Vitamin C and Vitamin E Protect the Rat Testes from Cadmium-induced Reactive Oxygen Species

Ronojoy Sen Gupta,Enakshi Sen Gupta,Bijaya Kumar Dhakal,Ashoke Ranjan Thakur,Joohong Ahnn 한국분자세포생물학회 2004 Molecules and cells Vol.17 No.1

Cadmium-Induced Gene Expression is Regulated by MTF-1, a Key Metal- Responsive Transcription Factor

Gupta, Ronojoy-Sen,Ahnn, Joohong The Korean Society for Integrative Biology 2003 Korean journal of biological sciences Vol.7 No.3

The transition metal cadmium is a serious occupational and environmental toxin. To inhibit cadmium-induced damage, cells respond by increasing the expression of genes that encode stress-responsive proteins. The metal-regulatory transcription factor 1 (MTF-1) is a key regulator of heavy-metal induced transcription of metallothionein-I and II and other genes in mammals and other metazoans. Transcriptional activation of genes by MTF-1 is mediated through binding to metal-responsive elements in the target gene promoters. Phosphorylation of MTF-1 plays a critical role in the cadmium-inducible transcriptional activation of metallothionein and other responses. Studies using inhibitors indicate that multiple kinases and signal transduction cascades, including those mediated by protein kinase C, tyrosine kinase and casein kinase II, are essential for cadmium-mediated transcriptional activation. In addition, calcium signaling is also involved in regulating metal-activated transcription. In several species, cadmium induces heat shock genes. Recently much progress has been made in elucidating the cellular machinery that regulates this metal-inducible gene expression. This review summarizes these recent advances in understanding the role of some known cadmium-responsive genes and the molecular mechanisms that activate metal-responsive transcription factor, MTF-1.

INDIA AND THE SUPERPOWERS: ILLUSION & REALITY OF REGIONAL INFLUENTIALS

Gupta, Bhabani Sen The Institute for Far Eastern Studies Kyungnam Uni 1979 ASIAN PERSPECTIVE Vol.3 No.2

Relationship with the two superpowers, the United States and the Soviet Union, has been the permanent pathological preoccupation of India's foreign policy. Without deliberately from the falcon poise of nonalignment, India has always sought, and never managed to get, a balanced relationship with the two leviathans. The raw materials of international politics have not produced a Washington-Delhi-Moscow triangle because no two sides of it would be stronger than the third. The other triangle-the Washington-Peking-Mascow one, always tantalizing to Indians-works because any two sides of it, combined, can threaten the third. The priority which China compels on the foreign policy agenda of the superpowers has therefore never been India's, a blunt fact to which Indians have more or less reconciled themselves. What galls them, however, and imparts an enduring instability to Indo-US relations, is that tile United States is still unable to fix for lndia a place in its strategic schema of the planet, which would respond to India's national pride and aspirations and reflect its considerable achievements in 32 years of independence. On the other hand, India finds that it has been allotted an agreeable placement on the Soviet strategic map of the world, especially in one of the most dynamic subsummit triangles in world politics, namely, the Moscow-Delhi-Pekiing triangle. This basic difference in the two superpowers' strategic perception of India became strikingly clear during this decade. Even as Indo-us relations have showed a remarkable recovery and jumped on the scale of friendship in the years of the Carter presidency in Washington and the Janata government in Delhi, the fundamental strategic cleavage between the two has remained unbridged, In contrast, even when there has been certain cooling off of the erstwhile political warmth between India and the Soviet Union, the basic strategic convergence of lndo-Soviet interests has stood out more or less unimpaired.

CHANGING PATTERNS OF CONFLICT IN SOUTH ASIA

Gupta, Bhabani Sen The Institute for Far Eastern Studies Kyungnam Uni 1985 ASIAN PERSPECTIVE Vol.9 No.2

Does Financial Sector Development Augment Cross-Border Capital Flows?

Abhijit Sen Gupta,Pragya Atri 한국국제경제학회 2018 International Economic Journal Vol.32 No.4

The sharp increase in volatility of capital flows in recent years has resulted in many countries altering the regulations governing the flow of foreign capital only to find such changes having a limited impact. We postulate that one reason for the limited effectiveness of such changes in regulations is the level of financial sector development in the country. As a country enhances its level of financial sector development, it also develops more and more sophisticated financial instruments. The more advanced the domestic financial instruments are, and the deeper is the integration of the domestic financial markets with the world markets, the greater is the likelihood of developing strategies to bypass capital account management measures. In this paper,weuse various empirical techniques to identify the impact of financial sector development on capital flows, after accounting for regulatory regime. The empirical results indicate that there is a threshold effect in the financial sector development capital flow relationship. In particular, financial sector development augments greater integration with global capital flows only above a threshold level. Below the threshold level we find financial development reduces the extent of integration with global capital markets.

