何仙姑의 八仙 진입과 形象化 고찰

周鶴群 ( Zhou He-qun ) 성균관대학교 대동문화연구원 2023 大東文化硏究 Vol.124 No.-

이 논문은 유일한 女神仙으로서 何仙姑가 八仙에 진입하게 된 과정을 살피고, 나아가 하선고가 팔선에 진입한 후의 이미지 변화를 고찰하는 데 그 목적이 있다. 하선고는 여러 다른 지역에서 명성을 떨쳤던 지방 여선이었다. 그러나 全眞教 교도들이 祖師 呂洞賓의 신통을 돋보이게 하기 위해 하선고 고사를 각색하였고 그로 인해 하선고는 道教 계보에 편입하게 되었다. 이후 하선고는 여동빈의 제자로서 서서히 팔선에 진입하였다. 하선고가 팔선에 합류된 것은 다른 7명의 신선보다 비교적 늦은 시기인 嘉靖 年間(1522~1566)이었다. 명대 이후 팔선 서사는 점차 世俗化하여 하선고의 이미지에서 女性性이 강조되기 시작하였다. 이는 특히 연극・소설 등 通俗文學에서 두드러졌다. 따라서 하선고 개인의 고사는 더 이상 주목받지 못하게 되었으며, 다만 팔선 멤버들과 함께 ‘親民的 신선’의 정체성을 공유하게 된다. 더불어 하선고의 여성성이 활용되어 극적인 스토리에 광채를 돋우는 역할을 담당했다. This paper aims to explore the process of He Xiangu’s entry into the Eight Immortals as the only female immortal and to further examine the changes in her image after she joined the group. He Xiangu was initially a local immortal who was well-known in several regions. However, The Quanzhen School altered her story to showcase the exceptional ability of their master, Lü Dongbin and included He Xiangu in the Taoist canon. Later, as a disciple of Lü Dongbin, she gradually became a member of the Eight Immortals. He Xiangu joined the Eight Immortals during the Jiajing period(1522~1566) of the Ming Dynasty, which was a relatively late date compared to the other seven members. After the Ming Dynasty, the narratives of the Eight Immortals began to be secularized, and He Xiangu’s image became more focused on femininity. This is especially evident in popular literature such as operas and novels. As a result, He Xiangu’s personal story no longer receives much attention, but she shares with the other members of the Eight Immortals the identity of ‘the god with the common touch’. In addition, the femininity of the female immortal He Xiangu adds flavor to the dramatic story.

Distribution of Cadherin in the Parahippocampal Area of Developing Domestic Chicken Embryos

He Zhou,XiaoFan Wang,Juntang Lin,Ze Zhao,Cheng Chang 한국뇌신경과학회 2020 Experimental Neurobiology Vol.29 No.1

Hippocampal formation is important in spatial learning and memory. Members of the cadherin superfamily are observed in the neural system with diverse spatial and temporal expression patterns and are involved in many biological processes. To date, the avian hippocampal formation is not well understood. In this study, we examined the expression of cadherin mRNA in chicken and mouse brains to investigate the morphological and cytoarchitectural bases of hippocampal formation. Profiles of the spatiotemporal expression of cadherin mRNAs in the developing chicken embryonic parahippocampal area (APH) are provided, and layer-specific expression and spatiotemporal expression were observed in different subdivisions of the APH. That fact that some cadherins (Cdh2, Cdh8, Pcdh8 and Pcdh10) showed conserved regional expression both in the hippocampus and entorhinal cortex of mice and the hippocampal formation of chickens partially confirmed the structural homology proposed by previous scientists. This study indicates that some cadherins can be used as special markers of the avian hippocampal formation.

