Isoelectronic Pt(ii)- and Au(iii)-N-heterocyclic carbene complexes: a structural and biological comparison

Rana, Bidyut Kumar,Mishra, Snehasis,Sarkar, Deblina,Mondal, Tapan Kumar,Seth, Saikat K.,Bertolasi, Valerio,Das Saha, Krishna,Bielawski, Christopher W.,Isab, Anvarhusein A.,Dinda, Joydev The Royal Society of Chemistry 2018 NEW JOURNAL OF CHEMISTRY Vol.42 No.13

<P>To elucidate the intrinsic biological activities displayed by platinum <I>versus</I> gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C∩N)(C)Cl][PF6] (2) and [Au(C∩N)(C)Cl][PF6]2 (3), which are supported by a common N-heterocyclic carbene, 1-methyl-2-pyridin-2-yl-2<I>H</I>-imidazo[1,5-<I>a</I>]pyridin-4-ylidene (1), were synthesized. The complexes were characterized using a range of spectroscopic techniques as well as single crystal X-ray diffraction and a series of computational studies were also performed to gain additional insight into their fundamental electronic bonding structures. The cytotoxicities of the complexes were tested <I>in vitro</I> against non-small lung carcinoma (A549), colorectal carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines. The measured IC50 values showed that the Au(iii)-NHC complex is more potent than its Pt analogue.</P>

Evolutionary conservation and expression of miR-10a-3p in olive flounder and rock bream

Jo, A.,Im, J.,Lee, H.E.,Jang, D.,Nam, G.H.,Mishra, A.,Kim, W.J.,Kim, W.,Cha, H.J.,Kim, H.S. Elsevier/North-Holland 2017 Gene Vol.628 No.-

MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that mainly bind to the seed sequences located within the 3' untranslated region (3' UTR) of target genes. They perform an important biological function as regulators of gene expression. Different genes can be regulated by the same miRNA, whilst different miRNAs can be regulated by the same genes. Here, the evolutionary conservation and expression pattern of miR-10a-3p in olive flounder and rock bream was examined. Binding sites (AAAUUC) to seed region of the 3' UTR of target genes were highly conserved in various species. The expression pattern of miR-10a-3p was ubiquitous in the examined tissues, whilst its expression level was decreased in gill tissues infected by viral hemorrhagic septicemia virus (VHSV) compared to the normal control. In the case of rock bream, the spleen, kidney, and liver tissues showed dominant expression levels of miR-10a-3p. Only the liver tissues in the rock bream samples infected by the iridovirus indicated a dominant miR-10a-3p expression. The gene ontology (GO) analysis of predicted target genes for miR-10a-3p revealed that multiple genes are related to binding activity, catalytic activity, cell components as well as cellular and metabolic process. Overall the results imply that the miR-10a-3p could be used as a biomarker to detect VHSV infection in olive flounder and iridovirus infection in rock bream. In addition, the data provides fundamental information for further study of the complex interaction between miR-10a-3p and gene expression.

A Study of Partial Carbonisation for the Development of Pitch Based Carbon Fibres

R.K. Aggarwal,G. Bhatia,V. Raman,M. Saha,A. Mishra 한국탄소학회 2004 Carbon Letters Vol.5 No.1

A study of partial carbonisation of green pitch fibres to temperatures in the range of 500-1000℃ was carried out on three precursors - a neat pitch and two polymer modified pitches, with a view to find out a suitable temperature at which the fibres acquire considerably improved toughness or handleability (compared to that in the green stage) for their subsequent processing into carbon fibres. A partial carbonisation temperature of 500-600℃ has been identified to result in a remarkable improvement in the toughness/handleability of the fibres in all the three cases. However, from techno-economical considerations, the neat pitch appears to provide the best precursor system for the production of pitch based carbon fibres.

Ru–NiO<i>x</i> nanohybrids on TiO₂ support prepared by impregnation-reduction method for efficient hydrogenation of lactose to lactitol

Mishra, Dinesh Kumar,Dabbawala, Aasif A.,Truong, Cong Chien,Alhassan, Saeed M.,Jegal, Jonggeon,Hwang, Jin Soo Elsevier 2018 Journal of industrial and engineering chemistry Vol.68 No.-

