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칠복음(七福飮)이 Glucose Oxidase에 의해 손상(損傷)된 대뇌피질(大腦皮質) 신경세포(神經細胞)에 미치는 영향(影響)
최공한,박승택,류도곤,최민호,엄상섭,허진영,강성도,고정수,서의석,성은경,조남수,이춘우,황일택,선성규,류영수,Choi, Kong-Han,Park, Seung-Taeck,Ryu, Do-Gon,Choi, Min-Ho,Um, Sang-Sub,Hea, Jin-Young,Kang, Sung-Do,Go, Jeong-Soo,Sou, Eui-Suk,Sung, Yeun-Ky 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2
As the average life span have been lengthened and the rate of senile population have been raised, chronic degenerative diseases incident to aging has been increased rapidly and become a social problem. With this social background, recently, the facts that oxygen radicals(OR) have toxic effects on Central Nervous System and Peripheral Nervous System and cause neuropathy such as Parkinson's Disease, Alzheimer Disease have been turned out, and accordingly lots of studies on the mechanism of the toxic effects of OR on nerves, the diseases caused by OR and the approaches to curing the diseases have been made. The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Chilbokyeum(CBY) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay 2. GO, a oxygen radical, increased lipid peroxidation and the amount of LDH. 3. CBY have efficacy of decreasing lipid peroxidation. 4. CBY have efficacy of decreasing the amount of LOH. From the above results, It is concluded that Chilbokyeum has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And Chilbokyeum is thought to have certain pharmacological effects on controlling over aging and treating Dementia. Further clinical study of this pharmacological effects of Chilbokyeum should be complemented.
석창포(石菖蒲) 전탕액(煎湯液)이 Glucose Oxidase에 의해 손상(損傷)된 대뇌피질(大腦皮質) 신경세포(神經細胞)에 미치는 영향(影響)
최공한,박승택,류도곤,최민호,허진영,강성도,고정수,양상철,성은경,조남수,이춘우,서의석,류영수,Choi, Kong-Han,Park, Seung-Taeck,Ryu, Do-Gon,Choi, Min-Ho,Hea, Jin-Young,Kang, Sung-Do,Go, Jeong-Soo,Yang, Sang-cheal,Sung, Yeun-Kyung,Cho, Nam-Su,L 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2
The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Acori Rhizoma(AR) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay. 2. GO, a oxygen radical, decreased the amount of neurofilaments and total protein. 3. AR have efficacy of increasing the amount of neurofilament. 4. AR have efficacy of increasing the amount of total protein. From the above results, It is concluded that AR has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And AR is thought to have certain pharmacological effects on controlling over aging. Further clinical study of this pharmacological effects of AR should be complemented.
Dry etching of polydimethylsiloxane using microwave plasma
Hwang, Sung Jin,Oh, Dong Joon,Jung, Phill Gu,Lee, Sang Min,Go, Jeung Sang,Kim, Joon-Ho,Hwang, Kyu-Youn,Ko, Jong Soo IOP 2009 JOURNAL OF MICROMECHANICS AND MICROENGINEERING - Vol.19 No.9
<P>This paper presents a new polydimethylsiloxane (PDMS) dry-etching method that uses microwave plasma. The applicability of the method for fabricating microstructures and removing residual PDMS is also verified. The etch rate of PDMS was dominantly influenced by the gas flux ratio of CF<SUB>4</SUB>/O<SUB>2</SUB> and the microwave power. While the PDMS etch rate increased as the flux ratio of CF<SUB>4</SUB> was increased, the etch rate decreased as the flux ratio of O<SUB>2</SUB> was increased. The maximum etch rate of 4.31 µm min<SUP>−1</SUP> was achieved when mixing oxygen (O<SUB>2</SUB>) and tetrafluoromethane (CF<SUB>4</SUB>) at a 1:2 ratio at 800 W power. The PDMS etch rate almost linearly increased with the microwave power. The ratio of the vertical etch rate to the lateral etch rate was in a range of 1.14–1.64 and varied with the gas fluxes. In consideration of potential applications of the proposed PDMS etching method, array-type PDMS microwells and network-type microprotrusion structures were fabricated. The contact angle was dramatically increased from 104° (non-etched PDMS surface) to 148° (etched PDMS surface) and the surface was thereby modified to be superhydrophobic. In addition, a thin PDMS skin that blocked holes and PDMS residues affixed in nickel microstructures was successively removed.</P>
BioSMACK: a Linux Live CD for genome-wide association analyses
( Chang Bum Hong ),( Young Jin Kim ),( Sang Hoon Moon ),( Young Ah Shin ),( Min Jin Go ),( Dong Joon Kim ),( Jong Young Lee ),( Yoon Shin Cho ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.1
