서울·경기지역 병원직원의 혈액매개 감염노출에 대한 다기관 조사연구

박미라,김정은,박은숙,최정실,정선영,송영구,홍성관,김준명,허애정,양동규,조영주 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

효과적인 우유 섭취지침에 관한 연구

신현아;이애정;이지선;우혜임;조아라;채유진;엄애선 한양대학교 2010 韓國 生活 科學 硏究 Vol.30 No.1

Over the past decade, there has been growing scientific evidence that dietary milk plays a role in beneficial effects for human health. Milk provides a number of good ingredients, in particular with growth factors and different types of proteins such as α -lactalbumin and β-casein. As well as essential amino acids of leucine and isoleucine are make to a positive way of human physical conditions. Therefore, those ingredients are directly involved in the human body, fluid composition and involved in metabolism of protein or carbohydrate. In addition, the development of physical strength and bone health associated with milk consumption. Thus, milk is one of good food for prevention of osteoporosis. Nowadays, several dietary guidelines suggest that people should intake two or three cups of dairy products including milk a day. However, some people cannot drink milk because they appear many adverse effects with regard to intake of milk like allergic reactions, lactose intolerance and weight gain problem. Consequently, it is worthy to discuss about these matters. Person pose the health problems regarding milk consumption should select dairy products carefully. Milk substitutes such as partially-hydrolyzed formula, yogurt, cheese and non- and low-fat dairy products are suggested. They prevent the allergy and lactose intolerance due to lactase in fermented milk digesting the lactose into glucose and galactose. Taking all of these into account, milk consumption is very important to maintain the human health. Although there are several adverse effects with regard to milk consumption, it would not be shown any health problem only if it follows the milk dietary guidelines. Therefore, a milk drinking should be actively encouraged for the public health.

중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

S-312 : A case of successful pulmonary resection of postinfectious bronchiectasis with massive hemoptysis

( Ae Ra Lee ),( Soo Jung Kim ),( Jung Hyun Kim ),( Ju Hee Park ),( Jung Kyu Lee ),( Deog Kyeom Kim ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Background: Although there are no prospective randomized case-control studies and large series comparing the efficacy of conservative and surgical treatment options, the indications of surgery for bronchiectasis have been considered in some situations. Surgery can be performed for eradication in some patients suitable for resection who do not respond to conservative treatment. Case history: A 32-year-old man was diagnosed with anaplastic astrocytoma in brainstem including medulla oblongata and treated with surgery and adjuvant chemoradiation. The tumor has leaded to aspiration tendency for several years, which finally induced bronchiectasis. The man suffering from massive hemoptysis and chronic bronchitis decided to get surgical resection. After operation, his recurrent hemoptysis was controlled by removing the worst part of bronchus. Results: After RLL lobectomy, recurrent massive hemoptysis was improved. Conclusions: We report here a case that pulmonary resection can be alternative method if the area of the lung affected by bronchiectactic change is localized. Key words: Bronchiectasis; pneumonia; lobectomy.

The Connection between Hand Washing and Brushing Teeth

Ra-Ae Bak,Sun-Jung Shin,Hee-Jung Park,Jin-Young Jung,Hwa-Young Lee,Nam-Hee Kim 한국치위생과학회 2023 치위생과학회지 Vol.23 No.2

Background: The purpose of this study was to identify the connection between handwashing and toothbrushing, focusing on eating habits, and to verify whether eating habits can be used as an action cue for forming health habits.Methods: This was a cross-sectional study using secondary data from the 2019 community health survey. The participants included 229,099 adults aged 19 years or older, representative of the South Korean people. We employed two dependent variables: one was washing hands, and the other was brushing teeth. Eating habits was a major independent variable. Socioeconomic variables, such as age, gender, income, occupation, economic activity, education, and residence were adjusted as confounders. Multivariate logistic regression was performed to calculate adjusted odds ratio and 95% confidence intervals. Results: Most of the participants had good health behaviors: those who wash their hands and brush their teeth were each approximately 80%. Our finding indicated that brushing teeth and washing hands can be connected with eating habits. After adjusting for confounders, it was found that people who wash their hands before meals (compared to those who did not wash their hands before meals) had a higher toothbrushing rate after meals (i.e., socioeconomic status) (Adjusted Odds Ratio: 2.0, Confidence Intervals: 1.9 to 2.1). Conclusion: Those who practice either washing hands before meals or brushing teeth after meals were found to have a connection between washing hands and brushing teeth based on the results of practicing other health behaviors. This implies that eating habits can be connected as a behavior cue to promote health habits, such as washing hands before meals and brushing teeth after meals.

