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Lee, Eujin,Kim, Sun-Gun,Park, Na-Young,Park, Hyo-Hyun,Jeong, Kyu-Tae,Choi, Jongkeun,Lee, In-Hae,Lee, Hwadong,Lee, Eunkyung Medknow PublicationsMedia Pvt Ltd 2017 Pharmacognosy magazine Vol.13 No.50
<P><B>Background:</B></P><P>A Korean herbal medicine, KOTMIN13, composed of <I>Inula japonica</I> Thunberg, <I>Trichosanthes kirilowii Maximowicz</I> var. <I>japonica kitamura</I>, <I>Peucedanum praeruptorum</I> Dunn, and <I>Allium macrostemon</I> Bge, has been used for anti-allergic and anti-asthmatic treatment in oriental clinics, but its activity has not been investigated.</P><P><B>Materials and Methods:</B></P><P>To evaluate the anti-inflammatory activity of KOTMIN13 for <I>in vitro</I> study, LPS-stimulated RAW 264.7 cells were used to induce the production and expression of inflammatory mediators and its mechanisms. 12-<I>O</I>-Tetradecanoylphorobol-13 aceate (TPA)-induced ear edema and carrageenan-induced paw edema models were also used to evaluate the effect of KOTMIN13 on acute inflammation <I>in vivo</I>.</P><P><B>Results:</B></P><P>KOTMIN13 reduced the release of inflammatory mediators [nitric oxide, prostaglandin E2, interleukin (IL)-1β, and IL-6] and the protein expression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-stimulated RAW 264.7 cells. Mechanism studies showed the attenuation of LPS-induced NF-κB activation by KOTMIN13 via IκBα degradation abrogation and a subsequent decrease in nuclear p65 levels. Activation of mitogen-activated protein kinases (ERK, JNK, and p38) was also suppressed. Furthermore, KOTMIN13 ameliorated the development of TPA-induced ear edema and carrageenan-induced paw edema in acute inflammatory edema mouse models.</P><P><B>Conclusion:</B></P><P>Our study demonstrates that KOTMIN13 inhibits inflammatory mediators through the inhibitions of NF-κB and MAPK activities in LPS-induced RAW 264.7 cells, as well as acute inflammation in edema models, indicating that KOTMIN13 is an effective suppressor for anti-inflammatory activities.</P><P><B>SUMMARY</B></P><P><P>KOTMIN13 decrease the production of No, PGE<SUB>2</SUB>, and proinflammatory cytokine (TNF-∝, IL-1β,IL-6).</P><P>KOTMIN13 Suppressed the degradation of NF-kβ and IKβα and the phosorylation of MAP Kinases.</P><P>Topical application of KOTMIN13 reduced mouse ear edema.</P><P>Oral administration of KOTMIN13 decreased carrageenan-induced paw edema.</P></P> >[FIG OMISSION]</BR><P><B>Abbreviations used:</B> NO: nitric oxide; PGE2: prostaglandin E2; iNOS: inducible NO synthase; COX-2: cyclooxygenase-2; TNF-α: tumor necrosis factor-α; IL: interleukin; NF-κB: nuclear factor kappaB; MAPK: mitogen-activated protein kinases; ERK: extracellular signal regulated kinase; JNK: c-jun N terminal kinase; TPA: 12-O-tetradecanoylphorbol-13-acetate</P>
이은경 ( Eunkyung Lee ),서민지 ( Minji Seo ),이경상 ( Kyeong-sang Lee ),최성원 ( Sungwon Choi ),이다래 ( Darae Lee ),진동현 ( Donghyun Jin ),권채영 ( Chaeyoung Kwon ),김홍희 ( Honghee Kim ),허모랑 ( Morang Huh ),한경수 ( Kyung-soo 대한원격탐사학회 2017 大韓遠隔探査學會誌 Vol.33 No.3
본 연구에서는 산출 방법에 따른 해빙 자료 간의 차이를 조사하기 위하여 1980-2010년 북극 지역의 EUMETSAT OSI SAF, NASA Team(NT)의 해빙 농도와 해빙 면적의 차이를 비교하였다. 그 결과 두 자료의 해빙 농도와 해빙 면적이 계절별, 해역별로 다른 일관성을 보였다. 계절별로는 OSI SAF의 해빙 농도가 전체적으로 0.85 %, 봄 0.48 %, 여름 0.97 %, 가을 1.38 %, 겨울 0.66 % 높게 나타났다. 해역별로는 북극해에서 OSI SAF의 해빙 농도가 2.7 %, 해빙 면적이 19.8만 ㎢ 높았으나 링컨해 일부에서는 해빙 농도가 2.3 %, 해빙 면적이 2만 ㎢ 낮게 나타났다. We compared sea ice concentration(SIC) and sea ice extent(SIE) using EUMETSAT Ocean and Sea Ice Satellite Application Facilities(OSI SAF) and NASA Team(NT) sea ice algorithm in the Arctic during 1980-2010 to investigate the difference between sea ice data applied different algorithms. SIC and SIE of the two data showed different consistency by season and by sea area. Seasonally, SIC of OSI SAF was 0.85 % overall, 0.48 % in spring, 0.97 % in summer, 1.38 % in autumn and 0.66 % in winter higher than NT SIC. By sea area, OSI SAF SIC was 2.7 %, SIE was 198,000 ㎢ higher than NT in Arctic Ocean, but in Lincoln Sea, OSI SAF SIC was 2.3 %, SIE was 20,000 ㎢ lower than NT.
