약용식물 17종 메탄올 추출물의 유기질문화재 생물학적 열화원에 대한 항진균 및 살충활성 조사

임진아,최윤아,정미화,강소영,정용재,Lim, Jin-A,Choi, Yun-A,Jung, Mi-Hwa,Kang, So-Yeong,Chung, Yong-Jae 국립문화재연구소 2008 保存科學硏究 Vol.29 No.-

To investigate bioactive materials for development of natural conservative agent on organic cultural heritage, methanol extracts from 17 medicinal plants were screened for antifungal and insecticidal activity against 6 wood rot fungi and adult of Lasioderma serricorne. Antifungal activity of extracts was tested by using paper disc soaking method against wood-rot fungi. Among these extracts, the most significant antimicrobial activity was observed from the extract of Coptis japonica at 5 mg/disc against all wood rot fungi tested. The insecticidal activity of extracts was examined by topical application against L. serricorne adults. The extracts from Asarum sieboldii gave 83.3 % mortality at $25{\mu}g/adult$ for 24hr. From these result, the methanol extract from C. japonica and A. sieboldii described could be useful for conservation of organic cultural heritage against biological deterioration by wood rot fungi and L. serricorne.

국내산 수목 추출물의 항진균 및 살충활성

임진아,최윤아,정미화,강소영,정용재,Lim, Jin-A,Choi, Yun-A,Jung, Mi-Hwa,Kang, So-Yeong,Chung, Yong-Jae 한국문화재보존과학회 2008 보존과학회지 Vol.23 No.-

유기질 문화재 보존 천연 살생물제 개발을 위한 후보물질 조사를 위해 국내 자생하는 11종 수목을 대상으로 각 수목 메탄올 추출물의 9종 목재오염균과 궐련벌레 성충에 대한 항진균 및 살충활성을 조사하였다. 항진균 활성은 목재부후균과 표면오염균에 대해 각각 paper disc soaking 방법과 feeder strip 방법으로 측정되었다. 그 결과, 수목 중 황벽(Phellodendron amurense) 메탄올 추출물은 5 mg/disc에서 Coniophora puteana, Lentinus lepideus, Tyromyces palustris 그리고 Aspergillus niger에 대해 우수한 항균활성을 나타냈다. 또한, 수목 메탄올 추출물의 살충활성은 topical application 방법에 의해 측정되었으며 특히 주목(Taxus cuspidata)과 전나무(Abies holophylla) 메탄올 추출물을 궐련벌레 성충에 25 ${\mu}g$/adult의 농도로 24시간 처리했을 때 56.7%의 치사율을 보였다. 위의 결과로부터 주목과 전나무 그리고 황벽 메탄올 추출물은 각각 충과 목재오염균에 의해 야기되는 생물학적 열화에 대한 유기질 문화재 보존을 위해 유용하게 사용가능할 것으로 사료된다. To investigate bioactive materials for development of natural conservative agent on organic cultural heritage, methanol extracts from 11 wood species which populate in Korea were screened for antifungal and insecticidal activity against 9 wood contaminant fungi and adult of Lasioderma serricorne. Antifungal activity of extracts was tested by using paper disc soaking method and feeder strip test against wood-rot fungi and wood surface contaminant fungi. Among these extracts, the most significant antimicrobial activity was observed from the extract of Phellodendron amurense at 5 mg/disc against Coniophora puteana, Lentinus lepideus, Tyromyces palustris and Aspergillus niger. The insecticidal activity of extracts was examined by topical application against L. serricorne adults. The extracts from Taxus cuspidata and Abies holophylla gave 56.7 % mortality at 25 ${\mu}g$/adult for 24 hr. From these result, the methanol extract from T. cuspidata, A. holophylla and P. amurense described could be useful for conservation of organic cultural heritage against biological deterioration by insect and wood contaminant fungi.

목재문화재 보존을 위한 수목추출물의 부위별 생리활성 탐색

강소영,최윤아,정용재,Kang, So-yeong,Choi, Yun-a,Chung, Yong-jae 국립문화재연구소 2007 保存科學硏究 Vol.28 No.-

Wooden artifacts are biologically damaged by animals, insects, and micro-organisms. We focused on the evaluation of the antifungal and insecticidal activities of tree extracts to control deterioration of wooden cultural properties. 12 kinds of methanol extracts from 9 species of tree were investigated for their biocidal activities against two micro-organisms and two spices of insect. Most tree extracts showed fungicidal activities to Tyromyces palustris and Trametes versicolor. Among 12 different tree extracts, the strongest antifungal activity against T.palustris and T.versicolor was observed from the extracts of Pinus densiflora stem-bark extract and Pinus koraiensis leaf extracts. However, in the insecticidal activity test, Pinus densiflora stem-bark extracts against termite was relatively effective. Chemical compositions of methanol extracts were analyzed by gas chromatography/mass spectrometry. As a result, it was confirmed that development of biocide based on the natural extracts can be expected to conservate of wooden cultural properties.

