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A Chromone-Based Fluorescent Chemosensor for Detecting Cu2+
Hangyul Lee,Cheal Kim 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.2
Selective detection of Cu2+ by OHC via fluorescence quenching response.
Hangyul Kim,Seung Do Lee,Hyo Jin Lee,Hye Ree Kim,Kyehwan Kim,Jin-Sin Koh,Seok-Jae Hwang,Jin-Yong Hwang,Jong-Hwa Ahn,Yongwhi Park,Young-Hoon Jeong,Jeong Rang Park,Min Gyu Kang 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.3
Background/Aims: Bleeding events after percutaneous coronary intervention (PCI) have important prognostic implications. Data on the influence of an abnormal ankle-brachial index (ABI) on both ischemic and bleeding events in patients undergoing PCI are limited. Methods: We included patients who underwent PCI with available ABI data (abnormal ABI, ≤ 0.9 or > 1.4). The primary endpoint was the composite of all-cause death, myocardial infarction (MI), stroke, and major bleeding. Results: Among 4,747 patients, an abnormal ABI was observed in 610 patients (12.9%). During follow-up (median, 31 months), the 5-year cumulative incidence of adverse clinical events was higher in the abnormal ABI group than in the normal ABI group: primary endpoint (36.0% vs. 14.5%, log-rank test, p < 0.001); all-cause death (19.4% vs. 5.1%, log-rank test, p < 0.001); MI (6.3% vs. 4.1%, log-rank test, p = 0.013); stroke (6.2% vs. 2.7%, log-rank test, p = 0.001); and major bleeding (8.9% vs. 3.7%, log-rank test, p < 0.001). An abnormal ABI was an independent risk factor for all-cause death (hazard ratio [HR], 3.05; p < 0.001), stroke (HR, 1.79; p = 0.042), and major bleeding (HR, 1.61; p = 0.034). Conclusions: An abnormal ABI is a risk factor for both ischemic and bleeding events after PCI. Our study findings may be helpful in determining the optimal method for secondary prevention after PCI.
A thiourea-based fluorescent chemosensor for bioimaging hypochlorite
Haeri So,Hangyul Lee,Gyu Dong Lee,Mingeun Kim,Mi Hee Lim,Ki-Tae Kim,Cheal Kim 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-
A thiourea-basedfluorescent turn-off chemosensor FHC was developed for recognizing hypochlorite. With the addition of hypochlorite to FHC, FHC displayed a specific desulfurization reaction of thethiourea group followed by thefluorescent quenching response. Thefluorescent turn-off response of FHCto hypochlorite was very fast tofinish within a few seconds. Detection limit of hypochlorite wasdetermined to be 0.43 mM. FHC can be applied for the bioimaging of hypochlorite in both HeLa cells andzebrafish. Response process of FHC to hypochlorite, via the desulfurization of the thiourea moiety, wasdemonstrated, based on 1H NMR titrations, ESI-mass,fluorescent and UV–vis titrations and DFTcalculations.
Kye-Hwan Kim,Seung Do Lee,Hyo Jin Lee,Hangyul Kim,Hye Ree Kim,Yun Ho Cho,Jeong Yoon Jang,Min Gyu Kang,Jin-Sin Koh,Seok-Jae Hwang,Jin-Yong Hwang,Jeong Rang Park 한국심초음파학회 2023 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.31 No.2
BACKGROUND: The prognostic utility of follow-up transthoracic echocardiography (FU-TTE) in patients with hypertrophic cardiomyopathy (HCM) is unclear, specifically in terms of whether changes in echocardiographic parameters in routine FU-TTE parameters are associated with cardiovascular outcomes. METHODS: From 2010 to 2017, 162 patients with HCM were retrospectively enrolled in this study. Using echocardiography, HCM was diagnosed based on morphological criteria. Patients with other diseases that cause cardiac hypertrophy were excluded. TTE parameters at baseline and FU were analyzed. FU-TTE was designated as the last recorded value in patients who did not develop any cardiovascular event or the latest exam before event development. Clinical outcomes were acute heart failure, cardiac death, arrhythmia, ischemic stroke, and cardiogenic syncope. RESULTS: Median interval between the baseline TTE and FU-TTE was 3.3 years. Median clinical FU duration was 4.7 years. Septal trans-mitral velocity/mitral annular tissue Doppler velocity (E/e’), tricuspid regurgitation velocity, left ventricular ejection fraction (LVEF), and left atrial volume index (LAVI) at baseline were recorded. LVEF, LAVI, and E/e’ values were associated with poor outcomes. However, no delta values predicted HCM-related cardiovascular outcomes. Logistic regression models incorporating changes in TTE parameters had no significant findings. Baseline LAVI was the best predictor of a poor prognosis. In survival analysis, an already enlarged or increased size LAVI was associated with poorer clinical outcomes. CONCLUSIONS: Changes in echocardiographic parameters extracted from TTE did not assist in predicting clinical outcomes. Cross-sectionally evaluated TTE parameters were superior to changes in TTE parameters between baseline and FU at predicting cardiovascular events.