Recent advances in high-throughput genotyping technologies have enabled us to conduct a genome-wide association study (GWAS) on a large cohort. However, analyzing millions of single nucleotide polymorphisms (SNPs) is still a difficult task for researchers conducting a GWAS. Several difficulties such as compatibilities and dependencies are often encountered by researchers using analytical tools, during the installation of software. This is a huge obstacle to any research institute without computing facilities and specialists. Therefore, a proper research environment is an urgent need for researchers working on GWAS. We developed BioSMACK to provide a research environment for GWAS that requires no configuration and is easy to use. BioSMACK is based on the Ubuntu Live CD that offers a complete Linux-based operating system environment without installation. Moreover, we provide users with a GWAS manual consisting of a series of guidelines for GWAS and useful examples. BioSMACK is freely available at http://ksnp.cdc. go.kr/biosmack. [BMB reports 2012; 45(1): 44-46]
Thickness-dependent spin-orbit torques in normal metal/Nb/ferromagnet tri-layers
Min Hyeok Lee,Gyungchoon Go,Yong Jin Kim,In Ho Cha,Gyu Won Kim,Taehyun Kim,Kyung-Jin Lee,Young Keun Kim 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
When electrical current flows to normal metal (NM)/ferromagnet (FM) heterostructures, a transverse spin current that exerting torque to the magnetization is generated. This torque, called spin-orbit torque (SOT), is drawing massive attention due to its applicability for the energy-efficient writing method of a next-generation memory device. For the application of SOT to memory or logic devices, it is crucial to quantify the mechanisms of this new physical phenomenon. Most SOT studies designed the simple NM/FM bilayer structures where NM (or NM/FM interface) serves as spin current source. Recently, the experimental system has been improved to more complicate structures containing more than one source [5, 6]. This study discussed the thicknessdependent SOT efficiency in NM/Nb/FM tri-layer structures where either NM1/NM2 or NM/FM bilayer serves as an additional spin current source. We investigate two types of NM/Nb/CoFeB tri-layer in which the NM was either Ta or Pt. The SOT value increased and saturated with increasing the Nb thickness in both series. However, there is switching polarity reversal in Pt/Nb/FM structures due to the different spin-orbit coupling signs between Pt and Nb when tNb changed around critical thickness. In contrast, there would be no such reverse in the Ta/Nb/FM structure. We confirm this polarity reversal behavior by both second harmonics and current-induced SOT switching measurements, suggesting well-designed systematical observation of the thickness dependence of SOT. These results provide a systematic understanding of the thickness-dependent SOT properties.
Jin, Hyun-Seok,Kim, Jeonghyun,Lee, Soo-Jin,Kim, Kyunga,Go, Min Jin,Lee, Jong-Young,Lee, Hye-Ja,Song, Jihyun,Jeon, Byeong Tak,Roh, Gu Seob,Kim, Sung-Jun,Kim, Bo-Young,Hong, Kyung-Won,Yoo, Young-Hyun,Oh Elsevier 2014 Molecular and cellular endocrinology Vol.382 No.1
<P><B>Abstract</B></P> <P>Several association studies have implicated the <I>PARK2</I> gene that encodes parkin – the key molecule orchestrating the mitochondrial quality control system – as a candidate susceptibility gene for diabetes. A total of 7551 unrelated Korean KARE cohort subjects were analyzed to investigate the association between the <I>PARK2</I> single nucleotide polymorphism (SNP) and quantitative glycemic traits. Two SNPs, rs10455889 and rs9365294, were significantly associated with fasting plasma glucose level (<I>p</I> =∼1.2×10<SUP>−4</SUP>) and insulin secretion indices (<I>p</I> =∼7.4×10<SUP>−5</SUP>) in male KARE subjects. Parkin was expressed predominantly in the rat pancreatic islets. Downregulation of the <I>Park2</I> gene in rat INS-1 β-cells resulted in a significant decrease in the glucose-stimulated insulin secretion, intracellular insulin gene expression, and intracellular ATP level. The <I>Park2</I>-depleted β-cells also exhibited increased mitochondrial fragmentation and ROS production and decreased mitochondrial membrane potential. Both population-based statistical evaluation and experimental evidence demonstrated a fundamental role of the <I>PARK2</I> gene in the maintenance of β-cell function.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Two <I>PARK2</I> SNPs are associated with fasting blood glucose and insulin secretion. </LI> <LI> The <I>Park2</I>-depleted rat β-cells exhibit decreased insulin production and secretion. </LI> <LI> Knockdown of <I>Park2</I> gene by RNAi causes mitochondrial alterations in rat INS-1 β-cells. </LI> <LI> <I>PARK2</I> gene plays an important role in the maintenance of pancreatic β-cell function. </LI> </UL> </P>
