Two new species of Camellia (Theaceae) from Vietnam

Lieu Thi Nguyen,Ninh Tran,Uematsu CHIYOMI,Katayama HIRONORI,Dung Van Luong,Son Thanh Hoang,Ky Danh NGUYEN,Hung Viet NGUYEN,Toan Canh THAI 한국식물분류학회 2018 식물 분류학회지 Vol.48 No.2

Two new species of Camellia (Theaceae) are described from Vietnam: Camellia vuquangensis Luong, Tran & L. T. Nguyen and Camellia hatinhensis Luong, Tran & L. T. Nguyen. The new taxa were col- lected from Vu Quang National Park in the center of Vietnam. The new finds are morphologically dissimilar to all known Camellia species. Recent Camellia discoveries have increased the number of species recorded in Viet- nam from 50 to 75, making Vietnam a center of diversity and a crucial area for more research into the diversity and distributions of Camellia.

Four novel mutations in the androgen receptor gene from Vietnamese patients with androgen insensitivity syndrome

Nguyen Thu Hien,Nguyen Duc Quan,Kim Lien Nguyen Thi,Thi Thanh Ngan Nguyen,Nguyen Thi Phuong Mai,Tran Ngoc Dung,Nguyen Huy Hoang 한국유전학회 2023 Genes & Genomics Vol.45 No.4

Background Androgens and androgen receptor (AR) are critical regulators of the masculinization process in male sexual development. The absence of a functioning AR results in the development of the androgen insensitivity syndrome (AIS), a rare disorder of sexual development (DSD) characterized by the external genitalia feminization, gynecomastia, and impaired spermatogenesis. Objective To determine the AR gene mutations associated with male DSD in four unrelated Vietnamese patients. Methods To detect the disease-causing mutations, whole exome sequencing (WES) was performed on four patients diagnosed with AIS. Sanger sequencing was then used for validation of the identified mutations. Finally, 12 web-based tools, three-dimensional protein modeling software, and the guidelines issued by the American College of Medical Genetics and Genomics were used to assess the potential pathogenicity of these mutations. Results Four distinct novel mutations, namely c.1834T > A (p.Cys612Ser), c.2122 C > G (p.Leu708Val), c.2630T > G (p.Phe877Cys), and c.2641 C > A (p.Leu881Met) in the AR gene, were identified in four AIS patients using WES. The in silico analysis results revealed that the Cys612, Leu708, Phe877, and Leu881 sites are important for an appropriate response to androgens of the AR, and mutation at these sites can have adverse effects on the AR functions, androgen–AR interaction, and AR signaling pathway. Conclusions WES and in silico analyses strongly suggested that four novel AR mutations are pathogenic and have led to the development of AIS in the four Vietnamese patients under consideration.

Carbon-Nanotube Growth over Iron Nanoparticles Formed on CaCO3 Support by Using Hydrogen Reduction

Nguyen Duc Dung,Nguyen Van Chuc,Ngo Thi Thanh Tam,Nguyen Hong Quang,Phan Hong Khoi,Phan Ngoc Minh 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5

Carbon nanotubes (CNTs) were grown by chemical vapor deposition on a mixture of iron salt and CaCO3. Salt mixtures of Fe(NO₃)₃9H₂O/CaCO₃ and FeCl₃6H₂O/CaCO₃ with various Fe weight contents were used as catalysts for growing the CNTs. A scanning electron microscope study revealed that the CNTs were densely grown on the Fe(NO₃)₃9H₂O/CaCO₃ catalyst containing 5 wt.% Fe. The effect of growth temperature on the segregation of Fe nanoparticles formed by hydrogen reduction is discussed. The result shows that 800 ℃ is the optimal temperature for the formation of Fe nanoparticles over which CNTs grow with the highest yield of 78.61 %. A raman spectroscope and a scanning transmission electron microscope were utilized to characterize the multiwall structure of the CNTs. The 92.16 % purity of the CNTs was determined by using thermal gravimetric analysis. Carbon nanotubes (CNTs) were grown by chemical vapor deposition on a mixture of iron salt and CaCO3. Salt mixtures of Fe(NO₃)₃9H₂O/CaCO₃ and FeCl₃6H₂O/CaCO₃ with various Fe weight contents were used as catalysts for growing the CNTs. A scanning electron microscope study revealed that the CNTs were densely grown on the Fe(NO₃)₃9H₂O/CaCO₃ catalyst containing 5 wt.% Fe. The effect of growth temperature on the segregation of Fe nanoparticles formed by hydrogen reduction is discussed. The result shows that 800 ℃ is the optimal temperature for the formation of Fe nanoparticles over which CNTs grow with the highest yield of 78.61 %. A raman spectroscope and a scanning transmission electron microscope were utilized to characterize the multiwall structure of the CNTs. The 92.16 % purity of the CNTs was determined by using thermal gravimetric analysis.

