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Nou, V.,Inoue, H.,Lee, H.G.,Matsunaga, N.,Kuwayama, H.,Hidari, H. Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.8
An increase in frequency of administration of exogenous growth hormone (GH) or GH-releasing hormone was reported to be a model to increase blood circulating insulin-like growth factor-1 (IGF-1) and to improve growth performance in animals. We have investigated the effect of twice daily administration of GH-releasing peptide-2 (GHRP-2) on growth performance, GH responsiveness and plasma insulin-like growth factor IGF-1 in swine. We administered to eight swine, 3 control and 5 treatment, a twice daily s.c. injections of GHRP-2 ($30{\mu}g/kg\;BW$) for a period of 10 days. Every day blood samples immediately taken before injections of GHRP-2 or saline, at 08:00 h and 16:00 h, were measured for IGF-1 concentrations. Blood samples for GH assay were collected every 20 min on days 1, 6 and 10, from 1 hour before and 3 h after GHRP-2 or saline injections at 08:00 h. GH peak concentrations and GH area under curve (GH AUC) on day 1, 6 and 10 in treatment group of swine were higher than those in control swine (p<0.05). Twice daily administration of GHRP-2 caused a significantly attenuation (p<0.05) of GH peak concentrations ($80.25{\pm}13.87$, $39.73{\pm}5.72$ and $27.57{\pm}6.06ng/ml$ for day 1, 6 and 10, respectively) and GH AUCs ($3,536.15{\pm}738.35$, $1,310.31{\pm}203.55$ and $934.37{\pm}208.99ng/ml$ for day 1, 6 and 10, respectively). However, there was no significant difference in GH peak concentration and GH AUC between day 6 and 10. Plasma IGF-1 concentration levels were higher in treatment than control group of swine (p<0.05) after 3 days of the treatment, and the levels reached a plateau from day 3 to 10 of experiment. Growth performance did not alter by GHRP-2 administration, even though a numerical increase of body weight gain and feed efficiency was observed. These results indicate that twice daily administration of GHRP-2 for 10 days in swine did not significantly influence on growth performance, caused an overall attenuation of GH response, and that elevation of plasma GH concentrations caused by GHRP-2 administration increased plasma IGF-1 concentrations, even though an attenuation of GH response was observed.
Surface modified Ti based metallic glasses for bioactivation by electrochemical treatment technique
Oak, J.J.,Inoue, A.,Rao, K.V.,Chun, H.H.,Park, Y.H. Elsevier Sequoia 2014 Journal of Alloys and Compounds Vol.615 No.suppl1
The aim of this study is surface modification of Ni-free type Ti based metallic glass (Ti<SUB>42</SUB>Hf<SUB>11</SUB>Cu<SUB>11</SUB>Pd<SUB>36</SUB>at.%) for increasing calcification by electrochemical treatment. Ni-free type Ti based metallic glass has excellent mechanical and chemical properties which are comparable with those of Ti based alloys. Surface of Ti based metallic glasses was prepared as follows; one is anodically-oxidized porous layer by potentiostatic control in 5M NaOH solution at 25<SUP>o</SUP>C for 2h, and the other is simple hydrothermal treated poros layer by immersion in 5M NaOH solution at 60<SUP>o</SUP>C for 24h. The synthesized surface structures were characterized by X-ray diffraction (XRD) identification, SEM observation, energy dispersive X-ray spectroscopy (EDS) analysis and Auger electron spectroscopy (AES) analysis. These surfaces on the modified specimens have nano-mesh laminated structures and are consist of sodium titanate and titanium oxide. In addition, the above two types surfaces with nano-mesh laminated layer were immersed in Hank's balance salt solution (HBSS) at 37<SUP>o</SUP>C for 21days for evaluation of calcification. The apatite-forming ability on these surfaces is observed by SEM observation and EDS analysis. As stated above surface modifications are also discussed about calcification effect by different surface treatment and different formability of porosity in this study.
H. Obara,M. Katayama,A. Kawamura,J. Xu,N. Shimosato,S. Inoue 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
DC power supplies for a battery testing are becoming significantly important for developments of electrical vehicles (EVs), mobile devices, and renewable energy generations. In the recent decade, modular multi-level converters (MMC) have been actively studied and started to use on some practical applications such as high- or mediumvoltage DC-AC or AC-DC power converters. However, the widely used MMC topology has a significant issue to extend to a DC-DC converter, because it cannot achieve capacitor voltage balancing of each cell unlike the case of the DC-AC and AC-DC conversions. Therefore, most of the MMC-based DC-DC converters are realized by combining the DC-AC converter, isolation transformer or inductor, and AC-DC converter. In this study, the DC-DC operation in the MMC and its problem are analyzed and clarified. This paper proposes a circuit topology and control method of the MMCbased DC-DC converter with cell voltage balancing and fast dynamic response while the DC-AC and AC-DC converters are not used. Simulation results verify the validity of the capacitor voltage balancing control. Finally, an experimental result in a prototype converter with 6-cells using SiCMOSFETs shows the performances of the voltage balancing control and fast dynamic response.
Changes of Serum Mineral Concentrations in Horses during Exercise
Inoue, Y.,Osawa, T.,Matsui, A.,Asai, Y.,Murakami, Y.,Matsui, T.,Yano, H. Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.4
We investigated the exercise-induced changes in the serum concentration of several minerals in horses. Four welltrained Thoroughbred horses performed exercise for 5 d. The blood hemoglobin (Hb) concentration increased during exercise, recovered to the pre-exercise level immediately after cooling down and did not change again up till the end of experiment. The changes in serum zinc (Zn) and copper (Cu) concentrations were similar to those of blood Hb during the experiment. The serum magnesium (Mg), inorganic phosphorus (Pi) and iron (Fe) concentrations also increased during exercise. Though the serum Pi concentration recovered to the pre-exercise level immediately after the cooling down, it decreased further before the end of the experiment. The serum Mg concentration was lower immediately after cooling down than its pre-exercise level but gradually recovered from the temporal reduction. The recovery of the serum Fe concentration was delayed compared to that of other minerals and recovered 2 h after cooling down. The serum calcium (Ca) concentration did not change during exercise but rapidly decreased after cooling down. As a result, it was lower immediately after cooling down than its pre-exercise level. It recovered, however, to the pre-exercise level 2 h after cooling down. The temporal increase in the serum concentrations of all minerals except Ca is considered to result from hemoconcentration induced by exercise and the stable concentration of the serum Ca during exercise is possibly due to its strict regulation of homeostasis. These results indicate that the serum concentration of each mineral responds differently to exercise in horses, which may be due to the difference in metabolism among these minerals.