中國과 東方 주변국가 사이의 哲學의 상호교류 및 그 영향

黃心川 漢陽大學校 民族學硏究所 1994 民族과文化 Vol.2 No.-

Enhanced Antitumor Efficacy with Combined Administration of Astragalus and Pterostilbene for Melanoma

Huang, Xin-Yan,Zhang, Song-Zhao,Wang, Wen-Xi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Astragalus, a commonly used traditional Chinese medicine, has exhibited antitumor actions in patients. In this study, in vitro and in vivo antitumor effects of astragalus and synergistic antitumor efficacy in combination with pterostilbene were investigated. Melanoma cells were treated with pterostilbene (Pt), graduated doses of astragalus injection (AI), or these in combination. Cell viability was measured using a MTT assay. Released nucleosomes and caspase activity were measured using enzyme-linked immunosorbent assay. Growth inhibition in vitro and in vivo was also assessed. Analysis of variance and t tests were used for statistical analysis. Significant reduction (p<0.05) in cellular proliferation were observed with AI and AI-Pt in a time- and concentration-dependent manner. Apoptosis and caspase-3/7 activity were significantly increased by AI and AI-Pt treatment (p<0.05). In vivo, AI inhibited melanoma tumor growth, with inhibition rates ranging from 36.5 to 62.3%, by inducing apoptosis via up-regulation Bax expression and the Bax/Bcl-2 ratio and down-regulating Bcl-2 expression. AI significantly inhibits the growth of melanoma in vitro and in vivo by inducing apoptosis. These data suggest that combined treatment of astragalus with pterostilbene enhances antitumor efficacy.

Pemetrexed as a Component of First-, Second- and Third-line Chemotherapy in Treating Patients with Metastatic Lung Adenocarcinoma

Huang, Xin-En,Tian, Guang-Yu,Cao, Jie,Xu, Xia,Lu, Yan-Yan,Wu, Xue-Yan,Liu, Jin,Shi, Lin,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Purpose: The current research was conducted to investigate the efficacy and safety of pemetrexed given continuously as a basement agent for first-, second- to third line chemotherapy of patients with metastatic lung adenocarcinoma. Patients and Methods: Patients with metastatic lung adenocarcinoma who were diagnosed in Jiangsu Cancer Hospital and Research Insitute, were enrolled. All received pemetrexed 500 $mg/m^2$ (intravenous; on day 1), and another chemotherapieutic agent every 3 weeks until disease progression, or intolerable toxicity. Then the patients were changed to a second line chemotherapy that was still based on pemetrexed 500 $mg/m^2$ and another chemotherapeutic agent differing from the first line example, until disease progression, or intolerable toxicity. When third line chemotherapy was needed, pemetrexed 500 $mg/m^2$ and another new chemotherapeutic agent were combined until disease progression. Evaluation of efficacy was conducted after two cycles of chemotherapy using the Response Evaluation Criteria for Solid Tumors. Toxicity was recorded according to NCI Criteria for Adverse Events version 3.0. Results: From January 2010 to September 2013, 15 patients were enrolled. Their median age was 56 years (range 43 to 77 years). Eight patients were male and 7 female. Five patients (33.3%) achieved PR, while 6 patients (40.0%) remained stable, no CR on first line; and 1 PR (7.7%), 5 stable (38.5%) were recorded when pemetrexed was ordered in second line; 5 patients (41.7%) were stable after pemetrexed was combined in third line; no complete response was observed. Main side effects were grade 1 to 2 neutrophil suppression and thrombocytopenia. Other toxicities included elevated transaminase and oral mucositis, but no treatment related death occurred. Conclusions: Pemetrexed continuously as a basement agent from first-, second- to third line chemotherapy is mildly effective in treating patients with metastatic lung adenocarcinoma with tolerable toxicity.

