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실측과 CFD을 통한 해인사 경내 및 판전에 대한 기류분포 특성의 조사
임종연(Lim Jong-Yeonn),송두삼(Song Doo-Sam),이상해(Lee Sang-Hae) 한국건축친환경설비학회 2007 한국건축친환경설비학회 논문집 Vol.1 No.3
Hae-In temple is located in Gaya Mountains, Hapcheon-gun, Korea and a thousand years old monastery. Tripitaka Koreana has been preserved during 750 years as good condition in Hae-In temple. The preservation technology is summarized as the passive design methods harmonized with the nature perfectly. Haein temple have dealt with a flow fields in the storage hall. In this study, an indoor and outdoor flow fields in the precincts of Haein temple were analysed with field measurement and numerical simulation. On the basis of the field measurement results, the restoration cases such as rearrangement of Tripitaka Koreana and relocation of the rear fence of Biro-Jean were analyzed with CFD.
Lee, Sang Youp,Kim, Sang Hae 한국유전학회 2003 Genes & Genomics Vol.25 No.4
The genetic variation and the molecular discrimination of Scapharca species in Korea were investigated through the mitochondrial DNA sequence analyses. A partial portion (646 bp) of the mitochondrial cytochrome c oxidase subunit I gene (COI) for these species was analyzed by DNA sequencing and restriction fragment length polymorphism (RFLP). A sequence comparison and phylogenetic analysis showed both S. broughtonii and S. satowi formed a sister group, with then S. subcrenata clustered with the clade. It was assumed that all Scapharca species could form a monophyletic clade, with high bootstrap support (99%). In order to effectively discriminate the morphologically hard to classified spats, a PCR-RFLP diagnostic marker was developed with two restriction enzyme (HaeⅢ and HinfI) digestions. Digestion of the 646-bp fragments of the COI gene amplified from each species with HaeⅢ produced no fragment in the S. broughtonii, and two fragments, but of different sizes in S. satowi and S. subcrenata. In the HinfI digestion, two distinct fragments were produced in S. broughtonii and S. subcrenata, but no fragment in S. satowi. Twenty individuals from each population were digested by these two restriction enzymes, but no individual variations occurred.
노인종합복지관 프로그램 이용 만족이 노인의 우울정서와 안녕감에 미치는 영향
이의용(Lee Eui-Yong),변상해(Byun, Sang-Hae) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.4
본 연구의 목적은 노인의 여가활동 중 노인종합복지관 프로그램 활용 및 이용 만족도에 따른 우울정서와 안녕감의 관계를 규명하는 것이다.연구를 위해 서울에 소재하고 있는 노인종합복지관 2곳을 선택하여 65세 이상 되는 노인 128명을 대상으로 설문을 배포하고 수집하여 분석하였다.자료분석은 SPSSv.21을 활용하였다.연구 결과,첫째,복지관 프로그램 중 가장 만족도가 높은 것은 노래교실이었다.이용 이유로는 친구를 만나기 위해서가 많았고,주요활동 분야는 취미활동이었 다.둘째,일반적 특성에 따른 우울정서의 차이는 연령과 학력에서 유의한 차이가 나타났고,심리적 안녕감은 학력수준에 따라서 유의한 차이가 나타났다.셋째,프로그램 이용 만족도는 우울정서와 안녕감에 유의한 영향을 미치고 있는 것으로 나타났다.넷째,프로그램 만족도와 우울정서의 사이에서 심리적 안녕감의 매개효과는 나타나지 않았다. The purpose of this study is to investigate how leisure programs are utilized by senior welfare centers, and analyze the relationship between the degree of satisfaction and the resulting effect on the depressive emotions and psychological well-being of program participants. To that end, a survey was made on 128 persons aged 65 or over who were participating in leisure programs at 2 senior centers located in Seoul. The collected data were analyzed using SPSS Ver. 21. The findings were as follows: First, the most satisfactory program was Sing-Along program, while the reason for using senior welfare centers was for meeting friends and the most favorite program was hobby classes; Second, significant differences were found in depressive emotions according to age and educational background and in psychological well-being according to educational background. Third, the degree of satisfaction in programs had a meaningful relationship with depressive emotion and well-being; Fourth, there was no mediating effect of psychological well-being between the degree of program satisfaction and depressive emotion.
