알코올리즘 입원치료프로그램 참가자들의 퇴원 후 경과에 대한 연구

최성빈(Sung-Bin Choi),박병권(Byung-Kwon Park),김한오(Han-O Kim),원민혜(Min-Hye Won),손인기(In-Ki Sohn),함 웅(Woong Hahm) 한국중독정신의학회 2006 중독정신의학 Vol.10 No.1

Objectives:The purpose of this study is to evaluate the outcome of alcoholics who participated in an inpatient alcoholism treatment program of a mental hospital. At the same time, We studied the various clinical variables affecting the recovery of alcoholism. Methods:The 261 subjects who were diagnosed as alcohol dependence took part in the treatment program at the alcohol center in Keyo hospital at least for 2 weeks between January 2004 and December 2004. The subjects were followed up by faceto-face or telephone interview, and medical records were reviewed to obtain data on demographic characteristics, alcohol-related clinical characteristics, treatment process, etc. Results:1) the mean follow-up period was 19.67 months. 2) 141 of the 261 subjects were followed up, so the follow-up rate was 54.02% 3) 43 of the 141 subjects (30.5%) were classified into abstinent group, 23 (16.3%) into controlled drinking group, and 75 (53.2%) into relapse group. Abstinent and controlled drinking groups were called recovery group. So 66 (46.8%) of the 141 subjects were classified into recovery group. 4) By the comparison of relapse and recovery groups, education, socioeconomic status, occupation, and marital status are significantly different between groups. 5) Recovery group had a longer duration of abstinence before admission than relapse group. 6) Completion of alcoholism treatment program during admission and a return to work after discharge from hospital were associated with recovery of alcoholism. 7) In a stepwise regression model, four risk factors were significantly correlated with the recovery:a return to work after discharge from hospital, completion of alcoholism treatment program during admission, marital status, and duration of abstinence before admission. Conclusion:The variables above mentioned were thought to be the points to be duly considered for the better outcome of alcoholism.

리아프노프 지수를 이용한 알쯔하이머형 치매 환자 뇌파의 비선형 역동 분석을 위한 예비연구

채정호,김대진,최성빈,박원명,이정태,김광수,정재승,김수용,Chae, Jeong-Ho,Kim, Dai-Jin,Choi, Sung-Bin,Bahk, Won-Myong,Lee, Chung Tai,Kim, Kwang-Soo,Jeong, Jaeseung,Kim, Soo-Yong 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

치매에서의 뇌파 연구는 주로 주파수 분석과 지형화 분석을 이용하여 정량화하는 것을 위주로 진행되어 왔으나, 이러한 선형적 분석은 뇌파와 같이 복잡한 신호를 분석하는 것에는 한계가 있었다. 최근 새로운 패러다임인 카오스 이론에 근거를 두고 뇌파를 비선형적으로 측정하는 방법이 소개되고 있다. 본 연구는 알쯔하이머형 치매 환자의 뇌파 신호를 최대 양수 리아프노프 지수를 이용하여 비선형적으로 분석하는 것이 가능한 가를 알아보고 그 결과를 대조군과 비교해보기 위하여 시도되었다. 3명의 알쯔하이머형 치매 환자와 3명의 대조군에서 뇌파 신호를 받아 디지털화한 후에 비선형 분석법 중 하나인 최대 양수 리아프노프 지수를 산출하였다. 알쯔하이머형 치매군은 전체 15개의 전극 부위 중 8곳의 전극 부위에서 대조군에 비하여 유의하게 낮은 최대 양수 리아프노프 지수를 나타내었다. 각 두뇌 영역별 및 반구별 분석에서도 알쯔하이머형 치매군이 대조군에 비하여 전 두뇌 영역에서 최대 양수 리아프노프 지수가 유의하게 낮았다. 이에 따라 알쯔하이머형 치매 환자의 뇌파를 비선형적 분석하여 조사한 이들 두뇌의 카오스적 성상이 감소되어 있다는 것을 확인할 수 있었다. 이 결과는 향후 뇌파의 비선형적 분석인 리아프노프 지수 산출이 두뇌 기능을 조사하는 데에 유용한 새로운 방법이 될 가능성이 있다는 것을 시사한다. The changes of electroencephalogram(EEG) in patients with dementia of Alzheimer's type are most commonly studied by analyzing power or magnitude in traditionally defined frequency bands. However because of the absence of an identified metric which quantifies the complex amount of information, there are many limitations in using such a linear method. According to the chaos theory, irregular signals of EEG can be also resulted from low dimensional deterministic chaos. Chaotic nonlinear dynamics in the EEG can be studied by calculating the largest Lyapunov exponent($L_1$). The authors have analyzed EEG epochs from three patients with dementia of Alzheimer's type and three matched control subjects. The largest $L_1$ is calculated from EEG epochs consisting of 16,384 data points per channel in 15 channels. The results showed that patients with dementia of Alzheimer's type had significantly lower $L_1$ than non-demented controls on 8 channels. Topographic analysis showed that the $L_1$ were significantly lower in patients with Alzheimer's disease on all the frontal, temporal, central, and occipital head regions. These results show that brains of patients with dementia of Alzheimer's type have a decreased chaotic quality of electrophysiological behavior. We conclude that the nonlinear analysis such as calculating the $L_1$ can be a promising tool for detecting relative changes in the complexity of brain dynamics.

