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Basic : A case of genotype 4 hepatitis E after ingestion of roe deer in Gyeongnam province (초)
( Ja Yoon Choi ),( Sang Soo Lee ),( Hong Jun Kim ),( Chang Yoon Ha ),( Hyun Ju Min ),( Hyun Jin Kim ),( Tae Hyo Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( Hae Sun Yun ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)
HBV : PE-031 ; Occult HBV infection in Korean blood donors
( Ja Kyung Kim ),( Hye Young Chang ),( Myung Hee Kim ),( Hyun Ok Kim ),( Mi Yeon Choi ),( Soo Youn Lee ),( Hyun Chung Chung ),( Yoo Sung Hwang ),( Kwan Sik Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Blood transfusion can transmit HBV-DNA and cause hepatitis B in blood recipient. Currently, serologic assay for the detection of HBsAg has been used in routine screening test of blood donors. Korea is an endemic area of HBV infection, prevalence of occult hepatitis B can be high. However, donors, who are suspected to have occult HBV infection, have not been evaluated further. We aimed to reveal clinical characteristics and to analyze HBV-DNA in liver tissue in these donors. Methods: Patients who donated blood in Hanmaeum Blood Center between May 16, 2011 and Dec 31, 2011 were enrolled in this study. Blood from these donors was screened HBsAg and HBV-DNA. HBV-DNA was detected by TMA (translationmediated amplification) method with PROCLEIX® TIGRIS® system (Novartis, USA). If a donor, who showed negative HBsAg but positive HBV-DNA, agreed to be evaluated, the donor underwent other serologic tests and liver biopsy. HBV-DNA in liver tissue was detected by direct sequencing. Results: Total 103,017 donors were enrolled. One hundred nineteen donors (0.11%) showed positive HBsAg. Among 102,898 donors with negative HBsAg (99.9%), HBV-DNA was positive in 16 donors (0.016%). Among negative HBsAg and positive HBV-DNA donors, 3 male donors agreed to evaluate further. All three donors had positive anti-HBs and negative HBeAg/anti-HBe, however, only one donor had positive anti-HBc. We confirmed HBV-DNA in liver tissue by PCR. Conclusion: Dual Screening tests with HBsAg and HBV-DNA for blood product can detect occult infection in blood donors. Clinical significance of donors with occult HBV infection needs to evaluated further.
Case Report : Genotype-4 hepatitis E in a human after ingesting roe deer meat in South Korea
( Ja Yoon Choi ),( Jeong Mi Lee ),( Yun Won Jo ),( Hyun Ju Min ),( Hyun Jin Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( Hae Sun Yun ),( Yeong Sil Yoon ) 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.3
The recent increase in the number of cases of indigenous hepatitis E virus (HEV) infection highlights the importance of identifying the transmission routes for the prevention of such infections. Presented herein is the first case of acute HEV infection after ingesting wild roe deer meat in South Korea. A 43-year-old male presented with abdominal discomfort and jaundice. He had not recently traveled abroad, but had eaten raw roe-deer meat 6-8 weeks before the presentation. On the 7th day of hospitalization the patient was diagnosed with acute viral hepatitis E. Phylogenetic analysis of his serum revealed genotype-4 HEV. This case supports the possibility of zoonotic transmission of HEV because the patient appears to have been infected with genotype-4 HEV after ingesting raw deer meat. ((Iin Mol HepatoI2013;19:309¬314)
HBV : PE-031 ; Occult HBV infection in Korean blood donors
( Ja Kyung Kim ),( Hye Young Chang ),( Myung Hee Kim ),( Hyun Ok Kim ),( Mi Yeon Choi ),( Soo Youn Lee ),( Hyun Chung Chung ),( Yoo Sung Hwang ),( Kwan Sik Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Blood transfusion can transmit HBV-DNA and cause hepatitis B in blood recipient. Currently, serologic assay for the detection of HBsAg has been used in routine screening test of blood donors. Korea is an endemic area of HBV infection, prevalence of occult hepatitis B can be high. However, donors, who are suspected to have occult HBV infection, have not been evaluated further. We aimed to reveal clinical characteristics and to analyze HBV-DNA in liver tissue in these donors. Methods: Patients who donated blood in Hanmaeum Blood Center between May 16, 2011 and Dec 31, 2011 were enrolled in this study. Blood from these donors was screened HBsAg and HBV-DNA. HBV-DNA was detected by TMA (translationmediated amplification) method with PROCLEIX® TIGRIS® system (Novartis, USA). If a donor, who showed negative HBsAg but positive HBV-DNA, agreed to be evaluated, the donor underwent other serologic tests and liver biopsy. HBV-DNA in liver tissue was detected by direct sequencing. Results: Total 103,017 donors were enrolled. One hundred nineteen donors (0.11%) showed positive HBsAg. Among 102,898 donors with negative HBsAg (99.9%), HBV-DNA was positive in 16 donors (0.016%). Among negative HBsAg and positive HBV-DNA donors, 3 male donors agreed to evaluate further. All three donors had positive anti-HBs and negative HBeAg/anti-HBe, however, only one donor had positive anti-HBc. We confirmed HBV-DNA in liver tissue by PCR. Conclusion: Dual Screening tests with HBsAg and HBV-DNA for blood product can detect occult infection in blood donors. Clinical significance of donors with occult HBV infection needs to evaluated further.
