Reparative, Neuroprotective and Anti-neurodegenerative Effects of Granulocyte Colony Stimulating Factor in Radiation-Induced Brain Injury Model

Gökhan Gürkan,Özüm Atasoy,Nilsu Çini,İbrahim Halil Sever,Bahattin Özkul,Gökhan Yaprak,Cansın Şirin,Yiğit Uyanıkgil,Ceren Kızmazoğlu,Mümin Alper Erdoğan,Oytun Erbaş 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.5

Objective : This animal model aimed to compare the rat group that received brain irradiation and did not receive additional treatment (only saline) and the rat group that underwent brain irradiation and received Granulocyte colony stimulating factor (G-CSF) treatment. In addition, the effects of G-CSF on brain functions were examined by magnetic resonance (MR) imaging and histopathologically. Methods : This study used 24 female Wistar albino rats. Drug administration (saline or G-CSF) was started at the beginning of the study and continued for 15 days after whole-brain radiotherapy (WBRT). WBRT was given on day 7 of the start of the study. At the end of 15 days, the behavioral tests, including the three-chamber sociability test, open field test, and passive avoidance learning test, were done. After the behavioral test, the animals performed the MR spectroscopy procedure. At the end of the study, cervical dislocation was applied to all animals. Results : G-CSF treatment positively affected the results of the three-chamber sociability test, open-space test and passive avoidance learning test, cornu Ammonis (CA) 1, CA3, and Purkinje neuron counts, and the brain levels of brain-derived neurotrophic factor and postsynaptic density protein-95. However, G-CSF treatment reduced the glial fibrillary acidic protein immunostaining index and brain levels of malondialdehyde, tumor necrosis factor-alpha, nuclear factor kappa-B, and lactate. In addition, on MR spectroscopy, G-CSF had a reversible effect on brain lactate levels. Conclusion : In this first designed brain irradiation animal model, which evaluated G-CSF effects, we observed that G-CSF had reparative, neuroprotective and anti-neurodegenerative effects and had increased neurotrophic factor expression, neuronal counts, and morphology changes. In addition, G-CSF had a proven lactate-lowering effect in MR spectroscopy and brain materials.

MINERAL NUTRITION OF GRAZING SHEEP IN NORTHERN CHINA I. MACRO-MINERALS IN PASTURE, FEED SUPPLEMENTS AND SHEEP

Masters, D.G.,Purser, D.B.,Yu, S.X.,Wang, Z.S.,Yang, R.Z.,Liu, N.,Lu, D.X.,Wu, L.H.,Ren, J.K.,Li, G.H. Asian Australasian Association of Animal Productio 1993 Animal Bioscience Vol.6 No.1

This study determined the macro-mineral levels in plants and sheep, at different times during the year, at three farms in northern China. Samples of plants, animal tissues and faeces were collected at 5 to 8 times during the year from each site. They were analysed for calcium, sodium, phosphorus, magnesium and potassium. Sodium concentrations in plants were below those recommended for optimum animal production at all sites for all or part of the year (0.01-1.66 g/kg DM). Low concentrations of sodium in faeces were measured and signs of sodium deficiency (soil ingestion) were observed on one farm. There were seasonal trends in other mineral levels in plants and animals. Plants were lowest in potassium (2.3-13.4 g/kg DM), magnesium (1.28-4.82 g/kg DM) and phosphorus (0.24-1.62 g/kg DM) in winter and spring. However, high levels of these elements were supplied in the feed supplements used at this time of the year. During the periods of rapid pasture growth, in summer and autumn, supplements of feed and salt are often not provide even though pasture concentrations of phosphorus and sodium are low. It may be at these times that sheep will be most susceptible to deficiencies of these elements.

Influence of access cavity design on calcium hydroxide removal using different cleaning protocols: a confocal laser scanning microscopy study

Falakaloğlu Seda,Yeniçeri Özata Merve,Güneş Betül,Silva Emmanuel João Nogueira Leal,Gündoğar Mustafa,Güçyetmez Topal Burcu 대한치과보존학회 2023 Restorative Dentistry & Endodontics Vol.48 No.3

