백혈병환자에서 Liposomal Amphotericin B로 치료된 파종성 Fusarium 감염 1예

이지연,김성범,박대원,신성희,김용현,윤소영,엄중식,최철원,정희진,김우주,김준석,김장수,이갑노 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

Fusarium spp.는 사람에서 드물게 각막염, 조갑진균증, 상처나 화상부위감염 등을 유발하는 것으로 알려져 있으나 최근에는 면역저하자에서 기회감염의 원인균으로 증가하고 있는 추세이다. 면역저하자에서 파종성 감염이 있는 경우에 예후는 치명적이나, 증례가 많지 않고 진단방법이 제한되어 있어 조기 진단과 신속한 치료가 쉽지 않다. 그러나 특징적으로 피부병변의 동반이 흔하여 면역저하자에서는 피부 병변의 면밀한 관찰과 함께 Fusarium 감염을 조기에 의심하여 피부생검이나 배양을 하는 것이 진단에 도움이 되리라 생각된다. 파종성 Fusarium 감염의 치료로는 감염 부위의 국소적 외과적 절제와 전신적 항진균제의 사용이 필요하고 현재까지는 amphotericin B가 비교적 효율적인 항진균제로 알려져 있으나 면역저하자에서 이에 반응을 하지 않는 경우가 많다. 저자들은 급성골수성백혈병 환자에서 관해유도화학요법 시행 후 호중구감소상태에서 피부병변과 폐침윤이 발견되었고 피부의 중심부 궤양을 동반한 구진성 병변에서 배양검사를 통해 파종성 Fusarium 감염을 진단하였으며 liposomal amphotericin B (AmBisome )를 사용하여 성공적으로 치료한 예를 경험하여 보고하는 바이다. Fusarium spp., basically a superficial pathogen, is a newly emerging fungal pathogen of opportunistic infections in immunocompromised patients. At present, although Fusarium spp. are relatively resistant to amphotericin B, the combination of amphotericin B and surgical debridement appear to be optimal treatment for disseminated infection. Recently we experienced a 32-year-old neutropenic patient after induction chemotherapy for acute myelocytic leukemia presented with skin lesions and infiltrations in both lungs. We diagnosed with disseminated fusariosis by skin culture and successfully treated the patient with liposomal amphotericin B. We emphasize a high index of suspicion for skin lesions especially in immunocopromised patients.

유압 호스 조립체의 길이변화시험에 대한 측정불확도 추정

엄학용(Hak-Yong Eom),이용범(Yong-Bum Lee),이기천(Gi-Chun Lee),최병오(Byung-Oh Choi),이규석(Kyu-Seok Lee) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.4

산업용 청소기 모터의 가속수명시험

엄학용(Hak-Yong Eom),이기천(Gi-Chun Lee),장무성(Mu-Seong Chang),박종원(Jong-Won Park),이용범(Yong-Bum Lee) 한국신뢰성학회 2018 신뢰성응용연구 Vol.18 No.3

Purpose: In this study, the life of the motor is investigated by performing the accelerated life test with the brush wear of the industrial cleaner motor as the main failure mode. Methods: The accelerating stress factor of the accelerated life test is a voltage, which can increase the number of revolutions of the motor to accelerate the brush wear due to the friction between the brush and the commutator. Also, the accelerating stress level was determined after determining the maximum allowable level of the voltage through the preliminary test. Results: The motor failure time at each accelerating stress level was predicted by regression analysis with brush wear length as performance degradation data. The main failure mode, which is brush wear, of the motor was reproduced by this test. The shape parameter of the Weibull distribution was confirmed to be the same statistically at all accelerating stress levels by the likelihood ratio test. Conclusion: The life of the motor was investigated by performing the accelerated life test with the brush wear of the industrial cleaner motor as the main failure mode. Through the accelerating test method of the cleaner motor, various life expectancy and life expectancy of the acceleration factor are predicted.

검교정된 토크미터의 측정 불확도에 관한 연구

엄학용(Hak-Yong Eom),이용범(Yong-Bum Lee),이종직(Jong-Jik Lee),김태석(Tae-Seok Kim),유한주(Han-Ju Yu) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.2

Surface oxidation behaviors of Cd-rich CdSe quantum dot phosphors at high temperature.