OK-JA CHOI,최선주,YOUNG-DON HONG,HUI-JEONG GWON,SANG-MU CHOI 한국원자력학회 2005 Nuclear Engineering and Technology Vol.37 No.4
N-(3-bromo-2,4,6-trimethylacetanilide)iminodiacetic acid (BrTIDA) was synthesized using nitrilotriacetic anhydride prepared in situ, and lyophilized vials were prepared which contained 20 mg of BrTIDA and 0.4 mg of SnCl2. To evaluate the clinical efficacy of the in-house prepared lyophilized kit, a technetium-99m complex of BrTIDA was prepared; its in vivo pharmacokinetic behavior was evaluated via animal studies to assess the hepatocytic function and the functional status of the cystic duct and the gallbladder. Serial static image scans of rabbits and the biodistribution in mice injected with 99mTc-BrTIDA revealed that none of the tissues except for the hepatobiliary system showed radioactivity concentrations, and a rapid clearance from the organs was observed. In conclusion, a lyophilized kit and its prepared 99mTc-BrTIDA can be applied as a hepatobiliary imaging agent for the evaluation of the functional status of the hepatocytes and the patency of the biliary duct.
Neuro-Behçet disease presented diplopia with hemiparesis following minor head trauma
Ja Yun Choi,Sun Young Park,In Ok Hwang,Young Hwang Lee 대한소아청소년과학회 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.9
Behçet disease (BD) is rare in childhood. We report a 9-year-old boy with neuro-Behçet disease who presented diplopia and weakness on the left side after a cerebral concussion. Brain magnetic resonance imaging (MRI) revealed hyperintensity of the right mesodiencephalic junction on T2-weighted and fluid attenuated inversion recovery images. Prednisolone administration resulted in complete remission and normalization of abnormal MRI finding. Brain MRI is a useful diagnostic tool when the neurological sign is the first symptom of subclinical BD.
Accumulation and Toxicity of Germanium in Cucumber under Different Types of Germaniums
Choi, Ik Won,Seo, Dong Cheol,Han, Myung Ja,DeLaune, R. D.,Ok, Yong Sik,Jeon, Weon Tai,Lim, Byung Jin,Cheong, Yong Hwa,Kang, Hang Won,Cho, Ju Sik Taylor Francis 2013 Communications in soil science and plant analysis Vol.44 No.20
Neuro-Behçet disease presented diplopia with hemiparesis following minor head trauma
Choi, Ja-Yun,Park, Sun-Young,Hwang, In-Ok,Lee, Young-Hwan The Korean Pediatric Society 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.9
Behçet disease (BD) is rare in childhood. We report a 9-year-old boy with neuro-Behçet disease who presented diplopia and weakness on the left side after a cerebral concussion. Brain magnetic resonance imaging (MRI) revealed hyperintensity of the right mesodiencephalic junction on T2-weighted and fluid attenuated inversion recovery images. Prednisolone administration resulted in complete remission and normalization of abnormal MRI finding. Brain MRI is a useful diagnostic tool when the neurological sign is the first symptom of subclinical BD.