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Yu, Kx2010,H.,Hong, Kx2010,S.,Lee, Bx2010,C.,Oh, Mx2010,S.,Cho, Yx2010,J.,Koo, Jx2010,S.,Park, Jx2010,M.,Bae, Hx2010,J.,Han, Mx2010,K.,Ju, Yx2010,S.,Kang, Dx2010,W.,Appelros, P. Blackwell Publishing Ltd 2011 Acta neurologica Scandinavica Vol.123 No.5
<P>Yu K‐H, Hong K‐S, Lee B‐C, Oh M‐S, Cho Y‐J, Koo J‐S, Park J‐M, Bae H‐J, Han M‐K, Ju Y‐S, Kang D‐W, Appelros P, Norrving B, Terent A. Comparison of 90‐day case‐fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis. Acta Neurol Scand: 2011: 123: 325–331. © 2010 John Wiley & Sons A/S.</P><P><B>Background – </B> It has not been clarified whether the disparity in ischemic stroke outcome between populations is caused by ethnic and geographic differences or by variations in case mix. Propensity score matching (PSM) analysis can overcome some analytical problems but is rarely used in stroke outcome research. This study was to compare the ischemic stroke case‐fatality between two PSM cohorts of Sweden and Korea.</P><P><B>Methods – </B> Prognostic variables related to baseline characteristics and stroke care were included in our PSM model. Then, we selected 7675 Swedish and 1220 Korean patients with ischemic stroke from each stroke registers and performed one‐to‐one matching based on propensity scores of each patient.</P><P><B>Results – </B> After PSM, all measured variables were well balanced in 1163 matched subjects, and the 90‐day case‐fatality was identical 6.2% (HR 0.997, 95%CI 0.905–1.099) in Sweden and Korea.</P><P><B>Conclusions – </B> No difference is found in the 90‐day case‐fatality in propensity score‐matched Swedish and Korean patients with ischemic stroke.</P>
Hong, Young B.,Park, Jinx2010,Mo,Yu, Jin S.,Yoo, Da H.,Nam, Da E.,Park, Hyung J.,Lee, Jix2010,Su,Hwang, Sun H.,Chung, Ki W.,Choi, Byungx2010,Ok Wiley Periodicals, Inc. 2017 Journal of the peripheral nervous system Vol.22 No.3
<P><B>Abstract</B></P><P>Mutations in the gap junction protein beta 1 gene (<I>GJB1</I>) cause X‐linked Charcot‐Marie‐Tooth disease type 1 (CMTX1). CMTX1 is representative of the intermediate type of CMT, having both demyelinating and axonal neuropathic features. We analyzed the clinical and genetic characterization of 128 patients with CMTX1 from 63 unrelated families. Genetic analysis revealed a total of 43 mutations including 6 novel mutations. Ten mutations were found from two or more unrelated families. p.V95M was most frequently observed. The frequency of CMTX1 was 9.6% of total Korean CMT family and was 14.8% when calculated within genetically identified cases. Among 67 male and 61 female patients, 22 females were asymptomatic. A high‐arched foot, ataxia, and tremor were observed in 87%, 41%, and 35% of the patients, respectively. In the male patients, functional disability scale, CMT neuropathy score, and compound muscle action potential of the median/ulnar nerves were more severely affected than in the female patients. This study provides a comprehensive summary of the clinical features and spectrum of GJB1 gene mutations in Korean CMTX1 patients.</P>
Chung, Kyungjae,Yu, Sunkyu,Heo, Chulx2010,Joon,Shim, Jae Won,Yang, Seungx2010,Man,Han, Moon Gyu,Lee, Hongx2010,Seok,Jin, Yongwan,Lee, Sang Yoon,Park, Namkyoo,Shin, Jung H. WILEY‐VCH Verlag 2012 ADVANCED MATERIALS Vol.24 No.18
<P>The image shows a schematic representation of close‐packed multilayer reflecting columns with the same periodicity but with random variations in location, both in horizontal and vertical dimensions, that form the Morpho‐mimetic thin‐film structural color reflectors described in the manuscript by J. H. Shin and co‐workers, on page 2375. Overlaid are photographs of an actual Morpho butterfly, a 6‐inch diameter Morpho‐mimetic thin film that demonstrates its color, brightness, and flexibility, and images of cyan, green, and red ‘Morpho butterflies’ created from photos of Morpho‐mimetic thin films with corresponding colors. </P>
Real-space observation of a two-dimensional skyrmion crystal
Yu, X. Z.,Onose, Y.,Kanazawa, N.,Park, J. H.,Han, J. H.,Matsui, Y.,Nagaosa, N.,Tokura, Y. Macmillan Publishers Limited. All rights reserved 2010 Nature Vol.465 No.7300