<P><B>Abstract</B></P> <P>Lactose is a reducing disaccharide consisting of two different monosaccharides such as galactose and glucose. The hydrogenation of lactose to lactitol is a formidable challenge because it is a complex process and several side products are formed. In this work, we synthesized Ru–Ni bimetallic nanohybrids as efficient catalysts for selective lactose hydrogenation to give selective lactitol. Ru–Ni bimetallic nanohybrids with Ru–NiO<I> <SUB>x</SUB> </I> (<I>x</I> =1, 5, and 10wt%) are prepared by impregnating Ru and Ni salts precursors with TiO<SUB>2</SUB> used as support material. Ru–Ni bimetallic nanohybrids (represented as 5Ru–5NiO/TiO<SUB>2</SUB>) catalyst is found to exhibit the remarkably high selectivity of lactitol (99.4%) and turnover frequency i.e. (374h<SUP>−1</SUP>). In contrast, monometallic Ru/TiO<SUB>2</SUB> catalyst shows poor performance with (TOF=251h<SUP>−1</SUP>). The detailed characterizations confirmed a strong interaction between Ru and NiO species, demonstrating a synergistic effect on the improvement on lactitol selectivity. The impregnation-reduction method for the preparation of bimetallic Ru–NiO/TiO<SUB>2</SUB> catalyst promoted Ru nanoparticles dispersed on NiO and intensified the interaction between Ru and NiO species. Ru–NiO/TiO<SUB>2</SUB> efficiently catalyzed the hydrogenation of lactose to lactitol with high yield/selectivity at almost complete conversion of lactose at 120°C and 55bar of hydrogen (H<SUB>2</SUB>) pressure. Moreover, Ru–NiO/TiO<SUB>2</SUB> catalyst could also be easily recovered and reused up to four runs without notable change in original activity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Highly active supported Ru–Ni bimetallic catalysts with NiO are prepared. </LI> <LI> Bimetallic Ru–5NiO/TiO<SUB>2</SUB> catalyst shows high selectivity to lactitol (99.4%). </LI> <LI> Optimization and kinetics studies of lactose hydrogenation. </LI> <LI> Bimetallic Ru–5NiO/TiO<SUB>2</SUB> catalyst is reused up to several consecutive times. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Experimental characterization of 1-D velocity selection

A. M. Steinberg,S. H. Myrskog,J. K. Fox,L. R. Segal,A. M. Jofre,S. R. Mishra 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.47 No.6

We demonstrate a 1-D velocity selection technique which relies on combining magnetic and optical potentials. We have selected atom clouds with temperatures as low as 2.9 % of the initial temperature, with an efficiency of 1 %. The efficiency (percentage of atoms selected) of the techniquecan vary as slowly as the square root of the final temperature. In addition to selecting the coldest atoms from a cloud, this technique imparts a sharp cut-off in the velocity distribution. The cold selected atoms are confined in a small well, spatially separated from higher energy atoms. Such a non-thermal distribution may be useful for atom optics experiments, such as studies of atom tunneling.

A Study of Partial Carbonisation for the Development of Pitch Based Carbon Fibres

Aggarwal, R.K.,Bhatia, G.,Raman, V.,Saha, M.,Mishra, A. Korean Carbon Society 2004 Carbon Letters Vol.5 No.1

A study of partial carbonisation of green pitch fibres to temperatures in the range of 500-$1000^{\circ}C$ was carried out on three precursors - a neat pitch and two polymer modified pitches, with a view to find out a suitable temperature at which the fibres acquire considerably improved toughness or handleability (compared to that in the green stage) for their subsequent processing into carbon fibres. A partial carbonisation temperature of 500-$600^{\circ}C$ has been identified to result in a remarkable improvement in the toughness/handleability of the fibres in all the three cases. However, from techno-economical considerations, the neat pitch appears to provide the best precursor system for the production of pitch based carbon fibres.

Effect of Sodium Hydroxide plus Hydrogen Peroxide Treated Mustard (Brassica campestris) Straw Based Diets on Rumen Degradation Kinetics (In sacco), Fermentation Pattern and Nutrient Utilization in Sheep

Mishra, A.S.,Misra, A.K.,Tripathi, M.K.,Santra, A.,Prasad, R.,Jakhmola, R.C. Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.3

Two experiments were conducted to determine the effect of alkaline hydrogen peroxide (AHP) treatment (1% NaOH+1.5% $H_2O_2$; 1 AHPMS, 2% NaOH+1.5% $H_2O_2$; 2AHPMS) on rate and extent of degradation of mustard straw (MS) in sacco in sheep, and its in vivo digestion and ruminal fermentation characteristics when fed to sheep with concentrate (200 g per sheep daily). The treatment of straw with 1 and 2% AHP increased its sodium content by 148 and 296% to that of untreated straw (UMS). There was significant decrease in NDF and hemicellulose contents of AHP treated straw and increase in cellulose and lignin contents. Phenolic acids like ferrulic, $\rho$-coumaric and o-coumaric significantly (p<0.001) reduced by AHP treatment of mustard straw. In first experiment the in sacco degradation of DM, OM and NDF was significantly (p<0.01) greater for 2 AHPMS than for UMS at all incubation periods. The disappearance of nutrient from 1 AHPMS and 2 AHPMS treated straws continue to increase up to 96 h whereas in UMS the peak disappearance was found at 48 h. By using the equation {(y=a+b) ($1-e^{-ct}$)} the degradation rates (c) for DM, OM, and NDF were significantly higher for UMS than AHP treated straws. Level of alkali (1 and 2%) had significant effect on degradation characteristics (a, b, c and $P_{0.05}$) of DM and NDF fraction of MS. However, the effect was not pronounced on OM fraction of MS. In feeding experiment, the intake of nutrients for DM, OM, cell wall constituents and energy was higher on 2 AHPMS, whereas no effect on the digestibility of these nutrients was observed. The apparent nitrogen retention was higher (p<0.05) both in 1 and 2 AHPMS groups. Water intake by animals was significantly increased due to AHP treated mustard straw feeding. Rumen liquor pH was higher in 2 AHPMS fed animals. The $NH_3-N$ of rumen liquor was not affected by feeding of AHP treated MS based diets. Total VFA concentration was significantly (p<0.01) higher in UMS fed group. The fractional out flow rate of DM was higher (p<0.05) in animals fed on 2 AHPMS diets compared to UMS and lAHPMS fed groups. The population of large holotrichs was higher (p<0.05) on AHP treated MS fed diets compared to UMS. The study indicated that treatment of mustard straw with AHP changed its chemical composition towards a better feed. The nutritive value of 2% AHP treated mustard straw was better in terms of dry matter intake and apparent nitrogen retention. The higher in sacco DM, OM and NDF disappearance however, was not confirmed by in vivo data in this study.

