 있는지 확인하고, β_2- 아드레날린 수용체 유전자가 아토피지표 및 기도과민성과 연관성이 있는지 조사하였다. 방법: 천식으로 진단된 99명과 아토피가 없는 정상아 73명을 대상으로, 말초혈액내 총 호산구수와 혈청 총 IgE를 측정하였고, 메타콜린 기관지 유발검사 및 폐기능 검사를 실시하였다. β_2- 아드레날린 수용체 유전자의 일배체형 분석을 위해 아미노산 16과 27의 부위를 포함하고 있는 β_2- 아드레날린 수용체의 유전자부위를 polymerase chain reaction(PCR)으로 증폭한 후 16번으로 유전형은 allele specific PCR 27번 유전형은 PCR-restriction fragment length polymorphism(RELP)방법으로 분석하였다. 결과: β_2- 아드레날린 수용체의 16번과 27번 대립 유전자의 빈도는 두 군 사이에 차이가 없었으며, 16번과 27번 아미노산의 일배체형 빈도도 두 군 사이에 차이가 없었다. 그러나 Arg16 Glu27은 한 례도 없어 Arg16 은 Gln27 과 강한 연쇄불평형이 관찰되었다. 천식군에서 총호산구 수와 호산구 분율(%) 및 총 IgE 농도는 각각의 일배체형에 따라 차이가 없었으며, PC_20 및 기도 자극 후 β_2- 항진제에 대한 반응 수치도 각각 일배체형에 따라 차이가 없었다. 결론: 한국 소아에서 β_2- 아드레날린 수용체 유전자 16번 27번 코돈 다형은 천식 자체와는 관련이 없으며, 천식 환아에서 아토피 지표와 기도과민성 및 속효성 β_2- 항진제에 대한 반응과도 의미있는 연관성이 관찰되지 않았다. Background: The role of β_2-agonist is still important to control bronchoconstriction in asthma. Polymorphisms at aminoacid positions 16 and 27 of the β_2-adrenoceptor gene are associated with asthma phenotype. Glu 27 allele is associated with negatively with bronchial hyperresponsiveness(BHR) in asthmatic subjects and Gln 27 allele is associated positively with IgE levels, and Gly 16 Gln 27 haplotype is suggested to be positively associated with BHR in a population study. And Gly 16 Gln 27 haplotypes are positively associated with nocturnal cough in atopic subjects. To evaluate the association between β_2-adrenoceptor polymorphisms as asthmatic phenotypes, the frequency of β_2-adrenoceptor polymorphsisms at 2 sites(Arg16→Gly16 and Gln27→Glu27) were examined in asthmatic and normal children. Methods: Ninety nine asthmatic children and seventy three normal children were enrolled. Asthma phenotypes were determined by physician and bronchial responsiveness and genotypes of β_2-adrenoceptor polymorphisms were determined with PCR based methods. Results: The polymorphisms at aminoacid 16 and 27 of β_2-adrenoceptor gene was not different between asthmatic and normal children. The haplotype frequency of aminoacid 16 and 27 polymorphisms of β_2-adrenoceptor gene was not different between asthmatic and normal children. Haplotypes of aminoacid 16 and 27 was not associated with total eosinophil count, eosinophil %, and total IgE in asthmatic children. Haplotypes of aminoacid 16 and 27 was not associated with PC_20, and response of FEV_1 after β_2agonist in asthmatic children. Conclusion: β_2- adrenoceptor polymorphisms is not associated with the expression of asthma, atopy, bronchial hyperresponsiveness, and response to β_2- agonist in Korean children.

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