종합병원 입원환자의 알코올중독 유병율과 주치의의 인지도 조사

조석군,김경빈,장환일 大韓神經精神醫學會 1993 신경정신의학 Vol.32 No.6

The authors studied prevalence and physician's detection rate of alcoholism in 478 adult patients admitted at Kyung-Hee Medical Center from June to July in 1992. In this study, the authors used self-report questionnaire consisting of Korean version of DSM-Ⅲ-R, MAST, NAST(I)(Alcoholism Screening Test of Seoul National Mental Hospital(I)), and additional demographic questions. The results were as following : 1) Among 478 patients, prevalence of alcoholism was 26.8%(76 patients) in male and 1.6%(e patients) in female. 2) Among the patients who are identified as alcoholism by the authors, detection rates of alcoholism by the charge physicians were 24.2% in internal medicine and none in other departments. 3) Compared to the alcoholic patients who are not detected by the charge physicians, the alcoholic patients who are detected are more aged patients showing high scored MAST significantly and having liver diseases.

발전기의 위상잡음 감소를 위한 DGS 공진기 설계 및 제작

설경태,조영빈,전계석 경희대학교 산학협력기술연구원 2002 산학협력기술연구논문집 Vol.8 No.-

In this paper, a novel resonator is designed using the resonant characteristic of the defected ground structure(DGS) from phase noise reduction in oscillator. To confirm the validity of the designed DGS resonator, two kinds of oscillators using DGS resonator and λ/4 microstrip line have been designed and measured in the same configuration except for the configuration of the resonator for the examination of the reduction of phase noise by the DGS. At the fundamental frequency of 8.6GHz, 4.83 dBm output power and -91.7 dBc @100kHz phase noise have been measured for oscillator with DGS resonator, and 5 dBm output power and -72.78 dBc @100kHz phase noise have been measured for one with λ/4 microstrip line. Measurement shows reduced phase noise by 18.92 dB in oscillator with DGS resonator compared to one with λ/4 microstrip line.

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

Theoretical predictions of a highly reactive non-heme Fe(<small>IV</small>)&z.dbd;O complex with a high-spin ground state

Cho, Kyung-Bin,Shaik, Sason,Nam, Wonwoo Royal Society of Chemistry 2010 Chemical communications Vol.46 No.25

<P>Computations show that a non-heme iron(<SMALL>IV</SMALL>)–oxo complex with a trigonal bipyramidal structure, [(Me<SUB>6</SUB>TREN)Fe<SUP>IV</SUP>&z.dbd;O]<SUP>2+</SUP>, has a quintet ground state and a low activation barrier for H-abstraction from cyclohexane, whereas its ruthenium analogue, [(Me<SUB>6</SUB>TREN)Ru<SUP>IV</SUP>&z.dbd;O]<SUP>2+</SUP>, has a triplet ground state and a high H-abstraction barrier.</P> <P>Graphic Abstract</P><P>A non-heme iron(<SMALL>IV</SMALL>)–oxo complex with a trigonal bipyramidal structure has a quintet ground state and a low activation barrier in the C–H bond activation of cyclohexane. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc00292e'> </P>

Feasibility of FAIR imaging for evaluating tumor perfusion

Cho, Jee-Hyun,Cho, Gyunggoo,Song, Youngkyu,Lee, Chulhyun,Park, Bum-Woo,Lee, Chang Kyung,Kim, Namkug,Park, Sung Bin,Kang, Jong Soon,Kang, Moo Rim,Kim, Hwan Mook,Kim, Young Ro,Cho, Kyoung-Sik,Kim, Jeong Wiley Subscription Services, Inc., A Wiley Company 2010 JOURNAL OF MAGNETIC RESONANCE IMAGING Vol.32 No.3