Photocatalytic removal of Rhodamine B in water using g-C3N4/MIL-53(Fe) material under LED visible light with persulfate activation

Nguyen Trung Dung,Nguyen Van Hiep,Manh B. Nguyen,Vu Dinh Thao,Nguyen Nhat Huy 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.10

Photocatalysis is usually considered as one of the most effective methods for treating non-biodegradable pollutants commonly found in textile wastewater. In this study, the photocatalyst of g-C3N4/MIL-53(Fe) was synthesized by the hydrothermal method and applied for the removal of Rhodamine B (RhB) in water. The photocatalytic material was characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Brunauer-Emmett-Teller analysis, UV-Vis diffuse reflectance spectroscopy, and X-ray photoelectron spectroscopy. The results showed that the g-C3N4 doped MIL-53(Fe) with 97 wt% of MIL- 53(Fe) works effectively under visible light and the presence of oxidants (Na2S2O8). RhB removal efficiency can be more than 99% with 20mg/L of RhB, 300mg/L of catalyst, 200mg/L of Na2S2O8, and pH 3. In addition, the photocatalytic degradation mechanism of RhB with g-C3N4/MIL-53(Fe) was also proposed, which could be improved and studied for a wide range of applications in textile wastewater treatment.

Spectrum of Lysosomal Storage Disease Targeted for Newborn Screening in Vietnam

Dung, Vu Chi,Ngoc, Can Thi Bich,Khanh, Nguyen Ngoc,Mai, Do Thi Thanh,Thao, Bui Phuong,Mai, Tran Thi Chi,Ha, Nguyen Thu,Huong, Nguyen Thi Mai,Nam, Nguyen Hoang,Hai, Le Thanh,Tomatsu, Shunji,Yoo, Han-Wo Association for Research of MPS and Rare Diseases 2017 Journal of mucopolysaccharidosis and rare disease Vol.3 No.1

Advanced Magnetic Materials Produced by Using Rapid Quenching Technology

Nguyen Hoang Nghi,Nguyen Van Dung,Trinh Thi Thanh Nga,Bui Thi Khanh Nhung,Mai Thanh Tung,Nguyen Huu Tinh,Hoang Nhat Hieu,Bui Xuan Chien,Nguyen Thi Hong Tam 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.6

Amorphous alloys produced by using a rapid quenching technique are considered to be a precursor for producing nanosized and multiphase structures by precipitation (the top-down method). By using this technique, several new magnetic materials with different magnetic properties based on different physical mechanisms have been manufactured and investigated. Three new magnetic materials, a nanocrystalline soft magnetic material, a soft-hard permanent magnet and a Me-3d granular alloy with a GMR effect, what were prepared under local conditions, are presented and discussed in the experimental point of view. Amorphous alloys produced by using a rapid quenching technique are considered to be a precursor for producing nanosized and multiphase structures by precipitation (the top-down method). By using this technique, several new magnetic materials with different magnetic properties based on different physical mechanisms have been manufactured and investigated. Three new magnetic materials, a nanocrystalline soft magnetic material, a soft-hard permanent magnet and a Me-3d granular alloy with a GMR effect, what were prepared under local conditions, are presented and discussed in the experimental point of view.

애기장대 화분 표현형 분석 및 화분 발달에 관련된 변이체 유전자의 탐색

박효진,Nguyen Thi Hoai Thuong,Tien Dung Nguyen,오성앵,박순기 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

비동형분열을 포함한 식물화분 발달과정에 관여하는 유전자를 탐색하기 위하여, Activation tagging vector를 이용 하여 조성된 3,500여개의 애기장대 T1세대 약 3,500개의 형질전환체 집단으로부터 4종의 화분 변이형을 보이는 돌 연변이체를 선발하였다. 4종의 변이체들은 20-40% 빈도의 성숙화분 변이표현형을 보였다. 변이체에서는 정상적 인 화분으로 발달하지 않은 aborted pollen type, 한 개의 핵만이 관찰되는 tio type, 비정상적으로 분열된 gemini type 등 다양한 변이표현형들이 관찰되었다. TAIL-PCR을 통하여 T-DNA의 삽입부위의 염색체 부위를 동정하여, co-segregation분석을 수행한 결과, 4종 모두 T-DNA삽입과 무관한 자연발생적 돌연변이로 밝혀졌으며, 현재 map-based cloning방법에 의해 변이유발 유전자를 탐색중이다. 이들 유전자들은 향후 식물의 화분발달에 핵심적 인 역할을 하는 유전자를 발굴하고 이를 이용한 기작을 이해하는데 매우 유용한 정보를 제공할 것으로 판단된다.

