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김성진,박석건,한동선,김성숙,Kim, Sung-Jin,Park, Seok-Gun,Han, Dong-Sun,Kim, Sung-Sook 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.2
We report a case of hepatoma with duodenal metastasis in a 53 year-old male patient. Hepatoma was confirmed by fine needle aspiration cytology technique, and duodenal metastasis by gastrofiberscopic biopsy. Duodenal metastasis of hepatoma is rare. We briefly review the role of fine needle aspiration cytology technique in diagnosis of hepatoma.
간흡충 감염에 의한 간내담도의 낭성변화와 동반된 아메바성 농양 - 세침흡인 세포학적 검사로 진단된 1례 -
김성숙,김정란,이현경,이승희,한동선,홍성태,Kim, Sung-Sook,Kim, Jung-Ran,Lee, Hyeon-Kyeng,Lee, Sung-Hee,Han, Dong-Sun,Hong, Sung-Tae 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2
Clonorchiasis is common in Korea. The coinfection of amebic abscess with clonorchiasis is not rare in endemic areas. The coinfection may influence on its manifestations each other. We experienced a human case with unusal manifestation of amebic liver abscess associated with coinfection by Clonorchisis sinensis. The case was an 80-year-old female. She lived in Yongil-gun, Kyongsangbuk-do, Korea, She had multiple amebic abscess cavities in the liver, one of which subsided spontaneously and others newly appeared. She was diagnosed by CT guided aspiration of the cyst, which revealed trophozoites of ameba and eggs of C. sinensis. She was treated with praziquantel and metronidazale and was cured.
가토 압력과부하 심근비후에서의 Nuclear DNA 의 변화
김도헌(Do Heon Kim),이예봉(Ye Bong Lee),한동선(Dong Sun Han),이학중(Hak Choong Lee),박이태(Yee Tae Park),김성숙(Sung Sook Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.3
N/A Background: During the development of cardiac hypertrophy, cytoplasmic contents of cardiac myocytes usually increase and nuclei of myocytes change as well. We used flow cytometry to study the changes of nuclear DNA in cardiac hypertrophy which was experimentally produced by aortic banding in New Zealand White Rabbits. This study was aimed to see how early these nuclear changes can occur and whether these changes correlate to the degree of cardiac hypertrophy. Methods: Each two rabbits were sacrificed at 0-,4-,8-,12- hours, and 1-,2-,4-,5-, and 9- days after experimental aortic constriction and their hearts were studied with flow cytometric analysis. Nuclear DNA was analyzed with FACScan (Becton-Dickinson Co.) after tissue preparatian using modified Hedley and Vindelov method, and staining with Krishan staining buffer. Results: The heart weight to body weight ratio (g/kg) increased progressively as a results of time lapsing after aortic banding. In control hearts (Group I ), flow cytometric analysie showed normal Diploidy pattern in all tissues. In hypertrophied hearts, Proliferative Indicies (S+GM Phase) were increased progressively in Group II (4, 8, 12 hours after aortic banding) and Group III (24 hours to 9 days after aortic banding). An Aneuploidy pattern was noticed in a severely hypertrophied heart produced 9 days aortic banding. Conclusions: Changes of nuclear DNA developed even in the early times in the experimental model of pressureoverload cardiac hypertrophy of rabbit after aortic banding and it was roughly correlated with the degree of heart hypertrophy. Abnormal DNA ploidy pattern can be observed in the severely hypertrophied heart.
