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Kenichi Harano,Akihiro Hirakawa,Takayuki Kato,Keisuke Suzuki,Sachiko Watanabe,Noriyuki Katsumata 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.2
Objective: To assess the use of colony-stimulating factors (CSFs) in patients with ovarian cancer who receive adjuvant paclitaxel and carboplatin chemotherapy in clinical practice and to assess whether the frequency of CSF use differs among hospitals in Japan. Methods: CSF use in patients with ovarian cancer who received first-line paclitaxel and carboplatin was analyzed retrospectively using data from the Japanese hospitalization payment system. Results: A total of 1,050 patients at 104 hospitals were identified. The median age was 60 years (range, 22 to 88 years). Of these, 163 patients (15.5%) were diagnosed with neutropenia and 134 patients (12.8%) received CSFs. Among the patients who received CSFs, 125 (93%) received them for the treatment of neutropenia without fever and 1 received them for febrile neutropenia. In total, CSFs were administered for 272 cycles of chemotherapy. Among them, CSFs were used as treatment for neutropenia without fever in 259 cycles (95%), as prophylaxis (primary or secondary) in 12 cycles (4%), and as treatment for febrile neutropenia in 1 cycle. Among hospitals, a median of 4.0% of patients received CSFs with an interquartile range of 25% (Q1, 0%; Q3, 25%). A logistic random effects model showed that the variation in the proportion of patients receiving CSFs among the 104 hospitals was 2.0 (p<0.001), suggesting that the use of CSFs varied across hospitals. Conclusion: Most patients received CSFs for neutropenia without fever. Standardized and evidence-based use of CSFs is critically required among hospitals in Japan.
한국인에서 발견된 이상혈색소에 관한 연구 : β22 glu→ala
김창세,최국주,Harano,Teruo 순천향대학교 1994 논문집 Vol.17 No.4
The abnormal hemoglobins, propositi Park oo and Sung O O, found in Korean, were analyzed for different kinds of methods;agar gel electrophoresis, polyacetate membrane electrophoresis, starch gel electrophoresis. CM-cellulose chromartography, reverse phase HPLC and amino acid sequencing. From the above investigations we were determined the propositi were β-chain variants and the substitution of 22nd amino acid alanine for glutamic acid; ??.
Akira Minematsu,Kan Hazaki,Akihiro Harano, M.D,Nozomi Okamoto 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.2
Objectives: This study aimed to investigate differences in physical function by bone mass category as assessed by speed of sound, and the association between bone mass and physical function in Japanese elderly women. Methods: Participants (65 years, n ¼ 954) were divided into the osteoporosis, osteopenia, and normal groups based on speed of sound values, and physical function parameters were compared among groups. In addition, the predictive ability of physical function for low bone mass was determined by area under the curve analysis. Data were collected in 4 cities in Nara, Japan, in 2007 or 2008. Results: All physical functions were significantly lower in the osteoporotic group than in the normal group. Lower bone mass was associated with poor muscle strength and physical function after adjusting for age, height and weight. In addition, one-leg standing time and 10-m gait time were predictive of low bone mass (osteopenia and osteoporosis levels, respectively). Elderly women with low physical function, especially those with a short one-leg standing time, should be suspected of having decreased bone mass. Conclusions: Measurements of physical function can effectively identify elderly women with low bone mass at an early stage without the need for bone mass measurements. In particular, one-leg standing time and 10-m gait time were good predictors of low bone mass, and is easy to measure, low-cost, and can be self-measured. These findings will be helpful in the prevention and treatment of osteoporosis.
Formation Characteristics of PM and SOF by Spray Combustion of Marine Heavy Fuel Oil
Kim, Houng-Soo,Murakami, T.,Nishida, Osami,Fujita, H.,Harano, W. The Korean Society of Marine Engineering 2004 한국마린엔지니어링학회지 Vol.28 No.2
This study is intended to check a temperature of the flame to raise by burning A heavy oil in a boiler. to measure the concentration of DS and SOF after collecting the PM(Particulate Matters). and to analyze the components ingredients of SOF by G.C Mass for presupposing the generation of particulate matters(soot). It is thought that the methyl(CH3) of the cyclic compound is changed to the materials of 2 cycles and 3 cycles after becoming CH by dehydrogenation and also mixing with the CH of a chain compound. form H-$\cdot$C=C$\cdot$-H that is mentioned before. in order to become Polycyclic Aromatic Hydrocarbon.
Suk-heon An,Osami Nishida,Hirotusgu Fujita,Wataru Harano,Masao Hiroi,Masaaki Sato,Masanori Tashiro,Hyung-soo Kim 한국자동차공학회 2001 한국자동차공학회 Symposium Vol.- No.-
This research makes a new attempt to use the activated seawater by electrolysis in the wet serubber for the large diesel engine as a sort of post, exhaust gas treatment. By means of eletrolysis using the seawater, the activated alkaline water made by a negative pole is used to neutralize sulfuric oxide (SOx). carbon dioxide (CO₂) and carbon monoxide (CO) ete., but on the other hand the activated acidic water made by a positive pole oxidizes nitrie monoxides (HO) of exhaust gas to nitrie dioxides (NO₂), thus the NO₂ become dissolved into the seawater. Moreover, the particulate matter of exhaust emissions is forced into direct, contact with seawater. The results found that the high alkaline water of pH 10 was effective in reduction of SOx. CO₂ and above all else, the acidic water of pH 3 converted NO into NO₂ when compared with the other pH. Besides, it was also adequate to reduce the, particulate matter. This experiment believes that the way to reduce emissions from the marine diesel engines is to make it. attractive from an operating perspective, as well as an environmental perspective.<br/> <br/>
Aikou Okamoto,Eiji Kondo,Toshiaki Nakamura,Satoshi Yanagida,Junzo Hamanishi,Kenichi Harano,Kosei Hasegawa,Takeshi Hirasawa,Kensuke Hori,Shinichi Komiyama,Motoki Matsuura,Hidekatsu Nakai,Hiroko Nakamur 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.2
Objective: To evaluate the efficacy and safety of niraparib in Japanese women with heavilypretreated ovarian cancer. Methods: This Phase 2 open-label, single-arm study enrolled Japanese women withhomologous recombination deficiency-positive relapsed, high-grade serous ovarian,fallopian tube, or primary peritoneal cancer who had completed 3–4 lines of therapy. The starting dose of niraparib was 300 mg administered once daily in continuous 28-daycycles until objective progressive disease, unacceptable toxicity, consent withdrawal ordiscontinuation. The primary endpoint, objective response rate (ORR), was assessed bythe investigator using RECIST version 1.1. Safety evaluations included the incidence oftreatment-emergent adverse events (TEAEs), including serious TEAEs. Results: Twenty women were enrolled and the confirmed ORR in the full analysis set (FAS)was 35.0% (7/20), consisting of 1 complete response and 6 partial responses. Diseasecontrol rate in the FAS was 90.0%. The most frequently reported TEAEs (>50%) wereanemia, nausea, and platelet count decreased. One patient (5.0%) had TEAEs leadingto discontinuation of niraparib whereas reductions or interruptions were reported in 14(70.0%) and 15 (75.0%) patients, respectively. The median dose intensity (202.9 mg daily)corresponded to a relative dose intensity of 67.6%. Conclusion: Efficacy and safety of niraparib in heavily pretreated Japanese women wascomparable to that seen in an equivalent population of non-Japanese women. No new safetysignals were identified.Trial Registration: ClinicalTrials.gov Identifier: NCT03759600