FORCE CONTROL RESEARCH OF ROBOT MANIPULATORS

Huang Xin Han,Yuan Jun,Hu Jian Yuan 대한전자공학회 1992 대한전자공학회 Conference Vol.1992 No.2

학교폭력 가해경험에 대한 메타분석

( Xin Huang ),신태섭 ( Tae Seob Shin ),최윤정 ( Youn-jeng Choi ),추지윤 ( Ji Yun Chu ),신민경 ( Min Kyoung Shin ),김예원 ( Ye Won Kim ) 한국청소년학회 2023 청소년학연구 Vol.30 No.7

본 연구에서는 학교폭력 가해경험 관련 보호요인과 위험요인의 효과크기를 파악하기 위해 논문 175편을 수집하여 메타분석을 실시하였다. 분석결과에 따르면 학교폭력 가해경험 관련 보호요인 중 개인특성 변인이 가장 큰 효과크기로 나타났으며, 학교환경, 가정환경의 효과크기가 그 뒤를 이었다. 개인특성하위요인 중에서는 자아탄력성, 가정환경 변인에서는 긍정적인 부모-자녀 관계, 학교환경 변인에서는 학급응집력이 가장 높은 상관을 나타냈다. 조절효과를 검증한 분석에서 학교급에 따른 학교환경 변인군에서 차이가 있으며, 초등학생의 관련성이 가장 높게 나타났다. 한편, 학교폭력 가해경험 관련 위험요인의 효과크기는 학교환경, 지역사회, 개인특성, 가정환경의 순으로 나타났다. 학교환경 하위요인 중 가해·피해경험, 지역사회 변인 중 유해환경, 개인특성 변인 중 폭력허용도, 가정환경 변인 중 부모-자녀 폭력과의 상관이 높은 것으로 나타났다. 학교급에 따라 중학생은 가정과 학교 변인 군, 초등학생은 지역사회 변인군에서 큰 관련성을 보였다. 본 결과를 토대로 청소년의 학교폭력 가해경험을 감소·예방하는 방안과 후속연구를 위한 시사점을 제안하였다. The purpose of this study was to conduct a meta-analysis to determine the effect size of protective and risk factors related to violence experiences at school. Results show that the individual level appeared to have the largest effect size among the protective factors associated with school violence perpetration experiences, followed by the school and family level. Specifically, we found the greatest effect size with resilience at the individual level, the positive parent-child relationship at the family level, and class cohesiveness at the school level. As for the risk factors, the school-level variable appeared to have the largest effect size associated with school violence experiences, followed by the community, individual and family level factors. Specifically, we found the greatest effect size with violence acceptability among the individual level factors, parent-child violence among the family level factors, previous experience of school violence victimization and bullying among the school level factors, and harmful environment among the community level factors. Based on these results, some implications and suggestions to reduce and prevent adolescents' experience of school violence perpetration were recommended for follow-up research.

A simple rat model of in situ reversible obstructive jaundice in situ reversible obstructive jaundice model

Xin Huang,Chong-Hui Li,Ai-Qun Zhang,Zhe Kong,Wan-Qing Gu,Jia-Hong Dong 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.6

Purpose: To develop a simple and reliable rat model of in situ reversible obstructive jaundice with low morbidity and mortality rates. Methods: Rats were divided into 4 groups with 8 rats each: the sham-operated (SH) group only underwent laparotomy, the control internal drainage (ID-C) group underwent choledochoduodenostomy, the new internal drainage (ID-N) group and the long-term internal drainage (ID-L) group underwent choledochocholedochostomy. Common bile duct ligation was performed in all the drainage groups 7 days before reversal procedures. All rats were sacrificed for samples 7 days after the last operation except rats of the ID-L group that survived 28 days before sacrifice. Body weight, liver function, histopathological changes, morbidity and mortality were assessed. Results: One rat died and 2 rats had complications with tube blockage in the ID-C group. No death or complications occurred in the ID-N and ID-L groups. The drainage tube remained patent in the long-term observation ID-L group. Body weight showed no significant difference between the ID-C and ID-N groups after 7 days drainage. Liver function was not fully recovered in the ID-C and ID-N groups after 7 days drainage, but statistical differences were only observed in the ID-C group compared with the SH and ID-L groups. Periportal inflammation and bile duct proliferation showed severer in the ID-C group than in the ID-N group. Conclusion: The present study provided an efficient, simple, and reliable rat model that is especially suitable for long-term or consecutive studies of reversible obstructive jaundice.