실험적으로 일이킨 백서에서의 바이러스성 심근염에 대한 연구
박언휘(Eun Hwi Park),김흥주(Heung Joo Kim),김성진(Sung Jin Kim),방인숙(In Sook Bang),박성진(Seong Jin Park),구정완(Jung Wan Ku),윤성철(Sung Chul Yun),한동선(Dong Sun Han),정준호(Joon Ho Jung),김성숙(Sung Sook Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.1
N/A Background: The authors injected EMC virus (Encephalomyocarditis virus) to induce viral myocarditis in ICR mice in order to study the survival rate and serial histopathologic change of viral myocarditis according to duration. Methods: Seventy adult male ICR mice of 8 to 10 weeks were used for experiment. Among 70 mice, 40 mice (Group I) were used to observe survival and 30 mice (Group II) were used to see serial histopathologic change (Each 5 mice were killed before and 5, 10, 20 days after virus injection). The hearts of animals were fixed in 10% buffered formalin and routinely processed. Hematoxylin & Eosin stain and Masson trichrome stain were done to observe inflammation and fibrosis. Results: 1) In Group I, 1 mouse died at each 2, 4, 5, 6 day after virus injection, and 4 mice died at 7 day and 2 mice died at 10 and 11 day. Total 10 animals among 40 died (mortality: 25%), and showed peak death period at 4-7 days, 2) In Group II, at 5th, 10th, 20th day after virus injection, average inflammatory grade in the myocardium were 1.8, 3.4, 2.0, respectively. 3) Histologic findings revealed monouclear cells infiltration, myofiber necrosis & degeneration. These changes occur multifocally rather than diffusely. Inflammation was most severe at 10 days. 4) Fibrosis was increased at 20 days after virus injection compared to early phase of myocarditis. Distribution of fibrosis is relatively parallel with the area of inflammation, but not with the degree of inflammation. 5) In some cases, dilation of both atriums and ventricles and thrombosis accompaning severe pulmonary congestion and edema were observed, indicating possible transition to dilated cardiomyopathy. Conclusions: It is considered that this experimental animal model may be useful not only to study the pathogenetic mechanisms of viral myocarditis but also to observe clinical course and evaluate the effect of possible drugs to treat myocarditis.
비후된 심근에서의 유세포 분석을 통한 Nuclear DNA 의 관찰
김성진(Sung Jin Kim),방인숙(In Sook Bang),박언휘(Eun Hwi Park),김홍주(Heung Joo Kim),김도헌(De Heon Kim),이예봉(Ye Bong Lee),윤성철(Sung Chul Yun),한동선(Dong Sun Han),김성숙(Sung Sook Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.2
N/A Background: During the development of the cardiac hypertrophy, cytoplasmic contents of cardiac myocyte usually increase, but the changes in the nucleus of myocytes are not well understood. Therefore, we used flow cytometry to study the changes of nuclear DNA in cardiac hypertrophy from human autopsy heart tissue. Besides, we also tried to see the DNA ploidy of developing heart of fetus. Method: Nine hypertrophied human hearts ranging from 350-620 g (Group II: 350-500 g, Group III: > 500 g) and 9 control hearts (Group I: 250-350 g) which we could obtain after the legal autopsy were studied with flow cytometric analysis. And 3 fetal hearts of 20-24 gestational weeks (Group IV) were also studied. Nuclear DNA was analyzed with FACScan (Becton-Dickinson Co.) after tissue preparation using Modified Hedley and Vindelov Method and staining with Krishan staining buffer. Results: In control hearts (Group I), Flow cytometric analysis showed normal Diploidy pattern in all tissue. However, in cardiac hypertrophy, Non-Diploidy pattern was predominant (3 out of 5 specimen in Group II, and all 4 specimen in Group III) and Tetraploidy was usually observed in this abnormal ploidy pattern, but Aneuploidy was also seen in 2 cases of severe hypertrophy of Group III. Proliferative indexes increased progressively in Group I, II, and III (17.8±5.55, 24.8±7.4%, and 36.4±5.2%, respectively) (p<0.05 between Group I and II, and p<0.01 between Group I k III). Normal growing heart tissue of fetus showed normal Diploidy pattern. Conclusions: In cardiac hypertrophy, abnormal nuclear DNA ploidy pattern can be obseved. This finding might say that, during the genesis of cardiac hyper- trophy, not only cytoplasmic change but also DNA synthesis in the nucleus occurs, but G2 phase arrest happens without further mitosis.
