Alcohol extract of Geum Chung Cho alleviates alcohol-induced short-term memory impairment in gerbils

Han-Sam Cho,Tae-Woon Kim,Sang-Seo Park,Mal-Soon Shin,Jae-Min Lee,Eun-Sang Ji,Chang-Ju Kim 한국운동재활학회 2015 한국운동재활학회 학술대회 Vol.2015 No.10

Chronic ethanol consumption leads to memory impairment and also induces brain damage. The hippocampus has been particularly regarded as a possible target organ of alcoholic intoxication, since this structure plays a prominent function in memory processes. Cordyceps has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including anti-tumor, anti-inflammatory, anti-viral, and immune modulatory effects. Guem Chung Cho is an artificial cultivated Cordyceps, and was supplied from GCordy (Seoul, Korea). Ethanol extract of Cordycep (50 g) was made by rotary evaporate, and resulting powder 8.29 g was obtained (yield 17%). In the present study, we investigated the effects of ethanol extract of Geum Chung Cho on short-term memory, cell proliferation and apoptosis in the hippocampus of ethanol-treated gerbils. The gerbils were divided into 5 groups (n = 10 in each group): Control group, alcohol-treated group, alcohol-treated and 0.001 mg/kg Geum Chung Cho-applied group, alcohol-treated and 0.01 mg/kg Geum Chung Cho-applied group, and alcohol-treated and 0.1 mg/kg Geum Chung Cho-applied group. Gerbils in the alcohol-treated groups were orally administered ethanol (1 g/kg) once a day for 2 weeks. Gerbils in the Guem Chung Cho-applied groups were orally administered Guem Chung Cho extract at each dosage 1 hour before ethanol consumption. Our results revealed that consumption of alcohol for 2 weeks deteriorated short-term memory, induced apoptosis, and inhibited cell proliferation, and reduced expressions of brain-derived neurotrophic (BDNF) and tyrosine kinase B (TrkB). However, Guem Chung Cho treatment alleviated alcohol-induced short-term memory impairment through enhancing cell proliferation and BDNF expression with inhibiting apoptosis in the hippocampus. Guem Chung Cho showed maximum effects at 0.1 mg/kg. Based on these results, alcohol extract of Guem Chung Cho may provide therapeutic value for the treatment of chronic alcohol-inducted brain injury. This study was supported by GCordy company.

