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Hyejin Hyeon,Boram Go,Ho Bong Hyun,Sung Chun Kim,Seon-A Yoon,So Yeon Oh,Yong-Hwan Jung,Young-Min Ham 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, the essential oil (EO) and the major non-volatile metabolites in white flower buds of Magnolia denudata and violet flower buds of Magnolia liliiflora were analyzed using GC-MS and HPLC. The dominant EO compounds found in the flower buds were monoterpene hydrocarbons (MO), e.g. sabinene (15.8-14.6%), β-myrcene (17.2-9.9%), and β-pinene (12.9-7.7%). Univariate and multivariate analysis were subsequently performed to reveal the relationships between EO compounds and non-volatile metabolites in white and violet flower buds. The results revealed that most of monoterpenes and phenolic acids in the white flower buds, such as sabinene, β-pinene, and rutin, were found to be significantly higher compared to violet flower buds. Furthermore, hierarchical clustering analysis of correlation coefficients suggested a positive correlation between MO and phenolic compounds. Our findings revealed that the metabolic patterns of both EO and non-volatile compounds could reflect the metabolic characteristics of the different colored flower buds. Further studies will be conducted to investigate the biological activities derived from EO and non-volatile compounds.
Do Hyejin,Lee Chunui,Hong Hyeon Don,Hong Hyejin,Lim Hyun Kyo,Kim Sujin 대한외상학회 2023 大韓外傷學會誌 Vol.36 No.2
Submental intubation is an effective alternative technique for airway management in patients with maxillofacial trauma. Compared with tracheostomy, it is less invasive, but has risks associated with potential airway compromise such as hypoxia due to tube obstruction, collapse, and kinking. To shorten procedure time and ensure a reinforced tube lumen, we used a laparoscopic trocar as a new device for submental intubation. A 54-year-old male patient sustained a zygomaticomaxillary complex fracture and was scheduled to undergo open reduction and internal fixation. We performed intraoral intubation and made a small 1-cm incision at the submandibular midline. After dissection of the tissue from the incision site, a reinforced tube was passed using a 12-mm laparoscopic trocar. The procedure took about 5 minutes, and apnea time from disconnecting the breathing circuit and passing through the internal lumen of the trocar until it was reconnected to the ventilator was 1 minute 5 seconds. Using a laparoscopic trocar for submental intubation can reduce the time required for dissection, prevent luminal occlusion complications due to soft tissues or blood clots in the endotracheal tube, and decrease soft tissue damage.
Hyejin Sim,Ji Hyeon Ahn,Jae-Chul Lee,Jung Hoon Choi,Ki Yeon Yoo,Choong Hyun Lee,Joon Ha Park,Tae-Kyeong Lee,Moo-Ho Won 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Angelica gigas Nakai root contains decursin which exerts beneficial properties such as anti-amnesic and anti-inflammatory activities. Until now, however, the neuroprotective effects of decursin against transient ischemic injury in the forebrain have been insufficiently investigated. Here, we revealed that post-treatment with decursin and the root extract saved pyramidal neurons in the hippocampus following transient ischemia for 5 minutes in gerbil forebrain. Through HPLC, we defined that decursin was contained in the extract as 7.3 ± 0.2%. Based on this, we post-treated with 350 mg/kg extract which is corresponding dosage of 25 mg/kg decursin that exerted neuroprotection in gerbil hippocampus against the ischemia. In addition, behavioral tests were conducted to evaluate ischemia-induced dysfunctions via tests of spatial memory and learning memory, and post-treatment with the extract and decursin attenuated ischemia-induced memory impairments. Furthermore, we carried out histochemistry, immunohistochemistry and double immunohistofluorescence. Pyramidal neurons located in the subfield cornu ammonis 1 (CA1) among the hippocampal subfields were dead at 5 days after the ischemia; however, treatment with the extract and decursin save the pyramidal neurons after ischemia. IgG, which is not found in the parenchyma in normal brain tissue, was apparently shown in CA1 parenchyma from 2 days after the ischemia, but IgG leakage was dramatically attenuated in the CA1 parenchyma treated with the extract and decursin. Furthermore, astrocyte end feet, which are a component of the blood-brain barrier (BBB), were severely damaged at 5 days after the ischemia, however, post-treatment with the extract and decursin dramatically attenuated the damage of the endfeet. Based on these findings, we suggest that Angelica gigas Nakai root containing decursin can be employed as pharmaceutical composition to develop therapeutic strategy for brain ischemic injury.