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The sex and age dependant differences in ECG values in C57BL6/N mice
Danbi Ka,Jieun Kim,Eun-Kyoung Kim,Hae-Rim Kim,Sang-Mi Cho,Seulgi Park,Faiz Ur Rahman,Mini Lee,Ki-Hoon Lee,Hoyoung Ghang,Won-Kee Yoon,Young-Suk Won,Hyoung-Chin Kim,Kyoung-Chul Choi,Ki-Hoan Nam 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Eelectrocardiogram (ECG) is a surface recording of the electric current passing through the heart, revealing the electrical activity associated with each heartbeat, and allowing visualization of the electrical state of the heart. In a state of consciousness, normal rat heart rates range from 500 to 700 beats per minute (bpm). ECG reflects the cycle of the heart and consists of P, Q, R, S and T waves. The non-invasive ECG system has the advantage of acquiring information not only on heart rate, but also on heart rate variability, RR, QT and PR intervals, as well as acquiring cardiac abnormalities in conscious animals. In this study, we conducted experiments ECG analysis with 12 weeks and 56 weeks aged male and female C57BL/6N mice. We compared the ECG values between male and female mice and between 12 weeks and 56 weeks aged mice, comparing age and gender differences. There were sex differences in HR and RR in 12 weeks aged mice and in HR and QRS in 56 weeks aged mice. We also found age dependant differences in QRS, ST, HR and RR in male mice and in PR, ST and QTc in female mice. These result indicate that there is age and sex differences in ECG values.
Rxfp2, an Insl3 receptor might be associated with the failure of spermatogenesis in Phf7 ko mice
Jieun Kim,Eun-Kyoung Kim,Hae-Rim Kim,Sang-Mi Cho,Danbi Ka,Hoyoung Ghang,Seulgi Park,Mini Lee,Faiz Ur Rahman,Ki-Hoon Lee,Won-Kee Yoon,Young-Suk Won,Hyoung-Chin Kim,Kyoung-Chul Choi,Ki-Hoan Nam 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
PHD finger protein 7 (Phf7) is a member of the PHF family, which contain the PHD domain known as a histone methylation reader and RING domain known as a E3 ubiquitin ligase. Phf7 is expressed testis, specifically in germ cells and Leydig cells but not in Sertoli cells. The deficiency of Phf7 induces male infertility. And it was found that Phf7 acts as a histone H2A E3 ligase in histone-to-protamine exchange during spermatogenesis. Until now, most studies on Phf7 have been focused on spermatogenesis. Here, we tried to found any phenotypes other than male infertility in the Phf7 Ko mice. We found that there are growth-retardation and reduction of bone mineral density in Phf7 knockout (ko) mice. We also tried to found any mechanism that may associated with abnormal spermatogenesis in the Phf7 ko mice. It is known that Rxfp2 is expressed in the postmeiotic germ cells in testis and that Rxfp2 with Insl3, a hormone released from Leydig cells constitute a paracrine hormone-receptor system in testis. Therefore, we determined the expression level of Insl3 and Rxfp2 in testis of Phf7 ko mice. We found that the Insl3 mRNA level was higher in the ko mice, but the Rxfp2 mRNA expression level was reduced in the mutant mice then wild mice. In conclusion, we suggest that the failure of spermatogenesis observed in Phf7 ko mice might related with the reduced expression of Rxfp2 in the developing germ cells.
Leesun Kim,Hyun Ho Noh,Chang Jo Kim,RaeKeun Lee,Xiu Yuan,Min Kim,Hee Jeong Shin,Danbi Kim,Hee-Dong Lee,Kee Sung Kyung 한국농약과학회 2021 한국농약과학회 학술발표대회 논문집 Vol.2021 No.11
Traditionally in Korea, Protaetia brevitarsis seulensis (white spotted flower rainbow snail) has been used as a traditional medicine, and recently has attracted increased attention due to its antithrombotic efficacy. Spent mushroom compost is a feedstock for P. brevitarsis that may contain three fungicides, carbendazim, dimethomorph, and fenoxanil, which could be transferred to the edible insect. In this study, the analytical method for three fungicides in the edible insect was optimized using a simple extraction method combined with liquid chromatography tandem mass spectrometry. After the pulverized samples (5g) were extracted with acetonitrile (10mL) and formic acid (100 μL), fat and lipids in the samples were slowly precipitated at -20oC for 24 hours. After eight different clean-up methods were investigated, a dispersive solid-phase extraction tube containing 150 mg MgSO₄/25mg PSA/25mg C18 was selected based on optimal recovery of the target compounds. Recovery of carbendazim, dimethomorph, and fenoxanil was 77.9%-80.8% ± relative standard deviation (RSD) 0.8%-4.0%, 111.2%-116.7% ± RSD 2.8%-3.0%, and 111.9%-112.5% ± RSD 2.5%-5.2%, respectively. The simplified analytical method developed in this study can provide important data for establishing that the food meets pesticide safety standards and may be used for screening pesticides in P. brevitarsis before use in medical applications.