소설에 나타난 諧謔性 硏究 : <흥보전>과 <봄봄>을 中心으로 Centering around the Life of HeungBo, Bom-Bom

조성항,김태순 경복대학 2001 京福論叢 Vol.5 No.-

웃음이란 골계에 대한 생리적인 표현이며, 해학(諧謔), 풍자(諷刺) 기지 등이 있다. 문학작품에서 사용되는 기법으로써의 해학은 어려운 삶 속에서 서로를 격려하고 현실을 극복하려는 우리 민족의 현실극복의 한 방법이었다. 작품 속에서 해학성이 뛰어나다고 평가되는 작품으로 <흥보전>과 김유정의 <봄봄>을 들수 있다. <흥보전>은 선량하지만 가난한 '흥보'와 부자이지만 악한의 대명사인 '놀보'를 대립적인 상황에서 과장을 통해 묘사했다. <봄봄> 역시 지주의 마름이며 약삭빠른 인물인 '장인님'과 바보스러울 정도로 순박한 '나'의 갈등을 과장함으로써 독자들로 하여금 고달픈 처지의 '흥보'나 '나'의 어려운 처지를 웃음으로 바라보도록 하고 있다. 끼니를 잇기조차 힘든 '흥보'의 처지를 표현하는 대목에서는 먹을 것을 찾아 헤매이지만 헛고생만을 하게되는 쥐의 모습으로 웃음을 유발하고, 해결할 수 없는 가난한 상황을 무성의한 '흥보'의 집짓기 태도에서 익살적인 표현으로 바꿈으로써 가난의 비극을 느끼지 않게 한다. 한편 '놀보'에게서 심술궂고 이기적이기는 하지만 열성적인 노력으로 부를 축적하는 긍정적인 모습을 볼 수 있었다. 또 무조건적인 헌신의 모습이 아니라 올바르지 않은 남편의 처사에 반대의사를 표현하는 '흥보'와 '놀보'의 아내들에게서 적극적인 인물상을 찾을 수 있었다. <봄봄>의 '나'는 순박하다는 점에서는 '흥보'와, 타인을 이용하여 이익을 보려했던 '장인님'은 이기적이라는 면에서는 '놀보'와 견주어 볼 수 있는 인물이다. '나'와 '장인님'의 갈등 역시 '나'의 어리숙한 점을 이용하여 엉뚱하게 육체적인 난투극 상황으로 변화됨으로써 익살적인 웃음을 유발하게 된다. 긍정적인 해학을 바탕을 한 이 작품은 인물들 간의 갈등관계가 지속될 수 없다. 따라서 타인을 위하는 선량한 '흥보'와 노동에 적극적이라는 미덕을 가진 '놀보'는 제비라는 매개체를 통해 이상적인 가정을 실현한 '흥보'와 화해를 이루게 된다. '점순'이를 매개로 설정된 '나'와 '장인님'과의 관계는 '나'의 성실함을 인정하고 있는 '장인님'과, '점순'과의 애정을 확인한 '나'의 사랑을 통해 김유정 식의 갈등해결 방법을 살펴보았다. Laughter is physiological expression on Golgye and consists of humor, satire and wit. It is not an usual purposeful speech with the object of general information communication or the instruction of knowledge but evokes a laughter enkindling unexpected meaningful purpose from getting out of words' original meaning. The life of HeungBo and Bom Bom are works valued the most excellent humors in our literature. In the Life of HeungBo, depicting through excessive process the personalities of good, poor HeungBo and rich, top villain NolBo, it makes readers evoke laughters. HeungBo devoting himself to close people was lazy and incompetent man for himself. Therefore his family has to go through miserable poverty. By the way, this extreme poverty preferably changes humor evoking a burst of laughter through exaggerated way. We cannot feel the suffering of realistic poverty because his topknot sweeps the ceiling in standing up and in stretching himself his head is shown in backyard and many childrens wear straw mat clothes due to want. Otherwise After NolBo monopolized his brother's heritage, he is well off thanks to doing eager farming. According to the concitions, he cultivates grains and even special agricultural products, so he becomes richer and richer. And we could see their wives images which are realistic and positive. We could see their wives obedient and devoting to their husbands according to their placed conditions. Besides they have an outstanding actual judgement in crisis. An altruisic, good HeungBo and a positive, hard-worker NolBo realize that only property is not everything through media called swallow. NolBo finding out his mistake is to reconcile HeungBo accompolished ideal home due to a favored swallow. In Bom Bom, the enmity between selfish father-in-law taking advantage of myself and sincere worker myself was drawn. Thgough two people called good myself like HeungBo and selfish father-in-law like NolBo finally makes a physical confused fight for the benefits of themselves, they come to reconsile by Jeomsoon roled media between themselves. Various unexpected actions evoking myself good, sincere and vagued caused humor, We made certain that Kim Yoo Jeong's literatural task that is love is original source of trouble settlement.

일반아동, 정신지체아동과 학습장애아동의 사회적 기술 발달 경향

조용태,김순자 대진대학교 1999 大眞論叢 Vol.7 No.-

The purpose of this study was to explore the developmental trends in social skills of the normal, mental retardation, and learning disabilities children at primary schools. A total of 314 children(100 normal children, 100 mental retardation children, and 114 learning disabilities children) participated in this study. Social skills(Cooperation, Assertion, and Self-control skill) of children measured by Gresham and Elliott's Social Skills Rating System(SSRS). The results of the study were as followings: First, social skill of the normal children was found to be linear trend. However, social skill of the mental retardation and learning disabilities children were not found consistent trend. Second, cooperative skill within social skills of the normal, mental retardation, and learning disabilities children were found to be linear trend. Third, assertive skill within social skills of the normal children was found to be linear trend. However, assertive skill of the mental retardation and learning disabilities children were not found to be consistent trend. Forth, self-control skill within social skill of the normal and mental retardation children were found to be linear trend. However, self-control skill of the learning disabilities children was not found to be consistent trend.

Ketoprofen誘導體의 效能檢索

趙台淳,李善美 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.1

In order to study the antiinflamatory efficacy of ketoprofen diesters (polyethylene glycol 400 and 1,000) and lysinate in comparison with that of ketoprofen, the effects on blood vessel perme ability in mice, granuroma formation in rats, swelling of rat hind paw and ulcer formation in rats were examined. As shown in results, the inhibitory effect of the diesters in blood vessel permeability was same as Rthat of ketoprofen. Granuloma formation induced by 2% carageenin was significantly inhibited by ketoprofen itself and the diesters, however, the exudate formation was markedly inhibited only diester 1,000. In carageenin induced rat paw edema test, the diesters exhibited antiinflamatory effect same as ketoprofen. In addition, the average ulcer index in rats were as follows in decreasing order; ketoprofen lysinate, the diester 400, ketoprofen itself and the diester 1,000.