Eom, NuSi A,Kim, Taek-Soo,Choa, Yong-Ho,Kim, Woo-Byoung,Kim, Bum Sung American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.10

<P>The optical properties of quantum dots (QDs) are altered by exposure to air and light; upon such exposure, the quantum yield is typically reduced. Improved understanding of surface oxidation and oxide-layer behavior, both of which influence the photoluminescence of QDs, is necessary for advancing the use of QDs. In this study, the oxide layer properties of QDs are investigated. The QDs are synthesized and subsequently oxidized by heat treatment in atmospheric conditions, and the luminescence properties of the resultant QDs are investigated. The emission properties of QDs are characterized by photoluminescence. The composition and bonding structure of oxidized CdSe QDs are investigated by X-ray photoelectron spectroscopy (XPS). The XRD peaks of oxidized CdSe QDs match CdSe and CdO peaks. CdO is formed by partial oxidation of CdSe QDs. Transmission electron microscopy (TEM) image is confirmed morphology of oxidation before and after of CdSe QDs.</P>

Texture Softening of Beef and Chicken by Enzyme Injection Process

Eom, Sung-Hwan,Lee, Sang-Hoon,Chun, Yong-Gi,Kim, Bum-Keun,Park, Dong-June Korean Society for Food Science of Animal Resource 2015 한국축산식품학회지 Vol.35 No.4

This research focuses on a new softening technology for use with chicken breast and eye of round beef in order to assist elderly individuals who have difficulty with eating due to changes in their ability to chew (masticatory function) or swallow. We investigated the hardness of chicken breast and eye of round beef through use of a texture analyzer after injection of a commercial enzyme. Among 7 commercial enzymes, bromelain and collupulin exhibited a marked softening effect on the tested chicken breast and eye of round beef given a 1.00% enzyme concentration. The hardness of bromelain-treated chicken breast reached 1.4×10⁴ N/m², of collupulin-treated chicken breast reached 3.0×10⁴ N/m², and of bromelain-treated eye of round beef reached 3.2×10⁴ N/m², respectively, while their original shapes did not change. To find the level of tissue degradation with specific enzyme concentrations, enzyme injections at 0.1%, 0.25%, 0.50%, and 1.00% concentration of bromelain and papain were also evaluated. The results of this research could be useful for softening chicken breast and eye of round beef and will contribute to the development of foods that can be more easily eaten as part of a balanced diet for elderly adults.

진공단열패널 열교부위 평가를 위한 수치해석적 연구

윤용한(Yong Han Yoon),소범식(Bum Sik So),조정호(Jung Ho Cho),엄영철(Young Chul Eom),심재술(Jaesool Shim) 대한기계학회 2019 大韓機械學會論文集B Vol.43 No.7

본 연구에서는 두 개의 외장패널이 맞닿는 부분에 형상을 가진 기계적 체결이 가능한 진공단열 외장패널의 3가지 CASE 열전달 해석을 수행하였다. 체결부의 열교부위 선형 열관류율 값을 계산하였으며, 열교를 비교함으로써 단열측면에서 우위의 설계안을 도출하였다. 열전달해석 분석결과, 열교부위의 길이가 0.039m, 0.083m, 0.1656m으로 약 2배씩 선형적으로 증가 했을 때, 열교부위의 선형 열관류율 값은 각각 0.0476W/m·K, 0.2113W/m·K, 0.2663W/m·K으로 열교부위 길이에 비례하여 선형적으로 증가하지 않음을 확인하였다. 2차원 열전달해석을 통해 얻은 데이터를 ISO 10211 기준에서 제시하는 계산식에 대입하여 선형 열관류율 값을 산출하였다. 3가지 CASE의 체결부 열교부위 선형 열관류율 값을 계산하여 비교한 결과, CASE 1 패널이 선형 열관류율 값이 가장 작아 열교 측면에서 가장 우수한 설계임을 확인하였다. In this study, a heat transfer simulation of three types of vacuum insulation panels that can be mechanically fastened with two external panels was conducted. The linear thermal transmittance of the thermal bridge was calculated and the design of superiority in terms of insulation was derived. Results of heat transfer analysis indicated that when the length of the thermal bridge was linearly increased by two times to 0.039, 0.083, and 0.1656 m, the linear thermal transmittance of the thermal bridge was 0.0476, 0.2113, and 0.2663 W/m·K, respectively. In addition, the linear thermal transmittance did not increase linearly in proportion to the length. The linear thermal transmittance was calculated by substituting the data obtained from the two-dimensional heat transfer analysis into the formula given in the ISO 10211 standard. A comparison of the values of the linear thermal transmittance of the joints of the three cases verified that Case 1 had the best thermal bridge design because it exhibited the smallest linear thermal transmittance.

