한국인의 G Protein $\beta$3 Subunit유전자의 다형성과 뇌혈관 질환과의 상관성에 대한 연구

최민희,이진우,이경진,이효정,노삼웅,최현,조기호,홍무창,신민규,김영석,배현수,Choi Min Hee,Lee Jin Woo,Lee Kyung Jin,Lee Hyo Jung,Rho Sam Woong,Choi Hyun,Cho Ki Ho,Hong Moo Chang,Shin Min Kyu,Kim Young Suk,Bae Hyun Su 대한동의생리학회 2003 동의생리병리학회지 Vol.17 No.3

Background and purpose: Hypertension and obesity has been implicated in the most important risk factors for stroke. The original finding that the G-protein beta3 subunit (GNB3) C825T allele associates with essential hypertension and obesity has been confirmed in several different populations. Hence, our objective was to determine whether the GNB3 C825T polymorphism predicts interindividual variation in stroke. Method: We recruited 361 stroke patients (cerebral infarction, n=278; intracerebral hemorrhage (ICH), n=83) and 199 healthy control subjects. Subjects were genotyped for GNB3 C825T mutation and findings were investigated for association with stroke. Result: The GNB3 T/T type was significantly associated with cerebral infarction prevalence (OR, 1.98; 95% Cl, 1.14-3.46; p=0.015). While, ICH was not found to be significantly associated with GNB3 T/T type (OR, 1.63; 95% ICH, 0.74-3.56; p=0.219). Similarly, no significant association was determined between GNB T/C type, and cerebral infarction (OR, 1.09; 95% Cl, 0.68-1.74; p=0.716), and ICH (OR, 1.14; 95% Cl, 0.59-2.21; p=0.697). Conclusion: In clinical characteristics, this study shows no differences among GNB3 genotypes, that are BMI, WH ratio. hypertension rate, and ischemic heart disease rate, total lipid level, triglycerides level, total cholesterol level, HDL cholesterol level, prothrombine time, with the exception of LDL cholesterol concentrations. However, our subjects showed an inverse relationship between LDL cholesterol level and the risk of cerebral infarction. We have shown that the GNB3 T/T genotype is strongly associated with cerebral infarction. (OR, 1.98; 95% Cl, 1.14-3.46; p=0.015).

케이슨 구조계의 설계 최적성 평가

최민희(Choi Min-Hee),류연선(Ryu Yeon-Sun),김정태(Kim Jeong-Tae),나원배(Na Won-Bae) 대한토목학회 2005 대한토목학회 학술대회 Vol.2005 No.10

