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MIMO-OFDM 시스템을 위한 가상 기준 신호를 이용한 채널 추정 기법
서희진(Heejin Seo),박선호(Sunho Park),김진홍(Jinhong Kim),심병효(Byonghyo Shim) 한국전자파학회 2016 한국전자파학회논문지 Vol.27 No.1
본 논문에서는 다중 입출력 안테나 OFDM 통신시스템에서 가상 기준 신호(virtual pilot signal)를 사용하는 한 연판정 지향 채널 추정 기법을 제안한다. 기준 신호만을 이용하여 채널을 추정하는 기존 방식과 달리 제안하는 기법은 기준신호와 데이터를 동시에 사용하여 채널을 추정한다. 또한, 제안하는 기법에서 채널을 추정하기 위해 사용할 데이터를 선택하는 알고리즘을 제안한다. 모의실험을 통해 제안하는 기법이 기존 채널 추정에 비해 향상된 성능을 갖는 것을 확인할 수 있다. In this paper, we proposed a soft decision-directed channel estimation based on MMSE estimation for MIMO-OFDM system. While the conventional method employs only pilot signals for channel estimation, the proposed algorithm performs channel estimation using pilot and reliable data signals. We also proposed selection criterion among reliable data signal for channel estimation. From numerical simulations, we show that the proposed channel estimator achieves 1 dB performance gain over conventional channel estimators.
Heejin Jeong,Myung Jin Oh,Nari Seo,Hyun Joo An 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07
In recent years, liquid biopsy has been noted for its outstanding advantages over tissue biopsy including ease of sampling, effective monitoring, and longitudinal assessment of treatment dynamics. In particular, Cerebrospinal fluid(CSF), a body fluid that directly interacts with the extracellular fluid of the brain and central nervous system, is a representative body fluid used for liquid biopsy and is becoming a potential source for neurological study. Mucopolysaccharidosis is a fatal neurodegenerative lysosomal storage disease caused by lysosomal β-gal deficiency and of galactose-containing substrates accumulate in various tissues such as brain and liver. Therefore, continuous monitoring of changes in the expression of galactose substrates in the brain is important for the diagnosis and treatment of disease. However, the low protein content of the biofluid makes this difficult. Here, we developed a highly sensitive, absolute quantitation platform for N-glycans containing terminal galactose(A2G2/A2G2F) to determine mucopolysaccharidosis using liquid biopsy of mouse CSF within 2hours. N-glycans labeled with InstantPC were quantified using hydrophilic interaction chromatography(HILIC) coupled with multiple response monitoring(MRM)-MS. In particular, A2G2/A2G2F glycans are present in less than 5% even in very small amount of mouse CSF, but it is possible to quantify glycans in 300nL mouse CSF at the femtomole level. Indeed, we were able to achieve high reproducibility within 15% of CV in experimental/instrumental replicates in the concentration range of 0.1 to 500pg/μL with quantitative linearity. Our glycan quantification platform can be potentially applied for diagnosis and monitoring of patients for neurodegenerative diseases at trace amounts of CSF (about 5μL) in a much more convenient and non-invasive manner.