골반 내 농양 1예

조인숙,이해혁,김태희,이권해,남계현,이임순,김정식,박성진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Pelvic inflammatory disease (PID) is a disease that affects young, sexually active, reproductive age women. Most pathogens are Chlamydia trachomatis and Neisseria Gonorrheae transmitted sexually. One of serious acute complication of PID is tubo-ovarian abscess (TOA) that involves the fallopian tube, ovary and adjacent structures (eg, bowel, pelvic peritoneum). The microbiology of TOAs is polymicrobial with anaerobic organisms and causal organisms of PID. Common anaerobic organisms are Peptostretococcus spp, Bacteriodes spp, Prevotella spp, Escherichia coli and aerobic streptococci. Treatment is necessary to admission for intravenous broad-spectrum antibiotics and surgery is often reserved for patients with suspected rupture or patients who fail to respond to antibiotics. So, we reported this case found pelvic abscess due to ruptured tube-ovarian abscess.

구치부 인접면 와동에서 유동성 복합레진 이장재의 두께가 치은 변연부 미세누출에 미치는 영향

조윤정,김태완,김현정,김영진,남순현 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

This in vitro study aimed to investigate the influence of flowable composite lining with different thicknesses on the marginal quality. One hundred twenty cavities, each preparated with proximal box-type(3mm of bucco-lingual width, 2mm of mesio-distal depth and gingival margin of 1mm supra-CEJ) were randomly dived into four groups. group I : Tetric ceram filling alone (control group) group II: 0.5mm thickness Tetric flow + Tetric ceram filling group III: 1.5mm thickness Tetric flow + Tetric ceram filling group IV: 2.5mm thickness Tetric flow + Tetric ceram filling The followings are the results: 1. Group II showed significantly less microleakage compared to group I(control group)(p<0.05). 2. There was no statistically significant difference between group III, IV and group I(p>0.05). 3. Group II showed significantly less microleakage compared to group III. IV(p<0.05). 4. There was microleakage more or less in all group. It was concluded that 0.5mm flowable composite lining improved cavity adaptation and marginal sealing. 구치부 인접면 와동에서 유동성 복합레진 이장재의 두께가 치은측 변연의 미세누출에 미치는 영향을 평가하기 위하여 발거된 소구치 및 대구치의 근, 원심면에 box 형태의 와동(협설폭경 3mm, 근원심폭경 2mm, 상아법랑경계 상방 1mm에 치은 변연) 120개를 형성한 뒤, 무작위로 30개씩 선정하여 다음과 같은 4개의 군으로 분류하였다. group I- Tetric ceram 충전군(대조군) group II- 0.5mm두께의 Tethc flow + Tetric ceram group III- 1.5mm두께의 Tetric flow + Tetric ceram group IV- 2.5mm두께의 Tetric flow + Tethc ceram 색소침투법으로 치은측 변연부 미세누출을 측정하여 다음과 같은 결론을 얻었다. l. group II는 groupI에 비해 낮은 미세누출을 보였다(p<0.05). 2. group III,IV과 group I 사이에는 통계적으로 유의한 미세누출의 차이가 없었다(p>0.05). 3. group II는 group III, IV에 비해 낮은 미세누출을 보였다(p<0.05). 4. 모든 group에서 정도의 차이는 있으나 치경부에서 미세누출을 보였다. 이상의 결과로, 혼합형 복합레진으로의 구치부 인접면 와동 수복시 0.5mm 두께의 유동성 레진으로의 와동저 이장은 치은측 변연의 봉쇄능을 향상시켜 변연부 미세누출을 감소시킬 수 있는 방법으로 사료된다.

매복된 하악 제1대구치의 외과적 노출술을 이용한 치험례

조윤정,박영옥,김태완,김현정,김영진,남순현 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.2

제1대구치는 저작과 혼합치열기 이후의 수직적 교합관계형성에 핵심적인 역할을 하고 악골의 성장발육에 관여한다. 제1대구치의 매복은 하안면 고경의 감소, 낭의 형성, 치관 주위염, 인접치의 치근 흡수, 부정 교합 등의 문제점을 야기할 수 있다. 치료방법으로는 주기적 관찰, 외과적 노출술, 교정적 견인, 외과적 재위치술, 발치 등이 있으며 이중 외과적 노출술이 가장 기본이 되는 술식이다. 외과적 노출술시에는 맹출로의 개방성을 유지하는 것이 중요하며 개방성을 유지시키기 위한 방법으로는 레진관의 접착, 산화 아연 유지놀 시멘트, 치주포대 등을 노출된 부위에 충전시키는 방법 등이 있다. 본 증례에서는 매복된 하악 제1대구치에서 장애물의 제거와 외과적 노출술을 시행한 결과 자발적인 맹출을 관찰할 수 있었다. 또한 surgical pack과 투명상유지장치를 사용하여 간편하고 효과적으로 맹출로의 개방성을 유지할 수 있었다.