중학생이 지각한 부모양육태도, 교사-학생 관계, 자존감 및 학업무기력 간의 구조적 관계: 성별에 따른 다집단 분석

( Huang Xin ),신태섭 ( Shin Tae Seob ) 충남대학교 교육연구소 2021 교육연구논총 Vol.42 No.1

본 연구에서는 중학생이 지각하는 부모양육태도, 교사-학생 관계, 자존감 및 학업무기력 간의 구조적 관계를 분석하고, 이 변인들 간의 관계에서 나타나는 자아존중감의 매개효과와 성별 간 차이를 탐색하고자 하였다. 이를 위해 한국아동청소년패널조사(KCYPS) 2018년의 중학교 1학년 2,541명의 데이터를 활용하여 주요 변인 간의 구조적 관계를 파악하고자 하였다. 주요 분석 결과는 다음과 같다. 첫째, 중학생이 지각하는 긍정적 부모양육태도와 교사-학생관계는 자존감에 정적 영향을 미치는 반면에 부정적 부모양육태도가 부적 영향을 미쳤다. 둘째, 부정적 부모양육태도는 학업무기력에 정적 영향, 교사-학생 관계와 자존감은 학업무기력에 부정 영향을 미쳤다. 셋째, 긍정적 부모양육태도와 학업무기력 관계에서 자존감이 완전매개가 나타났으며, 부정적 부모양육태도 및 교사-학생 관계와 학업무기력의 관계에서 자존감의 부분매개효과가 나타났다. 넷째, 성별에 따른 다집단분석 결과는 긍정적 부모양육태도에서 학업무기력까지 이르는 경로에서 차이가 통계적으로 유의하였다. 이러한 결과를 중심으로 본 연구의 의미와 시사점을 논의에 제시하였다 The purpose of this study was to examine the effects of parenting attitudes and teacher-student relationships on the academic helplessness of middle school student, investigate the mediating effect of self-esteem, and explore multi-group differences in these relations by gender. Data from 2,541 seventh-graders who participated in the“2018 Korean Children and Youth Panel Survey” were obtained. A structural equation model was set up to verify the relationship among the main variables. The results were as follows: First, a positive parenting attitude and teacher-student relationship showed positive effects on self-esteem, while a negative parenting attitude showed negative effects. Second, a negative parenting attitude showed positive effects on academic helplessness and teacher-student relationship, while self-esteem showed negative effects on academic helplessness. Third, positive parenting attitudes affected academic helplessness by completely mediating self-esteem, while negative parenting attitudes affected teacher-student relationships and academic helplessness by partially mediating the self-esteem. Fourth, there was a statistically significant difference between positive parenting attitudes and academic helplessness by gender. Based on these results, implications were discussed.

Thalidomide Combined with Chemotherapy in Treating Patients with Advanced Colorectal Cancer