‘儀鳳四年皆土’ 글씨기와의 ‘개토’ 재론

崔珉熙(Choi, Min-hi) 한국고대사탐구학회 2018 한국고대사탐구 Vol.30 No.-

신라에서 연호를 타날판에 새겨서 찍은 기와는 경주 전역에서 발견되는 ‘의봉4 년개토’ 글씨기와 그리고 부여 부소산성에서 발견된 ‘회창7년정묘년말인’ 글씨기와가 있다. 이 가운데 ‘의봉4년개토’ 글씨기와에서 ‘개토’를 해석함에 ‘모두 아울렀다.’는 의미로 삼국을 통일하였음을 나타낸다고 보아왔다. 여기에 ‘공사를 하였다.’ 는 의미로 해석한 견해도 있었다. 한 걸음 더 나아가 ‘모두 땅을 아울렀고, 이를 기념해서 대규모 공사를 하였는데, 이는 ’일통삼한‘을 의미한다.’로 확대 해석하는 견해가 있었다. 하지만 ‘개토’는 그런 의미가 아니라, ‘모두 ‘납음오행’의 토에 해당한다.’로 해석한 견해가 새롭게 제시되었다. 중국에서 경운2년 조성된 종에 “景雲二秊太歲辛亥金九月癸酉金朔一十五日丁亥土鑄成”이라고 되어 있다. 여기에서 연월일의 간지 다음에 납음오행을 표기하는 방식을 사용하였다. 이를 신라에서 도입하여 같은 방식을 사용하는데, 마침 의봉4년과 공사를 개시한 월과 일 모두의 납음오행이 똑같이 ‘토’가 되는 날을 선택하여 ‘개토’라고 표기하였다는 것이다. 하지만 ‘의봉4년’은 679년인데 ‘경운2년’은 711년으로, 당에서 사용한 납음오행의 영향으로 신라에서도 사용되었다고 해석하면 연대를 거슬러야 하는 등의 문제가 발생한다. 또 경운종에서 연월일 표기가 연간지[태세]+월간지[월건]+일간지[일진]라고 보았으나 연간지+삭간지+일간지로 바로잡아야 한다. 그러면 3월과 4월은 납음오행의 ‘토’가 되지 못하는 문제가 발생한다. 결과 연월일 모두 토이므로 ‘개토’라고 표기 하였다는 근거가 사라진다. 이외에 논문에 포함된 내용 가운데 합당하지 않다고 판단되는 예를 포함하여 납음오행에 의한 해석은 잘못된 것이라고 보았다. 따라서 납음오행의 토가 아니라 ‘모두 아울렀으니 우리 땅이 되었다.’는 의미가 맞고, 이 해에 대규모 토목공사를 시행하였다고 본 것이다. 결론적으로 ‘의봉4 년개토’ 글씨기와를 통해 신라는 ‘백제를 포함하는 땅을 모두 아울렀다.’는 의식의 표현이라고 보았다. Tiles produced during the Silla Dynasty with the imprint made by the beating plate incised with the era name are divided into 〈Euibong Sanyeon Gaeto〉tiles discovered all over Gyeongju area. Meanwhile, 〈Gaeto〉in 〈Euibong Sanyeon Gaeto〉 tile has been interpreted as ‘all-conquered’ and deemed to express the unification of the three kingdoms. However, there is a new opinion that interprets 〈Gaeto〉 as ‘all are the Land element of the 〈Nabeum Ohaeng〉’. According to this opinion, inscribed on the surface of the bell cast in the second year in Jingyun Era of China. Nonetheless, the fourth year in the Euibong Era is 679 and the second year in the Jingyun Era is 711. If it is interpreted that the Five Elements used during the Tang Dynasty were also used during the Silla Dynasty, there would be problems such as the inconsistency in time sequence. Also, the interpretation of the date on the Jingyun Bell shall be corrected as the combination of 「zodiac sign of year」+「zodiac sign of the first day of the month」+「zodiac sign of the day」. This indicates that the element for March and April is not ‘land.’ Therefore, 〈Gaeto〉 shall be interpreted that they ‘Conquered and made all lands ours’ and that a large-scale civil work was executed in that year instead of ‘zodiac signs of the year, month, and day are all Land element of the Five Elements.’ In summary, the 〈Euibong Sanyeon Gaeto〉 shall be interpreted that Silla ‘executed a large-scale construction in the fourth year in the Euibong Era in celebration of the unification of the Three Hans’ and it represents Silla people’s sense of unification.

전처리된 천연제올라이트를 지지체로 사용한 나노영가철@제올라이트를 이용한 박스형 반응기 내 6가 크롬 제거 연구

최민희(Minhee Choi),배성준(Sungjun Bae),윤선호(Sunho Yoon),정주은(Jueun Jung),신서연(Seoyeon Shin) 대한환경공학회 2021 대한환경공학회 학술발표논문집 Vol.2021 No.11

자연재난에 의한 전력설비 피해 예측을 위한 인공신경망(ANN) 알고리즘 개발

최민희(Min-Hee Choi),정남준(Nam-Joon Jung),이규철(Kyu-Chul Lee),정재성(Jae-Sung Jeong),서인용(In-Young Seo) 대한전기학회 2019 전기학회논문지 Vol.68 No.9

Damage to the power system caused by natural disasters, including typhoons, is gradually increasing. The amount of the power outage caused by major typhoons shows 1.25 million households by “Rusa” in 2002, 1.44 million by “Maemi” in 2003, 1.68 million by “Kompasu” in 2010, 1.93 million by “Bolaven” in 2012 and 0.25 million by “Chaba” in 2016. Power companies are striving to establish an integrated system and simulators to predict power facility damage by natural disasters in advance and to establish a rapid response system in case of damage. In this paper, we developed the power facility damage prediction algorithm applied artificial neural network (ANN) for 6 kinds of natural disasters such as typhoon, strong wind, heavy rain, heavy snow, cold wave and heat wave. The algorithm consists of three phases: ① the establishment of big data by extracting meteorological data from the Automatic Weather System from 2007 to 2018, ② the analysis of the correlation between the power failures and the weather conditions(such as wind speed, rainfall, etc.) and ③ the evaluation of damage prediction algorithms using the ANN. In particular, comparisons and analyses with the Linear Regression(REG) algorithm were performed to assess the accuracy of the ANN algorithm. This algorithm was applied to Typhoon “Chaba” in 2016 to predict the failure of electric wires and Cut Out Switch (COS) in Seogwipo. The prediction error(MAE) of the ANN is 0.127, which is better than the performance of the REG.

