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( Yoon Jin Ma ),( Hahn Kim ),( Hyun Hwa Lee ) 한국의류학회 2012 한국의류학회지 Vol.36 No.12
This article examines how individual differences on the need for cognitive closure and demographics influence consumer perception and the usage of consumer reviews in online shopping. Data were randomly collected from 2,381 U.S. online consumer review users through an online survey. The findings from multiple regression analyses revealed the different effects of the need for cognitive closure dimensions (i.e., preference for order and structure, preference for predictability, discomfort with ambiguity, closed-mindedness, and decisiveness) and demographic characteristics on consumer attitudes, perceived online review influence, benefits, persuasiveness, and review usage behavior. Finally, practical implications and prospects for future research are discussed.
Cytochrome P450-mediated herb-drug interaction potential of Galgeun-tang
( Sang Yoon Lee ),( Ji Yoon Lee ),( Wonku Kang ),( Kwang-il-kwon ),( Song Kyu Park ),( Soo Jin Oh ),( Jin Yeul Ma ),( Sang Kyum Kim ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
We evaluated the herb-drug interaction potential of Galgeun-tang (GGT) extracts, mediated by cytochrome P450 (CYP) inhibition/induction. Further, the effects of fermentation on the CYP-mediated herb-drug interaction potential of GGT extracts were determined. As measured by LC-ESI/MS/MS, GGT extracts (0-300μg/mL) showed no inhibitory activity toward eight CYP isoforms (1A2, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4) in pooled human liver microsomes, suggesting that GGT may have low potential for herb-drug interactions mediated by CYP inhibition. Hepatic CYP expression and activity in rats treated with GGT extracts twice per day for 1week was examined. Among the tested CYP isoforms (1A1, 1A2, 1B1, 2B1, 2C11, 2E1, 3A1, 3A2, and 4A1), CYP1B1 and 4A1 were increased by GGT extracts. Hepatic activities of 7-ethoxyresorufin-O-deethylase, 7-pentoxyresorufin-O-depentylase, and chlorzoxazone 6-hydroxylase, but not midazolam hydroxylase were also elevated. These results raise the possibility that GGT extracts may increase the toxicity of environmental toxicants through the elevating CYP-dependent metabolic activation. Interestingly, the increases in CYP1B1 and CYP4A1 levels, and 7-ethoxyresorufin-O-deethylase, 7-pentoxyresorufin-O-depentylase, and chlorzoxazone 6-hydroxylase activities were attenuated by fermentation of GGT extract using Lactobacillus plantarum KFRI 402, but not 144. Further studies are needed to identify the CYP regulatory component(s) from GGT and determination its metabolism. ⓒ2012 Elsevier Ltd. All rights reserved.
In vitro and vivo assessment of cytochrome P450-mediated herb-drug interaction of Ssang-hwa-tang
( Sang Yoon Lee ),( Ji Yoon Lee ),( Wonku Kang ),( Kwang Il Kwon ),( Soo Jin Oh ),( Jin Yeul Ma ),( Sang Kyum Kim ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
We have evaluated the herb-drug interaction potential of Ssang-hwa-tang (SHT) mediated by cytochrome P450 (CYP) inhibition/induction. Further, the effects of fermentation on the CYP-mediated herb-drug interaction potential were determined. SHT showed inhibitory activity toward CYP1A2, but not 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, and 3A4 in human liver microsomes. The results of the enzyme kinetic study suggested that the SHT-induced CYP1A2 inhibition is mixed reversible inhibition. The hepatic CYP expression and activity in rats treated with SHT were examined. The expression/activity of CYP2E1 increased as a result of SHT extract treatment (P<0.005 or P<0.001, respectively), which raises the possibility that SHT may increase the toxicity of environmental toxicants through the elevation of CYP2E1-mediated metabolic activation. SHT fermentation using Lactobacillus fermentum or Lactobacillus gasseri resulted in attenuation of the SHT-induced CYP1A2 inhibition, but not CYP2E1 induction, suggesting that changes in the chemical composition of SHT through fermentation can affect the inhibition of CYP1A2 activity. ⓒ2012 Elsevier Ltd, All rights reserved.ⓒ2012 Elsevier Ltd. All rights reserved.
