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Hirotaka Hasegawa,Masahiro Shin,Jun Kawagishi,Hidefumi Jokura,Toshinori Hasegawa,Takenori Kato,Mariko Kawashima,Yuki Shinya,Hiroyuki Kenai,Takuya Kawabe,Manabu Sato,Toru Serizawa,Osamu Nagano,Kyoko Ao 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.2
Background and Purpose To assess the long-term outcomes of intracranial dural arteriovenous fistula (DAVF) treated with stereotactic radiosurgery (SRS) alone or embolization and SRS (Emb- SRS) and to develop a grading system for predicting DAVF obliteration. Methods This multi-institutional retrospective study included 200 patients with DAVF treated with SRS or Emb-SRS. We investigated the long-term obliteration rate and obliteration-associated factors. We developed a new grading system to estimate the obliteration rate. Additionally, we compared the outcomes of SRS and Emb-SRS by using propensity score matching. Results The 3- and 4-year obliteration rates were 66.3% and 78.8%, respectively. The post-SRS hemorrhage rate was 2%. In the matched cohort, the SRS and Emb-SRS groups did not differ in the rates of obliteration (P=0.54) or post-SRS hemorrhage (P=0.50). In multivariable analysis, DAVF location and cortical venous reflux (CVR) were independently associated with obliteration. The new grading system assigned 2, 1, and 0 points to DAVFs in the anterior skull base or middle fossa, DAVFs with CVR or DAVFs in the superior sagittal sinus or tentorium, and DAVFs without these factors, respectively. Using the total points, patients were stratified into the highest (0 points), intermediate (1 point), or lowest (≥2 points) obliteration rate groups that exhibited 4-year obliteration rates of 94.4%, 71.3%, and 60.4%, respectively (P<0.01). Conclusions SRS-based therapy achieved DAVF obliteration in more than three-quarters of the patients at 4 years of age. Our grading system can stratify the obliteration rate and may guide physicians in treatment selection.
Hasegawa Tomohiko,Ushirozako Hiroki,Yamato Yu,Yoshida Go,Yasuda Tatsuya,Banno Tomohiro,Arima Hideyuki,Oe Shin,Yamada Tomohiro,Ide Koichiro,Watanabe Yuh,Matsuyama Yukihiro 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.4
Study DesignCombination of retrospective and prospective study.PurposeWe aimed to compare the clinical outcomes between local fixation surgery and spinopelvic fixation surgery for the treatment of kyphosis secondary to osteoporotic vertebral fractures with spinopelvic malalignment.Overview of LiteratureThe clinical characteristics of patients with rigid kyphosis due to osteoporotic vertebral fracture differ from that of middle-aged patients with vertebral fractures in terms of bone fragility and presence of spinopelvic malalignment. Little is known about the surgical strategies for these deformities, most especially the extent of fusion of vertebra involved.MethodsWe analyzed 24 patients with vertebral osteotomy at the level of the fracture and spinal fixation without pelvic fixation (local group), and 22 patients with vertebral osteotomy and pelvic fixation (pelvic group). Radiographic parameters, the incidence of proximal junctional kyphosis (PJK), distal junctional kyphosis (DJK), rod fractures, and the Oswestry Disability Index (ODI) were compared between the two groups over a 2-year follow-up period.ResultsIn the pelvic group, postoperative spinopelvic parameters significantly improved, with the improvements maintained. No remarkable changes in spinopelvic parameters were seen in the local group. The mean ODI scores 2 years after surgery were 45.3 and 33.0 in the local and pelvic group, respectively (p-value <0.05). There was no significant difference in the incidence of PJK in the local and pelvic groups, but there was a higher rate of DJK (41.7%) in the local group. In contrast, rod fractures were more common in the pelvic group (45.5%). Patients with DJK had higher ODI scores 2 years after surgery (52.0 in DJK patients vs. 34.8 in non-DJK patients; p-value <0.05).ConclusionsFor patients with rigid kyphosis due to osteoporotic vertebral fractures, better spinopelvic alignment and health-related quality of life can be achieved through extensive corrective surgery with pelvic fixation.
Hasegawa, Yasushi,Nakagawa, Erina,Kadota, Yukiya,Kawaminami, Satoshi Asian Australasian Association of Animal Productio 2017 Animal Bioscience Vol.30 No.1
Objective: Adipose tissue plays a key role in the development of obesity and diabetes. We previously reported that lignosulfonic acid suppresses the rise in blood glucose levels through the inhibition of ${\alpha}$-glucosidase activity and intestinal glucose absorption. The purpose of this study is to examine further biological activities of lignosulfonic acid. Methods: In this study, we examined the effect of lignosulfonic acid on differentiation of 3T3-L1 cells. Results: While lignosulfonic acid inhibited proliferation (mitotic clonal expansion) after induction of differentiation, lignosulfonic acid significantly increased the size of accumulated lipid droplets in the cells. Semi-quantitative reverse transcription polymerase chain reaction analysis showed that lignosulfonic acid increased the expression of the adipogenic transcription factor, peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$), leading to increased glucose transporter 4 (Glut-4) expression and 2-deoxyglucose uptake in differentiated 3T3-L1 cells. Additionally, feeding lignosulfonic acid to diabetic KK-Ay mice suppressed increase of blood glucose level. Conclusion: Lignosulfonic acid may be useful as a functional anti-diabetic component of food.
