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Kim Ah-Ra,Minn Dohsik,Kim Su Hwan,Do Hyeon-Nam,Kim Byoungguk,Choi Young Sill,Kim Dong-Hyun,Oh Eun-Jee,Oh Kyungwon,Kwon Donghyok,권준욱,Kim Sung Soon,Lee June-Woo 한국역학회 2022 Epidemiology and Health Vol.44 No.-
OBJECTIVES: The Korea National Health and Nutrition Examination Survey (KNHANES) is a nationwide cross-sectional surveillance system that assesses the health and nutritional status of the Korean population. To evaluate the occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the community, we investigated the prevalence of antiSARS-CoV-2 antibodies in the sera of KNHANES participants. METHODS: Subjects were recruited between April 24 and December 12, 2020. In total, 5,284 subjects aged 10-90 years from 17 regions participated. SARS-CoV-2 antibodies were screened using the Elecsys Anti-SARS-CoV-2 assay. Positive samples were verified using 4 different SARS-CoV-2 antibody assays and the plaque reduction neutralizing test. The final seropositivity criteria were a positive screening test and at least 1 positive result from the 5 additional tests. RESULTS: Almost half (49.2%; 2,600/5,284) of participants were from metropolitan areas, 48.9% were middle-aged (40-69 years), and 20.5% were in their 20s or younger. The seropositivity rate was 0.09% (5/5,284). Three of the 5 antibody-positive subjects had a history of infection, of whom 2 were infected abroad and 1 was infected in a local cluster outbreak. CONCLUSIONS: The low SARS-CoV-2 antibody seroprevalence in Korea indicates that there have been few coronavirus disease 2019 (COVID-19) cases due to successful COVID-19 management measures (e.g., diagnostic tests for overseas arrivals, national social distancing, and strict quarantine measures). Moreover, asymptomatic infections were uncommon due to active polymerase chain reaction testing. However, hidden infections may exist in the community, requiring the continuation of quarantine and vaccination measures.
어병세균 Edwardsiella tarda에 대한 한약재 추출물의 항균활성
김아라 ( Ah Ra Kim ),김도균 ( Do Kyun Kim ),변태환 ( Tea Hwan Byun ),조은지 ( Eun Jee Jo ),이은우 ( Eun Woo Lee ),권현주 ( Hyun Ju Kwon ),김병우 ( Byung Woo Kim ),김태훈 ( Tae Hoon Kim ),이경본 ( Kyung Bon Lee ),김영만 ( Young Man 한국식품저장유통학회(구 한국농산물저장유통학회) 2011 한국식품저장유통학회지 Vol.18 No.1
The methanol extracts of 19 commercial herb medicines was analyzed to antibacterial activities against Edwardsiella tarda, causing several fish diseases. Rhus javanica showed most strong antibacterial activity against E. tarda and Escherichia coli. Methanol extract of R. javanica was further extracted using several organic solvents having different polarity. Extract from ethyl acetate fraction showed strong activity against E. tarda as well as E. coli. Minimal inhibitory concentration, MIC of R. javanica extract was measured and resulted showing 64 ㎍/㎖ for E. tarda and 256 ㎍/㎖ for E. coli. It is needed that, from these results, further purification and isolation of reposible compound of these activities and further study on the synergy effect using combination with antibiotics against pathogenic bacteria.
Wafer-Scale Integration of Highly Uniform and Scalable MoS<sub>2</sub> Transistors
Kim, Yonghun,Kim, Ah Ra,Zhao, Guoqing,Choi, Sun Young,Kang, Soo Cheol,Lim, Sung Kwan,Lee, Kang Eun,Park, Jucheol,Lee, Byoung Hun,Hahm, Myung Gwan,Kim, Dong-Ho,Yun, Jungheum,Lee, Kyu Hwan,Cho, Byungjin American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.42
<P>Molybdenum disulfide with atomic-scale flatness has application potential in high-speed and low-power logic devices owing to its scalability and intrinsic high mobility. However, to realize viable technologies based on two-dimensional materials, techniques that enable their large-area growth with high quality and uniformity on wafer cale is a prerequisite. Here, we provide a route toward highly uniform growth of a wafer-scale, four-layered MoS2 film on a 2 in. substrate via a sequential process consisting of the deposition of a molybdenum trioxide precursor film by sputtering followed by postsulfurization using a chemical vapor deposition process. Spatial spectroscopic analyses by Raman and PL mapping validated that the as-synthesized MoS2 thin films exhibit high uniformity on a 2 in. sapphire substrate. The highly uniform MoS2 layers allow a successful integration of devices based on 4200 MoS2 transistor arrays with a yield of 95% because of their extreme homogeneity on Si wafers. Moreover, a pulse electrical measurement technique enabled investigation of the inherent physical properties of the atomically thin MoS2 layers by minimizing the charge-trapping effect. Such a facile synthesis method can be possibly applied to other 2D transition metal dichalcogenides to ultimately realize the chip integration of device architectures with all 2D-layered building blocks.</P>
Mutations of ACADS Gene Associated with Short-Chain Acyl-Coenzyme A Dehydrogenase Deficiency.