Observational approach on regional lymph node in cutaneous melanomas of extremities

Jang, Bum-Sup,Eom, Keun-Yong,Cho, Hwan Seong,Song, Changhoon,Kim, In Ah,Kim, Jae-Sung The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.1

Purpose: We evaluated failure pattern and treatment outcomes of observational approach on regional lymph node (LN) in cutaneous melanoma of extremities and sought to find clinico-pathologic factors related to LN metastases. Material and Methods: We retrospectively reviewed 73 patients with cutaneous melanoma of extremities between 2005 and 2016. If preoperative 18-F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) findings were non-specific for regional LNs, surgical resection of primary tumors with adequate margins was performed without sentinel lymph node biopsy (SLNB) and/or complete lymph node dissection (CLND), irrespective of tumor thickness or size. In patients with suspicious or positive findings on PET/CT or CT, SLNB followed by CLND or CLND was performed at the discretion of the surgeon. We defined LN dissection (LND) as SLNB and/or CLND. Results: With a median follow-up of 38 months (range, 6 to 138 months), the dominant pattern of failure was regional failure (17 of total 23 events, 74%) in the observation group (n = 56). Pathologic LN metastases were significant factor for poor regional failure-free survival (hazard ration [HR] = 3.21; 95% confidence interval [CI], 1.03-10.33; p = 0.044) and overall survival (HR = 3.62; 95% CI, 1.02-12.94; p = 0.047) in multivariate analysis. In subgroup analysis for cN0 patients according to the preoperative PET/CT findings, LND group showed the better trend of LRFFS (log rank test, p = 0.192) and RFFS (p = 0.310), although which is not statistically significant. Conclusion: Observational approach on regional LNs on the basis of the PET/CT in patients with cutaneous melanoma of extremities showed the dominant regional failure pattern compared to upfront LND approach. To reveal regional lymph node status, SLND for cN0 patients may of importance in managing cutaneous melanoma patients.

Texture Softening of Beef and Chicken by Enzyme Injection Process

Sung Hwan Eom,Sang Hoon Lee,Yong Gi Chun,Bum Keun Kim,Dong June Park 한국축산식품학회 2015 한국축산식품학회지 Vol.35 No.4

This research focuses on a new softening technology for use with chicken breast and eye of round beef in order to assist elderly individuals who have difficulty with eating due to changes in their ability to chew (masticatory function) or swallow. We investigated the hardness of chicken breast and eye of round beef through use of a texture analyzer after injection of a commercial enzyme. Among 7 commercial enzymes, bromelain and collupulin exhibited a marked softening effect on the tested chicken breast and eye of round beef given a 1.00% enzyme concentration. The hardness of bromelain-treated chicken breast reached 1.4×104 N/m2, of collupulin-treated chicken breast reached 3.0×104 N/m2, and of bromelain-treated eye of round beef reached 3.2×104 N/m2, respectively, while their original shapes did not change. To find the level of tissue degradation with specific enzyme concentrations, enzyme injections at 0.1%, 0.25%, 0.50%, and 1.00% concentration of bromelain and papain were also evaluated. The results of this research could be useful for softening chicken breast and eye of round beef and will contribute to the development of foods that can be more easily eaten as part of a balanced diet for elderly adults.

Three-Level 컨버터의 효율특성에 관한 연구

배진용(Jin-Yong Bae),김용(Yong Kim),이은영(Eun-Young Lee),계상범(Sang-Bum Gye),엄태민(Tae-Min Eom),백수현(Soo-Hyun Baek) 대한전기학회 2007 대한전기학회 학술대회 논문집 Vol.2007 No.4

This paper presents the Efficiency Characteristic of Three-Level Converter. Three-Level DC/DC Converter presented in this paper is used a phase shift control with a flying capacitor in the primary side to achieve ZVS for the outer switch. This converter reduces the voltage stress across the main switch to half of input voltage. This paper analyses the loss of each component and the various losses for efficiency variation. The result of the analysis are verified using 3㎾ prototype.