The Effect of Social Capital on Social Entrepreneurial Intention among Vietnamese Students

HA, Ngoc Thang,DOAN, Xuan Hau,VU, Trong Nghia,NGUYEN, Thi Phuong Linh,PHAN, Thanh Hoa,DUONG, Cong Doanh Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.8

This study develops the model to estimate the links between social capital, social entrepreneurial self-efficacy, perceived desirability and social entrepreneurial intention. Besides exploring the direct impacts of social capital, social entrepreneurial self-efficacy, and perceived desirability on social entrepreneurial intention, this study also focus on discovering the mediating roles of perceived desirability and social entrepreneurial self-efficacy on this relationship. Throughout adopting measures from some previous studies, the authors design the questionnaires and distribute to students in Vietnam. The study presents some demographic information of 289 students, who are studying at university and colleges in Vietnam. Then, the validity and reliability of scales are assessed using the value of Cronbach's alpha, Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA). In addition, by utilizing the structural modeling structure (SEM), the authors show that social capital plays the important role in shaping social entrepreneurial self-efficacy, perceived desirability, and social entrepreneurial intention. Interestingly, besides the direct effects on social entrepreneurial intention, perceived desirability and social entrepreneurial self-efficacy also mediate the correlation between social capital and social entrepreneurial intention. Also, with the interesting findings of the study, the authors propose several recommendations for policy-makers, educators and academics to promote the social entrepreneurship and innovation among Vietnamese students.

Fabrication and Evaluation of Human Dentin as Scaffold for Dental Pulp Stem Cells

Ha Le Bao Tran,My Thi Ngoc Nguyen,Vu Nguyen Doan 한국조직공학과 재생의학회 2015 조직공학과 재생의학 Vol.12 No.4

Scaffold is an important component of tissue engineering. Dentin is a potential material satisfying not only the physical and chemical characteristics of a standard scaffold, but also the inductive factors demand for dentin regeneration. Therefore, it is a promising material for tissue engineering. In this study, we aimed to create and characterize dentin scaffolds in order to serve as bioactive scaffolds for human dental pulp stem cells (hDPSCs) toward dentin-like tissue regeneration. Human dentin scaffolds were obtained from extracted teeth and irrigated in 17% ethylenediaminetetraacetic acid (EDTA) and 19% citric acid as chelate agents to remove smear layer. The treated scaffolds were examined morphology, the presence and secretion of dentin matrix protein, and in vitro cytotoxicity. The results demonstrated that 17% EDTA and 19% acid citric effectively removed smear layer. The presence of dentin matrix proteins, including transforming growth factor beta-1 and dentin matrix protein-1 were found to be secreted from human treated dentin scaffolds (hTDSs) during 5 days of investigation. hTDSs showed low level of cytotoxicity, which elicited a safe manner. Moreover, hTDSs provided a suitable surface for the attachment of hDPSCs, as well as supported their proliferation. When culturing hDPSCs onto the scaffolds, the formation of dentin-like tissue indicated their potential in directing differentiation of hDPSCs into dentin regeneration process, possibly, via bioactivity of the secreted dentin matrix proteins. Taken together, these data demonstrated that our proposed protocol was effective in generating hTDSs, and maintaining their compromising properties for application in regeneration of human dentin.

Influence of ionic liquids as additives on sol-gel immobilized lipase

Thanh Thi Ngoc Doan,Sang Hyun Lee,Sung Ho Ha,Woo-Jin Chang,Nguyen Minh Hiep,Yoon-Mo Koo 한국생물공학회 2007 한국생물공학회 학술대회 Vol.2007 No.4

Using Ionic Liquids and Carbon Nanotubes to Stabilize Lipase within Sol–Gel Derived Silica

Thanh Thi Ngoc Doan,Sang Hyun Lee,Sung Ho Ha,Woo-Jin Chang,Yoon-Mo Koo 한국생물공학회 2007 한국생물공학회 학술대회 Vol.2007 No.10