Case Reports : Embolization of Multiple Systemic Artery to Pulmonary Artery Fistula with Recurrent Hemoptysis

( Jung Kyu Lee ),( Ju Hee Park ),( Jung Hyun Kim ),( Soo Jung Kim ),( Ae Ra Lee ),( Chang Hoon Lee ),( Young Ho So ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.3

Herein, we report a case of multiple systemic arteries to pulmonary artery fistulas without any underlying causes, presenting recurrent hemoptysis. Transcatheter embolization was successfully performed several times on multiple systemic feeding arteries. Multiple systemic arteries to pulmonary fistulas can be a source of uncontrolled bleeding, and embolization may be a reasonable therapeutic option to control the bleeding.

S-260 : Three cases of endobronchial management in patients with advanced leiomyosarcoma

( Soo Jung Kim ),( Jung Hyun Kim ),( Ju Hee Park ),( Ae Ra Lee ),( Jung Kyu Lee ),( Tae Min Kim ),( Young Sik Park ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

재발성 다발 연골염은 연골로 이루어진 기관에 반복적이고 진행하는 양상의 염증이 발생하는 비교적 드문 질환으로 귀, 코, 기관의 연골에 염증성 병변을 초래하여 특징적 외형을 보이게 된다. 임상 경과는 매우 다양하며 자연 치유되기도 하지만 기도 협착, 협착에 따른 폐감염, 대동맥 판막 폐쇄 부전증에 의한 심부전으로 진행하기도 한다. 저자들은 만성 폐쇄성 폐질환으로 지역 의료 기관에서 치료하였으나 호전되지 않아 시행한 검사상 재발성 다발 연골염에 의해 대동맥궁의 지속적 압박으로 국소적 기관 협착소견을 보인 1예를 경험하여 보고하고자한다.증례: 70세 남자 환자로 내원 1년 전부터 천명음을 동반한 호흡 곤란으로 지역 의료기관에서 만성 폐쇄성 폐질환으로 치료하였으나 호전 보이지 않던 중 호흡 곤란 악화되어 본원 응급실 내원하였다. 과거력상 내원 수년 전부터 코와 귀에 염증소견 보여 이비인후과 진료 하였으나 원인 찾지 못하고 증상 호전과 악화 반복하는 양상을 보였다고 하였다. 활력 징후는 혈압 160/90, 맥박 분당 129회, 호흡수 분당 14회, 체온 36도였다. 호흡곤란 호소하였으며 청진상 천명음이 들려 기도 삽관 시행하였다. 혈액 검사에서 백혈구 14,910/mm3 (호중구 41%), 혈색소 12.8, 혈소판 295,000/mm3이었고 혈청 생화학 검사상 특이 소견 보이지 않았다. 흉부 전산화 단층 촬영을 시행하였고 대동맥궁 압박에 의한 기관지 협착 소견 보여 기관지 내시경 시행하였으며 기관 연골 연화증 소견을 확인할 수 있었다. 이에 재발성 다발 연골염을 진단하였으며 기관 절개술 시행 후 methylprednisolone 투여 후 증상 호전되어 현재 외래 추적 관찰 중이다. Endobronchial metastasis of leiomyosarcoma is rare, but it can cause life-threatening complications such as dyspnea, massive hemoptysis, respiratory failure, or death. The development of new endoscopic modalities including cryoextraction allows effective endobronchial management. However, there is little information about interventional bronchoscopy for endobronchial metastasis from advanced leiomyosarcoma. We report three patients with endobronchial metastases from advanced leiomyosarcomas that caused bronchial obstruction. The bronchoscopic examinations revealed masses obstructing the left main bronchus in all three patients. Recanalization of malignant endobronchial obstruction was successful in all three patients using cryoextraction. Two of them required repeated bronchoscopic intervention, which was effective and seemed safe. After removing the endobronchial tumor via interventional bronchoscopy, there was symptomatic and radiologic improvement. Moreover, the patients could undergo additional palliative chemotherapy. The experiences with our three patients suggest that interventional bronchoscopy helps to alleviate respiratory symptoms and improves clinical status. It also provides an opportunity for further treatment. Therefore, endobronchial management should be considered in the treatment of endobronchial metastasis, even in patients with advanced malignancies.