MiR-126-3p inhibits apoptosis and promotes proliferation by targeting phosphatidylinositol 3-kinase regulatory subunit 2 in porcine ovarian granulosa cells

Zhou, Xiaofeng,He, Yingting,Jiang, Yao,He, Bo,Deng, Xi,Zhang, Zhe,Yuan, Xiaolong,Li, Jiaqi Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.6

Objective: Numerous studies have indicated that the apoptosis and proliferation of granulosa cells (GCs) are closely related to the normal growth and development of follicles and ovaries. Previous evidence has suggested that miR-126-3p might get involved in the apoptosis and proliferation of GCs, and phosphatidylinositol 3-kinase regulatory subunit 2 (PIK3R2) gene has been predicted as one target of miR-126-3p. However, the molecular regulation of miR-126-3p on PIK3R2 and the effects of PIK3R2 on porcine GCs apoptosis and proliferation remain virtually unexplored. Methods: In this study, using porcine GCs as a cellular model, luciferase report assay, mutation and deletion were applied to verify the targeting relationship between miR-126-3p and PIK3R2. Annexin-V/PI staining and 5-ethynyl-2'-deoxyuridine assay were applied to explore the effect of PIK3R2 on GCs apoptosis and proliferation, respectively. Real-time quantitative polymerase chain reaction and Western Blot were applied to explore the regulation of miR-126-3p on PIK3R2 expression. Results: We found that miR-126-3p targeted at PIK3R2 and inhibited its mRNA and protein expression. Knockdown of PIK3R2 significantly inhibited the apoptosis and promoted the proliferation of porcine GCs, and significantly down-regulated the mRNA expression of several key genes of PI3K pathway such as insulin-like growth factor 1 receptor (IGF1R), insulin receptor (INSR), pyruvate dehydrogenase kinase 1 (PDK1), and serine/threonine kinase 1 (AKT1). Conclusion: MiR-126-3p might target and inhibit the mRNA and protein expressions of PIK3R2, thereby inhibiting GC apoptosis and promoting GC proliferation by down-regulating several key genes of the PI3K pathway, IGF1R, INSR, PDK1, and AKT1. These findings would provide great insight into further exploring the molecular regulation of miR-126-3p and PIK3R2 on the functions of GCs during the folliculogenesis in female mammals.

Hydro-mechanical interaction of reinforced concrete lining in hydraulic pressure tunnel

He-Gao Wu,Li Zhou,Kai Su,Ya-Feng Zhou,Xi-Yu Wen 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.71 No.6

The reinforced concrete lining of hydraulic pressure tunnels tends to crack under high inner water pressure (IWP), which results in the inner water exosmosis along cracks and involves typical hydro-mechanical interaction. This study aims at the development, validation and application of an indirect-coupled method to simulate the lining cracking process. Based on the concrete damage plasticity (CDP) model, the utility routine GETVRM and the user subroutine USDFLD in the finite element code ABAQUS is employed to calculate and adjust the secondary hydraulic conductivity according to the material damage and the plastic volume strain. The friction-contact method (FCM) is introduced to track the lining-rock interface behavior. Compared with the traditional node-shared method (NSM) model, the FCM model is more feasible to simulate the lining cracking process. The number of cracks and the reinforcement stress can be significantly reduced, which matches well with the observed results in engineering practices. Moreover, the damage evolution of reinforced concrete lining can be effectively slowed down. This numerical method provides an insight into the cracking process of reinforced concrete lining in hydraulic pressure tunnels.

Prevalence and Clinical Profile of EGFR Mutation In Non-Small-Cell Lung Carcinoma Patients in Southwest China

Zhou, Juan,Song, Xing-Bo,He, He,Zhou, Yi,Lu, Xiao-Jun,Ying, Bin-Wu Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3