Objectives The purpose of this study was to evaluate the influence of endodontic access cavities design on the removal of calcium hydroxide medication of the apical third of mandibular incisor root canal walls and dentinal tubules with different cleaning protocols: EDDY sonic activation, Er,Cr:YSGG laser-activated irrigation, or conventional irrigation with IrriFlex. Materials and Methods Seventy-eight extracted human mandibular incisors were assigned to 6 experimental groups (n = 13) according to the endodontic access cavity and cleaning protocol for calcium hydroxide removal: traditional access cavity (TradAC)/EDDY; ultraconservative access cavity performed in the incisal edge (UltraAC.Inc)/EDDY; TradAC/Er,Cr:YSGG; UltraAC.Inc/Er,Cr:YSGG; TradAC/IrriFlex; or UltraAC.Inc/IrriFlex. Confocal laser scanning microscopy images were used to measure the non-penetration percentage, maximum residual calcium hydroxide penetration depth, and penetration area at 2 and 4 mm from the apex. Data were statistically analyzed using Shapiro-Wilk and WRS2 package for 2-way comparison of non-normally distributed parameters (depth of penetration, area of penetration, and percentage of non-penetration) according to cavity and cleaning protocol with the significance level set at 5%. Results The effect of cavity and cleaning protocol interactions on penetration depth, penetration area and non-penetration percentage was not found statistically significant at 2 and 4 mm levels (p > 0.05). Conclusions The present study demonstrated that TradAC or UltraAC.Inc preparations with different cleaning protocols in extracted mandibular incisors did not influence the remaining calcium hydroxide at 2 and 4 mm from the apex. Objectives The purpose of this study was to evaluate the influence of endodontic access cavities design on the removal of calcium hydroxide medication of the apical third of mandibular incisor root canal walls and dentinal tubules with different cleaning protocols: EDDY sonic activation, Er,Cr:YSGG laser-activated irrigation, or conventional irrigation with IrriFlex. Materials and Methods Seventy-eight extracted human mandibular incisors were assigned to 6 experimental groups (n = 13) according to the endodontic access cavity and cleaning protocol for calcium hydroxide removal: traditional access cavity (TradAC)/EDDY; ultraconservative access cavity performed in the incisal edge (UltraAC.Inc)/EDDY; TradAC/Er,Cr:YSGG; UltraAC.Inc/Er,Cr:YSGG; TradAC/IrriFlex; or UltraAC.Inc/IrriFlex. Confocal laser scanning microscopy images were used to measure the non-penetration percentage, maximum residual calcium hydroxide penetration depth, and penetration area at 2 and 4 mm from the apex. Data were statistically analyzed using Shapiro-Wilk and WRS2 package for 2-way comparison of non-normally distributed parameters (depth of penetration, area of penetration, and percentage of non-penetration) according to cavity and cleaning protocol with the significance level set at 5%. Results The effect of cavity and cleaning protocol interactions on penetration depth, penetration area and non-penetration percentage was not found statistically significant at 2 and 4 mm levels (p > 0.05). Conclusions The present study demonstrated that TradAC or UltraAC.Inc preparations with different cleaning protocols in extracted mandibular incisors did not influence the remaining calcium hydroxide at 2 and 4 mm from the apex.

How demand for security influence the shaping of foreign policy: Using the theory of securitisation to understand Armenia–Iran relations

GöktürkTüysüzoğlu 한양대학교 아태지역연구센터 2014 Journal of Eurasian Studies Vol.5 No.2

This study assesses the alliance currently developing between Armenia and Iran using the framework provided by the Copenhagen School's securitisation theory. Armenia is resorting to securitisation with regard to Turkey on the basis of genocide, and with regard to Azerbaijan through the Nagorno-Karabakh Question. Iran, meanwhile, is securitising Azerbaijan and Turkey within the framework of its own regional activities. Examining the relationship developing between Armenia and Iran, in terms of the theory of securitisation, will be helpful in revealing the psycho-social aspects of the tensions in this region.

Effects of Partial Beef Fat Replacement with Gelled Emulsion on Functional and Quality Properties of Model System Meat Emulsions

Meltem Serdaroğlu,Berker Nacak,Merve Karabıyıkoğlu,Gökçen Keser 한국축산식품학회 2016 한국축산식품학회지 Vol.36 No.6

The objective of this study was to investigate the effects of partial beef fat replacement (0, 30, 50, 100%) with gelled emulsion (GE) prepared with olive oil on functional and quality properties of model system meat emulsion (MSME). GE consisted of inulin and gelatin as gelling agent and characteristics of gelled and model system meat emulsions were investigated. GE showed good initial stability against centrifugation forces and thermal stability at different temperatures. GE addition decreased the pH with respect to increase in GE concentration. Addition of GE increased lightness and yellowness but reduced redness compared to control samples. The results of the study showed that partial replacement of beef fat with GE could be used for improving cooking yield without negative effects on water holding capacity and emulsion stability compared to C samples when replacement level is up to 50%. The presence of GE significantly affected textural behaviors of samples (p<0.05). In conclusion, our study showed that GE have promising impacts on developing healthier meat product formulations besides improving technological characteristics.