Inhibitory effects of Hwang-Ryun-Hae-Dok-Tang on cytochrome P450 in human liver microsomes
Lee, Sang Yoon,Jang, Himchan,Lee, Ji-Yoon,Ma, Jin Yeul,Oh, Soo Jin,Kim, Sang Kyum Informa UK Ltd. 2015 Xenobiotica Vol.45 No.2
<P>1. The herb-drug interaction potential of Hwang-Ryun-Hae-Dok-Tang (HR) extracts mediated by cytochrome P450 (CYP) inhibition was determined using human liver microsomes.</P><P>2. HR strongly inhibited CYP1A2 and moderately inhibited CYP2C19, CYP2D6, and CYP3A4 (testosterone) but not CYP2A6, CYP2B6, CYP2C8, CYP2C9, and CYP3A4 (midazolam).</P><P>3. The enzyme kinetic results suggest that CYP1A2 inhibition is competitively reversible (K<I><SUB>i</SUB></I>, 13.4 ± 1.8 μg/ml), and CYP2D6 inhibition is quasi-irreversible (K<I><SUB>I</SUB></I>, 0.234 ± 0.138 μg/ml; k<SUB>inact</SUB>, 0.067 ± 0.006 min<SUP>−1</SUP>).</P><P>4. Fermentation using <I>Lactobacillus acidophilus</I> attenuated the HR-induced inhibition of CYP2D6, but not the other isoforms.</P><P>5. Neither CYP1A2 nor CYP3A4 was markedly inhibited by berberine, palmatine, and geniposide—major components in HR—and CYP2D6 was inhibited by berberine (IC<SUB>50</SUB>, 13.8 μg/ml) in a metabolism-dependent manner.</P><P>6. The results suggest the possibility of HR-drug interaction through inhibition of CYP—particularly CYP2D6—which may be attenuated by fermentation using <I>L. acidophilus</I>.</P>
Yoon Jeong Lee,Kyung Ho Ma,Jeong Hoon Lee,Jin Tae Jung,Myeong Won Oh,Young Ho Yoon,Jong Won Han 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Rehmannia glutinosa belongs to the perennial herb of Rehmannia in Scrophulariaceae. Rehmannia glutinosa has been used as an traditional medicine, and is important resource for natural medicines and functional foods. We compared the antioxidant components and antioxidant activity of Rehmannia glutinosa produced in Korea according to the cultivation area(4) and cultivation farms(10). The polyphenol content was found to be in the range of 28.25 to 45.09mg/100g, and the flavonoid content was found to be in the range from 19.43 to 37.70mg/100g. The antioxidant activity showed a tendency to be high in the farms with high polyphenol and flavonoid content. Also, as a result of measuring the antioxidant power(ABTS, and DPPH radical scavenging activity, reducing power activity) according to the farms, the difference was up to 1.5~1.6 times for each farm. Through this study, we could confirm that the antioxidant of Rehmannia glutinosa had a larger difference according to the growing farm than the cultivation area. Furthermore, this result was intended to be used as basic data for high-quality Rehmannia glutinosa production and setting of Rehmannia glutinosa quality standards.
Jin, Rong,Kim, Beg Hab,Ji, Chang Yoon,Kim, Ho Soo,Li, Hong Min,Ma, Dai Fu,Kwak, Sang-Soo Elsevier Science B.V., Amsterdam. 2017 Plant Physiology and Biochemistry Vol. No.