Safety of Balloon Kyphoplasty in the Treatment of Thoracic Osteoporotic Vertebral Compression Fractures in Vietnamese Patients

Nguyen Dinh HOA,Vu Duc-Dat,Doan Thi-Ngoc-Ha,Vo Hoang-Long 대한정형외과학회 2020 Clinics in Orthopedic Surgery Vol.12 No.2

Background: The evidence for the efficacy and safety of balloon kyphoplasty (BKP) in treating the Vietnamese patients is sparse. There is no convincing evidence regarding BKP’s efficacy in Vietnamese patients, especially in the patients with thoracic osteoporotic vertebral compression fractures (VCFs). This article aims to evaluate the outcomes of restoring the body height of the compressed thoracic vertebrae in patients undergoing BKP. Methods: We prospectively enrolled 65 consecutive patients with thoracic VCFs (73 vertebrae) due to osteoporosis who were treated with BKP between June 2018 and May 2019. Results: A trocar was inserted through the pedicle in 84.9% (62/73) and beside the pedicle in 15.1% (11/73). The mean amount of mixed cement injected was 4.1 ± 1.1 mL (range, 1.5–7 mL). Cement leakage was radiographically confirmed in 30.8% of 65 patients. Among patients with complications caused by cement extravasation, the leakage was through the anterior margin of the vertebrae in 15.4%, through the vertebral disc in 12.3%, and through the posterior margin of the vertebrae in 3.1%. In the last 3.1% of patients, there was no clinically notable lesions of the nerve roots or spinal cord. The mean visual analog scale score decreased significantly from 7.3 ± 1.1 preoperatively to 3.3 ± 0.6 at 24 hours after surgery, and then to 1.2 ± 1.1 at 3 months after surgery (p < 0.01). The mean reduction in Cobb angle measured on standing radiographs after treatment was 3.7°, showing statistical significance (p < 0.01). Conclusions: BKP is a minimally invasive treatment effective for immediate pain relief, early motor rehabilitation, and humpback correction. The present study provided convincing evidence to support the use of BKP by spine surgeons and clinical specialists in treating osteoporotic thoracic VCFs in Vietnamese patients.

HER2 Status and Its Heterogeneity in Gastric Carcinoma of Vietnamese Patient

Dang Anh Thu Phan,Vu Thien Nguyen,Thi Ngoc Ha Hua,Quoc Dat Ngo,Thi Phuong Thao Doan,Sao Trung Nguyen,Anh Tu Thai,Van Thanh Nguyen 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.4

Background: Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types of carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity have become potential candidates for targeted therapy with trastuzumab. Methods: We investigated 208 gastric cancer specimens using immunohistochemistry (IHC), fluorescence in situ hybridization and dual in situ hybridization (ISH). We also investigated the concordance between IHC and ISH. The correlation between HER2 status and various clinicopathological findings was also investigated. Results: In total, 15.9% (33/208) and 24.5% (51/208) of gastric cancers showed HER2 gene amplification and protein overexpression, respectively. A high level of concordance between ISH and IHC analyses (91.3%, κ = 0.76) was found. A significant correlation between HER2 status and intestinal-type (p < .05) and differentiated carcinomas (p < .05) was also noted. The HER2 heterogeneity was high in gastric cancers; we found 68.8% phenotypic heterogeneity and 57.6% genotypic heterogeneity. Heterogeneity in HER2 protein expression and gene amplification showed a close association with diffuse histologic type and IHC 2+. Conclusions: HER2 protein overexpression and gene amplification were detected in 24.5% and 15.9% of gastric cancer specimens, respectively. Intestinal-type showed a higher level of HER2 protein overexpression and gene amplification than diffuse type. HER2 status also showed a significant relationship with well- and moderately-differentiated carcinomas. The ratio of phenotypic and genotypic heterogeneity of HER2 was high in gastric carcinomas and was associated with HER2 IHC 2+ and diffuse histologic type.