Lee, Sang Jae,Choi, Jang-Sik,Bong, Seoung Min,Hwang, Hae-Jun,Lee, Jaesang,Song, Ho-Juhn,Lee, Jaekyoo,Kim, Jung-Ho,Koh, Jong Sung,Lee, Byung Il Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.6
Spleen tyrosine kinase (SYK) is a cytosolic non-receptor protein tyrosine kinase. Because SYK mediates key receptor signaling pathways involving the B cell receptor and Fc receptors, SYK is an attractive target for autoimmune disease and cancer treatments. To date, representative oral SYK inhibitors, including fostamatinib (R406 or R788), entospletinib (GS-9973), cerdulatinib (PRT062070), and TAK-659, have been assessed in clinical trials. Here, we report the crystal structures of SYK in complex with two newly developed inhibitors possessing 4-aminopyrido[4,3-D]pyrimidine moieties (SKI-G-618 and SKI-O-85). One SYK inhibitor (SKI-G-618) exhibited moderate inhibitory activity against SYK, whereas the other inhibitor (SKI-O-85) exhibited a low inhibitory profile against SYK. Binding mode analysis indicates that a highly potent SYK inhibitor might be developed by modifying and optimizing the functional groups that interact with Leu377, Gly378, and Val385 in the G-loop and the nearby region in SYK. In agreement with our structural analysis, one of our SYK inhibitor (SKI-G-618) shows strong inhibitory activities on the ${\beta}$-hexosaminidase release and phosphorylation of SYK/Vav in RBL-2H3 cells. Taken together, our findings have important implications for the design of high affinity SYK inhibitors.
Sang Hyun Lee,Jong Seon Byun,Pil Jae Kong,Hee Jae Lee,Duk Kyung Kim,Hae Sung Kim,Jong-Hee Sohn,Jae Jun Lee,So Young Lim,Wanjoo Chun,Sung Soo Kim 대한생리학회-대한약리학회 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.1
The serine/threonine kinase Akt has been shown to play a role of multiple cellular signaling pathways and act as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3K). It has been reported that phosphorylated Akt activates eNOS resulting in the production of NO and that NO stimulates soluble guanylate cyclase (sGC), which results in accumulation of cGMP and subsequent activation of the protein kinase G (PKG). It has been also reported that PKG activates PI3K/Akt signaling. Therefore, it is possible that PI3K, Akt, eNOS, sGC, and PKG form a loop to exert enhanced and sustained activation of Akt. However, the existence of this loop in eNOS-expressing cells, such as endothelial cells or astrocytes, has not been reported. Thus, we examined a possibility that Akt phosphorylation might be enhanced via eNOS/ sGC/PKG/PI3K pathway in astrocytes in vivo and in vitro. Phosphorylation of Akt was detected in astrocytes after KA treatment and was maintained up to 72 h in mouse hippocampus. 2 weeks after KA treatment, astrocytic Akt phosphorylation was normalized to control. The inhibition of eNOS, sGC, and PKG significantly decreased Akt and eNOS phosphorylation induced by KA in astrocytes. In contrast, the decreased phosphorylation of Akt and eNOS by eNOS inhibition was significantly reversed with PKG activation. The above findings in mouse hippocampus were also observed in primary astrocytes. These data suggest that Akt/eNOS/sGC/PKG/PI3K pathway may constitute a loop, resulting in enhanced and sustained Akt activation in astrocytes.
Power Factor Correction of Three Phase Voltage Source PWM Converter for Inverter Arc Welding Machine
Hae-Ryong Choi,Hong-Sung Kim,Seong-Yo Lee,Hyung-Soo Mok,Gyu-Ha Choe 전력전자학회 2000 전력전자학술대회 논문집 Vol.2000 No.11
Diode rectifier has been widely used as the preregulator of inverter arc welding machine(IAW). As it is linked to power utility, a disorder of other instruments can he burst out. The adoption of voltage source PWM converters can he considered, and which must catch the compromise of between performance and cost. So, in this paper voltage source PWM converters which have single(i.e. SMR) and six(i.e. PWM converter) control switch respectively, are analyzed and evaluated through digital simulation and experiment. In addition the improved input characteristics of IAW are shown and compared to those of conventional one.