Huang, Xin-En,Yan, Xiao-Chun,Wang, Lin,Ji, Zhu-Qing,Li, Li,Liu, Meng-Yan,Qian, Ting,Shen, Hui-Ling,Gu, Han-Gang,Liu, Yong,Gu, Ming,Deng, Li-Chun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Objective: To assess the safety and effectiveness of thalidomide (produced by CHANGZHOU PHARMACEUTICAL FACTORY CO.LTD) combined with chemotherapy in treating patients with advanced colorectal cancer. Method: A consecutive cohort of pretreated patients with advanced colorectal cancer were treated with thalidomide combined with chemotherapy. And chemotherapy for patients with advanced colorectal cancer were administered according to the condition of patients. Thalidomide was orally administered at a dosage of 50mg/day to 150mg/day before sleeping for at least 14 days. After at least 14 days of treatment, safety and side effects were evaluated. Results: There were 12 female and 3 male patients with advanced cancer recruited into this study, including 9 patients with colon, 6 patients with rectal cancer. The median age of patients was 57(41-82) years. Partial response was observed in 2 patients (2/15), and stable disease in 3 patients(3/15). Incidences of Grade 1 to 2 myelosuppression was observed in 1/15 patients, and Grade 1 to 2 elevation of hepatic enzyme was recorded in 1/15 patients. Adverse effects on the gastrointestinal tract were documented in 1/15 patients, and were Grade 1. No Grade 3-4 toxicities were diagnosed. No treatment related death was found. Conclusions: Thalidomide combined with chemotherapy was safe and mildly effective in treating patients with advanced colorectal cancer. However, further study should be conducted to clarify the effectiveness of this combination.

OsMSR15 encoding a rice C2H2-type zinc finger protein confers enhanced drought tolerance in transgenic Arabidopsis

Xin Zhang,Bin Zhang,Ming Juan Li,Xu Ming Yin,Li Fang Huang,Yan Chun Cui,Man Ling Wang,Xin Jie Xia 한국식물학회 2016 Journal of Plant Biology Vol.59 No.3

Zinc nger proteins (ZFPs) play important roles in plant responses to biotic and abiotic stresses. Through microarray analysis, an Oryza sativa L. multi-stress-responsive gene, OsMSR15, was identied and subsequently cloned from rice Pei’ai 64S (Oryza sativa L.). Expression of OsMSR15 was strongly up-regulated by cold, drought and heat stresses in different tissues at different developmental stages of rice. OsMSR15 contains two C2H2-type zinc nger motifs, a nuclear localization signal (B box), a Leu-rich domain (L-box) and a conserved EAR-motif close to its C-terminus. The OsMSR15-GFP fusion protein was localized to the nucleus. Yeast-one hybrid assay showed that OsMSR15 possesses transcriptional activation ability. Expression of OsMSR15 in Arabidopsis conferred drought tolerance, and transgenic plants showed hypersensitivity to exogenous ABA during the seed germination and post-germination stages. Transgenic plants also showed higher levels of free proline, less electrolyte leakage and increased expressions of a number of stress-responsive genes, including LEA3, RD29A, DREB1A and P5CS1 under drought stress. The obtained results indicate that OsMSR15 is an important regulator involved in plant response to drought stress.

The Aurora Kinase Inhibitor CYC116 Promotes the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells

Xin Xie,Wanzhi Tu,Chenwen Huang,Ziyang Chen,Xinyue Ren,Bingqing He,Xiaoyan Ding,Yuelei Chen,Xin Xie 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.12

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in applications such as regenerative medicine, cardiac disease modeling, and in vitro drug evaluation. However, hPSC-CMs are immature, which limits their applications. During development, the maturation of CMs is accompanied by a decline in their proliferative capacity. This phenomenon suggests that regulating the cell cycle may facilitate the maturation of hPSC-CMs. Aurora kinases are essential kinases that regulate the cell cycle, the role of which is not well studied in hPSC-CM maturation. Here, we demonstrate that CYC116, an inhibitor of Aurora kinases, significantly promotes the maturation of CMs derived from both human embryonic stem cells (H1 and H9) and iPSCs (induced PSCs) (UC013), resulting in increased expression of genes related to cardiomyocyte function, better organization of the sarcomere, increased sarcomere length, increased number of mitochondria, and enhanced physiological function of the cells. In addition, a number of other Aurora kinase inhibitors have also been found to promote the maturation of hPSC-CMs. Our data suggest that blocking aurora kinase activity and regulating cell cycle progression may promote the maturation of hPSC-CMs.