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Urushiol Induces Growth Inhibition and Apoptosis in MCF-7 Human Breast Cancer Cells
Seaho Kim,So-Hyun Jeong,Mohammad Akbar Hossain1,Min Young Kim,김동환,Jin-Ah Kim,윤정현,나천수,김남득 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.4
In this study, we investigated the effects of urushiol which was isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes), on the proliferation of MCF-7 human breast cancer cells. Forty-eight hour treatment of urushiol inhibited the growth of breast cancer cells and induced cell DNA fragmentation. This urushiol-induced apoptosis in the MCF-7 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of poly (ADP-ribose) polymerase. Urushiol also caused a marked increase in the level of p21WAF1/CIP1protein in a p53-dependent manner. Based on our data, urushiol can be considered as a good candidate for an effective chemotherapeutic agent inducing apoptosis of cancer cells, although further study will be needed to confirm this.
Morin Inhibits the Growth of Murine Hepatoma Cells via Cell Cycle Arrest and Induction of Apoptosis
Mi-Na Kim,Eun-Young Ahn,Sang Eun Park,Mohammad Akbar Hossain1,Min Young Kim,문전옥,김남득,윤정현 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.3
Morin (3,5,7,2’,4’-pentahydroxyflavone) is a common dietary flavonoid that exhibits various biological activities, including anti-proliferative, anti-tumor promotion, anti-oxidative, and anti-inflammatory effects. In the present study, we investigated the effects of morin on the cell growth and the viabilities of hepa1c1c7 murine hepatoma cells. Flow cytometric analysis showed that morin-treated cells increased sub-G1 peak accompanied by DNA cleavage and phosphatidylserine externalization, indicating early apoptosis. Flow cytometric analysis also revealed that morin treatment induced G2/M arrest in the cell cycle progression. In addition, morin treatment induced alterations in expression levels of proteins which are linked to cell cycle and apoptosis, such as cyclin B1, Cdc2, Fas, Fas ligand, Bax, Bcl-2, caspase-9,caspase-3, and poly (ADP-ribose) polymerase, in a concentration-dependent manner. Taken together, these results suggest that morin inhibit cell growth and induce cytotoxicity of murine hepatoma cells through G2/M phase arrest and apoptosis.
Development and Performance Evaluation of a Two-Wheeled Power-Tiller Multi-row Weeder
Saha Kowshik Kumar,Hossain Akbar,Hoque Muhammad Arshadul,Jahan Md. Abu Hena Sarwar,Ahmed Sharif,Timsina Jagadish 한국농업기계학회 2021 바이오시스템공학 Vol.46 No.1
Purpose This study was conducted to design, construct, and test a two-wheeled power tiller multi-row weeder (MRW) for effective weed control in wheat production field and other narrow-row crops. This concept was conceived from the high cost and labour-intensive methods required for hand weeding (HW) and the restrictions in chemical weed control borne by the resource-poor smallholder farmers of South Asia. Methods An MRW was designed, fabricated, and field tested with other weeding techniques (HW using khurpi, HWusing a hand spade, weeding using a Bangladesh Agricultural Research Institute (BARI) dry land weeder, and no weeding) at the Farm Machinery and Postharvest Process Engineering Division, Bangladesh Agricultural Research Institute BARI centre in Gazipur during 2013–2014 and 2014–2015 wheat growing seasons. Results The results have shown that the MRW had a higher percentage of plant damage (4.3–4.6%) but also higher actual field capacity (0.12–0.14 ha/h), resulting in lower weeding cost than other weed control techniques. Hand weeding using a khurpi treatment had significantly (p ≤ 0.05) higher weed control efficiency but had higher weeding cost and was labour-intensive (81–93%) than all other treatments, suggesting that it may not be a feasible option for smallholder farmers. Wheat grain yield was similar (p ≤ 0.05) for all weed control methods but significantly higher than the control treatment. In spite of the higher percentage of plant damage in MRW, there was no adverse effect on achieving the desired plant population as evidenced from the grain yield data. Conclusions Results suggest good performance and significant potential of MRWbut also a need for further improvement for its wider adoption by smallholder farmers in Bangladesh and South Asia.
( Jin Ah Kim ),( Dong Hwan Kim ),( Mohammad Akbar Hossain ),( Min Young Kim ),( Bokyung Sung ),( Jeong Hyun Yoon ),( Hongsuk Suh ),( Tae Cheon Jeong ),( Hae Yong Chung ),( Nam Deuk Kim ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including food such as grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using MCF-7 (wild-type p53) and MDA-MB-231 (mutant p53) human breast cancer cells. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent manner. The induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) poly-merase, alteration of Bax/Bcl-2 expression ratio and caspase activities. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in both types of cells. Of note, HS-1793 induced p53/p21WAF1/CIP1-dependent apoptosis in MCF-7 cells, whereas it exhibited p53-independent apoptosis in MDA-MB-231 cells. Furthermore, HS-1793 showed more potent anticancer effects in several aspects compared to resveratrol in MCF-7 and MDA-MB-231 cells. Thus, these findings suggest that HS-1793 has potential as a candidate chemotherapeutic agent against human breast cancer.