Crystal order is not restricted to the periodic atomic array, but can also be found in electronic systems such as the Wigner crystal or in the form of orbital order, stripe order and magnetic order. In the case of magnetic order, spins align parallel to each other in ferromagnets and antiparallel in antiferromagnets. In other, less conventional, cases, spins can sometimes form highly nontrivial structures called spin textures. Among them is the unusual, topologically stable skyrmion spin texture, in which the spins point in all the directions wrapping a sphere. The skyrmion configuration in a magnetic solid is anticipated to produce unconventional spin??electronic phenomena such as the topological Hall effect. The crystallization of skyrmions as driven by thermal fluctuations has recently been confirmed in a narrow region of the temperature/magnetic field (T??B) phase diagram in neutron scattering studies of the three-dimensional helical magnets MnSi (ref. 17) and Fe<SUB>1−x</SUB>Co<SUB>x</SUB>Si (ref. 22). Here we report real-space imaging of a two-dimensional skyrmion lattice in a thin film of Fe<SUB>0.5</SUB>Co<SUB>0.5</SUB>Si using Lorentz transmission electron microscopy. With a magnetic field of 50??70 mT applied normal to the film, we observe skyrmions in the form of a hexagonal arrangement of swirling spin textures, with a lattice spacing of 90 nm. The related T??B phase diagram is found to be in good agreement with Monte Carlo simulations. In this two-dimensional case, the skyrmion crystal seems very stable and appears over a wide range of the phase diagram, including near zero temperature. Such a controlled nanometre-scale spin topology in a thin film may be useful in observing unconventional magneto-transport effects.
Synthesis and characterization of electrospun PAN/2D MoS<sub>2</sub> composite nanofibers
Yu, X.,Park, H.S. Korean Society of Industrial and Engineering Chemi 2016 Journal of industrial and engineering chemistry Vol.34 No.-
<P>Ultrafine polyacrylonitrile/MoS2 (PM) nanofibers were fabricated by electrospinning. A homogeneous dispersion of two-dimensional (2D) MoS2 nanosheets in polymer solution is crucial to obtain a uniform distribution of nanofillers inside polymer matrices of nanofibers. Scanning electron microscopy and transmission electron microscopy images of PM revealed that the rough surface morphology resulted from the content of MoS2. X-ray diffraction analysis confirmed the reduced crystallinity of PM composite nanofibers. In contrast, the thermal properties of PM nanofibers improved, as confirmed by thermal analyses. These results indicate that the nanofiber morphology and crystallinity of PM nanofibers are significantly affected by the content of MoS2, while their thermal properties are improved by the uniform distribution of 2D nanofillers. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.</P>
Park, Hwangseo,Jung, Sukx2010,Kyeong,Yu, Keum R.,Kim, Ju H.,Kim, Yongx2010,Sam,Ko, Jeong H.,Park, Byoung C.,Kim, Seung J. Blackwell Publishing Ltd 2011 Chemical biology & drug design Vol.78 No.4
<P>Despite a series of persuasive experimental evidence for the involvement of eyes absent protein tyrosine phosphatases in various human cancers, no small‐molecule inhibitor has been reported so far. We have identified seven novel inhibitors of eyes absent homologue 2 (Eya2) with IC<SUB>50</SUB> values ranging from 1 to 70 μ<SMALL>m</SMALL> by the virtual screening with docking simulations and enzyme inhibition assay. Atomic charges of the active‐site Mg<SUP>2+</SUP> ion complex are calculated to enhance the accuracy of docking simulations. The newly discovered inhibitors are structurally diverse and have various chelating groups for the Mg<SUP>2+</SUP> ion. The interactions with the amino acid residues responsible for the stabilizations of the inhibitors in the active site of Eya2 are addressed in detail.</P>
Namkung, H.,Hu, X.,Kim, H.T.,Wang, F.,Yu, G. Elsevier Scientific Pub. Co 2016 Fuel processing technology Vol.149 No.-
Ash adhesion and elimination in the gasification process is one of the main challenges in maintaining a continuous operation of the plant. The properties of ash adhesion and elimination are mainly related to particle sintering behavior. Different sintering behaviors of Shenhua coal ash (SCA) and rice straw ash (RSA) below the inherent initial deformation temperature (IDT) were observed by using optical heating stage microscope (OHSM) under CO<SUB>2</SUB> and Ar environments. The particle interaction of the RSA, the IDT of which was lower than that of SCA, was higher than that of SCA at the same temperature. Adding RSA to the SCA was an effective means of increasing particle sintering of SCA. The sintering reaction rate of ash particles highly increased at beginning of sintering stage. The effects of inorganic chemicals in the sintering process were evaluated by using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) and typical fouling indices. The Ca and K were predominant contributors to the increase in sintering. The degree of sintering through the experiments was compared to a modified Frenkel sintering model, which accurately simulated the sintering tendency under isothermal conditions.