주의력결핍과잉행동장애와 Alpha-1C-Adrenergic 수용체 유전자와의 연관성에 대한 연구

조수철,김재원,김붕년,황준원,박미라,김순애,조대연,유희정,정운선,손정우,박태원 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : Neurobiological and pharmacological research has suggested that the dysregulation of the central noradrenergic systems might be involved in the pathophysiology of ADHD. The aim of this study was to examine the association of the alpha-1C-adrenergic receptor gene (ADRA1C) with ADHD in Korean subjects. Methods : In a case-control study, we assessed 186 DSM-IV ADHD probands and 150 normal controls. One hundred and eight trios were studied in a family-based association analysis. Psychiatric diagnoses were derived through structured diagnostic interviews. For the clinical evaluation of the ADHD subjects, the Child Behavior Checklist (CBCL), the ADHD Rating Scale-IV (ARS) and the Junior Temperament and Character Inventory (JTCI) were administered. A computerized continuous performance test (CPT) was used to measure the inattention and impulsivity of the ADHD children. Results : There were no significant differences in the genotype or allele frequencies of the ADRA1C PstI polymorphism between the ADHD and control group (p>0.05). The transmission disequilibrium test (TDT) analysis observed no evidence for biased transmission of any of the alleles of the PstI polymorphism. There were no significant differences in the CPT or JTCI profiles between those ADHD subjects with the CC genotype and those with the other (CT+TT) genotypes at the PstI polymorphism. Conclusion : The results of this study do not support the ADRA1C as a major genetic susceptibility factor in ADHD.

심실중격결손증-치험 1예-

조광현,우종수,황윤호,이양행,박철호,김종성,김철호,이경순,조영일,박태인 인제대학교 1985 仁濟醫學 Vol.6 No.4

A successful treatment of infants and children with congenital heart defects depends upon several factors: diagnosis must be accurate, the operative technique, including techniques of perfusion and myocardial preservation, must be suited to the needs of patients and intensive cares, including accurate anesthesia, must be applied through all stages of investigation and treatment, i.e. before, during and after the operation. Recently we performed a open heart surgery successfully for a six-years old girl who had suffered from frequent upper respiratory tract infection and mild to moderate exertional dyspnea with congenital heart defects (ventricular septal defect, Kirklin type II, with patent foramen ovale). The operation and postoperative course were very smooth. And now we report this with review of literatures.

만성 화농성 중이염의 세균학적 고찰

조남순,이영훈,강기훈,최제환,송태현,이병돈,장혁순,강주원,김연준 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background and Objectives : Chronic suppurative otitis media is one of the frequent diseases in otolaryngologic field. It is important to choose of antibiotics in the management of infectious disease. But the organisms in infections have been changed and resistance to antibiotics has been grown as the development of antibiotics has been achieved. And so it has been necessary to recognize the changes of organisms and resistance in antibiotics. Our study was performed to identify the pathogens isolated from discharges in chronic otitis media and evaluate the antibiotic agents, to recognize the change of to resistance to·antibiotic agents and to use the appropriate anitiotics. Materials and Methods : Retrospectively, authors reviewed the backeriologic study of 114 cases of chronic suppurative otitis media who visited the Department of Otolaryngology, Soonchunhyang University in Seoul from Nov. 1996 to Oct. 1999 and analyzed 101 strains and its sensitivity test to various antibiotics. Result : In 93 cases in which pathogenic organism was isolated, single infection was 85 cases(91.4%) and mixed infection was 8 cases(8.6%). The most frequent pathogenic organism was Staphylococcus aureus(59.4%), Pseudomonas aeruginosa(13.9%), Providencia(4.8%), Alcaligenes(3.0%) and Streptococcus pneumoniae(2.9%) were the next. Methicilline-Resistance Staphylococcus aureus was 34 cases(57.6%) of Staphylococcus aureus. Staphylococcus aureus was sensitive to Vancomycin(96.7%), Trimethoprim-Sulfamethoxazole (57.6%), Cefuroxime(42.4%) and Ciprofloxacin(40.7%) but resistant to Penicillin(94.9%). Pseudomonas aeruginosa was sentitive Amikacin(100%), Ciprofloxacin(100%) and Gentamicin(67%). Conclusion : As MRSA recently was wide spread in community accquired infection as well as nosocomial infection, we must consider strict control of MRSA.