Flow Field Change before Onset of Flow Separation
Hasegawa, Hiroaki,Sugawara, Takeru Korean Society for Fluid machinery 2009 International journal of fluid machinery and syste Vol.2 No.3
Jets issuing through small holes in a wall into a freestream has proven effective in the control of flow separation. This technique is known as the vortex generator jet (VGJs) method. If a precursor signal of separation is found, the separation control system using VGJs can be operated just before the onset of separation and the flow field with no separation is always attained. In this study, we measured the flow field and the wall static pressure in a two-dimensional diffuser to find a precursor signal of flow separation. The streamwise velocity measurements were carried out in the separated shear layer and spectral analysis was applied to the velocity fluctuations at some angles with respect to the diffuser. The pattern of peaks in the spectral analysis changes as the divergence angle increases over the angle of which the whole separation occurs. This change in the spectral pattern is related to the enhancement of the growth of shear layer vortices and appears just before the onset of separation. Therefore, the growth of shear layer vortices can be regarded as a precursor signal to flow separation.
Hasegawa, Ai,Kurita, Asami,Hayashi, Shinji,Fukumoto, Takeshi,Sasamoto, Hamako 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.2
The effects of sea salts, NaCl, KCl, $MgCl_2$, $MgSO_4$, and $CaCl_2$, on the growth of protoplast cultures of two mangrove species, Sonneratia alba and Avicennia alba, were investigated using 96-well culture plates. Plants of these two species naturally grow at the seaward side of a mangrove forest. Cotyledon protoplasts of S. alba showed halophilic nature to NaCl, KCl, and $MgCl_2$ at low concentrations (10-50 mM) when cultured in Murashige and Skoog's (MS) medium containing 0.6 M mannitol. $CaCl_2$ at a concentration higher than 25 mM was inhibitory to cell growth. On the other hand, in protoplast culture of A. alba suspension cells, which were induced from cotyledon tissues, in the modified amino acid (mAA) medium containing 1.2 M sorbitol, tolerance to NaCl, $MgCl_2$ and $MgSO_4$ were observed at a wide range of concentrations up to 400 mM. $CaCl_2$ was always inhibitory for cell divisions in A. alba, but stimulatory for spherical enlargement of cells. However, no difference in cell enlargement was observed among other salts. Similarity and difference in reactivity to salts between protoplasts and suspension cells from our previous studies were discussed in relation to the site of salt tolerance or halophilic adaptation within mangrove cells. For protoplast cultures, the site(s) for response of S. alba and A. alba are located in the cytoplasm and/or the cell membrane.
Hasegawa, S.,Shinozaki, K.,Honma, T.,Dimitrov, V.,Kim, H.G.,Komatsu, T. North-Holland 2016 Journal of non-crystalline solids Vol.452 No.-
<P>Glasses based on the system of Y2O3-BaO-Nb2O5-B2O3, corresponding to the pseudo-binary 64Ba(1 - x)Y(2x/3)Nb(2)O(6)-B2O3 with x = 0.1-0.5, were prepared, and their thermal properties, electronic polarizabilities, optical basicities, and crystallization behavior were clarified. The glasses showed the glass transition temperature of 602-610 degrees C, crystallization peak temperature of 686-676 degrees C, and refractive index of 1.967-2.007. All the glasses showed the bulk crystallization behavior, providing Ba1 - xY2x/3Nb2O6 nanocrystals with a tetragonal tungsten bronze structure. It was found from high resolution transmission electron microscope observations that the morphology of Ba1 - xY2x/3Nb2O6 nanocrystals is ellipsoidal and their average particle size is in the range of 20-40 nm. The glass-ceramics with Ba1 - xY2x/3Nb2O6 nanocrystals showed high dielectric constants (frequency: 1 kHz) of similar to 90 at room temperature and a ferroelectric nature. Highly oriented Ba1 - xY2x/3Nb2O6 crystal lines were patterned by laser (continuous wave Yb:YVO4 fiber laser with a wavelength of 1080 nm) irradiation with the condition of a laser power of 1.9 W and a laser scanning speed of 4 pm/s and with the laser focal position of 20 mu m beneath from the surface in 2NiO-1.1Y(2)O(3)-29.8BaO-33.1Nb(2)O(5)-36B(2)O(3) glass. (C) 2016 Elsevier B.V. All rights reserved.</P>
Gravitino problem in minimal supergravity inflation
Hasegawa, Fuminori,Mukaida, Kyohei,Nakayama, Kazunori,Terada, Takahiro,Yamada, Yusuke North-Holland Pub. Co 2017 Physics letters. Section B Vol.767 No.-
<P><B>Abstract</B></P> <P>We study non-thermal gravitino production in the minimal supergravity inflation. In this minimal model utilizing orthogonal nilpotent superfields, the particle spectrum includes only graviton, gravitino, inflaton, and goldstino. We find that a substantial fraction of the cosmic energy density can be transferred to the longitudinal gravitino due to non-trivial change of its sound speed. This implies either a breakdown of the effective theory after inflation or a serious gravitino problem.</P>