제4장 80년대의 동남아시아 : 인도의 견해

Bhabani Sen Gupta 경남대학교 극동문제연구소 1977 전환기의 동남아세아 Vol.- No.-

Southeast Asia in the Eighties : The View from India

Bhabani Sen Gupta 경남대학교 극동문제연구소 1977 SOUTHEAST ASIA IN TRANSITION Vol.- No.-

Does Capital Account Openness Lower Inflation?

Abhijit Sen Gupta 한국국제경제학회 2008 International Economic Journal Vol.22 No.4

This paper investigates the relationship between capital account openness and inflation since the 1980s. It argues that widespread capital account liberalization during the last two decades appears to have contributed to the worldwide disinflation observed during the same period. The paper builds a theoretical model to motivate the presence of a negative link between financial integration and inflation. It tests the prediction of the theoretical model by employing static and dynamic panel data procedures. Financial integration appears to discipline monetary authorities, or to help them convince the private sector that they will be more disciplined in the future.

LABORATORY SIMULATION OF LIGHT SCATTERING FROM REGOLITH ANALOGUES: EFFECT OF POROSITY

KAR, AMRITAKSHA,DEB, SANJIB,SEN, A.K.,GUPTA, RANJAN The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

The surfaces of most atmosphereless solar system objects are referred to as regolith, layers of loosely connected fragmentary debris, produced by meteorite impacts. Measurements of light scattered from such surfaces provides information about the composition and structure of the surface. A suitable way to characterize the scattering properties is to consider how the intensity and polarization of scattered light depends on the particle size, composition, porosity, roughness, wavelength of incident light and the geometry of observation. In the present work, the effect of porosity on bidirectional reflectance as a function of phase angle is studied for alumina powder with grain size of $0.3{\mu}m$ and olivine powder with grain size of $49{\mu}m$ at 543.5 nm. The optical constants of the alumina sample for each porosity were calculated with Maxwell Garnett effective medium theory. On using each of the optical constants of alumina sample in Mie theory with the Hapke model the variation of bidirectional reflectance is obtained as a function of phase angle with porosity as a parameter. Experimental reflectance data are in good agreement the model. For the olivine sample the effect of porosity is studied using Hapke (2008).

Optimal panel of immunohistochemistry for the diagnosis of B-cell non-Hodgkin lymphoma using bone marrow biopsy: a tertiary care center study

Nisha Marwah,Manali Satiza,Niti Dalal,Sudhir Atri,Monika Gupta,Sunita Singh,Rajeev Sen 대한혈액학회 2021 Blood Research Vol.56 No.1

Background Morphological diagnosis of non-Hodgkin lymphoma (NHL) is usually based on lymph node biopsy. Bone marrow biopsy (BMB) is important for staging, and morphology alone can be challenging for subtyping. Immunohistochemistry (IHC) allows a more precise diagnosis and characterization of NHL using monoclonal antibodies. However, there is a need for a minimal panel that can provide maximum information at an affordable cost. Methods All newly diagnosed cases of B-cell NHL with bone marrow infiltration between 2017 and 2019 were included. BMB was the primary procedure for diagnosing B-cell NHL. Subtyping of lymphomas was performed by immunophenotyping using a panel of monoclonal antibodies on IHC. The primary diagnostic panel of antibodies for B-cell NHL included CD19, CD20, CD79, CD5, CD23, CD10, Kappa, and Lambda. The extended panel of antibodies for further subtyping included CD30, CD45, CD56, Cyclin D1, BCL2, and BCL6. Results All cases of B-cell NHL were classified into the chronic lymphocytic leukemia (CLL) and non-CLL groups based on morphology and primary IHC panel. In the CLL group, the most significant findings were CD5 expression, CD23 expression, dim CD79 expression, and weak surface immunoglobulin (Ig) positivity. In the non-CLL group, they were CD5 expression, positive or negative CD23 expression, strong CD79 expression, and strong surface Ig expression. An extended panel was used for further subtyping of non-CLL cases, which comprised CD10, Cyclin D1, BCL2, and BCL6. Conclusion We propose a two-tier approach for immunophenotypic analysis of newly diagnosed B-cell NHL cases with a minimum primary panel including CD5, CD23, CD79, Kappa, and Lambda for differentiation into CLL/non-CLL group and Kappa and Lambda for clonality assessment. An extended panel may be used wherever required for further subtyping of non-CLL.