Effect of MAP and Vacuum Sealing on Sensory Qualities of Drysalted Olive

Nurcan Değirmencioğlu,Ozan Gürbüz,Ali Değirmencioğlu,Yasemin Şahan,Hasan Özbey 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.5

The ‘Gemlik’ olive, grown in Turkey, is the main variety used in the production of commercial table olives. The aim of the present work was to determine the effect on sensory qualities of dry-salted olives of the ‘Gemlik’ cultivar packed with vacuum sealing or modified atmosphere packaging and stored at 4 or 20^oC. Storage temperature did not have a significant effect on the sensory profile (p>0.05). However, with the exception of the color attribute, somewhat higher overall scores were given to samples stored at 4^oC. In both vacuum sealing and modified atmosphere packaging (MAP) samples stored at 4^oC, the lack of oxygen and dipping the olives in 10 ppm chlorine solution before dry-salting, prevented the growth of yeast and mold and therefore both rancidity and softness attributes scored higher points by panelists.

Preventive Effects of Intracisternal Alphatochopherol on Cerebral Vasospasm in Experimental Subarachnoid Hamorrhage

SerdarKemalo?lu,Umit?zkan,FahriYilmaz,ErdemAK,HamitAcemo?lu,G?n?l?lmez,Ramazan?ım?ek,AbdurrahmanBakir 연세대학교의과대학 2003 Yonsei medical journal Vol.44 No.6

Functional Outcomes and Long-term Durability of Artificial Urinary Sphincter Application: Review of 56 Patients With Long-term Follow-up

Ömer Gülpınar,Evren Süer,Mehmet İlker Gökce,Ahmet Hakan Haliloğlu,Erdem Öztürk,Nihat Arıkan 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.6

Purpose: To evaluate the long-term outcomes of artificial urinary sphincter (AUS) implantation and to report the complication rates, including mechanical failure, erosion,and infection. Materials and Methods: From June 1990 to May 2011, AUS (AMS 800) implantations were performed in 56 adult males by one surgeon. Various demographic and preoperative variables, surgical variables, and postoperative outcomes, including success and complication rates with a median follow-up of 96 months, were recorded retrospectively. Results: The mean age of the patients at the time of AUS implantation was 61.8 (±14.2)years. During the follow-up period, the total complication rate was 41.1% (23 patients). The incidence of complications was significantly lower during the follow-up period after 48 months (p<0.05). Kaplan-Meier analysis revealed that 5- and 10-year failure-free rates were 50.3% and 45.2%, respectively. Conclusions: Long-term durability and functional outcomes are achievable for the AMS 800, but there are appreciable complication rates for erosion, mechanical failure, and infection of up to 30%.

Evidence from Turkish and Syrian People for the Measurement Invariance of the CBBE Scale and Clues for the Distribution Strategies of the Brands

Ahmet KAYAOĞLU, Yavuz Selim GÜLMEZ 한국유통과학회 2023 유통과학연구 Vol.21 No.5

Purpose: This research aims to test the measurement invariance of the consumer-based brand equity scale on Turkish and Syrian university students who live together but are from different cultural groups. Research design, data, and methodology: The consumerbased brand equity scale developed by Buil et al. (2008) is applied to the participants. In testing the consumer-based brand equity scale, the Netflix brand, which is considered well-known by both cultural groups, is preferred. It is thought that choosing an internationally recognized brand would facilitate the conduct of this research. Structural invariance and measurement invariance are tested using structural equation modeling. Results: The consumer-based brand equity scale has measurement invariance on Turkish and Syrian university students. Therefore, it has been revealed that the responses of participants from both cultures regarding the Netflix brand are comparable. Conclusion: The findings of the study provide clues for practitioners to review their distribution strategies. As a matter of fact, cultural studies conducted in different countries are common. Still, the originality of this study is ensured by the profile of participants who live in the same country but come from different countries.

The Effects of Etodolac, Nimesulid and Naproxen Sodium on the Frequency of Sister Chromatid Exchange after Enclused Third Molars Surgery

Banu Gürkan Köseoğlu,Hülya Koçak,Şükrü Öztürk,Şükrü Palanduz,Kıvanç Çefle 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.5

Purpose: Non-steroidal anti-inflammatory drugs (NSAID) are frequently used in oral surgical procedures in dentistry. The evaluation of the frequency of sister chromatid exchange (SCE) is accepted as a reliable cytogenetic method to assess the genotoxic effects of environmental factors. Materials and Methods: In this study, the genotoxic effects of various NSAIDs were assessed in 30 patients to who they were administered following encluosed third molar surgery using SCE analysis before and after the operation. The frequency of SCE was evaluated before the operation and after 3 days of etodolac, nimesulid and naproxen use. Results: There was no statistically significant difference in the frequency of SCE between the preoperative and postoperative states in patients given etodolac, nimesulid or naproxen sodium. Conclusion: Short term use of selective and non-selective NSAIDs was not associated with a significant genotoxic effect that could be detected using the SCE method in peripheric lymphocytes.