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류마티스 관절염 환자에서 빈뇨로 발현된 방광의 유전분증 2예
이창재 ( Chang Jae Lee ),최세웅 ( Se Woong Choi ),문승환 ( Seung Hwan Mun ),허정훈 ( Jung Hoon Huh ),김경태 ( Kyoung Tae Kim ),원종진 ( Jong Jin Won ),안원석 ( Won Suk An ),윤성국 ( Sung Kuk Yun ),홍숙희 ( Sook Hee Hong ),이성원 ( 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.3
Secondary amyloidosis is characterized by accumulation of an amorphous proteinous material in the various tissue and organs with infectious disease or inflammatory disease. Symptoms of the amyloidosis are variable according to the involved organs. Reactive amyloidosis of bladder in rheumatoid arthritis (RA) is a rare condition with hematuria in the most cases. However, we report two cases of patients with RA, who have frequency due to secondary amyloidosis of bladder without hematuria. Therefore secondary amyloidosis of urinary bladder should be considered as a possible cause of frequency in patients with long-term RA.
정석희 ( Seuk Hee Chung ),문승환 ( Seung Hwan Moon ),백정환 ( Jeung Hoan Paik ),김경태 ( Kyoung Tae Kim ),최세웅 ( Se Woong Choi ),이창재 ( Chang Jae Lee ),조용락 ( Young Rak Cho ),나서희 ( Seo Heui Ra ),안원석 ( Won Suk An ),김 대한내과학회 2006 대한내과학회지 Vol.70 No.6
목적: 막증식성 사구체신염은 혈뇨를 동반한 무증상성 요이상에서 신증후군, 만성신부전 등 다양한 임상증상을 나타내며 아직까지 그 원인이나 병인에 대한 정확한 기전이 알려져 있지 않고 확립된 치료방법도 없는 상태이다. 이에 저자들은 성인에서 특발성 막증식성 사구 체신염으로 진단된 환자들의 임상적 특징을 알아보고자 본 연구를 시행하였다. 방법: 연구 대상은 1990년 3월부터 2004년 11월까지 동아대학교병원 내과에서 시행한 조직검사 약 1,500예 중에서 Background: The manifestation of Membranoproliperative glomerulonephritis (MPGN) is variable from asymptomatic hematuria, nephrotic syndrome to advanced chronic kidney disease. The etiology, pathogenesis, and treatment of MPGN are unclear. The incidence of
고속 확장된 작업공간을 가진 병렬 로봇을 위한 경량 3-DOF 손목 메커니즘의 ANSYS 기반 응력해석
박상혁(Sang Hyeok Park),정원지(Won Jee Chung),황희건(Hui Geon Hwang),김홍록(Hong Rok Kim),최세웅(Se Woong Choi),지명준(Myeong Jun Jee),홍우철(Woo Cheol Hong) 한국기계가공학회 2022 한국기계가공학회지 Vol.21 No.2
This study proposed a method of testing the stability when selecting gears to reduce the weight of a 3-DOF wrist mechanism for a pick-and-place 3-DOF parallel robot with an increased workspace by using an additional straight axis at its top. We performed SolidWorks<SUP>Ⓡ</SUP> modeling- and ANSYS<SUP>Ⓡ</SUP>-based structural analysis of a pinion gear, which is most vulnerable to the force from a 3-DOF wrist mechanism, to lighten the robot weight for performing various tasks. When the initial analysis results considerably differed from the theoretical values calculated in advance, we checked and identified the errors in the contact conditions or input values. Ultimately, it is believed that the methodology presented in this paper will help in mitigating errors during analysis and determine the accurate values for a lightweight 3-DOF wrist mechanism for a parallel robot with an expanded workspace.
양측성 내인성 안구내염을 동반한 Group G 사슬알균 심내막염
최세웅,정동식,김경호,문승환,이창재,백정환,정석희,강아영,오원섭,이혁 대한감염학회 2005 감염과 화학요법 Vol.37 No.5
본 증례의 환자는 발열과 양측 시력소실을 주소로 내원하였으며, 양측성 내인성 안구내염을 동반한 group G 사슬알균 심내막염으로 진단되었고, 원인균은 Streptococcus dysgalactiae subsp. Equisimilis로 동정되었다. 전신적 항생제 치료중 패혈성 색전증으로 우측 후두엽의 뇌경색이 생겼으며, 내인성 안구내염의 급속한 악화로 결국 안구적출술을 시행하였다. group G 사슬알균 심내막염은 매우 드물고, 심각한 신경계 합병증을 일으키는 것으로 알려져 있으며, group G 사슬알균에 의한 내인성 안구내염 또한 예후가 좋지 않으며, 전세계적으로도 보고된 예가 수례에 불과하다. 저자들은 양측성 내인성 안구내염을 동반한 group G사슬알균 심내막염 1예를 경험하고 문헌고찰과 함께 보고하는 바이다. The group G streptococcal endocarditis is a rare form of infective endocarditis when present, and it is associated with serious neurological complications. Also, endogenous endophthalmitis due to group G streptococcal endocarditis has rarely been reported, and usually leads to total loss of vision. We report a case of group G streptococcal endocarditis which presented clinically as endophthalmitis unrelated to trauma or surgery in a 85-year-old diabetic man.
