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P.K.Das,G.D.V. Pandiyan,P.R.Ghosh,B.C.Das,S. Sanyal 대한수의학회 2005 Journal of Veterinary Science Vol.6 No.4
Unilateral adrenalectomy was performed in six black Bengal goat (Capra hircus) to study electrocardiograph in connection with mineral metabolism with special reference to sodium and potassium and some other factors of physiological importance. The parameters were studied at every 12 hrs interval upto 120 hrs and 24 hrs interval from 120 to 240 hrs. Physiological parameters, like body weight and rectal temperature, changed non-significantly (p < 0.05) after adrenalectomy. Among minerals, plasma sodium (p < 0.01) and plasma potassium (p < 0.05) concentration were changed significantly between hours leaving impression in ECG as widening of QRS complex and peaked T wave with increased amplitude found after unilateral adrenalectomy. Heart rate also increased significantly (p < 0.01) between hours.
Different approaches of alternative medicines in $acne$ $vulgaris$ treatment
Ghosh, V.K.,Nagore, D.H.,Kadbhane, K.P.,Patil, M.J. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.1
Acne vulgaris is common dermatological disorder primarily acts on children and adolescents. This affects approximately 80% of the population between the ages of 12-25 years. The clinically used anti-acne drugs suffer from the disadvantage of side effects and high cost of treatment. Alternative to these drugs are traditional medicines and natural products, which offer a great hope in the identification of bioactive lead compounds and their development into drugs for the treatment of skin disorder like acne vulgaris. The use of traditional medicines and phytopharmaceuticals for treating various skin ailments dates back several centuries. The aim of the present review is to compile relevant data on the mechanisms of action of various natural compounds from ethnomedicinal plants and their role in the resolution of acne vulgaris. An attempt is also being made to enumerate the possible leads from Indian traditional medicinal system for the treatment of acne. We tried to provide the readers with the array of outcome variables, which can be further worked upon in clinical studies. Finally, this paper puts forth issues that need to be addressed by researchers in the future.
Stellar contents and star formation in the young star cluster Be 59
Pandey, A. K.,Sharma, Saurabh,Ogura, K.,Ojha, D. K.,Chen, W. P.,Bhatt, B. C.,Ghosh, S. K. Blackwell Publishing Ltd 2008 Monthly notices of the Royal Astronomical Society Vol.383 No.3
<P>ABSTRACT</P><P>We present <I>UBV I</I><SUB><I>c</I></SUB> CCD photometry of the young open cluster Be 59 with the aim to study the star formation scenario in the cluster. The radial extent of the cluster is found to be ∼10 arcmin (2.9 pc). The interstellar extinction in the cluster region varies between <I>E</I>(<I>B</I>−<I>V</I>) ≃ 1.4 to 1.8 mag. The ratio of total-to-selective extinction in the cluster region is estimated as 3.7 ± 0.3. The distance of the cluster is found to be 1.00 ± 0.05 kpc. Using near-infrared (NIR) colours and slitless spectroscopy, we have identified young stellar objects (YSOs) in the open cluster Be 59 region. The ages of these YSOs range between <1 and ∼2 Myr, whereas the mean age of the massive stars in the cluster region is found to be ∼2 Myr. There is evidence for second-generation star formation outside the boundary of the cluster, which may be triggered by massive stars in the cluster. The slope of the initial mass function, Γ, in the mass range 2.5 < <I>M</I>/M<SUB>⊙</SUB>≤ 28 is found to be −1.01 ± 0.11 which is shallower than the Salpeter value (−1.35), whereas in the mass range 1.5 < <I>M</I>/M<SUB>⊙</SUB>≤ 2.5 the slope is almost flat. The slope of the <I>K</I>-band luminosity function is estimated as 0.27 ± 0.02, which is smaller than the average value (∼0.4) reported for young embedded clusters. Approximately 32 per cent of Hα emission stars of Be 59 exhibit NIR excess indicating that inner discs of the T Tauri star (TTS) population have not dissipated. The Midcourse Space Experiment (MSX) and <I>IRAS-HIRES</I> images around the cluster region are also used to study the emission from unidentified infrared bands and to estimate the spatial distribution of optical depth of warm and cold interstellar dust.</P>
Role of animal models in biomedical research: a review