<P><B>Abstract</B></P> <P>Dehydration-responsive element-binding/C-repeat-binding factor (DREB/CBF) proteins regulate the transcription of genes involved in cold acclimation in several species. However, little is known about the physiological functions of CBF proteins in the low temperature-sensitive crop sweetpotato. We previously reported that the <I>DREB1/CBF-like</I> sweetpotato gene <I>SwDREB1/IbCBF3</I> is involved in responses to diverse abiotic stresses. In this study, we confirmed that IbCBF3 is localized to the nucleus and binds to the C-repeat/dehydration-responsive elements (CRT/DRE) in the promoters of cold-regulated (<I>COR</I>) genes. We generated transgenic sweetpotato plants overexpressing <I>IbCBF3</I> under the control of the CaMV 35S promoter (referred to as SC plants) and evaluated their responses to various abiotic stresses. <I>IbCBF3</I> expression was dramatically induced by cold and drought but much less strongly induced by high salinity and ABA. We further characterized two SC lines (SC3 and SC6) with high levels of <I>IbCBF3</I> transcript. The SC plants displayed enhanced tolerance to cold, drought, and oxidative stress on the whole-plant level. Under cold stress treatment (4 °C for 48 h), severe wilting and chilling injury were observed in the leaves of wild-type (WT) plants, whereas SC plants were not affected by cold stress. In addition, the <I>COR</I> genes were significantly upregulated in SC plants compared with the WT. The SC plants also showed significantly higher tolerance to drought stress than the WT, which was associated with higher photosynthesis efficiency and lower hydrogen peroxide levels. These results indicate that IbCBF3 is a functional transcription factor involved in the responses to various abiotic stresses in sweetpotato.</P> <P><B>Highlights</B></P> <P> <UL> <LI> IbCBF3 binds to CRT/DRE in the promoters of <I>COR</I> genes. </LI> <LI> Overexpression of <I>IbCBF3</I> increases cold and drought stress tolerance in sweetpotato. </LI> <LI> <I>IbCOR</I> expression is higher in <I>IbCBF3</I>-overexpressing sweetpotato than in the WT. </LI> </UL> </P>
Yoon Jeong Lee,Kyung Ho Ma,Jeong Hoon Lee,Jin Tae Jung,Myeong Won Oh,Young Ho Yoon,Jong Won Han 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Salvia miltiorrhiza Bunge is a well known and important traditional medicinal herb because of its use in treating cardiovascular and cerebrovascular diseases. In this study, the antioxidant components and activity of ‘DASAN’, the first domestic cultivar of Salvia miltiorrhiza, were compared according to the cultivation period. The polyphenol content of ‘DASAN’ by cultivation period (1, 2 and 3 year) was 574.87, 343.41, and 331 mg/100 g, respectively. In addition, ABTS (255.73 mgAEAC/100 g), DPPH (245.83 mgAEAC/100 g) radical scavenging activity, and reducing activity(33.85 mgAEAC/100 g) of 1-year-olds were higher than those of 2 and 3-year-old. As the cultivation period increased, the antioxidant power showed a tendency to decrease, showing results similar to the results of analysis on the content of antioxidants. These results are considered to be useful data for setting optimal conditions for the cultivation period of ‘DASAN’ to help farmers. In addition, the results suggested that ‘DASAN’ could be considered as a new potential source of natural phenolic antioxidants for food, pharmaceutical, cosmetics or nutraceutical industries.
( Yoon Ho Ja ),( Jin Hee Ma ),( Young Hyo Ahn ) 한국물류학회 2017 The Pan-Pacific Journal of Supply Chain Management Vol.1 No.1
In this study, we compare the management efficiency and productivity of Korean, Japanese and global logistics companies using DEA (Data Envelopment Analysis) model and Malmquist Productivity Index for three years from 2011 to 2013. Our results indicate that Hyundai Glovis, Pantos Logistics, Samsung Electronics Logitech, Hwaseung Networks, Yusen Logistics, Kuehne + Nagel, C.H. Robinson are considered to be benchmark firms. Based on the data of 2013, we analyzed the profitability and marketability of all companies. As a result, the number of firms with low marketability and profitability is 21 in total, accounting for more than half of the 30 firms analyzed. Overall, most logistics companies seem to be in need of efficiency improvement. As a result of marketability and profitability analysis, Korean companies, which are highly marketable, mainly have large corporations as parent companies. In Korea, large logistics companies are mainly focused on two-party logistics rather than three-party logistics, despite being logistics specialists.