전력설비 재난피해예측 시뮬레이션 시스템 설계 및 구현

최민희(MinHee Choi),박영준(YoungJun Park),왕세래(Serae Wang),김민수(MinSu Kim) 대한전기학회 2020 대한전기학회 학술대회 논문집 Vol.2020 No.7

지식 엔진 기반 당뇨 유헬스 서비스 개발 사례

최민희(Min-Hee Choi),김정아(Jeong-Ah Kim),한수나(Soo-Na Han),장학철(Hak-Chul Jang) 한국정보기술학회 2010 Proceedings of KIIT Conference Vol.2010 No.-

의료서비스의 전문화 및 다양화 그리고 디바이스의 발달은 대면 중심의 의료체계에서 예방 사후관리, 맞춤형 의료서비스 등 새로운 의료서비스의 형태로 진화하고 있다. 본 논문에서는 지식 엔진 기반 당뇨 유헬스 서비스에 대하여 사례를 통해 환자 데이터를 지능적으로 처리하고 판단한 개인 맞춤형 의료 서비스를 제공해주는 방법을 제공하고자 하였으며. 지식 엔진 기반 당뇨 유헬스 서비스 설계 및 개발 운영 과정에서 주요 이슈들을 도출하여 새로운 의료서비스에 더욱 효율적이고, 간편하게 수행하기 위한 방법을 제공하고자 한다. The specialization and diversity of medial service and the development of device have caused new types of medical services such as prevention, after-care service, and the medical service based on patients' needs. The study examined the examples of Glycosuria U-health service based on knowledge engine to provide the way of individual based medical services, which processes and infers patients' data intelligently. It also aims to provide more effective and convenient method of new medical services by identifying the problems which are caused in the process of Glycosuria U-health service based on knowledge engine.

녹차 섭취 경락마사지가 중년여성의 산화스트레스와 피로에 미치는 영향

최민희(Min-Hee Choi). 강상모(Sang-Mo Kang) 한국인체미용예술학회 2014 한국인체미용예술학회지 Vol.15 No.2

In terms of lactic acid levels, a statistically significant decrease was observed in both the control group (3.5%) and experimental group (35.4%). In terms of uric acid levels, a statistically significant decrease by 3.0% and 5.4% was found in the control and experimental groups, respectively. In terms of hormone changes, cortisol levels declined by 28.6% in the control group and by 32.4% in the experimental group with statistical significance. In terms of serotonin levels, no statistically significant difference was detected in either group. In terms of oxygen free radical-related changes, SOD increased with statistical significance by 22.9% in the control and by 41.3% in the experimental group. In terms of BAP, a 0.8% increase was found in the control group while a statistically significant increase (2.6%) was observed in the experimental group. In terms of d-ROMs, a statistically significant decrease was detected in the control (2.7%) and experimental (4.3%) groups. The results above reveal that the experimental group is weaker than the control group in terms of post-massage fatigue severity because of low lactic acid and uric acid levels. In addition, it appears that low cortisol, high SOD, high BAP and low d-ROMs had an effect on the results.

전신경락마사지 전 대추 섭취가 마사지 후 중년여성의 산화스트레스와 피로에 미치는 영향

최민희(Min Hee Choi),강상모(Sang Mo Kang) 한국인체미용예술학회 2014 한국인체미용예술학회지 Vol.15 No.4

This study attempted to develop and suggest a plan to maximize the effects of meridian massage for middle-aged women (aged 30s-50s) living in Seoul and Gyeonggi-do. For this, the effects of meridian massage with jujube tea. In this study, following meridian massage, fatigue sufferers were divided into two groups. A total of 8 people from the control group drank 100ml of water prior to the relaxing therapeutic treatment while those from the experimental group drank 100ml of jujube-infused (25g) water. After a 2-hour meridian massage, fatigue severity was assessed and a blood analysis performed. After meridian massage, fatigue severity improved from 'more than average' to 'mild or below' in five respondents (62.5%) in the jujube tea experimental group. The blood analysis revealed that after the meridian massage, lactic acid decreased by 4.0% and 32.1% in the control group and experimental group, respectively. In terms of uric acid, a significant decline was observed in both the control group (3.3%) and experimental group (6.6%). In terms of hormone changes, cortisol decreased by 28.7% and 39.5% in the control group and experimental group, respectively. Regarding serotonin, no significant difference was found in either group. Regarding oxygen free radical-related changes, SOD increased by 55.7% and 10.6% in the control group and experimental group, respectively. In terms of BAP, an 0.8% increase was found in the control group while a 4.9% increase was observed in the experimental group. In terms of D-ROMs, in contrast, the control group declined by 2.9% while the experimental group increased by 5.2%. Therefore, it appears that lowered fatigue was found after meridian massage in the experimental group because of the low lactic acid and uric acid levels. In addition, a decrease in cortisol levels, a slight increase in SOD and a significant increase of BAP had an effect on lowering fatigue as well. As a result,

지식 엔진을 이용한 당뇨 유헬스 서비스 개발과 적용 사례

최민희(Min-Hee Choi),김정아(Jeong-Ah Kim),장학철(Hak-Chul Jang) 한국정보기술학회 2010 한국정보기술학회지 Vol.8 No.-