Kim, Yu J.,Kim, Jux2010,Young,Yoon, Jin Y.,Kyung, Sun Y.,Lee, Sang P.,Jeong, Sung H.,Moon, Chanil,Park, Jeongx2010,Woong Blackwell Publishing Ltd 2011 Basic & clinical pharmacology & toxicology Vol.109 No.1
<P><B>Abstract: </B> Cigarette smoking is the principal cause of chronic obstructive pulmonary disease (COPD), especially emphysema, which is characterized by alveolar wall destruction and airspace enlargement. Apoptosis of lung structural cells is involved in the pathogenesis of COPD. Xanthine derivatives (aminophylline or theophylline) have been used for the treatment of COPD as a bronchodilator. But the effects of xanthine derivatives on apoptosis of the lung structural cells remain poorly understood, even though it is known that theophylline protects against ultraviolet irradiation–induced cell death in corneal epithelial cells. This study was designed to determine whether aminophylline would protect against cigarette smoke extract (CSE)–induced apoptosis in lung fibroblasts. We demonstrated that aminophylline protected against apoptosis of MRC‐5 cells at a relatively lower therapeutic range (10 μg/ml), resulting in a significant increase in cell viability occurring at 20% concentration after 8‐hr exposure. Annexin staining decreased from 68 ± 4% of the control to 12 ± 2% of aminophylline (10 μg/ml) pre‐treatment after 20% CSE exposure for 12 hr (<I>p </I><<I> </I>0.05). Aminophylline decreased caspase 3 and 8 activities and nuclear condensation or fragmentation in MRC‐5 cells after exposure to 20% CSE for 12 hr compared with control and high levels of aminophylline (>50 μg/ml) pre‐treatment. These findings suggest that aminophylline protected apoptosis of MRC‐5 cells through the inactivation of caspases 3 and 8 and could be an effective agent to reduce cigarette smoking–induced lung structural cell apoptosis.</P>
Magneto-transport properties of magnetic tunnelling transistors at low and room temperatures
Quang, H D,Huu, C X,Oh, S K,Dang, V S,Sinh, N H,Yu, S C IOP Pub 2006 Nanotechnology Vol.17 No.14
<P>Si(100)/CoFe/AlO<SUB><I>x</I></SUB><I>/</I>CoFe/FeMn/Cu/Ta magnetic tunnelling transistors (MTTs) with differing base thicknesses (<I>W</I>) were investigated. The magneto-transport properties of the MTTs were measured at 77?K and room temperature (RT). We obtained magneto-current ratios of 48.3% and 55.9% for emitter–base bias voltages of 1.45 and 2.0?V, respectively, at 77?K. The transfer ratios are 2.83 ? 10<SUP>−5</SUP> and 1.52 ? 10<SUP>−4</SUP>, respectively, corresponding to bias voltages of 1.45 and 2.0?V. Moreover, the highest tunnel magneto-resistance (TMR) ratios turned out to be 12% and 20% for a base thickness of 30?Šat RT and 77?K, respectively. These properties raise not only some fundamental questions regarding the phenomenon of spin-independent tunnelling at low and room temperatures, but also show some promising aspect for magneto-electronic applications. In addition, we attempted to elucidate the reason behind the outstanding TMR effect at low and room temperatures. Finally, the origin of the decrease in the mean free path asymmetry (<img SRC='http://ej.iop.org/images/0957-4484/17/14/004/nano218705ieqn1.gif' ALIGN='MIDDLE' ALT='\lambda^{ \uparrow }/\lambda^{\downarrow } '/>) was clarified by using x-ray photoelectron spectroscopy profile analysis of the elements existing in the interface between Si and the CoFe base (Co, Fe, Al, Si, O). </P>
Flexible, Angle‐Independent, Structural Color Reflectors Inspired by Morpho Butterfly Wings
Chung, Kyungjae,Yu, Sunkyu,Heo, Chulx2010,Joon,Shim, Jae Won,Yang, Seungx2010,Man,Han, Moon Gyu,Lee, Hongx2010,Seok,Jin, Yongwan,Lee, Sang Yoon,Park, Namkyoo,Shin, Jung H. WILEY‐VCH Verlag 2012 ADVANCED MATERIALS Vol.24 No.18
<P><B>Thin‐film color reflectors inspired by Morpho butterflies</B> are fabricated. Using a combination of directional deposition, silica microspheres with a wide size distribution, and a PDMS (polydimethylsiloxane) encasing, a large, flexible reflector is created that actually provides better angle‐independent color characteristics than Morpho butterflies and which can even be bent and folded freely without losing its Morpho‐mimetic photonic properties.</P>