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miRNA, PPI, 질병 정보를 이용한 마이크로어레이 데이터 통합 모델 설계
하경식(Kyung-sik Ha),임진묵(Jin-muk Lim),김홍기(Hong-gee Kim) 한국지능시스템학회 2012 한국지능시스템학회논문지 Vol.22 No.6
마이크로어레이는 수만 가지 이상의 DNA 또는 RNA를 기판위에 배열해 놓은 것이며 이 기술을 이용하여 대량의 유전자 발현을 탐색할 수 있게 되었다. 그렇지만 마이크로어레이는 실험자가 탐색하려는 특정 표현형에 대해서 설계된 실험방법을 이용하므로 제한된 숫자의 유전자 발현만을 관찰할 수 있다. 본 논문에서는 MicroRNAs(miRNAs)와 Protein-Protein Interaction(PPI) 정보를 포함하고 있는 데이터베이스를 활용하여 마이크로어레이 데이터의 의미적 확장 방법을 제시하고자 한다. 또한 Online Mendelian Inheritance in Man(OMIM) 및 International Statistical Classification of Diseases and Related Health Problems, 10th Revision(ICD-10)을 이용하여 질병 간 유전적 공통점 파악을 시도하였다. 이러한 접근방법을 통하여 새로운 생물학적 시각을 제공 할 수 있을 것으로 기대된다. A microarray is a collection of thousands of DNAs or RNAs arranged on a substrate, and it enables one to navigate large amounts of gene expression. However, a researcher uses his designed experimental methods to focus on particular phenotypes from the available mass of data. In this paper, we used MicroRNAs(miRNAs) and Protein-Protein Interation(PPI) databases to enhance and expand meanings in microarray data. Further, the expanded data are linked with the Online Mendelian Inheritance in Man(OMIM), and International Statistical Classification of Diseases and Related Health Problems, 10th Revision(ICD-10), in order to extract common genetic relationships between diseases. This approach, we expect, should provide new biological views.
가미사칠탕(加味四七湯)이 구속 Stress 생쥐의 뇌 부위별 Serotonin 함량에 미치는 영향
전찬용,박종형,한양희,김동우,박세기,최유경,백은기,한지완,하경식,홍의실,Jun, Chan-Yong,Park, Jong-Hyung,Han, Yang-Hi,Kim, Dong-U,Park, Se-Gi,Choi, You-Kyung,Baek, Eun-Gi,Han, Ji-Wan,Ha, Kyung-Sik,Hong, Ui-Sil 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.1
Background and Objectives ; This experimental study was conducted to evaluate an anti-stress effect of Gamisachi-tang(加味四七湯) on mice immobilized by stress. Methods : The experimental animals were immobilized by stress for 15 minutes, and administered 9mg/20g or 18mg/20g of Gamisachi-tang(加味四七湯) extract for seven days before they got stressed. The serotonin contents in the frontal cortex, hypothalamus, corpus striatum, hippocampus were measured by HPLC method in rat brain. Results : In frontal cortex, serotonin contents significantly decreased in both sample A and B group compared to the controlled group. In the hypothalamus, serotonin contents increased in both sample A and B group compared to the controlled group. In the corpus striatum, serotonin contents significantly increased in both sample A and B group compared to the controlled group. In the hippocamous, serotonin contents significantly increased in both sample A and B group compared to the controlled group. Conclusions : According to the above results, Gamisachi-tang(加味四七湯) had a significant impact on the changes in serotonin contents, which occurred in a separated part of mouse brain caused by stress.