장태원(Tae Won Jang),서보원(Bo Won Seo),김중경(Jung Kyung Kim),정만홍(Man Hong Jung),주운수(Woon Soo Joo),한동선(Dong Sun Han),이재우(Jae Woo Lee) 대한내과학회 1989 대한내과학회지 Vol.36 No.5
N/A To evaluate the effect of chronic alcohol ingestion on heart function, we performed a controlled study with 40 alcoholics and 34 non-alcoholics. The alcoholics ingested more than 90 grams of ethanol per day over 10 years, without any symptoms related to heart failure. Left ventricular size, ejection fraction, fractional shortening, LV mass, systolic time intervals, and transmitral flow velocities were measured by non-invasive methods using EKG, phonocardiogram, carotid pulse tracing, M mode and Doppler echocardiography. The results were as follows 1) Average daily alcohol consumption was 144±80.2 g/day of ethanol in alcoholics and 2.7±5.1 g in non- alcoholics. 2) There were no statistically significant differences in the left ventricular dimensions, ejection fraction, fractional shortening, left ventricular mass and systolic time intervals between the 2 groups. 3) Transmitral flow velocity in alcoholics showed an early peak flow velocity (EPFV) and atrial peak flow velocity (APFV) of 45±9cm/sec and 51.7±9cm/sec, and in non-alcoholics, 51.2±11.4 cm/sec and 46.9±9.3 cm/sec, respectively. Early to atrial peak flow velocity ratio (EPFV/APFV) was 0.895±0.245 in alcoholics and 1.135±0.333 in non-alcoholics, which was statistically significant (p<0.005). The results suggest that left ventricular dysfunciton may present in alcoholics before the development of alcoholic cardiomyopathy and that diastolic dysfunction precedes systolic dysfunction.
大氣汚染物質의 變異原性에 關한 硏究 : 마우스 母體 및 胎仔의 小核試驗을 中心으로
韓東宣,車喆煥,張聖薰,裵思相 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.3
This Study aimed at identifying the cytogenic effect of air pollutants in pregnant mouse and her fetus. Samples of air pollutants were collected by the high volume air sampler in several sites of Seoul from May through December in 1988. Total suspended particulates (TSP) were measured and those of benzene and methanol were extracted and dissolved in dimethyl sulfoxied (DMSO). Those were injected into peritoneal cavity by the concentration and the micronucleated polychromatic erythrocyte (MNPCE) was observed in the bone marrow of mother mice. IN addition, the liver of fetus was extracted and MNPCE was observed. Transplacental genetic toxicity due to air pollutants in both cases was measured in the end. 1. In case of the tar concentration equivalent to those residing in the volume of 100m³ of air, the MNPCEs in the mother's bone marrow were 0.57±0.15% and 0.70±.20% in Shinchon; 0.27±0.17% and 0.40±0.13 In Jungrung and in the underground shopping center ; 0.33±0.10% and 0.55±0.13% in the subway station. The MNPCEs measured in the sample of the tunnels, of which tar concentration was equivalent to that in 50m³ and 100m³ of air, were 0.86±0.24% and 1.06±0.17% in tunnel A and 0.70±0.15% and 0.96±0.23% in tunnel B; those were the highest MNPCE in the samples of mother mice. 2. The MNPCEs measured in the liver of featus were 0.60±0.25% and 0.80±0.15% in Shinchon. In Jungrung and the underground shopping center, the MNPCEs in the liver of fetus were the same as those in mothers. In the sample of the subway station, the MNPCEs in the liver of fetus, 0.73±0.20%, were higher than in mothers only in the 200? tar concentration. The MNPCEs in the 50m³ and 100m³ tar concentration were 0.87±0.10% and 1.27±0.27% in tunnel A, and 0.68±0.41% and 1.07±0.23% in tunnel B. It showed that the MNPCEs only in the 100m³ tar concentration were higher than those in mothers.