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Perpendicular Orientation of Diblock Copolymers Induced by Confinement between Graphene Oxide Sheets
Choi, Ki-In,Kim, Tae-Ho,Lee, Yeonhee,Kim, Hyeri,Lee, Hoyeon,Yuan, Guangcui,Satija, Sushil K.,Choi, Jae-Hak,Ahn, Hyungju,Koo, Jaseung American Chemical Society 2018 Langmuir Vol.34 No.4
<P>We have studied an orientation structure of self-assembled block copolymers (dPS-<I>b</I>-PMMA) of deuterated polystyrene (dPS) and poly(methyl methacrylate) (PMMA) confined between graphene oxide (GO) surfaces. The results of combination techniques, such as neutron reflectivity, time-of-flight secondary-ion mass spectrometry, grazing-incidence small-angle X-ray scattering, and scanning electron microscopy, show that self-assembled domains of the block copolymers in thin films near the GO sheets are oriented perpendicular to the surface of the GO monolayers, in contrast to the horizontal lamellar structure of the copolymer thin film in the absence of the GO monolayers. This is due to the amphiphilic nature of the GO, which leads to a nonpreferential interaction of both dPS and PMMA blocks. Double-sided confinement with the GO monolayers further extends the ordering behavior of the dPS-<I>b</I>-PMMA thin films. Continuous vertical orientation of the block copolymer thin films is also obtained in the presence of alternating GO layers within thick copolymer films.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2018/langd5.2018.34.issue-4/acs.langmuir.7b03991/production/images/medium/la-2017-03991k_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la7b03991'>ACS Electronic Supporting Info</A></P>
A clinicopathological study of lichen planus-like keratosis
( Hyeri Kim ),( Hyeongmok Kwon ),( Moonhyung You ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Lichen planus-like keratosis (LPLK), also known as benign lichenoid keratosis, usually presents as a single brown to red scaly flat-topped plaque. Several large reviews of LPLK in Caucasians were reported, but there are no studies conducted in Korea Objectives: The purpose of this study was to investigate the clinicopathological findings of LPLK. Methods: A total of 58 cases confirmed as LPLK by histologic examination at the Yeungnam university hospital from 2001 to 2019 were analyzed retrospectively. Results: Most of the lesions were single (96.4%), located on the face (65.5%) followed by trunk (15.5%) and upper extremities (12%). The ratio of females to males was 1.4:1 with an average age of 62.4 years. In 57% of the cases clinical concern was seborrheic keratosis and only 17% of specimens included LPLK as clinical differential diagnosis. Solar elastosis (60%) and red blood cells extravasation (55%) were seen frequently. Local parakeratosis (43%), dermal eosinophil (29%) and plasma cell (10%) were focally present. Conclusion: LPLK can be easily misdiagnosed due to familiarity with clinical characterisitcs of seborrheic keratosis and other lichenoid dermatosis. Skin biopsy and clinicopathologic correlation are necessary for differential diagnosis. Several histologic features, such as parakeratosis, infiltration of dermal eosinophils and plasma cells can help discriminate LPLK from lichen planus.
Necrobiotic xanthogranuloma coexists with diffuse normolipidemic plane xanthoma and multiple myeloma
( Hyeri Kim ),( Moonhyung You ),( Joongoon Kim ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Necrobiotic xanthogranuloma (NXG), is a rare multisystem disease that manifests as cutaneous inflammatory lesions, and is commonly associated with lymphoproliferative disease. Diffuse normolipidemic plane xanthoma (NX), is also a rare, acquired disease that is often associated with systemic diseases such as lymphoproliferative disease. Both these diseases have been reported to be associated with monoclonal immunoglobulins (MIg). However, there are few cases in which these diseases co-exist. A 78-year-old woman, who had a known case of NX on the neck and axillary area, presented with an asymptomatic erythematous plaque on her left supraclavicular area for 6 months. Histopathological examination showed lymphoid aggregates, necrobiotic areas, and granulomatous inflammation in the dermis. Numerous foreign-body and Touton type giant cells were noticed. Serum protein immunoelectrophoresis showed an IgG kappa type monoclonal gammopathy. Lipid profile of serum was normal. Bone marrow examination showed plasma cell myeloma. Based on these histologic and laboratory results, we diagnosed this lesion as NXG coexisting with NX and multiple myeloma. She was started on treatment with bortezomib and melphalan for multiple myeloma, and high-dose systemic corticosteroid and triamcinolone intralesional injection for the skin lesion. After 3 months of treatment, the NXG skin lesion and MIg improved.