Observation of spin-current transport in normal metal/Nb/ferromagnet tri-layers
Min Hyeok Lee,Gyungchoon Go,Yong Jin Kim,In Ho Cha,Gyu Won Kim,Taehyun Kim,Kyung-Jin Lee,Young Keun Kim 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.1
Spin-orbit torque (SOT) is drawing attention because it is applicable for the writing method of a brand-new memory device that is energy efficient and non-volatile. When electrical current is induced to normal metal (NM)/ferromagnet (FM) heterostructures, a transverse spin current is generated. An angular momentum transferred to magnetization by the generated spin current acts as a torque [1]. For the application of SOT to memory or logic devices, it is crucial to investigate the mechanisms of this new physical phenomenon. Many researchers had employed the experiment varying the NM thickness based on the NM/FM bi-layer structure to unveil the origin [2-4]. In this system, NM (or NM/FM interface) plays a single spin current source. However, to enhance the SOT efficiency, the experimental system has been improved to tri-layer structures containing more than one source [5, 6]. This study would like to discuss how the thickness dependence of SOT efficiency behaves in NM/Nb/FM tri-layer structures where either NM1/NM2 or NM/FM bilayer act as an additional spin current source. The SOT efficiency decreased as the Nb thickness (t<sub>Nb</sub>) increased in Ta 3/Nb t<sub>Nb</sub>/CoFeB 0.9 structure. This result suggested that the thicker Nb layer suppressed the spin current, which was generated from Ta (or Ta/Nb), from reaching the FM layer. However, in the Pt/Nb/CoFeB series in which Pt with a different SOC sign from Ta and Nb was employed, the behavior of SOT efficiency is different. When t<sub>Nb</sub> ≤ 3 nm, the device showed a positive signal but negative for t<sub>Nb</sub> > 3 nm. The current-induced SOT switching also confirmed this sign reversal, which showed a well-designed experiment. These results provide a systematic understanding of the thickness-dependent SOT properties.
Go, Min-Jin,Min, Hae-Sook,Lee, Jong-Young,Kim, Sung-Soo,Kim, Yeon-Jung Korea Genome Organization 2011 Genomics & informatics Vol.9 No.3
Chronic inflammation has been implicated as one of the important etiological factors in insulin resistance and type 2 diabetes mellitus (T2DM). To investigate the role of anti-inflammatory cytokines in the development of T2DM, we conducted a case-control study to assess the association between IL4/IL4R polymorphisms and disease risk. We firstly identified single nucleotide poly-morphisms (SNP) at IL4 and IL4RA loci by sequencing the loci in Korean participants. Case-control studies were conducted by genotyping the SNPs in 474 T2DM cases and 470 non-diabetic controls recruited from community-based cohorts. Replication of the associated signals was performed in 1,216 cases and 1,352 controls. We assessed effect of IL4 -IL4RA interaction on T2DM using logistic regression method. The functional relevance of the SNP associated with disease risk was determined using a reporter expression assay. We identified a strong association between the IL4 promoter variant rs2243250 and T2DM risk (OR=0.77; 95% CI, 0.67~0.88; p=$1.65{\times}10^{-4}$ in the meta-analysis). The reporter gene expression assay demonstrated that the presence of rs2243250 might affect the gene expression level with ~1.5-fold allele difference. Our findings contribute to the identification of IL4 as a T2D susceptibility locus, further supporting the role of anti-inflammatory cytokines in T2DM disease development.
Min Ji Kim,Jong Min Kim,Jong Hyun Moon,Hyo Lim Lee,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, anti-inflammatory effect of the ethyl acetate fraction of Eucommia ulmoides leaves (EFEL) on particulate matter (PM)2.5-induced intestinal damage mice model was evaluated. The EFEL showed a cytoprotective effect against PM2.5-induced cell death in HT29 cells. The EFEL ameliorated reduced glutathione (GSH) and superoxide dismutase (SOD) level in intestinal tissue. In addition, EFEL inhibited the intestinal malondialdehyde (MDA) levels. Furthermore, myelin peroxidase (MPO) level using the marker of intestinal inflammation was decreased in the EFEL group. Furthermore, the inflammatory cytokines such as (IL-1β, TNF-α and p-IκB-α) levels were decreased in the EFEL group. Also, intake of EFEL protected the tight junction proteins such as occluding and claudin-1 on PM2.5-induced intestine damage mice.