Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

유량변동에 따른 소양강유역 수질의 통계학적 해석

최한규,백경원,최용묵,최진우 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

This research was conducted with the aim of efficiently managing large scale of rivers such like Songyang-river through predicting water quality change with analyzing the characteristics of the flowing in nutrients and pollutants. The main result will be used as basic data for effectively operating reservoirs through controling water quality and quantity. The relationship between quantity of flow and water quality was analyzed and pollution loading into the basin was estimated. Three areas of Soyang-river upstream and one area of Suip-cheon in Yanggu-gun were selected as research sites. Flow and water quality were measured simultaneously. The relation between quantity of discharge and pollution concentration and between quantity of discharge and pollution loading were analyzed by statistical method, respectively. We provided a rating curve through measuring quantity of discharge(collection quantity of discharge)and pollutograph and pollution loading curve through water quality data. Also, we analyzed the correlation between quantity of discharge per unit area and pollution loading per unit area in each basin. As resurt of this research, Buk-cheon spot revealed an excellent first grade water quality for the items including BOD5, DO, and SS. The correlation coefficient between Buk-cheon spot's quantity of discharge and pollution loading was 0.896~0.996, showing the validity of analysis applying correlation curve formula of quantity of discharge and pollution loading in the same spot. Also, pollution loading per unit area of the items including BOD5, COD, DO, SS, T-N, T-P increased as area of basins get increased following the sequence of Buk-cheon, Suip-cheon, Naelin-cheon spots.

월 PMP 개념의 적용에 관한 연구

최한규,김남원,최용묵,윤희섭 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

Normally at a flood season the operation of the dam depends on a short range weather forecast that makes many difficulties of the management at a dry season. It is needed to study the pattern of the long period rainfall. The concept of PMP(Probable Maximum Precipitation) was used for designing dam. From the concept, this study is applied the concept of monthly probable maximum precipitation for operating dam. It can be possible to let us know the appropriateness of a limiting water level at a rainy season. For the operation of dam at a dry season this study can predict roughly the flood season's pattern of precipitation by month or period, therfore the prediction of precipitation can rise efficient operation of a dam.

英國 土地登錄의 基礎

崔龍奎 청주대학교 1987 한국사회과학연구 Vol.6 No.-

A system of registration of title was introduced into England as far back as 1982, but only on an optional basis. The revised system of resistration of title contained in the Land Registration Acts 1925~1971 and Rules of 1925 - which must be kept wholly distinct from systems of registration of deeds and charges - is, however, in the process of being made, area by area, compulsory over the whole of England and Wales. One method for simplifying the purchase of land, though only very slightly, is the system of registration of deeds which was first put for word in a draft Bill sufmitted to parliament in 1529. The idea originated in records accumulated by royal officials in the centuries after the Norman Conquest and the proposals had as many political and administrative advantages as they had private advantages for parties desiring greater security for their Conveyancing transactions. The system is a simple one as it makes no change in the method of conveyancing since all it does is to set out on a register a copy of memorial of all deeds dealing with the property which have been seen by the registrar. A purchaser is entitled to disregard all dealings with the land which do not appear on the register and so is protected against the danger of concealed and secret documents, though not forged documents. It is still up to the purchaser to investigate title in the traditional complex way.

3χ-amino-5α-cholestane의 니트로소우레아 유도체들의 합성

崔舜圭,李龍均 東亞大學校 大學院 1984 大學院論文集 Vol.9 No.-

Nitrosourea derivatives of cholestane have been synthesized for the purpose to obtain antitumor agents respectively. The isomeric intermediate, 3α-and 3β-amino-5α-choestane required for the synthesis of nitrosourea derivatives were obtained through a reaction of 5α-cholestance-3-one oxime with lithium aluminium hydride reduction followed by the column chromatography; N-(2-chloroethyl) carbamoyl-3α-amino-5α-cholestane, and N-methylcarbamoyl-3α-amino-5α-cholestane were prepared by the treatment of each amine with isocyanate (2-chloroethyl iscocyanate and methlisocyanate) in anhydrous CHCl3 and corresponding nitrosourea derivatives, N-(2-chloroethyl) nitrosocarbamoyl-3α-cholestane, and N-methylnitrosocarbamoyl-3α-amino-5α-chloestane were obtained by the nitrososation of urea derivatives with CH3COOH (or HCOOH)/NaNO2 in ice-cold condition. The structural proof of these compounds was done by TLC. m.p., IR and NMR.