P. Mukherjee,S. Roy,D. Ghosh,S. K. Nandi 한국실험동물학회 2022 Laboratory Animal Research Vol.38 No.3
The animal model deals with the species other than the human, as it can imitate the disease progression, its’ diagnosis as well as a treatment similar to human. Discovery of a drug and/or component, equipment, their toxicological studies, dose, side effects are in vivo studied for future use in humans considering its’ ethical issues. Here lies the importance of the animal model for its enormous use in biomedical research. Animal models have many facets that mimic various disease conditions in humans like systemic autoimmune diseases, rheumatoid arthritis, epilepsy, Alzheimer’s disease, cardiovascular diseases, Atherosclerosis, diabetes, etc., and many more. Besides, the model has tremendous importance in drug development, development of medical devices, tissue engineering, wound healing, and bone and cartilage regeneration studies, as a model in vascular surgeries as well as the model for vertebral disc regeneration surgery. Though, all the models have some advantages as well as challenges, but, present review has emphasized the importance of various small and large animal models in pharmaceutical drug development, transgenic animal models, models for medical device developments, studies for various human diseases, bone and cartilage regeneration model, diabetic and burn wound model as well as surgical models like vascular surgeries and surgeries for intervertebral disc degeneration considering all the ethical issues of that specific animal model. Despite, the process of using the animal model has facilitated researchers to carry out the researches that would have been impossible to accomplish in human considering the ethical prohibitions.
Differential responses of two rice varieties to salt stress
Ghosh, N.,Adak, M.K.,Ghosh, P.D.,Gupta, S.,Sen Gupta, D.N.,Mandal, C. The Korean Society of Plant Biotechnology 2011 Plant biotechnology reports Vol.5 No.1
Two rice varieties, viz. Nonabokra and Pokkali, have been evaluated for their responses to salinity in terms of some physiological and biochemical attributes. During the exposure to salinity (200 mM concentration of sodium chloride for 24, 48, and 72 h), a significant increase in sodium was recorded which was also concomitant with the changes of other metabolic profiles like proline, phenol, polyamine, etc. The protein oxidation was significantly increased and also varied between the two cultivars. The changes in activities of anti-oxidative enzymes under stress were significantly different to the control. The detrimental effects of salinity were also evident in terms of lipid peroxidation, chlorophyll content, protein profiles, and generation of free radicals; and these were more pronounced in Pokkali than in Nonabokra. The assessment and analysis of these physiological characters under salinity could unravel the mechanism of salt responses revealed in this present study and thus might be useful for selection of tolerant plant types under the above conditions of salinity.
Different approaches of alternative medicines in acne vulgaris treatment
V. K. Ghosh,D. H. Nagore,K. P. Kadbhane,M. J. Patil 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.1
Acne vulgaris is common dermatological disorder primarily acts on children and adolescents. This affects approximately 80% of the population between the ages of 12–25 years. The clinically used anti-acne drugs suffer from the disadvantage of side effects and high cost of treatment. Alternative to these drugs are traditional medicines and natural products, which offer a great hope in the identification of bioactive lead compounds and their development into drugs for the treatment of skin disorder like acne vulgaris. The use of traditional medicines and phytopharmaceuticals for treating various skin ailments dates back several centuries. The aim of the present review is to compile relevant data on the mechanisms of action of various natural compounds from ethnomedicinal plants and their role in the resolution of acne vulgaris. An attempt is also being made to enumerate the possible leads from Indian traditional medicinal system for the treatment of acne. We tried to provide the readers with the array of outcome variables, which can be further worked upon in clinical studies. Finally, this paper puts forth issues that need to be addressed by researchers in the future.