<B>Purpose:</B><P>To evaluate the feasibility of flow-sensitive alternating inversion recovery (FAIR) for measuring blood flow in tumor models.</P><B>Materials and Methods:</B><P>In eight mice tumor models, FAIR and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was performed. The reliability for measuring blood flow on FAIR was evaluated using the coefficient of variation of blood flow on psoas muscle. Three regions of interest (ROIs) were drawn in the peripheral, intermediate, and central portions within each tumor. The location of ROI was the same on FAIR and DCE-MR images. The correlation between the blood flow on FAIR and perfusion-related parameters on DCE-MRI was evaluated using the Pearson correlation coefficient.</P><B>Results:</B><P>The coefficient of variation for measuring blood flow was 9.8%. Blood flow on FAIR showed a strong correlation with Kep (r = 0.77), percent relative enhancement (r = 0.73), and percent enhancement ratio (r = 0.81). The mean values of blood flow (mL/100 g/min) (358 vs. 207), Kep (sec<SUP>−</SUP><SUP>1</SUP>) (7.46 vs. 1.31), percent relative enhancement (179% vs. 134%), and percent enhancement ratio (42% vs. 26%) were greater in the peripheral portion than in the central portion (P < 0.01).</P><B>Conclusion:</B><P>As blood flow measurement on FAIR is reliable and closely related with that on DCE-MR, FAIR is feasible for measuring tumor blood flow. J. Magn. Reson. Imaging 2010;32:738–744. © 2010 Wiley-Liss, Inc.</P>

A theoretical study into a <i>trans</i>-dioxo Mn^V porphyrin complex that does not follow the oxygen rebound mechanism in C–H bond activation reactions

Cho, Kyung-Bin,Nam, Wonwoo The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.5

<P>Previous experimental results revealed that the C-H bond activation reaction by a synthetic trans-dioxo Mn-V porphyrin complex, [(TF(4)TMAP)(OMnO)-O-V](3+), does not occur via the well-known oxygen rebound mechanism, which has been well demonstrated in (FeO)-O-IV porphyrin pi-cation radical reactions. In the present study, theoretical calculations offer an explanation through the energetics involved in the C-H bond activation reaction, where a multi-spin state scenario cannot be excluded.</P>

Nonheme iron-oxo and -superoxo reactivities: O₂ binding and spin inversion probability matter

Cho, Kyung-Bin,Chen, Hui,Janardanan, Deepa,de Visser, Sam P.,Shaik, Sason,Nam, Wonwoo The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.16

<P>DFT calculated barriers for C–H activation of 1,4-cyclohexadiene by nonheme iron(<SMALL>IV</SMALL>)-oxo and iron(<SMALL>III</SMALL>)-superoxo species show that the experimental trends can be explained if the spin inversion probability of the TMC iron(<SMALL>IV</SMALL>)-oxo is assumed to be poor. Also, the TMC iron(<SMALL>III</SMALL>)-superoxo reaction proceeds with an endothermic O<SUB>2</SUB>-binding energy followed by an intrinsically reactive quintet state.</P> <P>Graphic Abstract</P><P>DFT calculations on C–H activation by nonheme iron(<SMALL>IV</SMALL>)-oxo and iron(<SMALL>III</SMALL>)-superoxo species are done to compare their reactivities and spin states. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc17610f'> </P>

To rebound or dissociate? This is the mechanistic question in C–H hydroxylation by heme and nonheme metal–oxo complexes

Cho, Kyung-Bin,Hirao, Hajime,Shaik, Sason,Nam, Wonwoo The Royal Society of Chemistry 2016 Chemical Society reviews Vol.45 No.5

<P>Enzymatic reactions that involve C-H bond activation of alkanes by high-valent iron-oxo species can be explained by the rebound mechanism (RM). Hydroxylation reactions of alkane substrates effected by the reactive compound I (Cpd I) species of cytochrome P450 enzymes are good examples. There was initially little doubt that the rebound paradigm could be carried over in the same form to the arena of synthetic nonheme high-valent iron-oxo or other metal-oxo complexes. However, the active reaction centres of these synthetic systems are not well-caged, in contrast to the active sites of enzymes; therefore, the relative importance of the radical dissociation pathway can become prominent. Indeed, accumulating experimental and theoretical evidence shows that introduction of the non-rebound mechanism (non-RM) is necessary to rationalise the different reactivity patterns observed for synthetic nonheme complexes. In this tutorial review, we discuss several specific examples involving the non-RM while making frequent comparisons to the RM, mainly from the perspective of computational chemistry. We also provide a technical guide to DFT calculations of RM and non-RM and to the interpretations of computational outcomes.</P>