오동나무상자의 항균활성 분석 및 활성 증진을 위한 천연 살생물제 적용연구

정용재,강소영,최윤아,Chung, Yong-Jae,Kang, So-Yeong,Choi, Yun-A 한국문화재보존과학회 2008 보존과학회지 Vol.24 No.-

고문서 보관을 위해 사용되고 있는 오동나무상자의 항균활성을 측정하기 위해 오동나무로부터 방출된 휘발성 물질에 대한 항균활성과 휘발성 유기물질의 주성분을 정성분석 하였다. 항균활성은 상자 내부에 TSA 배지를 장착한 미생물 포집기를 설치하고 포집 후 배지에 성장한 미생물의 집락수를 관찰하였다. 그 결과 실외에서 포집한 배지의 집락수 85개 대비 14.82%가 감소한 72개 집락수가 관찰되었다. 포집된 공기질을 열탈착시스템 및 가스크로마토그래피/질량분석법을 통해 분석한 결과, 오동나무 상자 내 VOCs에서 limonene이 특징적으로 검출되었다. Eugenol과 anethole을 주성분으로 하는 천연 살생물제 I과 II를 상자 내에 첨가하여 훈증에 의한 항균활성을 측정한 결과, 약제 모두 실외와 오동나무 상자 내부에서 포집된 미생물 개체수 대비 각각 92.6%, 99.9% 이상 감소율을 보였다. 위의 결과로부터 사용된 오동나무 상자로부터 방출된 휘발성 유기화합물에 의한 항균활성 및 그 유효성분은 분석되지 않았으며, 생물피해로부터 고서적을 장기보관하기 위한 유물 보관함의 효율을 증진시키기 위해 천연 살생물제의 적용 가능성을 확인할 수 있었다. In order to assess antifungal activity of a wooden storage box, which was made of Paulownia tomentosa and used for keeping ancient documents, antifungal activity of volatile organic compounds emitted from the box was investigated along with qualitative analysis on major substances of the compounds. After collecting floating microorganisms inside air tester, the fungal activity was assessed by counting the number of colonies growing on TSA media. Compared to the control which collected 85 colonies from outdoor, 72 colonies were observed showing reduction rate of 14.82%. Through GC/MS and TDS system analysis, limonene was detected from the volatile organic compounds as characteristic features. When the fungal activity was assessed through fumigation by adding natural biocide BI and BII containing eugenol and anethole as major substances, both biocides showed a strong fungal activity with respectively 92.6%(inside the box) and 99.9%(outdoor) of reduction rate. Although these results didn't clarify antifungal activity of the volatile organic compounds emitted from the Paulownia-wood storage box and their functional components, it was at least confirmed that there is application possibility of natural biocide to use for preservation of ancient documents with increased efficiency in controlling pests of wooden storage boxes.

IoT를 활용한 에너지절약 시스템 구축

이수진 ( Su-jin Lee ),임상현 ( Sang-hyeon Lim ),최윤아 ( Yun-a Choi ),유상오 ( Sang-oh Yoo ) 한국정보처리학회 2021 한국정보처리학회 학술대회논문집 Vol.28 No.2

우리나라의 1인당 전력 소비량이 가파르게 증가하고 있으며 이에 따른 에너지 절약의 필요성이 대두되고 있다. 본 논문은 IoT 기술을 활용하여 더욱 간단하고 효율적인 저비용 에너지 절약 시스템을 제안한다. 실시간 모니터링과 센서 데이터를 기반으로 한 에너지 절약 시나리오 제공이 큰 특징이다. 구현한 시스템은 전력 사용량 peak 값과 전체적인 편차가 줄어드는 결과를 가져왔다. 더 나아가 가정뿐만 아니라 더 넓은 범위에 적용 가능할 것으로 기대된다.

과도 안정도 관점에서 분산전원이 미치는 영향에 관한 연구

서지수(Ji-Su Suh),이주희(Ju-Hyi Lee),이지현(Ji-Hyeon Lee),최윤아(Yun-A Choi),이동현(Dong-Hyeon Lee),김인수(Insu Kim) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.7

외래환자 처방전상에 나타난 약물 상호작용 실태 및 병원 조제담당 약사의 인지도 조사

김민선,최윤아,류윤미,한현주,이병구,박경호,조남춘 한국병원약사회 1999 병원약사회지 Vol.16 No.2

The importance of pharmacotherapies, as a medical treatment on diseases, is on the increase. By using various medicines at one time, it may give a rise to higher beneficial effects than using one medicine and adverse effects may be protected. Accordingly, many patients use more than two medicines or several ones against a complication. Because the likelihood of drug-drug interactions increase with the number of drugs prescribed for a patient, rigorous(or careful) attention and follow up are needed. As well as, the role of a special inspection for pharmacists becomes more important. The existence of drug interactions, the type of drug interactions, the possibility of administration, the extent and the range of effects, and the necessity of some managements must be checked. According as the above check points, the prescription must be certified. If it happens any problem, the most safe and effective pharmacotherapy must be adopted through the discussion with doctors. In this research, through the investigation of prescription for out patients and the evaluation of a possibility of drug interactions, the paper for questionnaire was made. A degree of recognition of pharmacists in hospitals about drug interaction was checked by the paper for questionnaire.