Factors Affecting Night-Time Economic Development: Research in Hanoi, Vietnam

Ngoc Son NGUYEN(Ngoc Son NGUYEN ),Vu Hiep HOANG(Vu Hiep HOANG ),Quoc Dung NGO(Quoc Dung NGO ),Van Hoa HOANG(Van Hoa HOANG ) 한국유통과학회 2023 Asian Journal of Business Environment (AJBE) Vol.13 No.2

Purpose: The purpose of the study is to explore the factors which influence the night-time economic development in Hanoi, Vietnam. The results can help policymakers achieve a scientific basis to plan the development of night-time economy in Hanoi. Research design, data and methodology: The research model is developed from literature review with 7 independent variables, including natural conditions and resources, infrastructure, safety, environmental issues, promotion and international integration, development of sharing economy, and institution and policy. This model is then adjusted by exploratory factors analysis to have 4 new variables: Institution and environment, Infrastructure and safety, Promotion and sharing, and Nature and resources. The model is regressed based on the data of 463 observations of night-time economy in Hanoi, Vietnam. Results: Consistent with the current literature addressing night-time economy, the results show positive impacts of all of the independent variables studied. Conclusions: It is recommended for the local authorities to strengthen advertising and promoting investment for NTE development in Hanoi city and also enhance the role of state management in NTE activities by raising awareness of the state management apparatus towards a more open-minded multi-dimensional view of the NTE, developing the NTE to overcome the barrier of thinking “if it cannot be managed, it is forbidden” in state management agencies, and defining responsibilities and authority among state management agencies in the management of NTE activities and strengthening decentralization and decentralization of powers for localities in the management and development of NTE.

Identification of three novel mutations in PCNT in vietnamese patients with microcephalic osteodysplastic primordial dwarfism type II

Thu Hien Nguyen,Ngoc‑Lan Nguyen,Chi Dung Vu,Can Thi Bich Ngoc,Ngoc Khanh Nguyen,Huy Hoang Nguyen 한국유전학회 2021 Genes & Genomics Vol.43 No.2

Background Primordial dwarfsm (PD) is a group of genetically heterogeneous disorders related to developmental disabilities occurring in the uterus and prolongs during all stages of life, resulting in short stature, facial deformities and abnormal brain. Objective To determine the exact cause of the disease in two Vietnamese patients priory diagnosed with PD by severe preand postnatal growth retardation with marked microcephaly and some bone abnormalities. Methods Whole-exome sequencing was performed for the two patients and mutations in genes related to PD were screened. Sanger sequencing was applied to examine the mutations in the patients of their families. Results Three novel mutations in the PCNT gene which have not been reported previously were identifed in the two patients. Of which, two frameshift mutations (p.Thr479Profs*6 and p.Glu2742Alafs*8) were detected in patient I and one stop-gained mutation (p.Gln1907*) was detected in the patient II. These mutations may result in a truncated PCNT protein, leading to an inactivated PACT domain corresponding to residue His3138–Trp3216 of PCNT protein. Therefore, the three mutations may cause a defciency of protein functional activity and result in the phenotypes of primordial dwarfsm in the two patients. Conclusions Clinical presentations in combination with genetic analyses supported an accurate diagnosis of the two patients with microcephalic osteodysplastic primordial dwarfsm type II (MOPD II). In addition, these results have important implications for prenatal genetic screening and genetic counseling for the families.

Effects of Trang Phuc Linh Plus-Food Supplement on Irritable Bowel Syndrome Induced by Mustard Oil

Thong T. Nguyen,Duong T. Dau,Dung C. Nguyen,Huong T.T.G. Nguyen,Phuong T.B. Ngo,Thai Q. Nguyen,Bo Han,Ba X. Hoang 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.4

Trang phuc linh plus (TPLP) is a food supplement product derived from dried extracts of herbal agents Atractylodes macrocephala, Poria cocos, Paeonia lactiflora, Phellodendron amurense, and added lactobacillus fermentum lysate (ImmuneGamma®) and 5-hydroxytryptophan. TPLP is a functional food used as adjunctive treatment for treating irritable bowel syndrome (IBS). However the biological effect and its mechanism of action in IBS have not been elucidated. In this study, we aimed to determine the pharmacological activities and mode of action of TPLP on IBS animal models. Mice were given a single administration of 5% mustard oil (MO) intracollonically. Acute colitis induction by MO resulted in later development of an IBS-like accelerated upper gastrointestinal transit in mice. Mice were treated with different does of TPLP and controls. Results showed that TPLP at the dose of 654 mg/kg/day given orally significantly decreased intestinal motility (IM) compared with the control animals. The effect was similar to Duspatalin (80 mg/kg/day) (Mebeverine Hydrochloride, an antispasmodic that helps to relieve the pain and discomfort associated with gastrointestinal spasms). Increased TPLP dose (1962 mg/kg/day) had a better effect on relief of IM than Duspatalin (80 mg/kg/day). TPLP also reduced peristalsis frequency and decreased fluid volume and electrolytes excretion in intestine tested in ex vivo models. Overall, TPLP may be an effective nutraceutical supplement for IBS.