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RISS 인기검색어
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- 저자 : 裵思相 (검색결과 2 건)
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벤젠이 마우스 胎仔 肝組織細胞의 小核出現에 미치는 經胎盤效果
李在東,車喆煥,裵思相 고려대학교 의과대학 1988 고려대 의대 잡지 Vol.25 No.3
To investigate the transplacental effects of benzene inducing cytotoxicity of fetal mouse liver, number of micronuclei in cells tissue extraced from fetus of which dams were administered with benzene per os by doses of 0.5, 1.0, and 2.0 ml/kg were measured. Furthermore, vitamine C was administered to check whether it inhibits the production of micronucleus when exposed to benzene at the same time. On the other hand, alcohol was also administered to check whether it increases the production of them. The summarized results were follows; 1. The frequency of micronuclei produced from liver cells of fetus whose dams were administered with benzene by single doses of 0.5, 1.0, and 2.0 ml/kg body wt. were 1.89±0.49, 2.16±0.76 and 3.94±0.22% each, whereas it was 1,41±0.27% in normal group. 2. In cases of additional doses of 0.5 and 1.0ml/kg body wt. after 6 hours of initial same doses, the frequencies of them were 2.48±0.67 and 3.18±0.37% each which were significantly higher than those of single dosed group. 3, When 2g/kg body wt. of vitamine C was administered at the same time with 0.5ml/kg body wt. of benzene administration, the frequency of micronuclei produced was 1.45±0.37% which was not different from that of normal group. In cases of 1ml/kg of benzene and 2g/kg of vitamine C administration, it was1.67±0.26% which was significantly lower than that of benzene alone treated group. 4. Alchohol (2m1/kg body wt.) was also administered together with 0.5ml/kg of benzene and 3.20±0.56%, fetal cells showed micronuclei which was significantly higher than 1.89 ±0.49% of benzene alone treated group.
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大氣汚染物質의 變異原性에 關한 硏究 : 마우스 母體 및 胎仔의 小核試驗을 中心으로
韓東宣,車喆煥,張聖薰,裵思相 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.3
This Study aimed at identifying the cytogenic effect of air pollutants in pregnant mouse and her fetus. Samples of air pollutants were collected by the high volume air sampler in several sites of Seoul from May through December in 1988. Total suspended particulates (TSP) were measured and those of benzene and methanol were extracted and dissolved in dimethyl sulfoxied (DMSO). Those were injected into peritoneal cavity by the concentration and the micronucleated polychromatic erythrocyte (MNPCE) was observed in the bone marrow of mother mice. IN addition, the liver of fetus was extracted and MNPCE was observed. Transplacental genetic toxicity due to air pollutants in both cases was measured in the end. 1. In case of the tar concentration equivalent to those residing in the volume of 100m³ of air, the MNPCEs in the mother's bone marrow were 0.57±0.15% and 0.70±.20% in Shinchon; 0.27±0.17% and 0.40±0.13 In Jungrung and in the underground shopping center ; 0.33±0.10% and 0.55±0.13% in the subway station. The MNPCEs measured in the sample of the tunnels, of which tar concentration was equivalent to that in 50m³ and 100m³ of air, were 0.86±0.24% and 1.06±0.17% in tunnel A and 0.70±0.15% and 0.96±0.23% in tunnel B; those were the highest MNPCE in the samples of mother mice. 2. The MNPCEs measured in the liver of featus were 0.60±0.25% and 0.80±0.15% in Shinchon. In Jungrung and the underground shopping center, the MNPCEs in the liver of fetus were the same as those in mothers. In the sample of the subway station, the MNPCEs in the liver of fetus, 0.73±0.20%, were higher than in mothers only in the 200? tar concentration. The MNPCEs in the 50m³ and 100m³ tar concentration were 0.87±0.10% and 1.27±0.27% in tunnel A, and 0.68±0.41% and 1.07±0.23% in tunnel B. It showed that the MNPCEs only in the 100m³ tar concentration were higher than those in mothers.
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