김정범(Kim JeongBeom),임채원(Lim ChaeWon),하재현(Ha JaeHyub),김문기(Kim MoonKi),박연지(Park YeonJi),신진슬(Shin JinSeol),김유지(Kim Yooji),이단비(Lee Danbi),이진형(Lee Jinhyung),하송미(Ha Songmi),김지현(Kim Jihyon),김은석(Kim Enseok) 한국정보기술학회 2019 Proceedings of KIIT Conference Vol.2019 No.6
빅데이터를 사용할 때 가장 중요한 요소 중 하나는 비식별 전략입니다. 개인 정보를 식별 할 수없는 식별불가능한 정보는 빅데이터 분석 및 출력으로 만 사용할 수 있습니다. 비식별 조치는 대용량 데이터 수집을 위한 개인 정보 적용 정책에 따라 적절하게 수행되어야합니다. 비식별전략은 큰 데이터 세트에서 개인을 식별할 수있는 요소 전부 또는 일부의 삭제, 대체 등을 통해 개인을 식별하는 것을 불가능하게 하는 정책입니다. 비식별 정보는 전략 수립을 통해 개인 정보 이외의 정보로 추정되므로 정보 주체의 동의없이 제 3 자에게 사용 또는 제공 할 수 있습니다. 따라서 빅데이터 분석과 결과의 활용에 있어서 가장 중요한 전략입니다. 식별되지 않은 결과는 비 개인 정보로 간주되지만 새로운 바인딩 기술이 나타나거나 결합 될 수있는 정보가 다시 식별 될 수 있으므로, 필수적인 관리 및 기술 안전장치를 구현해야합니다. One of the most important factors in using big data is the de-identification strategy. Non-identifiable information that does not identify personal information can only be used as a big data analysis and output. De-identification measures should be appropriately performed in accordance with the personal information application policy for the collection of big data types. De-identification is a policy that makes it impossible to identify an individual through deletion, substitution, etc., of all or some of the elements that can identify an individual in a big data set. Since the de-identification information is estimated as information other than personal information by establishing strategy, the information can be used or provided to a third party without consent from the information subject. Therefore, in the analysis of big data and utilization of the result it is the most important strategy. Although non-identified outputs are assumed to be non-personal information, essential management and technical safeguards should be implemented, as new binding techniques may appear or information that can be combined may be re-identified. Through this paper, we will examine the related strategies and implementation example.
Increases in Soil Active Carbon and Yield of Spring Chinese Cabbage by Rice Husk Application
Young-Nam Kim(김영남),Young Sang Cho(조영상),Ji-Hyun Lee(이지현),Jung-Hwan Yoon(윤정환),Danbi Lee(이단비),Han-Ryul Seo(서한률),Jeong-Woo Kim(김정우),Eun-Ji Joo(주은지),Bo-Hyun Kim(김보현),Kwang-Lai Park(박광래),Kye-Hoon Kim(김계훈) 한국토양비료학회 2020 한국토양비료학회 학술발표회 초록집 Vol.2020 No.10
Lee, Jung Eun,Kim, Koung Li,Kim, Danbi,Yeo, Yeongju,Han, Hyounkoo,Kim, Myung Goo,Kim, Sun Hwa,Kim, Hyuncheol,Jeong, Ji Hoon,Suh, Wonhee DOVE MEDICAL PRESS 2017 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.12 No.-
<P>Pathological angiogenesis is one of the major symptoms of severe ocular diseases, including corneal neovascularization. The blockade of vascular endothelial growth factor (VEGF) action has been recognized as an efficient strategy for treating corneal neovascularization. In this study, we aimed to investigate whether nanoparticle-based delivery of apatinib, a novel and selective inhibitor of VEGF receptor 2, inhibits VEGF-mediated angiogenesis and suppresses experimental corneal neovascularization. Water-insoluble apatinib was encapsulated in nanoparticles composed of human serum albumin (HSA)-conjugated polyethylene glycol (PEG). In vitro angiogenesis assays showed that apatinib-loaded HSA-PEG (Apa-HSA-PEG) nanoparticles potently inhibited VEGF-induced tube formation, scratch wounding migration, and proliferation of human endothelial cells. In a rat model of alkali burn injury-induced corneal neovascularization, a subconjunctival injection of Apa-HSA-PEG nanoparticles induced a significant decrease in neovascularization compared to that observed with an injection of free apatinib solution or phosphate-buffered saline. An in vivo distribution study using HSA-PEG nanoparticles loaded with fluorescent hydrophobic model drugs revealed the presence of a substantial number of nanoparticles in the corneal stroma within 24 h after injection. These in vitro and in vivo results demonstrate that apatinib-loaded nanoparticles may be promising for the prevention and treatment of corneal neovascularization-related ocular disorders.</P>