Kim, Se Hwa,Park, Hyung-Doo,Sohn, Young Bae,Park, Sung Won,Cho, Sung Yoon,Ji, Suntae,Kim, Su Jin,Choi, Eun Wha,Kim, Chi Hwa,Ko, Ah-Ra,Yeau, Sunghee,Paik, Kyung-Hoon,Jin, Dong-Kyu Institute for Clinical Science] 2011 Annals of clinical and laboratory science Vol.41 No.1
<P>Short-chain acyl-coenzyme A dehydrogenase deficiency (SCADD) is an autosomal recessive disorder of mitochondrial fatty acid oxidation associated with mutations in the ACADS gene (Acyl-CoA Dehydrogenase, Short-chain, OMIM #606885). SCADD is a heterogeneous condition that has been associated with various clinical phenotypes ranging from fetal metabolic decompensation in infancy to asymptomatic individuals. Here, the first Korean neonate diagnosed with SCADD by biochemical and genetic findings is reported. The patient has remained asymptomatic by avoiding hypoglycemia. An increased concentration of butylcarnitine was detected on newborn screening. Subsequent urine organic acid analysis showed increased urinary excretion of ethylmalonic acid. To confirm the presence of the genetic abnormality, all the coding exons of the ACADS gene and flanking introns were amplified by the polymerase chain reaction (PCR). Sequence analysis of the ACADS gene revealed novel homozygous missence mutations, c. 1031A>G (p.E344G) in exon 9. In summary, the first Korean patient with confirmed SCADD by genetic analysis is reported with novel mutation.</P>
Physicochemical Composition and Antioxidative Effects of Yacon (Polymnia Sonchifolia)
Ah Ra Kim(김아라),Jae Joon Lee(이재준),Hae Ok Jung(정해옥),Myung Yul Lee(이명렬) 한국생명과학회 2010 생명과학회지 Vol.20 No.1
야콘의 생리활성 기능과 이용 가능성에 관한 연구의 일환으로 야콘 분말의 영양성분 및 항산화 활성을 측정한 결과는 다음과 같다. 야콘 분말의 일반성분은 건물량(dry matter basis)을 기준으로 수분 함량은 3.53%, 조단백질 1.13%, 조지방 0.40%, 조회분 0.79%, 식이섬유소 1.63% 및 탄수화물 92.52%를 함유하였다. 구성당은 fructose가 1320.84 ㎎/l로 가장 많았고 glucose가 1283.70 ㎎/l 검출되어 총 2종이 검출되었다. 아미노산은 glutamic acid 함량이 123.12 ㎎%로 가장 높았고, 다음으로 aspartic acid, proline, arginine, alanine, valine, histidine, lysine순이었다. 구성 지방산 중 포화지방산인 palmitic acid와 lauric acid 2종류의 지방산만 각각 51.72%와 48.28%로 검출되었으며, 불포화지방산은 검출되지 않았다. 유기산은 총 3종의 유기산이 검출되었으며, 이 중 oxalic acid가 2519.29 ㎎/l로 가장 많았고, 다음으로 benzoic acid 1895.17 ㎎/l, formic acid 247.84 ㎎/l 순이었다. 비타민 A, C 및 E의 함량은 각각 0.057 ㎎%, 0.670 ㎎% 및 0.001 ㎎%로 검출되었으며, 무기질은 총 5종의 무기질 성분이 검출되었고, 이 중 K 함량이 가장 많았으며, 다음으로 Na, Ca, Mg 순이었고 Zn의 함량은 미량이었다. 야콘 에탄올 추출물을 n-hexane, chloroform, ethylacetate, n-butanol, water로 계통 분획하여 항산화 활성을 측정한 결과 Rancimat으로 측정한 항산화지수는 pH 1.2 조건에서 분획 중 ethylacetate 분획이 1.45로 가장 높게 나타났으나 양성대조군으로 사용한 BHT 1.83에 비해서는 낮은 활성을 나타내었다. 아질산염 소거능에서도 ethylacetate 분획이 49.82%로 분획 중 가장 높은 아질산염 소거능을 보였으나, 양성대조군인 BHT의 75.29%보다는 낮게 나타났다. 이상의 결과 야콘은 체내 신진대사와 생리활성을 증진시킬 수 있는 영양소들이 다량 함유하고 있으며 항산화 효과를 나타내는 물질을 함유하고 있는 것으로 판단되어 야콘의 기능성 식품으로써의 이용화가치가 한층 더 높아질 것으로 기대해 본다. This study was carried out to investigate the physicochemical and functional properties of Yacon (Polymnia Sonchifolia) powder. The proximate composition of Yacon powder as a dry matter basis was 3.53% moisture content, 1.13% crude protein, 0.40% crude fat, 0.79% crude ash, 1.63% dietary fiber and 92.52% carbohydrate. The major free sugars were identified as fructose and glucose. Analysing total amino acids, 18 kinds of components were isolated from Yacon powder. The essential amino acid contained in Yacon powder accounted for 28.40% of total amino acid, while the non-essential amino acid accounted for 73.61%. Analysing total fatty acids, only 2 kinds - palmitic acid and lauric acid - were detected. Oxalic acid was the major organic acid. The contents of vitamin A, vitamin C and vitamin E were 0.057 mg%, 0.670 mg% and 0.001 mg%, respectively. The mineral contents of Yacon powder were in the order of Zn<Mg<Ca<Na<K. Antioxidant index by Rancimat test and nitrite scavenging ability of ethylacetate fraction of Yacon ethanol extract were the highest among fractions and were less than that of BHT. These results suggest that Yacon is recommendable as a vegetable of high nutritional quality and possesses potential antioxidative capacity.