Aims: To investigate the distribution of epidermal growth factor receptor (EGFR) mutations, and explore any relationships with clinical characteristics in non-small-cell lung carcinoma (NSCLC) patients. Materials and Methods: EGFR mutations were assessed by ADx-ARMS in 261 NSCLC patients from West China Hospital of Sichuan University. Relationships between EGFR mutation and clinical characteristics were analyzed by SPSS. Results: The EGFR mutation rate was 48.7% (127/261), 19-del and L858R mutations occurred predominantly, accounting for 33.1% and 40.9%, respectively, in mutated cases. Moreover, 10.2% patients were found to carry double mutations. EGFR mutations occurred more frequently in women (57.5%) than in men (41.8%) (P=0.01), and were more frequent in non-smokers (61.2%) than in former or current smokers (31.2%) (P<0.00). In addition, they were more common in adenocarcinomas (52.8%) and adenosquamous carcinomas (42.8%) than in squamous cell carcinomas (14.8%) (p<0.00). However, only smoking history and pathological types, rather than gender, proved to be associated with EGFR mutations on multivariate logistic regression analysis. No significant differences in pathological stage and metastasis status were found between EGFR wild-type and mutated cases, although EGFR mutation type was related to pathological type (p=0.00) - 19-del, L858R and other mutation types respectively occurred in 34.2%, 42.5% and 23.3% of adenocarcinomas, but in 14.3%, 0% and 85.7% of non-adenocarcinomas. Conclusions: The EGFR mutation rate was 48.7% in NSCLCs in Southwest China, so that nearly 40% patients might benefit from targeted therapies. Smoking status and pathological types were independent predictors of EGFR mutation, while EGFR mutation type was related to only pathological type, rather than smoking status.

Prognostic Values of Various Clinical Factors and Genetic Subtypes for Diffuse Large B-cell lymphoma Patients: A Retrospective Analysis of 227 Cases

Zhou, De,Xie, Wan-Zhuo,Hu, Ke-Yue,Huang, Wei-Jia,Wei, Guo-Qing,He, Jing-Song,Shi, Ji-Min,Luo, Yi,Li, Li,Zhu, Jing-Jing,Zhang, Jie,Lin, Mao-Fang,Ye, Xiu-Jin,Cai, Zhen,Huang, He Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Aim: To analyze the significance of different clinical factors for prognostic prediction in diffuse large B-cell lymphoma (DLBCL) patients. Methods: Two hundred and twenty-seven DLBCL patients were retrospectively reviewed. Patients were managed with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen or rituximab plus the CHOP (RCHOP) regimen. Results: Lactate dehydrogenase (LDH), ${\beta}2$-microglobulin (${\beta}2$-M), B symptoms, Ann Arbor stage and genetic subtypes were statistically relevant in predicting the prognosis of the overall survival (OS). In the CHOP group, the OS in patients with germinal center B-cell-like (GCB)(76.2%) was significantly higher than that of the non-GCB group (51.9%, P=0.032). With RCHOP management, there was no statistical difference in OS between the GCB (88.4%) and non-GCB groups (81.9%, P=0.288). Conclusion: Elevated LDH and ${\beta}2$-M levels, positive B symptoms, Ann Arbor stage III/IV, and primary nodal lymphoma indicate an unfavorable prognosis of DLBCL patients. Patients with GCB-like DLBCL have a better prognosis than those with non-GCB when treated with the CHOP regimen. The RCHOP treatment with the addition of rituximab can improve the prognosis of patients with DLBCL.

Fluorinated and Charged Non-woven Polypropylene Electret Fiber Membrane: A Novel Way in Transformer Oil Regeneration

Nianrong Zhou,Xiao He,Yuyang Yan,Xinliang Guo,Linshan Zhang,Yunhua He,Xiangyu Tan,Zhengyun Fang 한국전기전자재료학회 2022 Transactions on Electrical and Electronic Material Vol.23 No.2

The regeneration of transformer oil is a trending topic in the dielectric research field. However, the normal way of regeneration requires high cost and complicate process. In this paper, the non-woven polypropylene (PP) electret films were modifi ed by fluorination and corona method to achieve the regeneration function for transformer oil. The results show that the C-H bonds in polypropylene were replaced by C-F bonds during the fluorination process, resulting in the mean diameter of the fibers being decreased to a value of 1.7 μm. The increased roughness of the fi bers leads to super hydrophobicity. Further research revealed that the insulation properties of aging oil recovered after fi ltration by corona charged fl uorinated fi ber membranes. The result is especially signifi cant for breakdown voltage, the values of which reached half of the original insulating oil. In conclusion, the combination of fl uorinating and corona charging method on PP fi ber membrane shows great potential for insulation oil regeneration.