Three-Phase AC-to-DC Resonant Converter Operating in High Power Factor Mode in High-Voltage Applications

Madhuri A. Chaudhari,Hiralal M. Suryawanshi,Abhishek Kulwal,Mahesh K. Mishra 전력전자학회 2008 JOURNAL OF POWER ELECTRONICS Vol.8 No.1

In this paper a three-phase ac-to-dc resonant converter with high input power factor and isolated output is proposed. To improve the input power factor of the converter, high frequency current is injected into the input of the three-phase diode bridge rectifier. It is injected through an impedance network consisting of a series of L-C branches from the output of the high frequency three-phase inverter. A narrow switching frequency variation is required to regulate the output voltage. A design example with different design curves is illustrated along with the component ratings. Experimental verification of the converter is performed on a prototype of 3 kW, 1000 V output, operating above 300 kHz. Experimental results confirm the concept of the proposed converter. Narrow switching frequency variation is required to regulate the output voltage.

Ru–NiOx nanohybrids on TiO2 support prepared by impregnation-reduction method for efficient hydrogenation of lactose to lactitol

Dinesh Kumar Mishra,Aasif A. Dabbawala,Cong Chien Truong,Saeed M. Alhassan,Jonggeon Jegal,황진수 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.68 No.-

Lactose is a reducing disaccharide consisting of two different monosaccharides such as galactose and glucose. The hydrogenation of lactose to lactitol is a formidable challenge because it is a complex process and several side products are formed. In this work, we synthesized Ru–Ni bimetallic nanohybrids as efficient catalysts for selective lactose hydrogenation to give selective lactitol. Ru–Ni bimetallic nanohybrids with Ru–NiOx (x = 1, 5, and 10 wt%) are prepared by impregnating Ru and Ni salts precursors with TiO2 used as support material. Ru–Ni bimetallic nanohybrids (represented as 5Ru–5NiO/TiO2) catalyst is found to exhibit the remarkably high selectivity of lactitol (99.4%) and turnover frequency i.e. (374 h−1). In contrast, monometallic Ru/TiO2 catalyst shows poor performance with (TOF = 251 h−1). The detailed characterizations confirmed a strong interaction between Ru and NiO species, demonstrating a synergistic effect on the improvement on lactitol selectivity. The impregnation-reduction method for the preparation of bimetallic Ru–NiO/TiO2 catalyst promoted Ru nanoparticles dispersed on NiO and intensified the interaction between Ru and NiO species. Ru–NiO/TiO2 efficiently catalyzed the hydrogenation of lactose to lactitol with high yield/selectivity at almost complete conversion of lactose at 120 °C and 55 bar of hydrogen (H2) pressure. Moreover, Ru–NiO/TiO2 catalyst could also be easily recovered and reused up to four runs without notable change in original activity.

Three-Phase AC-to-DC Resonant Converter Operating in High Power Factor Mode in High-Voltage Applications

Chaudhari, Madhuri A.,Suryawanshi, Hiralal M.,Kulwal, Abhishek,Mishra, Mahesh K. The Korean Institute of Power Electronics 2008 JOURNAL OF POWER ELECTRONICS Vol.8 No.1

In this paper a three-phase ac-to-dc resonant converter with high input power factor and isolated output is proposed. To improve the input power factor of the converter, high frequency current is injected into the input of the three-phase diode bridge rectifier. It is injected through an impedance network consisting of a series of L-C branches from the output of the high frequency three-phase inverter. A narrow switching frequency variation is required to regulate the output voltage. A design example with different design curves is illustrated along with the component ratings. Experimental verification of the converter is performed on a prototype of 3 kW, 1000 V output, operating above 300 kHz. Experimental results confirm the concept of the proposed converter. Narrow switching frequency variation is required to regulate the output voltage.