6주간의 淸暑益氣湯 經口投與가 에너지대사 및 호르몬 변화에 미치는 영향

최용어,강명신,유종만,이규성,오재근,조준용 韓國體育大學校附屬 體育科學硏究所 1994 韓國體育大學校附屬 體育科學硏究所論文集 Vol.13 No.1

The purpose of this study was to investigate the effects of chung-seo-ik-gi -tang administration on the metabolic responses and hormones in 18 healthy-male elite boxes. All subjects were divided randomly with two groups, Chung-sea-ik-gi-tang Group(N=18) and placebo group(N=18) and perfored with 70% of HR max using bycicle ergometer unfil exhaustion. During the submaximal exercise, heart rate was maesured every two min. The blood samples were collected from antecubital vein by 10ml syranges(6ml/each) before immediately after exhaustion, recover-10 min, recover-20 min and recover-30 min. The samples were to analyzed for the level of glucose, lactate, TG, TC, HDL-C, insulin and catecholamine. The results of various blood parameters were summarized as follow; l. Energy substrates (plasma glucose, TG, TC, HDL-C) changes in group C were significantly different from group P. Plasma glucose in group C was significantly lowered at recover-10 min compared to group P (P<0.05). and also TG, TC and HDL-C in group C were significantly increased after 3 weeks compared to group P (P<0.05) whereas. Lactate accumulation in group C was significantly decreased after 3 weeks compared to group P (P<0.05). 2. Plasma insulin level was not showed significant difference between two groups. But insulin depression tendency after 3, 6 weeks in group C was allevated compared to group P. Increasing rate of norepinephrine in group C at Post-exhaustion after 3weeks lowered compared to group P. Norepinephrine in group C at rest periods after 3 weeks showed significant difference compared to group C. The results indicated that Chung-seo-ik-gi-tang had the effects of ergogenic aids on fatigue resistance and recovery from exhaustive exercise at the level of 70% HR max.

Semiclassical Analysis for O + Pb Elastic Scattering at E=216.6 and 312.6 Mev

최치규,현남규,김용주,홍성락 제주대학교 1992 논문집 Vol.34 No.-

실험실계에서의 입사핵?? 에너지가 216.6과 312.6 MeV이고 표적핵?? 인 탄성산란에 대한 실험데이타를 수정된 Glauber모델을 사용하여 분석하였다. 계산된 결과들은 실험데이타와 좋은 일치를 보여주었다. .

冬蟲夏草의 抗轉移와 免疫增進에 關한 硏究

최우진,유화승,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

This experimental study was carried out to evaluate the effects of Cordiceps sinensis on the antimetastasis and immune activity. In order to investigate the effect of Cordiceps sinensis, the followings were performed; Cytotoxicity, inhibition of MMP-2 & MMP-9 gene expression, fraction of CD4+, CD8+, CD19+ in splenic cell, the moprphological change of splenic cells, gene expression of IL-12(p35), IL-12(p40), IFN-?? and splenic cell proliferation by CS-E. The results were obtained as follows. 1. CS-E did not present cytotoxic effect on L+14, B16-F10 melanoma cells and HMCB. 2. CS-E inhibited MMP-2 and MMP-9 gene expression more effectively compared with control group. 3. CS-E inhibited invasion of B16-F10 melanoma cells more effectively compared with control group. 4. CS-E helped CD4+, CD8+, CD19+ expression more effectively compared with control group. 5. CS-E activated phagocytic cells in spleen more effectively compared with control group. 6. CS-E helped IL-12(p35), IL-12(p40), IFN-?? gene expression in splenic cell more effectively compared with control group. 7. CS-E activated splenic cell proliferation more effectively compared with control group. From above findings, it is suggested that CS-E is able to inhibit metastasis of cancer and activate immune response system.

現代地籍理論의 體系化 構想(Ⅱ)

崔龍奎 청주대학교 사회과학연구소 1991 한국사회과학연구 Vol.10 No.-

The government, regarding the problem of land as one of the most important policies, has made every effort for settling an ever-increasing serious problem of land. The theory of land registration and management is a science which surveys the present state of land, records the present state, manages the recorded content, and operates them, and the land registration and management is understood as the official register recording the informations of the land. The more the importance of land is stressed to the modern people, the more the academic studies is increased. The theory of land registration and management which has been developed on a working level until now shall be developed to an academic study according to a request of the times. Therefore, this study comprehends (1) The academic necessity and character of the land registration and management, (2) The subject and scope of study of the land registration and management, (3) The approach to the land registration and management, and this is the latter part of the systemized concrete of the modern theory of the land registration and management.