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Leukocytes as a Prognostic Factor for Patients with Pulmonary Embolism
최원일,조준연,최원일,권용식,이진욱,전영준 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
Background: Hemodynamic status and cardiac function are major pulmonary embolism (PE) prognostic factors. Although inflammation is considered a risk factor for deep vein thrombosis, the prognostic significance of the systemic inflammatory response syndrome (SIRS) and leukocytosis has not been well studied. Objective: This study evaluates PE prognostic factors, including SIRS and leukocytes. Patients/Methods: This retrospective cohort study included 667 PE patients. Risk evaluation included SIRS and leukocytosis. A prediction model was developed based on independent predictors of 30-day mortality. Results and Conclusions: Fifty-seven patients (8.5%) died within 30 days. Multivariate analysis showed that SIRS satisfying the WBC criteria (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.6-7.1), altered mental status (OR, 2.9; 95% CI, 1.2-7.4), and right-to-left ventricle diameter ratio (OR, 2.0; 95% CI, 1.1-3.7) were associated with 30-day mortality. SIRS criteria including body temperature (OR, 4.6; 95% CI, 1.4-14.8), heart rate (OR, 2.0; 95% CI, 1.1-3.6), respiratory rate (OR, 2.5; 95% CI, 1.4-4.6), and WBC count (OR, 1.9; 95% CI, 1.2-3.5) predicted short-term mortality in PE. The area under the receiver operating characteristic curve for the prognostic model`s prediction performance was 0.76 (95% CI, 0.66-0.85), and for pulmonary embolism severity index (PESI) and PESI + WBC count were 0.72 (95% CI, 0.68-0.75) and 0.76 (95% CI, 0.72-0.79, P<0.01 versus PESI), respectively. Leukocytoes and SIRS are important factors in determining short-term outcomes.
일반강도 콘크리트의 건조수축 저감방안에 관한 기초적 연구
최원일,남경용,하정수,정상진 단국대 부설 리모델링연구소 2012 리모델링 연구소 논문집 Vol.10 No.1
In this study, the drying shrinkage of concrete used for the reduction of expansive additive and shrinkage reducing agent committed to the concrete Mixing characteristics, compressive strength and drying shrinkage of examining my new honhwajaeryoin elements by putting in concrete Their characteristics were compared and analyzed. Experiments, SP was fixed jeryangeul equally expansive additive and shrinkage reducing agent in the formulation of the Injection rate increased with increasing fluidity, shrinkage reducing air flow rates increase the amount of air even if the input Increases with, and if the expansion of re-injection rates increase rather than decrease was found that the volume of air. I committed to the elements of the concrete, but an increase in inputs even if the air content of concrete or no liquidity Were confirmed to have no effect. In addition, the compressive strength test Shrinkage Reducing the dosage increases, Tended strength falls, inflation 5.0% of material inputs in the formulation was found to be the highest. Element material Concrete with Shrinkage Reducing committed a similar compressive strength falls with increasing dosage tended Unlike the small degree of shrinkage reducing agent was affected. Shrinkage characteristics include all three admixture With increasing dosage can reduce the drying shrinkage was observed that, if the shrinkage reducing agent, of the elements and almost Reducing the level of contraction was found to be. Therefore, the element first, if you commit to concrete admixtures to Characteristics of the concrete mix does not affect the lapse rate contract that can be used as a highly admixture is judged to be here.
골수기질세포와 진피섬유모세포의 이식이 교원질 합성에 미치는 영향
최원일,한승규,이병일,김우경 대한성형외과학회 2007 Archives of Plastic Surgery Vol.34 No.2
Purpose: In the previous in vitro studies the bone marrow stromal cells(BSCs) have shown the superior effect for wound healing activity than fibroblasts, which includes cell proliferation, type I collagen synthesis, and the production of bFGF, VEGF and TGF-β in chronic wound healing. The aim of this study is to compare the effects of BSCs and fibroblasts on wound healing activity in vivo, especially on collagen synthesis.Methods: The fibroblasts and BSCs were harvested from patients and cultured. The cultured cells were infiltrated into the pores of polyethylene discs. These discs were divided into three groups according to the mixed cells. In groups I, II and III the discs were loaded with no cells, fibroblasts and BSCs, respectively. Twelve discs per group(total 36 discs) were made for this study. After creating 6 pockets in the back of each rats, each discs was implanted into each pockets. At three time intervals from 1 to 3 weeks, the implanted discs were harvested for the histological and quantitative analysis. The amount of collagen produced was evaluated using ELISA. Statistical comparisons were made using the Mann-Whitney U-test.Results: There was great difference in the collagen synthesis among the three groups by the 1st and 2nd weeks. The BSC group showed highest collagen level, followed by fibroblast group and no cell group(p<0.05). The 3rd week specimens also showed greater collagen amount in BSC and fibroblast groups compared to those of no cell group(p<0.05). However, there was little difference between BSC and fibroblast groups.Conclusion: This result demonstrates that BSC has superior effect on stimulating wound healing than fibroblast, which is currently used for wound healing.
최원일,Yoon Jae-Hyun,Choi Seo-Hyun,Jeon Bu-Nam,Kim Hail,Hur Man-Wook 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Zbtb7c is a proto-oncoprotein that controls the cell cycle and glucose, glutamate, and lipid metabolism. Zbtb7c expression is increased in the liver and white adipose tissues of aging or high-fat diet-fed mice. Knockout or knockdown of Zbtb7c gene expression inhibits the adipocyte differentiation of 3T3-L1 cells and decreases adipose tissue mass in aging mice. We found that Zbtb7c was a potent transcriptional repressor of SIRT1 and that SIRT1 was derepressed in various tissues of Zbtb7c -KO mice. Mechanistically, Zbtb7c interacted with p53 and bound to the proximal promoter p53RE1 and p53RE2 to repress the SIRT1 gene, in which p53RE2 was particularly critical. Zbtb7c induced p53 to interact with the corepressor mSin3A-HADC1 complex at p53RE. By repressing the SIRT1 gene, Zbtb7c increased the acetylation of Pgc-1α and Pparγ, which resulted in repression or activation of Pgc-1α or Pparγ target genes involved in lipid metabolism. Our study provides a molecular target that can overexpress SIRT1 protein in the liver, pancreas, and adipose tissues, which can be beneficial in the treatment of diabetes, obesity, longevity, etc.