일차 항결핵제 모두에 과민반응을 보인 환자의 성공적 탈감작 결핵 치료 1예

이애라 ( Ae Ra Lee ),김수정 ( Soo Jung Kim ),김정현 ( Jung Hyun Kim ),박주희 ( Ju Hee Park ),이정규 ( Jung Kyu Lee ),김주영 ( Ju Young Kim ),이서영 ( Suh Young Lee ),강혜련 ( Hye Ryun Kang ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4

Tuberculosis is an infectious disease that can be treated using a combination of antitubercular drugs. First-line antitubercular agents such as isoniazid and rifampin are considered pivotal to successful treatment. However, they are also known to have relatively high rates of adverse events including hypersensitivity reactions. Discontinuing the first-line agents in the event of hypersensitivity may significantly compromise the cure rate of tuberculosis. Drug desensitization can be an effective method allowing continued use of the first-line agents and achieving successful cure of tuberculosis. A 70-year-old man was diagnosed with culture proven pulmonary tuberculosis and treated with first-line antitubercular agents (isoniazid, 300 mg; rifampin, 600 mg; pyrazinamide, 1,500 mg; and ethambutol, 800 mg). After 2 weeks of treatment, generalized erythematous papular rash and fever developed, for which all drugs were discontinued. Since he had hypersensitivity to all 4 first-line antitubercular agents, we tried desensitization for all 4 drugs one by one to resume antituberculosis treatment. After successful desensitization of all 4 first-line antituberculosis drugs, 6 months-antitubercular therapy was completed without any complications. We report here a case of multiple desensitization in a pulmonary tuberculosis patient having hypersensitivity to all of the 4 first-line antitubercular drugs, successfully completing 6-month antitubercular therapy without any complications. (Allergy Asthma Respir Dis 2013;1:395-399)

Up-regulation of inhibitors of DNA binding/differentiation gene during alendronate-induced osteoblast differentiation

Kang, Ae Ra,Oh, Young Rim,Kim, Heung Yeol,Park, Min Jung,Joo, Bo Sun,Choi, Won Jun,Lee, Ji Young,Jung, Min Hyung,Ji, Yong Il,Choi, Jong Soon Springer-Verlag 2012 Archives of gynecology and obstetrics Vol.285 No.5

<P><B>Purpose</B></P><P>To investigate the effect of alendronate on the expression of <I>Id</I> genes in osteoblast differentiation.</P><P><B>Methods</B></P><P>C2C12 cells were treated with alendronate for various concentrations and time periods. For evaluation of alendronate-induced osteoblast differentiation in C2C12 cells, alkaline phosphatase (ALP) activity was measured. The expression of osteoblast differentiation markers such as ALP, type-1 collagen (Col 1), and osteocalcin (OCN), and the expression of Id-1 and Id-2 were measured by RT-PCR. In order to understand the mechanism underlying the regulation of <I>Id</I> genes, the promoter region of the <I>Id</I>-<I>1</I> gene was identified. Database analysis of the promoter region for <I>Id</I>-<I>1</I> using known consensus sequences identified several putative response elements, including CCAAT/enhancer-binding protein beta (C/EBPβ).</P><P><B>Results</B></P><P>Alendronate treatment significantly increased not only ALP activity but also the expression of ALP, Col 1, and OCN, Id-1 and Id-2. C/EBPβ and alendronate cooperatively increased the promoter activity and expression of Id-1.</P><P><B>Conclusions</B></P><P>These results suggest that C/EBPβ-mediated <I>Id</I>-<I>1</I> transcriptional activation may regulate alendronate-induced osteoblast differentiation of C2C12 cells.</P>

Immune Modulation Effect of Pig Placenta Extracts in a Mouse Model: Putative Use as a Functional Food Supplement

Hyun Jung Park,Han Geuk Suh,Jin Hoi Kim,Ae Ra Jang,Hyun Jung Jung,Sung Dae Lee,Woo Tae Ha,Ran Lee,Ji Hyuk Kim,Sang Ho Kim,Si Heung Sung,Sang Ho Moon,Bo Kyung Kim,Hyuk Song 한국축산식품학회 2011 한국축산식품학회지 Vol.31 No.5

This study was performed to establish an effective extraction method of pig placenta extract that could be used for a putative functional food supplement with immunomodulatory effects. In the present study, we used different temperatures (4, 37, 60, 80, and 100oC) and different solvents (chloroform, NaOH, and phosphate buffered saline [PBS]) to extract the pig placenta. Among the different placenta extracts yielded by the different extraction methods, placenta extract (PE) in PBS at 80oC for 30 min (referred to as PE-PBS80) showed a significant increase of nitric oxide production of up to 22.97 μM/105 cells at a 1 mg/mL dose (p