조화

이종헌 안암어문학회 1956 어문논집 Vol.1 No.1

리브-웨브형 정밀단조에 관한 상계요소해석

이종헌,김영호,배원병 대한기계학회 1995 대한기계학회논문집 Vol.19 No.5

An upper bound elemental technique (UBET) program has been developed to analyze forging load, die-cavity filling and effective strain distribution for flash and flashless forgings. The simulation for flash and flashless forgings are applied axisy mmetric and plane-strain closed-die forging with rib-web type cavity. Inverse triangular and inverse trapezoidal elements are used to analyze flashless forging. The analysis is described for merit of flashless precision forging. Experiments have been carried out with pure plasticine billets at room temperature. Theoretical predictions of the forging load and the flow pattern are in good agreement with experimental results.

고온 연강 유동특성을 상사하는 모델재료 개발에 관한 연구

이종헌,김영호,배원병,이원화 대한기계학회 1993 대한기계학회논문집 Vol.17 No.5

본 연구에서는 모델실험을 통해 실제재료에 관한 정량적인 정보를 얻기 위하 여 모델재료인 플리스티신에 라놀린(lanolin), 레진(resin)등을 첨가하여 새로운 유 동특성을 갖는 혼합 플라스티신을 개발하고자 하였다. 개발된 모델재료와 기존의 플라스티신을 MTS(Material Testing System)을 이용하여 링 압축실험과 실린더 압축 실험으로 온도와 변형률속도 변화에 따라 재료에 혼합된 첨가제가 모델재료의 마찰 특성과 기계적 성질에 미치는 영향을 조사하고 비교 검토하고자 한다. 또한 실제 재료의 다양한 가공공정을 시뮬레이션하기 위한 모델재료의 상사실험에서 다이와 소재 의 분리가 비교적 용이한 윤활제로 실링 페이퍼(sealing paper), 바셀린(vaseline)을 바른 실링페이퍼, 파우다(talc powder)의 마찰특성에 대해서도 연구되었다.그리고 조사된 모델재료들이 연강인 0.15%C강의 고온 (900.deg. C∼1100.deg. C)에서의 온도변화에 따 른 상사재료로 사용될 수 있는지의 타당성을 검토하고자 한다. Model materials are developed to achieve similarity of flow patterns for mild steels in forming processes at high temperatures. The model materials consist of pure plasticine and one or two additives such as resin and lanolin. To verify the similarity of flow patterns between physical modeling and compression of mild steels at high temperatures, ring and compression tests have been carried out with the developed-model materials at various strain rates, temperatures and lubricants. The test results are in good agreement with the flow patterns obtained from upsetting of a mild steel at high temperatures.

삼국지 명구선 ( 2 ) : 역사란 분열과 통합의 연속 - 천하대세 분구필합 합구필분 -

이종헌 전국한자교육추진총연합회 2002 한글한자문화 Vol.33 No.-

Cyclosporin A Enhance Docetaxel Induced Apoptosis in Immortalized Human Oral Keratinocyte and Human Oral Squamous Cell Carcinoma Cell Line

이종헌,송영성,박경주 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.2

Oral squamous cell carcinoma (SCC) is one of the leading causes of cancer mortality worldwide. It is generally thought that adjuvant chemotherapy provides modest prolongation of survival in various carcinoma. Docetaxel (Taxotere, TXT) play a significant role in the treatment of various solid tumors of epithelial origin. CsA (immunosuppressive drug) was widely used as adjunct for the treatment of cancer. Thus, it is important to pursue the apoptosis of IHOK and oral SCC induced by TXT combined with CsA related to the pathogenesis of oral SCC. But TXT combined CsA effect on IHOK and oral SCC remains unclear. After cultured IHOK and HN 22 oral squamous cell carcinoma cell line treated by 10 nM TXT and 1 μM, and caspase inhobitor, respectively, apoptosis index, cytochrome c and caspase-3 -8, -9 mRNA expression by RT-PCR, and procaspase-3 protein amount by immunoslot blotting was prepared. The purpose of this study were to examine the TXT-induced apoptosis pathway via caspase activation by CsA enhancement, and to apply these results to an effective therapeutic treatment plan for oral SCC by TXT combined CsA . 10 nM TXT showed about 60%, 55% celluar apoptosis of IHOK and HN 22, cell line, respectively, while CsA alone did not induce apoptosis in IHOK and HN 22 cell line. 1 μM CsA combined with 10 nM TXT increased apoptosis in IHOK and HN 22 cell line through caspase-3 and cytochrome c mRNA expression, while could not effect on caspase-8 and -9. Caspase inhibitor suppressed apoptosis of IHOK and HN 22 cell line induced by a combination of 1 μM CsA and 10 nM TXT. Immnoslot blotting showed procaspase-3 activation by a combination 1 μM CsA and 10 nM TXT, while caspase inhibitor inhibited activation. It suggested that a combination of CsA and TXT might induce increased apoptosis of IHOK and HN 22 oral squamous cell carcinoma cell line through caspase-3 activation. This treatment with a combination of TXT and CsA may be an effective therapeutic strategy for oral squamous cell carcinoma.