Mechanistic Insights into the C–H Bond Activation of Hydrocarbons by Chromium(IV) Oxo and Chromium(III) Superoxo Complexes

Cho, Kyung-Bin,Kang, Hyeona,Woo, Jaeyoung,Park, Young Jun,Seo, Mi Sook,Cho, Jaeheung,Nam, Wonwoo American Chemical Society 2014 Inorganic Chemistry Vol.53 No.1

<P>The mechanism of the C–H bond activation of hydrocarbons by a nonheme chromium(IV) oxo complex bearing an N-methylated tetraazamacrocyclic cyclam (TMC) ligand, [Cr<SUP>IV</SUP>(O)(TMC)(Cl)]<SUP>+</SUP> (<B>2</B>), has been investigated experimentally and theoretically. In experimental studies, reaction rates of <B>2</B> with substrates having weak C–H bonds were found to depend on the concentration and bond dissociation energies of the substrates. A large kinetic isotope effect value of 60 was determined in the oxidation of dihydroanthracene (DHA) and deuterated DHA by <B>2</B>. These results led us to propose that the C–H bond activation reaction occurs via a H-atom abstraction mechanism, in which H-atom abstraction of substrates by <B>2</B> is the rate-determining step. In addition, formation of a chromium(III) hydroxo complex, [Cr<SUP>III</SUP>(OH)(TMC)(Cl)]<SUP>+</SUP> (<B>3</B>), was observed as a decomposed product of <B>2</B> in the C–H bond activation reaction. The Cr<SUP>III</SUP>OH product was characterized unambiguously with various spectroscopic methods and X-ray crystallography. Density functional theory (DFT) calculations support the experimental observations that the C–H bond activation by <B>2</B> does not occur via the conventional H-atom-abstraction/oxygen-rebound mechanism and that <B>3</B> is the product formed in this C–H bond activation reaction. DFT calculations also propose that <B>2</B> may have some Cr<SUP>III</SUP>O<SUP>•–</SUP> character. The oxidizing power of <B>2</B> was then compared with that of a chromium(III) superoxo complex bearing the identical TMC ligand, [Cr<SUP>III</SUP>(O<SUB>2</SUB>)(TMC)(Cl)]<SUP>+</SUP> (<B>1</B>), in the C–H bond activation reaction. By performing reactions of <B>1</B> and <B>2</B> with substrates under identical conditions, we were able to demonstrate that the reactivity of <B>2</B> is slightly greater than that of <B>1</B>. DFT calculations again support this experimental observation, showing that the rate-limiting barrier for the reaction with <B>2</B> is slightly lower than that of <B>1</B>.</P><P>The C−H bond activation of hydrocarbons by nonheme chromium(IV) oxo and chromium(III) superhydroxo complexes, [Cr<SUP>IV</SUP>(O)(TMC)(Cl)]<SUP>+</SUP> and [Cr<SUP>III</SUP>(O<SUB>2</SUB>)(TMC)(Cl)]<SUP>+</SUP>, has been investigated experimentally and theoretically. The C−H bond activation by the chromium(IV) oxo complex does not occur via the conventional H-atom-abstraction/oxygen-rebound mechanism. The reactivity of the chromium(IV) oxo complex is slightly greater than that of the chromium(III) superoxo complex in the C−H bond activation reactions.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2014/inocaj.2014.53.issue-1/ic402831f/production/images/medium/ic-2013-02831f_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic402831f'>ACS Electronic Supporting Info</A></P>

Design of exhaust manifold for pulse converters considering fatigue strength due to vibration

Kyung-Sang Cho,Kyung-Bin Son,Ue-Kan Kim 한국마린엔지니어링학회 2013 한국마린엔지니어링학회지 Vol.37 No.7