Causative species of sporotrichosis in Korea
( Hyeri Kim ),( Moonhyung You ),( Joongoon Kim ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Sporotrichosis is a chronic cutaneous fungal infection caused by Sporothrix (S.) schenckii complex. Sporotrichosis was common deep mycosis in Korea. All strains were reported as S. schenckii. There was no molecular studies until 2016. In northeast China and Japan, S. globosa was main species of Sporothrix, and S. schenckii sensu stricto was very rare. Objectives: We want to know accurate species of Korean strains reported as S. schenckii. Methods: We searched the Korean strains of Sporothrix spp. at fungus collection centers or private collections and reviewed literatures of molecular studies for Korean strains. We found 6 strains of S. schenckii and 3 strains of S. globosa. Ribosomal DNA ITS sequences were compared with those of the species of Sporothrix schenckii complex. Results: Ribosomal ITS sequences of 9 strains were 100 % identical with S. globosa. There was no S. schenckii sensu stricto. We found one study about molecular analysis of Korean S. schenckii . It was published in 2004 by Ishizaki et al. All of 8 strains of Korean S. schenckii were mitochondrial subtype group 2, that was S. globosa. So all 17 strains of Korean S. schenckii complex were S. globosa. Conclusion: S. globosa was the causative species in tested Korean sporotrichosis.
Sporotrichosis caused by direct infection of Sporothrix globosa in family
( Hyeri Kim ),( Moonhyung You ),( Joongoon Kim ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Sporotrichosis is one of the most common subcutaneous mycosis caused by Sporothrix(S.) schenckii complex. S.schenckii complex comprises at least six closely related dimorphic fungi including S.brasiliensis, S.globosa, S.mexicana, S.albicans, S.luriei, and S.schenckii sensu stricticto. Spirotrichosis usually occur through skin injury from contaminated plant debris or scratches from felines carrying the disease. Human-to-human transmission of the sporotrichosis is very rare in the world. A 3-year-old boy presented with a single indurated ulcer and crust on the left inner thigh. The lesion appeared a year ago, and gradually grew up in size. His father was diagnosed as sporotrichosis caused by S.globosa 2 years ago. He and his father used different room at bed time, and denied raising any animals or plants. Histopathologic examination of the lesion revealed granulomatous infiltration containing lymphocytes, histiocytes, and giant cells. GMS and PAS histochemical staining showed positive for many spherical yeast cells. The fungal culture on Sabouraud dextrose agar showed dark brown to black, moist and wrinkle colonies. The sequences of ribosomal DNA internal transcribed spacer region of clinical sample was 100% similarity with S. globosa. We diagnosed the lesion as sporotrichosis and treated with itraconazol. We report a rare case of sporotrichosis caused by direct infection of S.globosa.
A case of vulva hematoma with rupture of pseudoaneurysm of pudendal artery
( Hyeri Hong ),( Sun Gae Kim ),( Hye Won Jeon ),( Ji Eun Choi ),( Young Ho So ),( Kyu Ri Hwang ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
Vulvar hematomas are relatively uncommon outside the obstetric population but may be the result of trauma to the perineum. It most often present with low abdominal pain and urologic, neurologic symptoms. The vulva presents rich vascularization, supplied by the pudendal artery, a branch of the anterior division of the internal iliac artery. We describe a rare case of a 15-cm sized vulvar hematoma with suggested rupture of pseudoaneurysm of left pudendal artery without trauma injury. A 14-year-old girl presented with sudden-pain and swelling in her left labium and successfully treated with selective arterial embolization and surgical evacuation. The literature is reviewed and managements discussed.
A case of chronic tinea cruris due to Trichophyton rubrum
( Hyeri Kim ),( Hyeongmok Kwon ),( Moonhyung You ),( Donghoon Shin ),( Jongsoo Choi ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Chronic dermatophyte infection rarely fails to respond to topical or systemic antifungal therapy. Such refractory condition may be related to many factors and one of them is the decreased cell-mediate immunity to the infectious agents. A 61-year-old male patient had diffuse scaly brownish patch on the trunk, buttock, and both groin, along with thickening of both big toenails for several years. Trichophyton rubrum was identified by fungal culture study. It was diagnosed as tinea cruris with tinea unguium and treated with various systemic antifungal agents, such as itraconazole, terbinafine, and voriconazole and topical agents, such as ketoconazole, terbinafine, and amphotericin B for 5 years. With any kind of treatment, the skin lesion showed initial improvement but did not resolve completely and reaggravated 2 or 3 months later. He also showed elevated serum total immunoglobulin E(IgE) level, and suffered from urticaria, correlated with severity of tinea cruris. We report a case of chronic dermatophytosis recalcitrant to various antifungal agents. This case may be related to the decreased cell-mediated immunity and IgE-mediated immediate hypersensitivity reaction.