Lee, Eunkyung,Choi, So-Young,Yang, Jae-Ho,Lee, Youn Ju The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.4
Early life neuronal exposure to environmental toxicants has been suggested to be an important etiology of neurodegenerative disease development. Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds, is widely distributed environmental contaminants. We have reported that PFHxS induces neuronal apoptosis via ERK-mediated pathway. Imperatorin is a furanocoumarin found in various edible plants and has a wide range of pharmacological effects including neuroprotection. In this study, the effects of imperatorin on PFHxS-induced neuronal apoptosis and the underlying mechanisms are examined using cerebellar granule cells (CGC). CGC were isolated from seven-day old rats and were grown in culture for seven days. Caspase-3 activity and TUNEL staining were used to determine neuronal apoptosis. PFHxS-induced apoptosis of CGC was significantly reduced by imperatorin and PD98059, an ERK pathway inhibitor. PFHxS induced a persistent increase in intracellular calcium, which was significantly blocked by imperatorin, NMDA receptor antagonist, MK801 and the L-type voltage-dependent calcium channel blockers, diltiazem and nifedipine. The activation of caspase-3 by PFHxS was also inhibited by MK801, diltiazem and nifedipine. PFHxS-increased ERK activation was inhibited by imperatorin, MK801, diltiazem and nifedipine. Taken together, imperatorin protects CGC against PFHxS-induced apoptosis via inhibition of NMDA receptor/intracellular calcium-mediated ERK pathway.
Lee, Min Kyung,Clay, Nicholas E.,Ko, Eunkyung,Smith, Cartney E.,Chen, Lin,Cho, Nicholas,Sung, Hak-Joon,DiPietro, Luisa,Lee, Jonghwi,Kong, Hyunjoon American Chemical Society 2018 Langmuir Vol.34 No.50
<P>Superparamagnetic iron oxide nanoparticles (SPIONs) are often encapsulated into drug-carrying nano/microsized particles for simultaneous magnetic resonance (MR) imaging and treatment of diseased tissues. Unfortunately, encapsulated SPIONs may have a limited ability to modulate the <I>T</I><SUB>2</SUB>-weighted relaxation of water protons, but this insight has not been examined systematically. This study demonstrates that SPIONs immobilized on 200 nm diameter poly(lactic-<I>co</I>-glycolic acid) (PLGA) nanoparticles using Pickering emulsification present 18-fold higher relaxivity than encapsulated SPIONs and 1.5-fold higher relaxivity than free SPIONs. In contrast, the SPIONs immobilized on 10 μm diameter PLGA particles exhibit a minor increase in MR relaxivity. This interesting finding will significantly impact current efforts to synthesize and assemble advanced MR contrast agents.</P> [FIG OMISSION]</BR>
( Eunkyung Lee ),( Jungtaek Shin ) 한국스포츠정책과학원(구 한국스포츠개발원) 2016 International Journal of Applied Sports Sciences Vol.28 No.2
The purpose of this study was to examine the effects of performance routine on competitive state anxiety, psychological skills and perceived performance of Taekwondo form players. The participants were composed of three women Taekwondo form players in university. The instruments of this study were composed of TOPS (Test of Performance Strategy Inventory), Revised Competitive State Anxiety-2 (Revised CSAI-2), Competition reflection Questionnaires, and perceived performance inventory. The performance routine program for Taekwondo form players was the broad routine (behavioral routine, cognitive routine), mistake coping routine, unexppected condition coping routine. 8 session performance routine program was applied to participants about 50-minute session (1 times session a week) every week. The results were as follows. Firstly, performance routine program decreased cognitive anxiety and somatic anxiety intensity but increased self-confidence intensity of Taekwondo form players. Also, performance routine program positively changed direction of cognitive anxiety, somatic anxiety and self-confidence of Taekwondo form players. Secondly, performance routine program increased self-talk, relaxation, emotion control level of Taekwondo form players. Thirdly, performance routine program enhanced perceived performance of Taekwondo form players. Lastly, qualitative data such as interview examined that performance routine program positively impacted positive thinking, competitive state anxiety, psychological skills and perceived performance of Taekwondo form players.
Lee, Hyunju,Park, Chansu,Lee, Eunkyung,Lee, Ju Dong,Kim, Yangdo American Chemical Society 2017 Journal of chemical and engineering data Vol.62 No.12
<P>HFC-134a gas was investigated as a potential guest molecule to improve the thermodynamic conditions and formation rate for CO<SUB>2</SUB> hydrate. In the phase equilibrium study, the equilibrium pressure of CO<SUB>2</SUB> + HFC-134a was lower than that of pure CO<SUB>2</SUB> gas, and the equilibrium pressure decreased gradually with increasing HFC-134a concentration. The dissociation enthalpy (Δ<I>H</I><SUB>d</SUB>) was calculated using the Clausius–Clapeyron equation, and the Δ<I>H</I><SUB>d</SUB> value also changed with increasing HFC-134a concentration. In particular, the Δ<I>H</I><SUB>d</SUB> of 8 mol % HFC-134a-added CO<SUB>2</SUB> hydrate was 143.2 kJ/mol, which was similar to that of pure HFC-134a (structure-II). In the kinetic study, the reactor was initially filled with CO<SUB>2</SUB> + HFC-134a gas only and pure CO<SUB>2</SUB> gas was then supplied as a source when the hydrate reaction proceeded. As a result, the formation rate of the HFC-134a mixture in the initial 2 min was faster than that of pure CO<SUB>2</SUB>. This was consistent with the gas chromatography results, which showed that HFC-134a occupies the cage at the beginning of hydrate formation. These results suggest that the addition of HFC-134a influences the CO<SUB>2</SUB> hydrate thermodynamic equilibrium and kinetic characteristics.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jceaax/2017/jceaax.2017.62.issue-12/acs.jced.7b00756/production/images/medium/je-2017-007568_0007.gif'></P>