알코올 의존 환자에서 K-MMSE를 이용한 인지 기능 연구

서승진(Suhng-Jin Suh),최성빈(Sung-Bin Choi),김한오(Han-O Kim),원성두(Sung-Doo Won),손인기(In-Ki Sohn),함 웅(Woong Hahm),신경철(Kyung Chul Shin) 한국중독정신의학회 2009 중독정신의학 Vol.13 No.2

Objectives:This study aimed to characterize the cognitive functions of chronic alcohol dependent patients in their forties as compared to normal controls, via the K-MMSE (Korean version of the Mini-Mental State Examination). Methods:Participants were 25 male volunteers from the curative program at the Keyo hospital alcohol center, recruited from June 2007 to November 2007, and 25 male social drinkers who constituted the normal controls. We compared demographic characteristics, such as age, level of education, occupation, and socioeconomic status, and also K-MMSE results between the two groups. Results:Even though the demographic characteristics showed statistically significant differences between the two groups, their K-MMSE scores were not significantly different. Also, there was no identifiable correlation between demographic variables and K-MMSE total scores and subscales. The alcohol dependent patients varied significantly from the control group with regard to visuospatial area. Conclusion:In this study the cognitive functions and demographical variables such as education, occupation and socioeconomic status were not correlated. The subjects in two groups scored similar on K-MMSE in total score ; they had different scores in the test on their visuospatial area. In conclusion, some specific items of K-MMSE are thought to be applicable to predict whether patients with alcoholic dependence will have disability in their cognitive function.

하이테크 발전과 한국의 방위산업 조망

한희,최성빈 한국전략문제연구소 1999 전략연구 Vol.6 No.1

It is not difficult that new concept of warfare requires dramatical changes of not only force building structures but also national defense industry structures in near future. We can find a system in recent event that platform oriented industries in U. S. A. demolished or reduced after Gulfwar. A concept known as "information warfare" is rooted in the indisputable fact that information technologies are increasingly important to national security in general and to future warfare specifically which will increasingly by the struggle over information systems. Therefore, those who master the techniques of information warfare will find themselves at an advantage over those who have not: information warfare will relegate other, more traditional and conventional forms of warfare to the side lines. Now, we must accept a new paradigm of warfare which is for information warriors than maneuver warriors. It means that our force building policy have to change dramatically, may be after unification of Korea peninsula, and local defence industry to information defence industry. Information warfare force structure will requite defence industry change from quantitative based to quality based system. So, the MND policy will drive the defence industry changing to the high-tech oriented industry which can concentrated to the information warfare weapon system development rather than platform system only. This kind of changing will increase the dependency of commercially used technology and product to the development process. Function management system will be also shifted to project based management system.