비틀림을 이용한 후방압출에 관한 연구

이종헌,김진욱 한국기계기술학회 2002 한국기계기술학회지 Vol.4 No.2

Higher Expression of Urokinase - type Plasminogen Activator And Plasminogen Activator Inhibitor Type 1 in SGT Cell Line

이종헌,유상원,박경주 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.3

Urokinase-type plasminogen activator (uPA) and plasminogen activator type 1 (PAI-1) inhibitor contribute to the invasiveness of many carcinomas. It will be helpful to study clinical behavior of patients with malignant tumor by analysis of their expression. Expression of uPA and PAI-1 in human salivary gland tumors has been rarely reported in vitro. The purpose of this study were to investigate the protein expression of uPA and PAI-1 in SGT cell line compared to oral SCC and HeLa cell lines and to study migration and adhesion assay. All the cell lines were cultured under DMEM with 10% FBS at at 37oC in a 5% CO2 incubator. We studied a possible association between cytosolic uPA and PA-1 concentrations in SGT cell line compared to any other cell lines through cell migration and adhesion assay, and enzyme-linked immunoassay(ELISA). In migration assay SGT cell line was about 2 .5-4 folds higher than another cell lines. In adhesion assay SGT cell line was about 1.1-2 folds higher than another cell lines. uPA cytosolic concentrations of SGT cell line was about 3-10 folds, while PAI-1 was about 2.5-10 folds. Oral SCC cell lines were the lowest value. Both uPA and PAI-1 concentrations were correlated with migration and adhesion assay. High cytosolic concentrations of uPA and PAI-1 was correlated with migration and adhesion assay. It suggested that these markers might be specific marker for SGT cell line and would be contributed to treatment and prognosis of human salivary gland adenocarcinoma.

Transgluraminase 2 Expression Was Associated with Nuclear Factor Kappa in Salivary Gland Tumor Cell Line

이종헌,김인수,박경주 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.2

The transcription factor nuclear factor-kB (NF-kB) plays an important role in regulating cell growth, apoptosis,and metastatic functions. Constitutive activation of NF-KB has been observed in various cancers; however, molecular mechanisms resulting in such activation remain elusive. Numerous evidences showed that over expression of TGase 2 might be linked with constitutive activation of NF-KB. To understand the pathways responsible for constitutive activation of NF-kB is important for rational design of NF-kB inhibitors for cancer therapy. Human salivary gland adenocarcinoma has been most aggressive solid tumors. Current therapy does not significantly improve survival rates. Thus, to investigate new therapeutic modalities against this adenocarcinoma is necessary. The purpose of this study was to study a constitutive activation of NF-kB with the expression of TG2 in SGT cell line origianted from human salivary gland adenocarcinoma by TGase 2 activity, RT-PCR and immunoslot blotting method. SGT cell line showed the highest TGase 2 activity and NF-kB activation than any other cell line. All the cell lines showed increased NF-kB mRNA activation after A231027 treatment than that of control. In immunoslot blotting,SGT cell line showed NF-kB activation correlated with TGase 2 expression after A231027 and BSA. It suggested that there might be a direct correlation between TGase 2 expression and NF-kB activation in SGT cell line.

북한 핵문제의 경제학적 고찰

이종헌 한국국방연구원 2008 국방정책연구 Vol.23 No.4

This paper is aimed at exploring motives behind North Korea’s nuclear aspirations by employing an economic framework of analytical tools. Applying the concepts of utility and efficiency helps understand puzzling political behaviors. The rational choice model provides an effective tool for understanding North Korea’s behaviors, which appeared irrational, unreasonable and often mysterious, as shown the choice of nuclear weapons. Behavioral economics, a sub-field combining psychology and economics, can also be fruitfully applied to explain behaviors that hardly be understood as rational. This research examines North Korea’s nuclear choice from these two points of view. From rational choice terms which assumes leaders are self-interested and calculate costs and benefits of alternative course of actions that maximize their utility, North Korea’s nuclear option is the outcome of the process of goal-setting, recognition of circumstances and choice of the best option to achieve the goal of survival in the face of threats from the outside. This research analyzes the country's “goal”, “recognition” and “choice” under the rational choice framework. This paper also uses behavioral economics approach, which shows that North Korea’s decision to develope nuclear weapons might be motivated by the leader’s prompt emotions, such as flash antagonism against foreign enemies rather than rational calculation.

결합조직형성 법랑모세포종의 면역조직화학연구

이종헌 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.4

Desmoplastic ameloblastoma(DA) is histologically characterized by extensive stromal collagenization or desmoplasia. ln this study, anti-cytokeratin 8/18, 13, 19 for pathogenesis as well as anti-PCNA for cellular proliferation, were used to det ect the expression of these proteins in the desmoplastic ameloblastoma Basal layers of tumor nest were negatively stained by CKl3, while suprabasal and inner cells were positive for CK13. CK8/18 and CK 19 was negatively stained in the peripheral portion of tumor nest in DA, whereas CK 8/18 was in central portion and CKl9 was positive in the su prabasal and some of central portion of the cel l nest. PCNA index of DA was 60 ::!: 14.6% to 95 ::!: 17 .2%. The peripheral tumor cells of the islets presented higher PCNA labeling index, while some cells in the central area of foll icle containing squamous like cells also presented negative PCNA labeling index. Especially tumor islands showed higher PCNA index than in main tumor mass. lt suggested that desmoplastic ameloblastoma might be composed of many different tumor cell types‘ and have hi gher pr이 ife r a ting activity in tumor islands of the desmoplastic stroma