IgE 감작비만세포의 Histamine 방출에 대한 Flavonoids 및 그의 Acetate의 억제작용
최세웅,김창종 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-
Effect of flavonoids and their acetate such as morin, quercetin, naringin and hesperidin on histamine release from the degradation of lgE-sensitized mast cell induced by antigen challenge was studied in vitro. Flavonoids, morin and quercetin showed more potent inhibitory activity on histamine release than falvonones, naringin and hesperidin. At the concentration of 10^-4M, the inhibitory of flavonoids on histamine release was morin, quercetin. naringin and hesperidin inthe order named, respectively. From the concentration of 10^-8M to 10^-5M, quercetin had more potent inhibitory effect on histamine release than morin, but in 10^-4M, both of them showed similar inhibitory activity. Quercetinacetate at the concentration of 10^-8M, 10^-7M, 10^-6M and 10^-5M had better inhibitory effect on histamine release than its genin. The inhibitory effect of morin on histamine release was slightly reduced by acetylation. Acetylated flavonones reduced slightly the inhibitory effect on histamine release in lgE-sesitized mast cell in comparison with their genin. All flavonoids and their acetate showed the inhibitory effect on histamine release concentration of 10^-4M, quercetin have strongest activity, and flavonols have more potent inhibitory activity on histamine release than falvanones. Generally acetyl flavonoids decrease the inhibitory activity of histamine release in IgE-sensitized mast cell as compared with their flavonoids respectively, but quercetin acetate increase the inhibitory activity as compared as quercetin.
간염성 심내막염을 합병한 대동맥-대퇴동맥 간 우회로 인조혈관 감염 1예
정동식,문승환,최세웅,이창재,김경태,백정환,정영진,조광조,강도영,이혁 대한감염학회 2005 감염과 화학요법 Vol.37 No.5
본 증례는 복부 대동맥류와 양 장골동맥 폐색증으로 대동맥-양대퇴동맥 간 우회로 인조혈관 이식술을 시행했던 환자에서 술 후 이식편 감염과 심내막염이 발병한 예이다. 환자는 이식편 감염의 진단이 모호할 때 Tc-99m HMPAO 백혈구 스캔을 통해 감염을 확인하고, 재수술을 시행하여 특별한 합병증 없이 회복하여 퇴원하였다. 이식편 감염의 진단에 있어서 대개는 일반적인 창상감염에서 볼 수 있는 발열, 백혈구 증다증, 수술부위의 농양, 화농성 분비물 등을 통해 진단한다. 또한 영상학적 검사로 컴퓨터 단층촬영, 자기공명영상 등의 검사를 통해 이식편 감염을 진단하기도 한다. 하지만 술 후 초기 내지저독성의 감염인 경우 그리고 진단이 모호한 경우에는 백혈구 스캔을 통해 신속히 이식편 감염을 더 잘 진단할 수도 있어 국내에서 이식편 감염 진단방법으로써 백혈구스캔의 더 많은 활용과 연구가 요구된다. Prosthetic vascular graft infection (PVGI) is a relatively uncommon complication of peripheral vascular surgery and although rare, is the most severe complication in reconstructive vascular surgery. The early diagnosis of this complication can reduce the mortality. We report a case of aorto-femoral bypass graft infection, which was diagnosed by Tc-99m HMPAO WBC scan, complicated with infective endocarditis. A 60-year-old man had been operated with aortofemoral bypass graft because of aortojejunal fistula due to abdominal aortic aneurysm. Nine months later, he was admitted with fever of two months' duration. On echocardiolography, aortic regurgitation and vegetation were observed, and then he was diagosed with infective endocarditis. He was treated with antibiotics for 6 weeks. Recurrent bacteremia of unknown origin persisted despite antibiotic therapy. Multiple microorganisms were separately isolated from the blood cultures. He complained of intermittent right groin pain. Imaging study (CT, MRI, US) showed no definite evidence of graft infection. However, Tc-99m HMPAO WBC scan demonstrated uptake in the aortofemoral bypass graft site. The patient underwent emergent aortofemoral graft removal with axillobifemoral bypass and right femoropopliteal bypass.