Potter syndrome - Bilateral renal agenesis with club foot : An autopsy case
( Ah-ra Lee ),( Sung-eun Park ),( Ji-young Kim ),( Young-shin Han ),( In-cheol Jung ),( Su-mi Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Potter's syndrome is a rare condition occurring at a frequency of 1:2000 to 1:5000 fetuses. Here we present a case of Potter syndrome with bilateral renal agenesis with low-set abnormal ears, right ventricular hypertrophy with club foot diagnosed on autopsy. A 28 year-old primi-para woman was referred from local clinic at pregnancy 20weeks and 6days for decreased amniotic fluid index. She had no underlying disease or previous operation history except laparoscopic ovarian cystectomy done three years ago. She had never smoked cigarettes and exposed to drinking alcohols during pregnancy. Under transabdominal sonography, the amniotic fluid was nearly absent. On the day of arrival, amniocentesis and 300cc of amnioinfusion was done. The amniotic fluid normalized after amniotic infusion. Chromosomal study was performed by using Giemsa-Trypsin-Leishman Banding technique, it is confirmed to have no numerical or structural chromosome abnormalities under the microscope of 550 resolving power We performed target sonography. Estimated fetal body weight was approximately 323g at the top 20 percentile on the graph. Under doppler sonography, bladder filling and renal arteries were not visible. Lying down adrenal sign with empty renal fossa and right ventricular hypertrophy was seen. The chest was 19weeks sized suggesting pulmonary hypoplasia. For religious reason, she decided to continue pregnancy. One week later, she admitted via emergency department due to labor pain with amniotic membrane rupture. A 350gram weighted stillborn male baby was delivered by spontaneous vaginal delivery. < Autopsy finding > The stillborn baby had no kidney, ureter, bladder and showed low-set ears, suppressed mandible and club foot. When the antenatal sonography shows severely decreased amniotic fluid with intact amnion, we have to suspect urinary anomaly. If severe oligohydramnios, non-visualization of the bladder and empty renal fossa is seen through sonography, it reflects bilateral renal agenesis.
Kim, Su Jin,Bieganski, Tadeusz,Sohn, Young Bae,Kozlowski, Kazimierz,Sem?nov, Mikhail,Okamoto, Nobuhiko,Kim, Chi Hwa,Ko, Ah-Ra,Ahn, Geung Hwan,Choi, Yoon-La,Park, Sung Won,Ki, Chang-Seok,Kim, Ok-Hwa,Ni Springer-Verlag 2011 HUMAN GENETICS Vol.129 No.5
<P>Sclerosteosis and Van Buchem disease are related recessive sclerosing bone dysplasias caused by alterations in the SOST gene. We tested the hypothesis that craniodiaphyseal dysplasia (CDD) (MIM 122860), an extremely rare sclerosing bone dysplasia resulting facial distortion referred to as 'leontiasis ossea', could also be caused by SOST mutations. We discovered mutations c.61G>A (Val21Met) and c.61G>T (Val21Leu) two children with CDD. As these mutations are located in the secretion signal of the SOST gene, we tested their effect on secretion by transfecting the mutant constructs into 293E cells. Intriguingly, these mutations greatly reduced the secretion of SOST. We conclude that CDD, the most severe form of sclerotic bone disease, is part of a spectrum of disease caused by mutations in SOST. Unlike the other SOST-related conditions, sclerosteosis and Van Buchem disease that are inherited as recessive traits seem to be caused by a dominant negative mechanism.</P>