Genome wide methylation analysis to uncover genes related to recurrent pregnancy loss

Lixia Zhou,Yudong Pu,Yuxun Zhou,Bin Wang,Ye Chen,Yang Bai,Shuzhen He 한국유전학회 2021 Genes & Genomics Vol.43 No.4

Background Recurrent pregnancy loss (RPL) refers to two or more consecutive spontaneous abortion before 24 weeks of gestation, representing 1% of couples of childbearing age. Epigenetic factors including dysregulation of DNA methylation of some genes may play a role in RPL. Objective To identify RPL related genes modulated by DNA methylation expressed in decidua and blood. Methods Three decidua samples each from RPL patients and normal controls were recruited to perform genome-wide bisulfte sequencing (GWBS) and transcriptome sequencing. Based on the above results, 22.52 kb of diferential methylation regions (DMRs) from 17 genes were verifed by bisulfte sequencing PCR at specifc region (Hi-MethylSeq) in another 15 decidua (7RPL vs. 8 Controls) and 13 blood (5RPL vs. 8 Controls) samples. Results 23 genes showed signifcantly diferential cytosine methylation status and distinct expression level between PRL patients and healthy controls synergistically. Three signaling pathways were found to be shared between genes with both hypomethylated diferential methylation regions (DMR) and upregulated diferential gene expression (DGE). The results from Hi-MethylSeq showed that the hypermethylation of SGK1 in both blood and decidua samples in RPL patients, which was consistent to its lower expression in endometrium reported earlier. SGK3 and CREB5 also showed modulated methylation level in RPL decidua. Conclusion Our fnding supported that aberrant methylation of SGK1 and CREB5 could be a cause of the dysregulation of these gens in the endometrium, which is one of cause of reproductive failure. The function of SGK3 in reproduction system deserves further investigation.

Failure analysis for hoisting wire ropes with local accumulated broken wire damage on the surface

Ping Zhou,Gongbo Zhou,Lianfeng Han,Xiaodong Yan,Hanyu Wang,Zhenzhi He 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.7

Surface broken wire (BW) damage to hoisting steel wire ropes (SWR) is unavoidable during the service process, and it continues to accumulate locally during the evolution process. The specific influence analysis of the surface damage with local cumulative BWs on the performance of the hoisting SWR is insufficient at present, which seriously affects the safety of the rope system. In this paper, a failure analysis method for the state of surface cumulative BW rope based on the integration of finite element (FE) and mechanical tension is proposed. First, a method for creating an FE model of surface BW damage is presented, and the stress-strain distribution features of damaged section under tensile load are revealed. Then, the residual mechanical strength of SWR under local cumulative BW damage is determined by performing a tensile test. Finally, based on the analysis of FE and breaking behavior, combined with the regulations, the state of the damaged SWR is comprehensively evaluated. The results show that the breaking position of the SWR under mechanical tension is the maximum stress distribution in the simulation analysis, which verifies the consistency between the simulation and the experiment; and the accumulation degree and distribution of local BW affect the residual mechanical strength of the SWR. This method explores the influence of different degrees of local BW damage on the mechanical properties of the SWR, which provides a direct basis for the non-destructive evaluation of the SWR state.

Research of Autonomous Navigation Strategy for an Outdoor Mobile Robot

Miaolei Zhou,Shanbo He 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.12

A kind of autonomous navigation strategy for an outdoor mobile robot is proposed in the real world environment. Encoder disk, electronic compass and GPS are used in the dead reckoning system of outdoor mobile robot. To reduce dead reckoning error, the extend Kalman filter method is adopted to realize data fusion from encoder disk and electronic compass. GPS receiver is used to correct the dead reckoning data to eliminate the accumulation error of the dead reckoning. Laser range finder is used to detect the obstacle and establish the environment map. Filed D* algorithm and DWA method are used to realize the obstacle avoidance and path planning. The experimental results show that the outdoor mobile robot can realize the autonomous navigation under the complex road condition.