Lee, Ji-Hyeon,Park, Sang-Eun,Hossain, Mohammad Akbar,Kim, Min-Young,Kim, Mi-Na,Chung, Hae-Young,Choi, Jae-Sue,Yoo, Young-Hyun,Kim, Nam-Deuk 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
In this study, we investigated the effects of 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (TDB), isolated from Symphyocladia latiuscula (marine red algae), on the proliferation of MCF-7 human breast cancer cells. TDB treatment for 48 h inhibited cancer cell growth and induced DNA fragmentation. Furthermore, morphological characterizations such as apoptotic bodies and membrane blebs were shown by electronic microscopy. TDB-induced apoptosis in the MCF-7 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of caspase-3 substrates, with poly(ADP-ribose) polymerase cleavage occurring by TDB treatment. TDB treatment also caused a marked increase in the level of $p21^{WAF1/CIP1}$ protein in a p53-dependent manner. In addition, the upregulation of$p21^{WAF1/CIP1}$ in the MCF-7 cells was related to a decrease in c-Myc protein in a dose-dependent manner. Based on our data, TDB is a good candidate for further evaluation as an effective chemotherapeutic agent, acting through the induction of apoptosis.
Ji-Hyeon Lee,박상은,Mohammad Akbar Hossain,김민영,김미나,정해영,최재수,유영현,김남득 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
In this study, we investigated the effects of 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (TDB), isolated from Symphyocladia latiuscula (marine red algae), on the proliferation of MCF- 7 human breast cancer cells. TDB treatment for 48 h inhibited cancer cell growth and induced DNA fragmentation. Furthermore, morphological characterizations such as apoptotic bodies and membrane blebs were shown by electronic microscopy. TDB-induced apoptosis in the MCF-7 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of caspase-3 substrates, with poly(ADP-ribose) polymerase cleavage occurring by TDB treatment. TDB treatment also caused a marked increase in the level of p21WAF1/CIP1 protein in a p53-dependent manner. In addition, the upregulation of p21WAF1/CIP1 in the MCF-7 cells was related to a decrease in c-Myc protein in a dose-dependent manner. Based on our data, TDB is a good candidate for further evaluation as an effective chemotherapeutic agent, acting through the induction of apoptosis.
KIM, JIN-AH,KIM, DONG HWAN,HOSSAIN, MOHAMMAD AKBAR,KIM, MIN YOUNG,SUNG, BOKYUNG,YOON, JEONG-HYUN,SUH, HONGSUK,JEONG, TAE CHEON,CHUNG, HAE YOUNG,KIM, NAM DEUK Spandidos Publications 2014 International journal of oncology Vol.44 No.2
Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including food such as grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using MCF-7 (wild-type p53) and MDA-MB-231 (mutant p53) human breast cancer cells. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent manner. The induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) polymerase, alteration of Bax/Bcl-2 expression ratio and caspase activities. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in both types of cells. Of note, HS-1793 induced p53/p21(WAF1/CIP1)-dependent apoptosis in MCF-7 cells, whereas it exhibited p53-independent apoptosis in MDA-MB-231 cells. Furthermore, HS-1793 showed more potent anticancer effects in several aspects compared to resveratrol in MCF-7 and MDA-MB-231 cells. Thus, these findings suggest that HS-1793 has potential as a candidate chemotherapeutic agent against human breast cancer.
HWANG, HYE JUNG,KANG, YONG JUNG,HOSSAIN, MOHAMMAD AKBAR,KIM, DONG HWAN,JANG, JUNG YOON,LEE, SUN HWA,YOON, JEONG-HYUN,MOON, HYUNG RYONG,KIM, HYUNG SIK,CHUNG, HAE YOUNG,KIM, NAM DEUK Spandidos Publications 2012 International journal of oncology Vol.41 No.6
<P>Colorectal cancer (CRC) is the second most frequent cancer in men and the third most common cancer in women in Korea. In spite of the significant advances in conventional therapeutic approaches to CRC, most patients ultimately die of their disease. There is a need to develop novel preventive approaches for this malignancy. This study was carried out to investigate the anticancer effect of the diastereoisomeric compounds, MHY-449 and MHY-450, novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivatives, on HCT116 human colon cancer cells. MHY-449 exhibited more potent cytotoxicity than MHY-450, against HCT116 cells. Treatment of cells with MHY-449 resulted in growth inhibition and induction of apoptosis in a concentration-dependent manner, and inhibition of proliferation in a time-dependent manner. The induction of apoptosis was observed by decreased cell viability, DNA fragmentation, activation of protein levels involved in death receptors. Moreover, activation of caspase-3, -8 and -9 and cleavage of poly(ADP-ribose) polymerase and alteration in the ratio of Bax/Bcl-2 protein expression was observed. MHY-449 induced G2/M phase arrest in the cell cycle progression which was observed by flow cytometry analysis, and a decrease in the protein expression of cyclin?B1 and its activating partners Cdc25c and Cdc2. MHY-449 also caused increase in the expression levels of p53, a tumor suppressor gene, and p21WAF1/CIP and p27KIP, G2/M phase inhibitors. These results suggest that MHY-449 may be a useful candidate for chemo-prevention and/or treatment of colon cancer.</P>
Montiporyne A Induces Apoptosis in SK-MEL-2 Human Melanoma Cells
김남득,Kyoung-Mi Lee,Hye Joung Choi,Mohammad Akbar Hossain,Dong Hwan Kim,Jung Yoon Jang,정지형,윤정현 대한암예방학회 2011 Journal of cancer prevention Vol.16 No.2
In this study, we investigated the effects of montiporyne A which was isolated from the stony coral Montipora species, on the proliferation of SK-MEL-2 human skin melanoma cells (mutant p53). Twenty-four hour treatment of montiporyne A inhibited the growth of melanoma cells and induced apoptotic cell death. This montiporyne A-induced apoptosis in the SK-MEL-2 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of poly(ADP-ribose) polymerase. Montiporyne A treatment also caused a marked increase in the level of p21WAF1/CIP1 protein in a p53-independent manner. Based on our data, montiporyne A can be considered as a good candidate for an effective chemotherapeutic agent inducing apoptosis of cancer cells, although further study will be needed to be confirm. (Cancer Prev Res 16, 141-146, 2011)